CN85101722A - 制备二氢哒嗪酮衍生物的方法 - Google Patents
制备二氢哒嗪酮衍生物的方法 Download PDFInfo
- Publication number
- CN85101722A CN85101722A CN198585101722A CN85101722A CN85101722A CN 85101722 A CN85101722 A CN 85101722A CN 198585101722 A CN198585101722 A CN 198585101722A CN 85101722 A CN85101722 A CN 85101722A CN 85101722 A CN85101722 A CN 85101722A
- Authority
- CN
- China
- Prior art keywords
- compound
- methyl
- group
- pyridazinone
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848400863A GB8400863D0 (en) | 1984-01-13 | 1984-01-13 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN85101722A true CN85101722A (zh) | 1987-01-31 |
Family
ID=10554924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN198585101722A Pending CN85101722A (zh) | 1984-01-13 | 1985-04-01 | 制备二氢哒嗪酮衍生物的方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4654342A (enExample) |
| EP (1) | EP0150937B1 (enExample) |
| JP (3) | JPS60158181A (enExample) |
| KR (1) | KR920006781B1 (enExample) |
| CN (1) | CN85101722A (enExample) |
| AT (1) | ATE37179T1 (enExample) |
| AU (1) | AU572252B2 (enExample) |
| CA (2) | CA1251209A (enExample) |
| CS (1) | CS248731B2 (enExample) |
| DD (1) | DD231350A5 (enExample) |
| DE (1) | DE3564941D1 (enExample) |
| DK (1) | DK162519C (enExample) |
| ES (3) | ES8607949A1 (enExample) |
| FI (1) | FI850140L (enExample) |
| GB (1) | GB8400863D0 (enExample) |
| GR (1) | GR850068B (enExample) |
| HU (1) | HU193591B (enExample) |
| IE (1) | IE57969B1 (enExample) |
| IL (1) | IL74031A (enExample) |
| JO (1) | JO1351B1 (enExample) |
| MY (1) | MY100124A (enExample) |
| NO (1) | NO850129L (enExample) |
| NZ (1) | NZ210816A (enExample) |
| PH (1) | PH22136A (enExample) |
| PL (1) | PL147123B1 (enExample) |
| PT (1) | PT79819B (enExample) |
| RO (1) | RO92607A (enExample) |
| SU (1) | SU1396963A3 (enExample) |
| WO (1) | WO1985003076A1 (enExample) |
| ZA (1) | ZA85251B (enExample) |
| ZW (1) | ZW385A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104987310A (zh) * | 2015-06-03 | 2015-10-21 | 青岛农业大学 | 左西孟旦的合成工艺 |
| WO2019149259A1 (zh) * | 2018-02-05 | 2019-08-08 | 安徽省新星药物开发有限责任公司 | 一种含胍基的p2y12受体拮抗剂、制备方法及其用途 |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1251448A (en) * | 1985-03-27 | 1989-03-21 | William J. Coates | Pyridazinone derivatives |
| AU581324B2 (en) * | 1985-07-05 | 1989-02-16 | Smith Kline & French Laboratories Limited | Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones |
| GB8603780D0 (en) * | 1986-02-15 | 1986-03-19 | Smith Kline French Lab | Chemical compounds |
| GB8722776D0 (en) * | 1987-09-28 | 1987-11-04 | Smith Kline French Lab | Chemical compounds |
| US5011837A (en) * | 1988-08-09 | 1991-04-30 | E. R. Squibb & Sons, Inc. | Aryl cyanoguanidines: potassium channel activators and method of making same |
| NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
| AU2002254124A1 (en) | 2001-02-27 | 2002-09-12 | Mitokor | Aryl-n-cyanoguanidines and methods related thereto |
| DE60213841T2 (de) * | 2001-11-05 | 2007-02-15 | Merck Patent Gmbh | Hydrazono-malonitrile |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| DE102004011512B4 (de) | 2004-03-08 | 2022-01-13 | Boehringer Ingelheim Vetmedica Gmbh | Pharmazeutische Zubereitung enthaltend Pimobendan |
| US8980894B2 (en) * | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| AU2006311577B2 (en) | 2005-11-09 | 2013-02-07 | Zalicus Inc. | Methods, compositions, and kits for the treatment of medical conditions |
| PL1951227T3 (pl) * | 2005-11-14 | 2017-09-29 | Boehringer Ingelheim Vetmedica Gmbh | Zastosowania pimobendanu do leczenia bezobjawowej(utajonej) niewydolności serca |
| EP1920785A1 (en) * | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US8664252B2 (en) | 2008-11-25 | 2014-03-04 | Boehringer Ingelheim Vetmedica Gmbh | Phosphodiesterase type III (PDE III) inhibitors or CA2+-sensitizing agents for the treatment of hypertrophic cardiomyopathy |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EA201391254A1 (ru) | 2011-03-01 | 2014-02-28 | Синерджи Фармасьютикалз Инк. | Способ получения агонистов гуанилатциклазы c |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| ES2924478T3 (es) | 2012-03-15 | 2022-10-07 | Boehringer Ingelheim Vetmedica Gmbh | Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos |
| JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CN105764916B (zh) | 2013-06-05 | 2021-05-18 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| PL3021832T3 (pl) | 2013-07-19 | 2021-08-23 | Boehringer Ingelheim Vetmedica Gmbh | Konserwowana ciekła wodna kompozycja farmaceutyczna zawierająca eteryfikowane pochodne cyklodekstryny |
| EP3492106B1 (en) | 2013-08-09 | 2021-02-17 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| BR122019024673B1 (pt) | 2013-12-04 | 2023-04-11 | Boehringer Ingelheim Vetmedica Gmbh | Composições farmacêuticas aprimoradas de pimobendan |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| EP3972599B1 (en) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3822260A (en) * | 1970-10-09 | 1974-07-02 | American Cyanamid Co | 6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones |
| BE791539A (fr) * | 1971-11-19 | 1973-05-17 | Basf Ag | Dihydropyridazones, leur preparation et leurs utilisations therapeutiques |
| EP0030835B1 (en) * | 1979-12-05 | 1983-05-11 | Morishita Pharmaceutical Co. Ltd. | Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them |
| EP0059688B1 (de) * | 1981-03-04 | 1985-05-15 | Ciba-Geigy Ag | Pyridazinone, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen und deren Verwendung |
| JPS58113180A (ja) * | 1981-12-28 | 1983-07-05 | Mitsui Toatsu Chem Inc | ピリダジノン誘導体 |
| JPS58140076A (ja) * | 1982-02-09 | 1983-08-19 | Mitsubishi Chem Ind Ltd | ピリダジノン誘導体又はその塩類 |
| DE3204375C2 (de) * | 1982-02-09 | 1983-12-01 | J. Rettenmaier & Söhne GmbH + Co, 7091 Holzmühle | Verfahren zur Herabsetzung der Saugfähigkeit von Holz |
| DE3302021A1 (de) * | 1983-01-22 | 1984-07-26 | Basf Ag, 6700 Ludwigshafen | 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung |
| AU581324B2 (en) * | 1985-07-05 | 1989-02-16 | Smith Kline & French Laboratories Limited | Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones |
-
1984
- 1984-01-13 GB GB848400863A patent/GB8400863D0/en active Pending
-
1985
- 1985-01-02 JO JO19851351A patent/JO1351B1/en active
- 1985-01-07 CA CA000471594A patent/CA1251209A/en not_active Expired
- 1985-01-07 ZW ZW3/85A patent/ZW385A1/xx unknown
- 1985-01-08 DK DK009185A patent/DK162519C/da not_active IP Right Cessation
- 1985-01-09 PH PH31697A patent/PH22136A/en unknown
- 1985-01-10 CS CS85202A patent/CS248731B2/cs unknown
- 1985-01-10 DD DD85272500A patent/DD231350A5/de not_active IP Right Cessation
- 1985-01-10 GR GR850068A patent/GR850068B/el unknown
- 1985-01-10 PT PT79819A patent/PT79819B/pt not_active IP Right Cessation
- 1985-01-10 ES ES539446A patent/ES8607949A1/es not_active Expired
- 1985-01-10 IL IL74031A patent/IL74031A/xx unknown
- 1985-01-11 EP EP85300196A patent/EP0150937B1/en not_active Expired
- 1985-01-11 AT AT85300196T patent/ATE37179T1/de active
- 1985-01-11 DE DE8585300196T patent/DE3564941D1/de not_active Expired
- 1985-01-11 ZA ZA85251A patent/ZA85251B/xx unknown
- 1985-01-11 HU HU85109A patent/HU193591B/hu not_active IP Right Cessation
- 1985-01-11 IE IE69/85A patent/IE57969B1/en not_active IP Right Cessation
- 1985-01-11 NO NO850129A patent/NO850129L/no unknown
- 1985-01-11 NZ NZ210816A patent/NZ210816A/en unknown
- 1985-01-11 AU AU37611/85A patent/AU572252B2/en not_active Ceased
- 1985-01-11 JP JP60003912A patent/JPS60158181A/ja active Pending
- 1985-01-11 FI FI850140A patent/FI850140L/fi not_active Application Discontinuation
- 1985-01-11 PL PL1985251516A patent/PL147123B1/pl unknown
- 1985-01-11 WO PCT/GB1985/000014 patent/WO1985003076A1/en not_active Ceased
- 1985-01-12 KR KR1019850000179A patent/KR920006781B1/ko not_active Expired
- 1985-01-14 US US06/690,911 patent/US4654342A/en not_active Expired - Fee Related
- 1985-04-01 CN CN198585101722A patent/CN85101722A/zh active Pending
- 1985-09-12 RO RO85120090A patent/RO92607A/ro unknown
- 1985-09-12 SU SU853958649A patent/SU1396963A3/ru active
- 1985-12-05 ES ES549629A patent/ES8703846A1/es not_active Expired
-
1986
- 1986-05-14 ES ES554965A patent/ES8706645A1/es not_active Expired
-
1987
- 1987-06-02 MY MYPI87000758A patent/MY100124A/en unknown
-
1988
- 1988-05-09 JP JP63113411A patent/JPS63313776A/ja active Pending
- 1988-05-09 JP JP63113410A patent/JPS63313775A/ja active Pending
- 1988-10-21 CA CA000581012A patent/CA1260471A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104987310A (zh) * | 2015-06-03 | 2015-10-21 | 青岛农业大学 | 左西孟旦的合成工艺 |
| WO2019149259A1 (zh) * | 2018-02-05 | 2019-08-08 | 安徽省新星药物开发有限责任公司 | 一种含胍基的p2y12受体拮抗剂、制备方法及其用途 |
| CN110117257A (zh) * | 2018-02-05 | 2019-08-13 | 安徽省新星药物开发有限责任公司 | 一种含胍基的p2y12受体拮抗剂、制备方法及其用途 |
| CN110117257B (zh) * | 2018-02-05 | 2022-12-06 | 安徽省新星药物开发有限责任公司 | 一种含胍基的p2y12受体拮抗剂、制备方法及其用途 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |