CN1620413B - 还原型辅酶q10的稳定方法和组合物 - Google Patents
还原型辅酶q10的稳定方法和组合物 Download PDFInfo
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- CN1620413B CN1620413B CN038024462A CN03802446A CN1620413B CN 1620413 B CN1620413 B CN 1620413B CN 038024462 A CN038024462 A CN 038024462A CN 03802446 A CN03802446 A CN 03802446A CN 1620413 B CN1620413 B CN 1620413B
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- reduced coenzyme
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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| PCT/JP2003/000394 WO2003062182A1 (fr) | 2002-01-18 | 2003-01-20 | Procede de stabilisation d'une coenzyme q10 reduite et composition associee |
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| JP3742602B2 (ja) * | 2001-05-09 | 2006-02-08 | 株式会社カネカ | 還元型補酵素ｑの安定な溶液 |
| JP4567945B2 (ja) * | 2003-01-17 | 2010-10-27 | 太陽化学株式会社 | ユビデカレノン製剤 |
| WO2004064543A1 (ja) | 2003-01-17 | 2004-08-05 | Taiyo Kagaku Co., Ltd. | コエンザイムq10含有組成物 |
| KR20060130016A (ko) * | 2003-09-10 | 2006-12-18 | 가부시키가이샤 가네카 | 안정성이 우수한 환원형 보효소 ｑ10 결정 및 환원형보효소 ｑ10 결정을 함유하는 조성물 |
| ES2631152T3 (es) | 2004-01-22 | 2017-08-28 | University Of Miami | Formulaciones de coenzima Q10 tópicas o intravenosas para su uso en el tratamiento del cáncer |
| US7708990B2 (en) | 2004-03-23 | 2010-05-04 | Kaneka Corporation | Coenzyme Q compositions persisting in blood |
| EP1728506A1 (en) * | 2004-03-23 | 2006-12-06 | Kaneka Corporation | Coenzyme q composition with long-term persistence in blood |
| US20060051462A1 (en) * | 2004-09-03 | 2006-03-09 | Wang Jimmy X | Self emulsifying compositions for delivering lipophilic coenzyme Q10 and other dietary ingredients |
| AU2004326297B2 (en) * | 2004-11-16 | 2008-08-07 | Bioavailability, Inc. | High concentration self-microemulsifying coenzyme Q10 preparations for nutritional use |
| US20060147542A1 (en) * | 2004-12-24 | 2006-07-06 | Tadao Ono | Solid preparation containing reduced coenzyme Q10 and method for producing the same |
| JP5053544B2 (ja) * | 2004-12-28 | 2012-10-17 | 株式会社カネカ | 還元型補酵素ｑ１０の保存方法 |
| US8067217B2 (en) * | 2004-12-28 | 2011-11-29 | Kaneka Corporation | Method for preserving reduced coenzyme Q10 |
| KR20080021140A (ko) * | 2005-06-15 | 2008-03-06 | 가부시키가이샤 가네카 | 코엔자임 ｑ10 함유 수용성 조성물 및 그의 제조 방법 |
| US8506956B2 (en) | 2005-10-31 | 2013-08-13 | Kaneka Corporation | Method for stabilizing reduced coenzyme Q10 |
| JP5015548B2 (ja) * | 2005-10-31 | 2012-08-29 | 株式会社カネカ | 還元型補酵素ｑ１０を安定化するための方法 |
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| EP2002832A4 (en) | 2006-03-31 | 2009-11-11 | Suntory Holdings Ltd | COMPOSITION WITH A LIGNAN CONNECTION |
| AU2007261943B2 (en) * | 2006-06-22 | 2012-11-01 | Kaneka Corporation | Reduced coenzyme Q10-containing composition and method for producing the same |
| KR100786884B1 (ko) * | 2006-06-27 | 2007-12-20 | 영진약품공업주식회사 | 코엔자임 ｑ１０ 함유 수용성 조성물 |
| EP2062574B1 (en) * | 2006-09-08 | 2015-03-25 | Kaneka Corporation | Composition comprising reduced coenzyme q10 and lysolecithin |
| US20080145411A1 (en) * | 2006-10-06 | 2008-06-19 | Kaneka Corporation | Composition of high absorbability for oral administration comprising oxidized coenzyme q10 |
| CA2823407C (en) | 2007-03-22 | 2016-10-18 | Berg Pharma Llc | Topical formulations having enhanced bioavailability |
| US20100092560A1 (en) * | 2007-04-16 | 2010-04-15 | Kaneka Corporation | Reduced coenzyme q10-containing particulate composition and method for producing the same |
| WO2008129980A1 (ja) * | 2007-04-16 | 2008-10-30 | Kaneka Corporation | 還元型補酵素ｑ１０含有粒子状組成物及びその製造方法 |
| KR100871050B1 (ko) * | 2007-05-14 | 2008-12-01 | 다윈이십일주식회사 | 코엔자임큐텐을 함유한 미세캡슐의 제조방법 |
| WO2009025277A1 (ja) | 2007-08-22 | 2009-02-26 | Kaneka Corporation | 還元型補酵素ｑ10の製造方法、ならびに、その安定化方法 |
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| JP2009149584A (ja) * | 2007-12-21 | 2009-07-09 | Kaneka Corp | 還元型補酵素ｑ１０含有粒子状組成物及びその製造方法 |
| DK200800040U3 (da) | 2008-03-06 | 2009-06-26 | Pharma Nord Aps | Lægemiddel og kosttilskud med indhold af stabiliseret ubiquinol i beskyttende pakning. |
| EP2271325A4 (en) | 2008-04-11 | 2011-11-09 | Cytotech Labs Llc | METHODS AND USE OF INDUCING APOPTOSIS IN CANCER CELLS |
| EP2342328B1 (en) * | 2008-10-03 | 2016-04-20 | E. I. du Pont de Nemours and Company | Enzymatic peracid generation formulation |
| CN101514148B (zh) * | 2009-03-27 | 2015-05-13 | 玉溪健坤生物药业有限公司 | 一种还原型辅酶q10的制备方法 |
| US10519504B2 (en) | 2009-05-11 | 2019-12-31 | Berg Llc | Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
| WO2011045934A1 (ja) * | 2009-10-16 | 2011-04-21 | 株式会社カネカ | 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物 |
| CN102057991B (zh) * | 2009-12-31 | 2013-11-06 | 山东三星玉米产业科技有限公司 | 一种富含辅酶q10的玉米油及其生产方法 |
| US11400058B2 (en) | 2010-03-12 | 2022-08-02 | Berg Llc | Intravenous formulations of coenzyme Q10 (CoQ10) and methods of use thereof |
| EP2694463B8 (en) | 2011-04-04 | 2019-10-09 | Berg LLC | Treating central nervous system tumors with coenzyme q10 |
| EA201490047A1 (ru) | 2011-06-17 | 2014-08-29 | Берг Ллк | Ингаляционные фармацевтические композиции |
| CN102754829A (zh) * | 2012-07-03 | 2012-10-31 | 广东仙乐制药有限公司 | 一种含辅酶q10的保健组合物、胶囊制剂及制备方法 |
| JP5999765B2 (ja) * | 2012-12-07 | 2016-09-28 | バイオアバイラビリティ，インク． | 栄養学的に使用するための高濃度自己マイクロエマルジョン化コエンザイムｑ１０調製物 |
| JP5722299B2 (ja) * | 2012-12-07 | 2015-05-20 | バイオアバイラビリティ，インク． | 栄養学的に使用するための高濃度自己マイクロエマルジョン化コエンザイムｑ１０調製物 |
| EA032775B1 (ru) | 2013-04-08 | 2019-07-31 | Берг Ллк | Способы лечения злокачественной опухоли с использованием комбинированной терапии с коферментом q10 |
| CN103211217A (zh) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | 一种增强免疫力功能的保健软胶囊及其制备方法 |
| US9757332B2 (en) | 2013-05-20 | 2017-09-12 | Uha Mikakuto Co., Ltd. | Gel-like composition having high ubiquinol content |
| WO2015035094A1 (en) | 2013-09-04 | 2015-03-12 | Berg Llc | Methods of treatment of cancer by continuous infusion of coenzyme q10 |
| CN103859395B (zh) * | 2014-01-24 | 2015-08-26 | 天津科技大学 | 一种高吸收率的辅酶q10的自乳化释药体系及其制备方法及应用 |
| WO2016038150A1 (en) * | 2014-09-10 | 2016-03-17 | Pharma Nord Aps | Ubidecarenone composition |
| WO2017087576A1 (en) | 2015-11-16 | 2017-05-26 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| CN105831767A (zh) * | 2016-03-24 | 2016-08-10 | 袁洪 | 用于增强免疫力和抗疲劳的组合物及其制备方法和应用 |
| SG11202102527SA (en) * | 2018-10-26 | 2021-05-28 | Suntory Holdings Ltd | Oral composition containing reduced coenzyme q10, method for producing same, method for preventing discoloration and discoloration preventing agent |
| IT201900006573A1 (it) * | 2019-05-06 | 2020-11-06 | Gricar Chemical S R L | Composizione liquida per la veicolazione di sostanze a bassa solubilità e bio-accessibilità enterica |
| WO2020255411A1 (ja) * | 2019-06-21 | 2020-12-24 | 株式会社ベリタス | ラブダン型ジテルペンを含有する経口投与用安定化製剤およびその製造方法 |
| DE102019218244A1 (de) * | 2019-11-26 | 2021-05-27 | Beiersdorf Ag | Wirkstoffkombinationen aus Ubichinol und einem oder mehreren Emulgatoren aus der Gruppe der Phosphate und Sulfate sowie kosmetische oder dermatologische Zubereitungen, solche Wirkstoffkombinationen enthaltend |
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| JPS5581813A (en) * | 1978-12-16 | 1980-06-20 | Nisshin Flour Milling Co Ltd | Composition containing coenzyme q10 and its perparation |
| DE3224619A1 (de) * | 1981-07-14 | 1983-05-19 | Freund Industrial Co., Ltd., Tokyo | Orale pharmazeutische zusammensetzung |
| IT1265312B1 (it) * | 1993-12-21 | 1996-10-31 | Indena Spa | Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di |
| FR2714600B1 (fr) * | 1993-12-30 | 1996-02-09 | Oreal | Composition protectrice, nutritive et/ou raffermissante pour le traitement simultané des couches superficielles et profondes de la peau, son utilisation. |
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| US6835408B2 (en) * | 1998-11-13 | 2004-12-28 | The Nisshin Oillio Group, Ltd. | Oil or fat composition |
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| US8753675B1 (en) * | 2000-01-20 | 2014-06-17 | Raj K. Chopra | Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications |
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| US6300377B1 (en) * | 2001-02-22 | 2001-10-09 | Raj K. Chopra | Coenzyme Q products exhibiting high dissolution qualities |
| JP3742602B2 (ja) | 2001-05-09 | 2006-02-08 | 株式会社カネカ | 還元型補酵素ｑの安定な溶液 |
| JP4170657B2 (ja) | 2001-07-13 | 2008-10-22 | 株式会社カネカ | 還元型補酵素ｑ１０の結晶化法 |
| TWI235146B (en) * | 2001-07-16 | 2005-07-01 | Kaneka Corp | Method of stabilizing reduced coenzyme q10 and method of acidic crystallization |
| JP4170656B2 (ja) | 2001-07-30 | 2008-10-22 | 株式会社カネカ | 還元型補酵素ｑ１０結晶の製造方法 |
| TWI329510B (en) * | 2001-10-10 | 2010-09-01 | Kaneka Corp | Method of stabilizing reduced coenzyme q10 |
| JP3822479B2 (ja) * | 2001-10-10 | 2006-09-20 | 株式会社カネカ | 還元型補酵素ｑ水溶液の安定化組成 |
| JP3892881B2 (ja) * | 2001-10-10 | 2007-03-14 | 株式会社カネカ | 還元型補酵素ｑ１０の安定化法 |
-
2003
- 2003-01-17 TW TW092100937A patent/TW200302056A/zh not_active IP Right Cessation
- 2003-01-20 JP JP2003562066A patent/JP4572073B2/ja not_active Expired - Lifetime
- 2003-01-20 CN CN038024462A patent/CN1620413B/zh not_active Expired - Lifetime
- 2003-01-20 AU AU2003201924A patent/AU2003201924B2/en not_active Ceased
- 2003-01-20 KR KR1020047011042A patent/KR100895912B1/ko not_active Expired - Fee Related
- 2003-01-20 CA CA2473700A patent/CA2473700C/en not_active Expired - Lifetime
- 2003-01-20 WO PCT/JP2003/000394 patent/WO2003062182A1/ja not_active Ceased
- 2003-01-20 US US10/501,698 patent/US8562975B2/en not_active Expired - Fee Related
- 2003-01-20 EP EP03700597.2A patent/EP1475363B1/en not_active Expired - Lifetime
- 2003-01-20 RU RU2004125169/04A patent/RU2304573C2/ru not_active IP Right Cessation
- 2003-01-20 DK DK03700597.2T patent/DK1475363T3/da active
-
2010
- 2010-05-13 JP JP2010111359A patent/JP2010189437A/ja active Pending
Non-Patent Citations (1)
| Title |
|---|
| US 2002/0001660 A1,权利要求. |
Also Published As
| Publication number | Publication date |
|---|---|
| US8562975B2 (en) | 2013-10-22 |
| CN1620413A (zh) | 2005-05-25 |
| JPWO2003062182A1 (ja) | 2005-05-19 |
| JP2010189437A (ja) | 2010-09-02 |
| WO2003062182A1 (fr) | 2003-07-31 |
| JP4572073B2 (ja) | 2010-10-27 |
| CA2473700A1 (en) | 2003-07-31 |
| EP1475363A4 (en) | 2006-07-19 |
| EP1475363B1 (en) | 2014-06-18 |
| RU2004125169A (ru) | 2006-01-27 |
| KR100895912B1 (ko) | 2009-05-07 |
| TWI358268B (enExample) | 2012-02-21 |
| CA2473700C (en) | 2012-07-24 |
| AU2003201924B2 (en) | 2009-09-03 |
| RU2304573C2 (ru) | 2007-08-20 |
| US20050147598A1 (en) | 2005-07-07 |
| KR20040086275A (ko) | 2004-10-08 |
| TW200302056A (en) | 2003-08-01 |
| EP1475363A1 (en) | 2004-11-10 |
| DK1475363T3 (da) | 2014-08-25 |
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