AR042202A1 - Derivados de piridazinona como medicamentos y composiciones farmaceuticas que los contienen - Google Patents

Derivados de piridazinona como medicamentos y composiciones farmaceuticas que los contienen

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Publication number
AR042202A1
AR042202A1 ARP030104278A ARP030104278A AR042202A1 AR 042202 A1 AR042202 A1 AR 042202A1 AR P030104278 A ARP030104278 A AR P030104278A AR P030104278 A ARP030104278 A AR P030104278A AR 042202 A1 AR042202 A1 AR 042202A1
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AR
Argentina
Prior art keywords
alkyl
aryl
heteroaryl
nr1r2
trifluoromethoxy
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ARP030104278A
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English (en)
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Aventis Pharma Gmbh
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Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of AR042202A1 publication Critical patent/AR042202A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
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    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se refiere a derivados de piridazinona de fórmula general (1), uso del compuesto para fabricar un medicamento para el tratamiento de enfermedades neurodegenerativas, ataques de apoplejía, traumas craneales y espinales, y neuropatías periféricas, obesidad, enfermedades metabólicas, diabetes de tipo II, hipertensión esencial, enfermedades cardiovasculares ateroescleróticas, síndrome del ovario poliquístico, síndrome X, inmunodeficiencia o cáncer. Reivindicación 1: Un compuesto de fórmula (1),en la que A representa un grupo de fórmula (2); R es alquilo C1-10, arilo, aril-(alquilo C1-10)-, heteroarilo, heteroaril-(alquilo C1-10)-, cicloalquilo C3-10, policicloalquilo, alquenilo C2-10 o alquinilo C2-10, no sustituido o al menos monosustituido, donde los sustituyentes se seleccionan de halógeno, -CN, alquilo C1-10, -NO2, -OR1, -C(O)OR1, -O-C(O)R1, -NR1R2, -NHC(O)R1, -C(O)NR1R2, -SR1, -S(O)R1, -SO2R1, -NHSO2R1, -SO2NR1R2, -C(S)NR1R2, -NHC(S)R1, -O-SO2R1, -SO2-O-R1, oxo, -C(O)R1, -C(NH)NH2, heterociclilo, cicloalquilo C3-10, aril-(alquilo C1-6)-, arilo, heteroarilo, trifluorometilo, trifluorometilsulfanilo y trifluorometoxi, y arilo, heterociclo y heteroarilo pueden estar a su vez al menos monosustituidos con alquilo C1-6, alcoxi C1-6, halógeno, trifluorometilo, trifluorometoxi u OH; Ar es arilo o heteroarilo no sustituido o al menos monosustituido; donde los sustituyentes se seleccionan de halógeno, -CN, NO2, alquilo C1-10, -OR1, -C(O)OR1, -O-C(O)R1, -NR1R2, -NHC(O)R1, -C(O)NR1R2, -NHC(S)R1, -C(S)NR1R2, -SR1, -S(O)R1, -SO2R1, -NHSO2R1, -SO2NR1R2, -O-SO2R1, -SO2-O-R1, arilo, heteroarilo, aril-(alquilo C1-6)-, formilo, trifluorometilo, y trifluorometoxi, y arilo y heteroarilo pueden estar a su vez al menos monosustituidos con alquilo C1-6, alcoxi c1-6, halógeno, trifluorometilo, trifluorometoxi u OH; R1 y R2 son independientemente entre sí hidrógeno; alquilo C1-10, cicloalquilo C3-10, arilo, aril-(alquilo C1-10)-, alquenilo C2-10, alquinilo C2-10, heterociclilo, heterociclil-(alquilo C1-10)- o heteroarilo, no sustituido o al menos monosustituido, donde los sustituyentes se seleccionan de halógeno, alquilo C1-6, alcoxi C1-6, CN, NO2, (alquil C1-6)amino-, di(alquil C1-6)amino-, OH, COOH, -COO-(alquilo C1-6)-, -CONH2, formilo, trifluorometilo y trifluorometoxi; heteroarilo es un heteroarilo mono o bicíclico aromático, de 5 a 10 miembros, que contiene uno o más heteroátomos seleccionados de N, O y S; arilo es fenilo, indanilo, indenilo o naftilo; heterociclilo es un heteroarilo mono o bicíclico, alifático, de 5 a 10 miembros, que contiene uno o más heteroátomos seleccionados de N, O y S; o los racematos, enantiómeros, diastereoisómeros y sus mezclas, los tautómeros, o sus sales fisiológicamente aceptables; con la condición de que A no es -C(O)NH(alquilo C1-6), en el caso en el que Ar sea fenilo que está al menos monosustituidos con heterociclilo o heteroarilo que contiene nitrógeno.
ARP030104278A 2002-11-19 2003-11-19 Derivados de piridazinona como medicamentos y composiciones farmaceuticas que los contienen AR042202A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0214443A FR2847253B1 (fr) 2002-11-19 2002-11-19 Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant

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AR042202A1 true AR042202A1 (es) 2005-06-15

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ARP030104278A AR042202A1 (es) 2002-11-19 2003-11-19 Derivados de piridazinona como medicamentos y composiciones farmaceuticas que los contienen
ARP030104280A AR042089A1 (es) 2002-11-19 2003-11-19 Derivados de piridazinona como medicamentos, metodos para su preparacion y composiciones farmaceuticas que los contienen

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EP (2) EP1581505B1 (es)
JP (1) JP2006509748A (es)
KR (1) KR20050083918A (es)
CN (1) CN1741999A (es)
AR (2) AR042202A1 (es)
AT (2) ATE368651T1 (es)
AU (2) AU2003296586A1 (es)
BR (1) BR0316720A (es)
CA (2) CA2518917A1 (es)
CO (1) CO5700722A2 (es)
DE (2) DE60315354T2 (es)
FR (1) FR2847253B1 (es)
MA (1) MA27814A1 (es)
MX (1) MXPA05005270A (es)
NO (1) NO20052887L (es)
PL (1) PL376129A1 (es)
RU (1) RU2005119151A (es)
TW (2) TW200418478A (es)
WO (2) WO2004046117A1 (es)

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