CN1741999A - 用作GSK－3β抑制剂的哒嗪酮衍生物 - Google Patents

用作GSK－3β抑制剂的哒嗪酮衍生物 Download PDF

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Publication number
CN1741999A
CN1741999A CNA2003801050578A CN200380105057A CN1741999A CN 1741999 A CN1741999 A CN 1741999A CN A2003801050578 A CNA2003801050578 A CN A2003801050578A CN 200380105057 A CN200380105057 A CN 200380105057A CN 1741999 A CN1741999 A CN 1741999A
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alkyl
aryl
oxo
heteroaryl
heterocyclyl
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Pending
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CNA2003801050578A
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Chinese (zh)
Inventor
S·赫尔德
T·瑙曼
K·舍纳芬格
D·W·威尔
H·马特
G·米勒
D·勒叙斯
B·博杜安
T·鲁尼
F·阿莱
G·蒂拉博斯奇
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Sanofi Aventis Deutschland GmbH
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Aventis Pharma Deutschland GmbH
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Publication of CN1741999A publication Critical patent/CN1741999A/zh
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2003801050578A 2002-11-19 2003-11-19 用作GSK－3β抑制剂的哒嗪酮衍生物 Pending CN1741999A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0214443 2002-11-19
FR0214443A FR2847253B1 (fr) 2002-11-19 2002-11-19 Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant

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CN1741999A true CN1741999A (zh) 2006-03-01

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CNA2003801050578A Pending CN1741999A (zh) 2002-11-19 2003-11-19 用作GSK－3β抑制剂的哒嗪酮衍生物

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EP (2) EP1611121B1 (enExample)
JP (1) JP2006509748A (enExample)
KR (1) KR20050083918A (enExample)
CN (1) CN1741999A (enExample)
AR (2) AR042089A1 (enExample)
AT (2) ATE368651T1 (enExample)
AU (2) AU2003283414A1 (enExample)
BR (1) BR0316720A (enExample)
CA (2) CA2506022A1 (enExample)
CO (1) CO5700722A2 (enExample)
DE (2) DE60315354T2 (enExample)
FR (1) FR2847253B1 (enExample)
MA (1) MA27814A1 (enExample)
MX (1) MXPA05005270A (enExample)
NO (1) NO20052887L (enExample)
PL (1) PL376129A1 (enExample)
RU (1) RU2005119151A (enExample)
TW (2) TW200503727A (enExample)
WO (2) WO2004046130A1 (enExample)

Cited By (9)

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CN102731379A (zh) * 2009-03-02 2012-10-17 Irm责任有限公司 用作wnt信号调节剂的n-(杂)芳基、2-(杂)芳基取代的乙酰胺类
CN102958917A (zh) * 2010-06-29 2013-03-06 Irm责任有限公司 用于调节wnt信号通路的组合物和方法
US8501731B2 (en) 2008-03-18 2013-08-06 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Derivatives of 6[3-(trifluoromethyl)phenyl]pyridazin-3(2H)-one having antitumor activity
US9212146B2 (en) 2008-03-18 2015-12-15 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Substituted pyridazinones for the treatment of tumors
CN106458910A (zh) * 2014-02-19 2017-02-22 亚倍生技制药公司 线粒体醛脱氢酶2(aldh2)结合多环酰胺和其用于治疗癌症的用途
CN108558889A (zh) * 2013-10-18 2018-09-21 赛尔基因昆蒂赛尔研究公司 布罗莫结构域抑制剂
CN109863140A (zh) * 2016-05-25 2019-06-07 拜耳医药股份有限公司 3-氧代-2,6-二苯基-2,3-二氢哒嗪-4-甲酰胺
CN110577564A (zh) * 2012-01-20 2019-12-17 医药研究委员会 多肽和方法
CN111533697A (zh) * 2020-05-07 2020-08-14 成都大学 4-氨基哒嗪酮类化合物及其制备方法

Families Citing this family (57)

* Cited by examiner, † Cited by third party
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US20030176437A1 (en) 2001-08-31 2003-09-18 D.M. Watterson Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death
DE102004010207A1 (de) 2004-03-02 2005-09-15 Aventis Pharma S.A. Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate
DE102004010194A1 (de) * 2004-03-02 2005-10-13 Aventis Pharma Deutschland Gmbh 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate, ihre Herstellung und Verwendung in Arzneimitteln
EP1604988A1 (en) 2004-05-18 2005-12-14 Sanofi-Aventis Deutschland GmbH Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals
EP1598348A1 (en) 2004-05-18 2005-11-23 Aventis Pharma Deutschland GmbH Novel pyridazinone derivatives as inhibitors of CDK2
MX2007003327A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
MX2007003332A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
JP4958786B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体および治療薬としてのそれらの使用
MX2007003319A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
EP2269610A3 (en) 2004-09-20 2011-03-09 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP1799667B1 (en) 2004-09-20 2013-03-20 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
EP1812408B1 (en) 2004-11-02 2013-10-09 Northwestern University Pyridazine compounds, compositions and methods
WO2006050359A2 (en) 2004-11-02 2006-05-11 Northwestern University Pyridazine compounds and methods
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007127474A2 (en) * 2006-04-28 2007-11-08 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
BRPI0710938A2 (pt) 2006-04-28 2012-06-26 Univ Northwestern formulações contendo compostos de piridazina para o tratamento de doenças neuroinflamatórias
WO2007127475A2 (en) * 2006-04-28 2007-11-08 Northwestern University Pyridazines for demyelinating diseases and neuropathic pain
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
BRPI0715160A2 (pt) 2006-08-08 2013-06-11 Sanofi Aventis imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
AU2012203023C1 (en) * 2009-03-02 2013-11-07 Novartis Ag N-(hetero)aryl, 2- (hetero)aryl-substituted acetamides for use as Wnt signaling modulators
DK2470552T3 (en) 2009-08-26 2014-02-17 Sanofi Sa NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE
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