CO4970722A1 - Derivados de eritromicina con puente en 6, 9 - Google Patents

Derivados de eritromicina con puente en 6, 9

Info

Publication number
CO4970722A1
CO4970722A1 CO98050780A CO98050780A CO4970722A1 CO 4970722 A1 CO4970722 A1 CO 4970722A1 CO 98050780 A CO98050780 A CO 98050780A CO 98050780 A CO98050780 A CO 98050780A CO 4970722 A1 CO4970722 A1 CO 4970722A1
Authority
CO
Colombia
Prior art keywords
group
bridge
erythromycin derivatives
hydrogen
cladinose
Prior art date
Application number
CO98050780A
Other languages
English (en)
Inventor
Yat Sun Or
Richard F Clark
Daniel T Chu
Jacob J Plattner
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CO4970722A1 publication Critical patent/CO4970722A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Un compuesto seleccionado de un grupo consistente en:así como sales, ésteres y profármacos de los mismos, farmacéuticamente aceptables, en dondeRp es un hidrógeno o un grupo protector de hidróxido;una de las Y y Z es H y la otra es seleccionada del grupo consistente de hidrógeno, hidroxi protegido y -O-cladinosa, o Y y Z son tomados junto con el átomo al cual están enlazados para formar un grupo oxo.
CO98050780A 1997-09-08 1998-09-04 Derivados de eritromicina con puente en 6, 9 CO4970722A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/925,582 US5780605A (en) 1997-09-08 1997-09-08 6,9-bridged erythromycin derivatives

Publications (1)

Publication Number Publication Date
CO4970722A1 true CO4970722A1 (es) 2000-11-07

Family

ID=25451953

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98050780A CO4970722A1 (es) 1997-09-08 1998-09-04 Derivados de eritromicina con puente en 6, 9

Country Status (24)

Country Link
US (1) US5780605A (es)
EP (1) EP1015467B1 (es)
JP (1) JP2001515915A (es)
KR (1) KR20010023756A (es)
CN (1) CN1269803A (es)
AR (1) AR015434A1 (es)
AT (1) ATE257484T1 (es)
AU (1) AU9216298A (es)
BG (1) BG104288A (es)
BR (1) BR9812148A (es)
CA (1) CA2301643A1 (es)
CO (1) CO4970722A1 (es)
DE (1) DE69821009T2 (es)
DK (1) DK1015467T3 (es)
ES (1) ES2213915T3 (es)
HU (1) HUP0003571A2 (es)
IL (1) IL134220A0 (es)
NO (1) NO20001169L (es)
PL (1) PL339137A1 (es)
PT (1) PT1015467E (es)
SK (1) SK3032000A3 (es)
TR (1) TR200000620T2 (es)
WO (1) WO1999012947A1 (es)
ZA (1) ZA987688B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7464097B2 (en) * 2002-08-16 2008-12-09 Sap Ag Managing data integrity using a filter condition
AR043050A1 (es) * 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
JP2006523229A (ja) * 2003-03-05 2006-10-12 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性複素環式化合物ならびにその製造および使用方法
EP1682563A1 (en) * 2003-10-30 2006-07-26 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and mehtods of making and using the same
US20070270357A1 (en) * 2003-11-18 2007-11-22 Farmer Jay J Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
WO2005080408A1 (en) * 2004-01-23 2005-09-01 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
WO2005085266A2 (en) * 2004-02-27 2005-09-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
BRPI0610477A2 (pt) * 2005-05-04 2010-06-22 Enanta Pharm Inc composto, composição farmacêutica que compreende o mesmo, método de tratamento de uma infecção bacteriana, de uma inflamação e de fibrose cìstica em um paciente com necessidade do mesmo
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
MX2010002932A (es) * 2007-09-17 2010-05-27 Enanta Pharm Inc Macrolidos de biarilo con puente en 6, 11.
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6248696A (ja) * 1985-08-27 1987-03-03 Kanegafuchi Chem Ind Co Ltd Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2662094B2 (ja) * 1992-01-21 1997-10-08 アボツト・ラボラトリーズ ４″−デオキシエリスロマイシン誘導体
US5591837A (en) * 1992-04-22 1997-01-07 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide a derivative
MY113693A (en) * 1992-05-26 2002-05-31 Chugai Pharmaceutical Co Ltd Erythromycin derivatives having an enterokinesis stimulating action
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5712253A (en) * 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B

Also Published As

Publication number Publication date
HUP0003571A2 (hu) 2001-02-28
ZA987688B (en) 1999-02-24
IL134220A0 (en) 2001-04-30
SK3032000A3 (en) 2000-07-11
EP1015467A1 (en) 2000-07-05
PL339137A1 (en) 2000-12-04
AR015434A1 (es) 2001-05-02
WO1999012947A1 (en) 1999-03-18
ATE257484T1 (de) 2004-01-15
PT1015467E (pt) 2004-05-31
BG104288A (bg) 2001-01-31
DK1015467T3 (da) 2004-05-03
KR20010023756A (ko) 2001-03-26
EP1015467B1 (en) 2004-01-07
JP2001515915A (ja) 2001-09-25
CN1269803A (zh) 2000-10-11
BR9812148A (pt) 2000-07-18
TR200000620T2 (tr) 2000-09-21
US5780605A (en) 1998-07-14
NO20001169D0 (no) 2000-03-07
NO20001169L (no) 2000-04-05
DE69821009D1 (de) 2004-02-12
AU9216298A (en) 1999-03-29
CA2301643A1 (en) 1999-03-18
ES2213915T3 (es) 2004-09-01
DE69821009T2 (de) 2004-11-18

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