FR2847253B1 - Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant - Google Patents

Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant

Info

Publication number
FR2847253B1
FR2847253B1 FR0214443A FR0214443A FR2847253B1 FR 2847253 B1 FR2847253 B1 FR 2847253B1 FR 0214443 A FR0214443 A FR 0214443A FR 0214443 A FR0214443 A FR 0214443A FR 2847253 B1 FR2847253 B1 FR 2847253B1
Authority
FR
France
Prior art keywords
pyridazinones
medicaments
pharmaceutical compositions
novel derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0214443A
Other languages
English (en)
French (fr)
Other versions
FR2847253A1 (fr
Inventor
Dominique Lesuisse
Franck Halley
Bernard Baudoin
Thomas Rooney
Swen Hoelder
Thorsten Naumann
Gilles Tiraboschi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0214443A priority Critical patent/FR2847253B1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to ARP030104280A priority patent/AR042089A1/es
Priority to MXPA05005270A priority patent/MXPA05005270A/es
Priority to KR1020057009083A priority patent/KR20050083918A/ko
Priority to AT03775372T priority patent/ATE368651T1/de
Priority to TW092132459A priority patent/TW200503727A/zh
Priority to US10/715,358 priority patent/US7309701B2/en
Priority to EP03811383A priority patent/EP1611121B1/en
Priority to JP2004552660A priority patent/JP2006509748A/ja
Priority to CA002506022A priority patent/CA2506022A1/en
Priority to RU2005119151/04A priority patent/RU2005119151A/ru
Priority to PCT/EP2003/012950 priority patent/WO2004046117A1/en
Priority to US10/715,556 priority patent/US7462613B2/en
Priority to AT03811383T priority patent/ATE369356T1/de
Priority to ARP030104278A priority patent/AR042202A1/es
Priority to TW092132354A priority patent/TW200418478A/zh
Priority to PCT/EP2003/012949 priority patent/WO2004046130A1/en
Priority to AU2003283414A priority patent/AU2003283414A1/en
Priority to PL03376129A priority patent/PL376129A1/xx
Priority to DE60315516T priority patent/DE60315516T2/de
Priority to DE60315354T priority patent/DE60315354T2/de
Priority to AU2003296586A priority patent/AU2003296586A1/en
Priority to BR0316720-8A priority patent/BR0316720A/pt
Priority to CNA2003801050578A priority patent/CN1741999A/zh
Priority to CA002518917A priority patent/CA2518917A1/en
Priority to EP03775372A priority patent/EP1581505B1/en
Publication of FR2847253A1 publication Critical patent/FR2847253A1/fr
Priority to MA28287A priority patent/MA27814A1/fr
Priority to CO05048069A priority patent/CO5700722A2/es
Priority to NO20052887A priority patent/NO20052887L/no
Application granted granted Critical
Publication of FR2847253B1 publication Critical patent/FR2847253B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR0214443A 2002-11-19 2002-11-19 Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant Expired - Fee Related FR2847253B1 (fr)

Priority Applications (29)

Application Number Priority Date Filing Date Title
FR0214443A FR2847253B1 (fr) 2002-11-19 2002-11-19 Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant
AU2003283414A AU2003283414A1 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as gsk-3beta inhibitors
KR1020057009083A KR20050083918A (ko) 2002-11-19 2003-11-19 Ｇｓｋ-3베타 억제제로서의 피리다지논 유도체
AT03775372T ATE368651T1 (de) 2002-11-19 2003-11-19 Pyridazinon-derivate als gsk-3beta-hemmer
TW092132459A TW200503727A (en) 2002-11-19 2003-11-19 Novel pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
US10/715,358 US7309701B2 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
EP03811383A EP1611121B1 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as cdk2-inhibitors
JP2004552660A JP2006509748A (ja) 2002-11-19 2003-11-19 Ｇｓｋ−３ベータ阻害剤としてのピリダジノン誘導体
CA002506022A CA2506022A1 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as gsk-3beta inhibitors
RU2005119151/04A RU2005119151A (ru) 2002-11-19 2003-11-19 Производные пиридазинона в качестве gsk-3бета-ингибиторов
PCT/EP2003/012950 WO2004046117A1 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as gsk-3beta inhibitors
US10/715,556 US7462613B2 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
AT03811383T ATE369356T1 (de) 2002-11-19 2003-11-19 Pyridazinon-derivate als cdk2-hemmer
ARP030104278A AR042202A1 (es) 2002-11-19 2003-11-19 Derivados de piridazinona como medicamentos y composiciones farmaceuticas que los contienen
ARP030104280A AR042089A1 (es) 2002-11-19 2003-11-19 Derivados de piridazinona como medicamentos, metodos para su preparacion y composiciones farmaceuticas que los contienen
PCT/EP2003/012949 WO2004046130A1 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as cdk2-inhibitors
DE60315516T DE60315516T2 (de) 2002-11-19 2003-11-19 Pyridazinon-derivate als cdk2-hemmer
MXPA05005270A MXPA05005270A (es) 2002-11-19 2003-11-19 Nuevos derivados de piridazinona como productos farmaceuticos y composiciones farmaceuticas que los contienen.
PL03376129A PL376129A1 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as gsk-3beta inhibitors
DE60315354T DE60315354T2 (de) 2002-11-19 2003-11-19 Pyridazinon-derivate als gsk-3beta-hemmer
AU2003296586A AU2003296586A1 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as cdk2-inhibitors
BR0316720-8A BR0316720A (pt) 2002-11-19 2003-11-19 Derivados de piridazinona como inibidores de gsk-3beta
CNA2003801050578A CN1741999A (zh) 2002-11-19 2003-11-19 用作GSK－3β抑制剂的哒嗪酮衍生物
CA002518917A CA2518917A1 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as cdk2-inhibitors
EP03775372A EP1581505B1 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as gsk-3beta inhibitors
TW092132354A TW200418478A (en) 2002-11-19 2003-11-19 Novel pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
MA28287A MA27814A1 (fr) 2002-11-19 2005-05-17 Derives de pyridazinones en tant qu'inhibiteurs de gsk-3beta
CO05048069A CO5700722A2 (es) 2002-11-19 2005-05-18 Nuevos derivados de piridazinona como productos farmaceutico y composiciones farmaceuticas que los contienen
NO20052887A NO20052887L (no) 2002-11-19 2005-06-14 Pyridazinonderivater som GSK-3Beta inhibitorer.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0214443A FR2847253B1 (fr) 2002-11-19 2002-11-19 Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
FR2847253A1 FR2847253A1 (fr) 2004-05-21
FR2847253B1 true FR2847253B1 (fr) 2007-05-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
FR0214443A Expired - Fee Related FR2847253B1 (fr) 2002-11-19 2002-11-19 Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant

Country Status (19)

Country Link
EP (2) EP1581505B1 (enExample)
JP (1) JP2006509748A (enExample)
KR (1) KR20050083918A (enExample)
CN (1) CN1741999A (enExample)
AR (2) AR042202A1 (enExample)
AT (2) ATE369356T1 (enExample)
AU (2) AU2003283414A1 (enExample)
BR (1) BR0316720A (enExample)
CA (2) CA2506022A1 (enExample)
CO (1) CO5700722A2 (enExample)
DE (2) DE60315354T2 (enExample)
FR (1) FR2847253B1 (enExample)
MA (1) MA27814A1 (enExample)
MX (1) MXPA05005270A (enExample)
NO (1) NO20052887L (enExample)
PL (1) PL376129A1 (enExample)
RU (1) RU2005119151A (enExample)
TW (2) TW200503727A (enExample)
WO (2) WO2004046117A1 (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030176437A1 (en) 2001-08-31 2003-09-18 D.M. Watterson Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death
DE102004010207A1 (de) 2004-03-02 2005-09-15 Aventis Pharma S.A. Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate
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