CO2020015231A2 - Polinucleótidos para la amplificación y detección de chlamydia trachomatis - Google Patents

Polinucleótidos para la amplificación y detección de chlamydia trachomatis

Info

Publication number
CO2020015231A2
CO2020015231A2 CONC2020/0015231A CO2020015231A CO2020015231A2 CO 2020015231 A2 CO2020015231 A2 CO 2020015231A2 CO 2020015231 A CO2020015231 A CO 2020015231A CO 2020015231 A2 CO2020015231 A2 CO 2020015231A2
Authority
CO
Colombia
Prior art keywords
detection
chlamydia trachomatis
polynucleotides
amplification
sample
Prior art date
Application number
CONC2020/0015231A
Other languages
English (en)
Inventor
Daniel Capule
Andrea C Dedent
Matthew B Lee
Shuyuan Ma
Hédia Maamar
Dana Kelly Vanatta
Original Assignee
Talis Biomedical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Talis Biomedical Corp filed Critical Talis Biomedical Corp
Publication of CO2020015231A2 publication Critical patent/CO2020015231A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/10—Nucleotidyl transfering
    • C12Q2521/107—RNA dependent DNA polymerase,(i.e. reverse transcriptase)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/101—Linear amplification, i.e. non exponential
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/10—Detection mode being characterised by the assay principle
    • C12Q2565/101—Interaction between at least two labels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La invención proporciona métodos y composiciones para la detección de Chlamydia trachomatis en una muestra de prueba. Su presencia o ausencia en la muestra se determina mediante métodos de prueba basados en ácidos nucleicos que utilizan cebadores y/o sondas y/o balizas moleculares que se unen a los genes ribosomales 23S o transcripciones génicas.
CONC2020/0015231A 2018-05-09 2020-12-03 Polinucleótidos para la amplificación y detección de chlamydia trachomatis CO2020015231A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862669236P 2018-05-09 2018-05-09
US15/976,733 US10450616B1 (en) 2018-05-09 2018-05-10 Polynucleotides for the amplification and detection of Chlamydia trachomatis
PCT/US2019/031439 WO2019217627A1 (en) 2018-05-09 2019-05-09 Polynucleotides for the amplification and detection of chlamydia trachomatis

Publications (1)

Publication Number Publication Date
CO2020015231A2 true CO2020015231A2 (es) 2020-12-21

Family

ID=68241766

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0015231A CO2020015231A2 (es) 2018-05-09 2020-12-03 Polinucleótidos para la amplificación y detección de chlamydia trachomatis

Country Status (14)

Country Link
US (4) US10450616B1 (es)
EP (1) EP3790996A4 (es)
JP (2) JP7402180B2 (es)
KR (1) KR20210006964A (es)
CN (1) CN112368400A (es)
AU (1) AU2019265733A1 (es)
BR (1) BR112020022762A2 (es)
CA (1) CA3098140A1 (es)
CO (1) CO2020015231A2 (es)
MX (1) MX2020011892A (es)
PH (1) PH12020551880A1 (es)
SG (1) SG11202010697YA (es)
WO (1) WO2019217627A1 (es)
ZA (1) ZA202007173B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10450616B1 (en) * 2018-05-09 2019-10-22 Talis Biomedical Corporation Polynucleotides for the amplification and detection of Chlamydia trachomatis
US10954572B2 (en) 2019-07-25 2021-03-23 Talis Biomedical Corporation Polynucleotides for the amplification and detection of Neisseria gonorrhoeae
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
CA3153514A1 (en) * 2019-09-05 2021-03-11 Gen-Probe Incorporated Detection of chlamydia trachomatis nucleic acid variants
US11891662B2 (en) 2019-12-02 2024-02-06 Talis Biomedical Corporation Polynucleotides for amplification and detection of human beta actin
KR102392567B1 (ko) * 2021-11-30 2022-04-29 주식회사 에이아이더뉴트리진 클라미디아 진단용 조성물 및 다중 등온증폭 프라이머 세트, 그리고 이를 이용한 신속성, 정확성 및 휴대성이 향상된 키트와 진단키트를 통한 육안진단방법

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
US5155018A (en) 1991-07-10 1992-10-13 Hahnemann University Process and kit for isolating and purifying RNA from biological sources
DE4321904B4 (de) 1993-07-01 2013-05-16 Qiagen Gmbh Verfahren zur chromatographischen Reinigung und Trennung von Nucleinsäuregemischen
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
US20100267012A1 (en) * 1997-11-04 2010-10-21 Bergeron Michel G Highly conserved genes and their use to generate probes and primers for detection of microorganisms
ES2230631T3 (es) 1997-03-20 2005-05-01 F. Hoffmann-La Roche Ag Cebadores modificados.
US7572902B2 (en) * 1997-12-09 2009-08-11 Monsanto Technology Llc Nucleic acid molecules seq id No. 16372 and other molecules associated with plants
GB0103424D0 (en) 2001-02-12 2001-03-28 Chiron Spa Gonococcus proteins
US7807802B2 (en) 2002-11-12 2010-10-05 Abbott Lab Polynucleotides for the amplification and detection of Chlamydia trachomatis and Neisseria gonorrhoeae
EP1815863A1 (en) 2006-02-03 2007-08-08 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Use of TLR3 agonists for the treatment of neurodegenerative disorders
WO2008095152A2 (en) 2007-02-01 2008-08-07 Veridex, Llc Methods and materials for identifying the origin of a carcinoma of unknown primary origin
JP4410268B2 (ja) 2007-03-28 2010-02-03 株式会社東芝 メチレンテトラヒドロ葉酸還元酵素（ｍｔｈｆｒ）の遺伝子型を検出するための核酸プライマーセット及び核酸プローブ
WO2008127921A2 (en) * 2007-04-13 2008-10-23 Abbott Laboratories Primer and probe sequences for detecting chlamydia trachomatis
US8524444B2 (en) * 2007-06-15 2013-09-03 President And Fellows Of Harvard College Methods and compositions for detections and modulating O-glycosylation
JP2009000044A (ja) 2007-06-21 2009-01-08 Hitachi High-Technologies Corp 核酸増幅法
JP5313157B2 (ja) 2007-10-19 2013-10-09 栄研化学株式会社 核酸増幅法、それに用いる試薬及び試薬キット
WO2010010951A1 (ja) 2008-07-24 2010-01-28 Kuroda Masahiko 子宮内膜症関連疾患の指標ｍＲＮＡの発現の検出方法およびそれに用いるプローブ
CN101831488A (zh) 2009-03-11 2010-09-15 孙星江 利用环介导等温扩增技术快速检测淋病奈瑟菌
GB0922097D0 (en) 2009-12-17 2010-02-03 Atlas Genetics Ltd Microbial assay
CN101886122B (zh) 2010-05-10 2012-10-17 珠海市银科医学工程有限公司 环介导恒温扩增检测肺炎衣原体的方法及检测试剂盒
EP2388312A1 (en) 2010-05-17 2011-11-23 Curetis AG Universally applicable lysis buffer and processing methods for the lysis of bodily samples
US9568575B2 (en) 2010-10-22 2017-02-14 T2 Biosystems, Inc. Conduit-containing devices and methods for analyte processing and detection
JP2012085605A (ja) 2010-10-22 2012-05-10 Sony Corp 核酸増幅反応装置、核酸増幅反応装置に用いる基板、及び核酸増幅反応方法
JP5838550B2 (ja) * 2010-12-22 2016-01-06 東ソー株式会社 クラミジア・トラコマチスｒｎａの検出方法及び検出試薬
CN102559861B (zh) * 2010-12-30 2016-08-10 上海星耀医学科技发展有限公司 沙眼衣原体核酸快速检测试剂盒
US20130017539A1 (en) * 2011-07-11 2013-01-17 Program For Appropriate Technology In Health Methods and compositions for chlamydia trachomatis diagnostic testing
KR101958048B1 (ko) 2011-10-31 2019-03-13 에이껜 가가꾸 가부시끼가이샤 표적 핵산의 검출법
US9074249B2 (en) 2012-06-04 2015-07-07 New England Biolabs, Inc. Detection of amplification products
WO2014025337A1 (en) 2012-08-06 2014-02-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Methods and reagents for amplifying nucleic acids
US20140072971A1 (en) 2012-08-30 2014-03-13 Abbott Laboratories Prame detection assays
EP2922966A2 (en) * 2012-10-20 2015-09-30 Selfdiagnostics Oü Method and its compositions for detection of nucleic acid target from biological samples and body fluids
US20140114215A1 (en) 2012-10-20 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Methods for Renal Neuromodulation and Associated Systems and Devices
UA117921C2 (uk) 2012-10-22 2018-10-25 Байєр Кропсаєнс Нв Композиція, пристрій та спосіб ампліфікації нуклеїнових кислот
US10329629B2 (en) * 2013-07-26 2019-06-25 Cepheid Methods of detecting chlamydia and gonorrhea and of screening for infection/inflammation based on genomic copy number
EP3058100A4 (en) 2013-10-18 2017-04-19 California Institute of Technology Enhanced nucleic acid identification and detection
GB201319180D0 (en) 2013-10-30 2013-12-11 Mast Group Ltd Nucleic acid probe
EP3169793B1 (en) 2014-07-16 2022-07-06 Tangen Biosciences Inc. Isothermal methods for amplifying nucleic acid samples
CN113943773A (zh) 2014-11-05 2022-01-18 加州理工学院 生物体对药物的响应的微流体测量
US10227661B2 (en) 2014-11-21 2019-03-12 GeneWeave Biosciences, Inc. Sequence-specific detection and phenotype determination
WO2016105508A2 (en) 2014-12-23 2016-06-30 California Institute Of Technology Devices and methods for autonomous measurements
US9657353B2 (en) 2015-06-26 2017-05-23 Great Basin Scientific, Inc. Specific detection of organisms derived from a sample
JP6651735B2 (ja) * 2015-08-21 2020-02-19 東ソー株式会社 クラミジア・トラコマチスを検出するためのオリゴヌクレオチドプライマーおよび当該プライマーを用いたクラミジア・トラコマチスの検出方法
CA3008949A1 (en) * 2015-12-18 2017-06-22 Selfdiagnostics Deutschland Gmbh Method for the detection of a sexually transmitted infectious pathogen
EP3452197A4 (en) * 2016-05-04 2020-01-22 Children's Hospital & Research Center at Oakland FAST EXTRACTION OF NUCLEIC ACIDS FROM CLINICAL SAMPLES FOR DOWNSTREAM APPLICATIONS
CN110225919A (zh) 2016-11-10 2019-09-10 达丽斯生物医学公司 用于扩增和检测淋病奈瑟氏菌的多核苷酸
CN110177887B (zh) * 2016-11-10 2024-10-29 达丽斯生物医学公司 用于扩增和检测沙眼衣原体的多核苷酸
WO2018089943A1 (en) 2016-11-10 2018-05-17 Slipchip Corporation Probe detection of loop-mediated amplification products
CN107099618A (zh) 2017-05-03 2017-08-29 上海速创诊断产品有限公司 一种用于检测泌尿生殖道致病微生物的lamp引物组合物及其相关应用
US10450616B1 (en) 2018-05-09 2019-10-22 Talis Biomedical Corporation Polynucleotides for the amplification and detection of Chlamydia trachomatis

Also Published As

Publication number Publication date
US20230073971A1 (en) 2023-03-09
US11326214B2 (en) 2022-05-10
US20210301325A1 (en) 2021-09-30
JP2024028922A (ja) 2024-03-05
WO2019217627A1 (en) 2019-11-14
JP2021522818A (ja) 2021-09-02
SG11202010697YA (en) 2020-11-27
MX2020011892A (es) 2021-02-22
JP7402180B2 (ja) 2023-12-20
US10450616B1 (en) 2019-10-22
AU2019265733A1 (en) 2020-12-24
PH12020551880A1 (en) 2021-07-12
KR20210006964A (ko) 2021-01-19
BR112020022762A2 (pt) 2021-03-02
CA3098140A1 (en) 2019-11-14
US20190345541A1 (en) 2019-11-14
EP3790996A1 (en) 2021-03-17
CN112368400A (zh) 2021-02-12
EP3790996A4 (en) 2022-06-01
ZA202007173B (en) 2024-04-24
US20200002752A1 (en) 2020-01-02

Similar Documents

Publication Publication Date Title
CO2020015231A2 (es) Polinucleótidos para la amplificación y detección de chlamydia trachomatis
WO2018089942A8 (en) Polynucleotides for the amplification and detection of chlamydia trachomatis
BR112017008082A2 (pt) composições e métodos para detectar um vírus de rna
AU2017257624A1 (en) Hybridization chain reaction methods for in situ molecular detection
CY1122632T1 (el) Μεθοδοι για μελετη πυρηνικων οξεων
BR112016029583A2 (pt) ?kit ou dispositivo para a detecção de câncer esofágico e método de detecção?
BR112018069849A2 (pt) kit, dispositivo e método para a detecção de câncer pancreático precoce ou de lesão precursora do câncer pancreático
BR112017008931A2 (pt) dispositivo microfluídico para detecção de gene-alvo, método para fabricação do mesmo e método para detecção com o uso do mesmo
BR112016027475A2 (pt) kit, dispositivo e método para a detecção de câncer pancreático
BR112016028944A2 (pt) kit ou dispositivo para a detecção de câncer do trato biliar e método de detecção
MX2017003790A (es) Detección de secuencias diana por percepción de nanoporos de sondas sintéticas.
CO2018011856A2 (es) Composiciones, métodos y kits para la síntesis y detección de ácidos nucleicos
BR112018074853A2 (pt) métodos para detectar a presença de pelo menos um genogrupo de norovírus em uma amostra de fezes e para selecionar um paciente que sofre de gastroenterite aguda, e, kit
KR20230002943A9 (ko) 핵산 검출을 위한 등온 방법, 조성물, 키트, 및 시스템
AR110677A1 (es) Anticuerpos anti-c1s y métodos para usarlos
CO2019004124A2 (es) Método y sistema para la preparación y secuenciación de biblioteca basada en crispr
TR201819546T4 (tr) Numune tür kökeni için tespit yöntemleri.
CL2022000126A1 (es) Polinucleótidos para la amplificación y detección de neisseria gonorrhoeae
BR112022019764A2 (pt) Ensaios para detecção de sars-cov-2
WO2020123961A3 (en) Methods and compositions for sequentially detecting targets
AR106214A1 (es) Composiciones y métodos para la detección rápida de salmonella
EP4328327A3 (en) Reporter dye for isothermal nucleic acid amplification, isothermal-based dual functional oligonucleotide containing quencher, and method for nucleic acid amplification and measurement using same
BR112021026672A2 (pt) Detecção de sequências genômicas usando combinações de sondas, moléculas de sonda e matrizes compreendendo as sondas para a detecção específica de organismos
BR112017001500A2 (pt) composições e métodos para a detecção e análise de tuberculose por micobactéria
AR104805A1 (es) Métodos y composiciones para evaluar la capacidad de respuesta de los cánceres a los inhibidores de bet