BR9812148A - Derivados de eritromicina 6,9-ligados em ponte - Google Patents

Derivados de eritromicina 6,9-ligados em ponte

Info

Publication number
BR9812148A
BR9812148A BR9812148-0A BR9812148A BR9812148A BR 9812148 A BR9812148 A BR 9812148A BR 9812148 A BR9812148 A BR 9812148A BR 9812148 A BR9812148 A BR 9812148A
Authority
BR
Brazil
Prior art keywords
erythromycin derivatives
compound
effective amount
pharmaceutically acceptable
bridged erythromycin
Prior art date
Application number
BR9812148-0A
Other languages
English (en)
Inventor
Yat Sun Or
Richard F Clark
Daniel T Chu
Jacob J Plattner
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BR9812148A publication Critical patent/BR9812148A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

"DERIVADOS DE ERITROMICINA 6,9-LIGADOS EM PONTE" São revelados novos compostos eritromicina multicíclicos e sais farmaceuticamente aceitáveis e ésteres dos mesmos possuindo atividade antibacteriana possuindo a fórmula (I), (II) ou (III), composições compreendendo uma quantidade terapeuticamente eficaz de um composto da invenção, em combinação com um veículo farmaceuticamente aceitável, bem como um processo para tratamento de infecções bacterianas por administração a um mamífero, de uma composição farmacêutica contendo uma quantidade farmaceuticamente eficaz de um composto da invenção.
BR9812148-0A 1997-09-08 1998-09-01 Derivados de eritromicina 6,9-ligados em ponte BR9812148A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/925,582 US5780605A (en) 1997-09-08 1997-09-08 6,9-bridged erythromycin derivatives
PCT/US1998/018225 WO1999012947A1 (en) 1997-09-08 1998-09-01 6,9-bridged erythromycin derivatives

Publications (1)

Publication Number Publication Date
BR9812148A true BR9812148A (pt) 2000-07-18

Family

ID=25451953

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812148-0A BR9812148A (pt) 1997-09-08 1998-09-01 Derivados de eritromicina 6,9-ligados em ponte

Country Status (24)

Country Link
US (1) US5780605A (pt)
EP (1) EP1015467B1 (pt)
JP (1) JP2001515915A (pt)
KR (1) KR20010023756A (pt)
CN (1) CN1269803A (pt)
AR (1) AR015434A1 (pt)
AT (1) ATE257484T1 (pt)
AU (1) AU9216298A (pt)
BG (1) BG104288A (pt)
BR (1) BR9812148A (pt)
CA (1) CA2301643A1 (pt)
CO (1) CO4970722A1 (pt)
DE (1) DE69821009T2 (pt)
DK (1) DK1015467T3 (pt)
ES (1) ES2213915T3 (pt)
HU (1) HUP0003571A2 (pt)
IL (1) IL134220A0 (pt)
NO (1) NO20001169L (pt)
PL (1) PL339137A1 (pt)
PT (1) PT1015467E (pt)
SK (1) SK3032000A3 (pt)
TR (1) TR200000620T2 (pt)
WO (1) WO1999012947A1 (pt)
ZA (1) ZA987688B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7464097B2 (en) * 2002-08-16 2008-12-09 Sap Ag Managing data integrity using a filter condition
US7091196B2 (en) * 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
KR20060002800A (ko) * 2003-03-05 2006-01-09 립-엑스 파마슈티칼즈, 인크. 이관능성 헤테로시클릭 화합물, 및 그의 제조 및 사용 방법
EP1682563A1 (en) * 2003-10-30 2006-07-26 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and mehtods of making and using the same
US20070270357A1 (en) * 2003-11-18 2007-11-22 Farmer Jay J Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
WO2005080408A1 (en) * 2004-01-23 2005-09-01 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
MX2007013730A (es) * 2005-05-04 2008-01-28 Enanta Pharm Inc Derivados de eritromicina oxima con puente 6-11.
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
JP5642548B2 (ja) * 2007-09-17 2014-12-17 エナンタ ファーマシューティカルズ インコーポレイテッド ６，１１−架橋ビアリールマクロライド
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6248696A (ja) * 1985-08-27 1987-03-03 Kanegafuchi Chem Ind Co Ltd Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
MX9300278A (es) * 1992-01-21 1993-12-31 Abbott Lab Compuestos de arilalcoxifenoxi-imidazolina.
DK0638584T3 (da) * 1992-04-22 1996-04-15 Taisho Pharmaceutical Co Ltd 5-O-desosaminyl-erythronolid-A-derivat
MY113693A (en) * 1992-05-26 2002-05-31 Chugai Pharmaceutical Co Ltd Erythromycin derivatives having an enterokinesis stimulating action
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5712253A (en) * 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B

Also Published As

Publication number Publication date
EP1015467B1 (en) 2004-01-07
IL134220A0 (en) 2001-04-30
ZA987688B (en) 1999-02-24
JP2001515915A (ja) 2001-09-25
DK1015467T3 (da) 2004-05-03
DE69821009D1 (de) 2004-02-12
EP1015467A1 (en) 2000-07-05
CO4970722A1 (es) 2000-11-07
CN1269803A (zh) 2000-10-11
HUP0003571A2 (hu) 2001-02-28
NO20001169D0 (no) 2000-03-07
SK3032000A3 (en) 2000-07-11
BG104288A (bg) 2001-01-31
PT1015467E (pt) 2004-05-31
AU9216298A (en) 1999-03-29
AR015434A1 (es) 2001-05-02
NO20001169L (no) 2000-04-05
KR20010023756A (ko) 2001-03-26
TR200000620T2 (tr) 2000-09-21
US5780605A (en) 1998-07-14
ATE257484T1 (de) 2004-01-15
ES2213915T3 (es) 2004-09-01
WO1999012947A1 (en) 1999-03-18
PL339137A1 (en) 2000-12-04
CA2301643A1 (en) 1999-03-18
DE69821009T2 (de) 2004-11-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O, 7O, 8O E 9O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.