CN1610662A - 一种获得基于黄体素的新制剂的方法 - Google Patents
一种获得基于黄体素的新制剂的方法 Download PDFInfo
- Publication number
- CN1610662A CN1610662A CNA028264215A CN02826421A CN1610662A CN 1610662 A CN1610662 A CN 1610662A CN A028264215 A CNA028264215 A CN A028264215A CN 02826421 A CN02826421 A CN 02826421A CN 1610662 A CN1610662 A CN 1610662A
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- Prior art keywords
- preparation
- lutein
- oil
- ester
- starch
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- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 1
- 229940022405 astaxanthin Drugs 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 235000002360 beta-cryptoxanthin Nutrition 0.000 description 1
- 239000011774 beta-cryptoxanthin Substances 0.000 description 1
- DMASLKHVQRHNES-ITUXNECMSA-N beta-cryptoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CCCC2(C)C DMASLKHVQRHNES-ITUXNECMSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 229940043232 butyl acetate Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000001659 canthaxanthin Substances 0.000 description 1
- FDSDTBUPSURDBL-DKLMTRRASA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-DKLMTRRASA-N 0.000 description 1
- 229940008033 canthaxanthin Drugs 0.000 description 1
- 235000018889 capsanthin Nutrition 0.000 description 1
- WRANYHFEXGNSND-LOFNIBRQSA-N capsanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC(=O)C2(C)CCC(O)C2(C)C WRANYHFEXGNSND-LOFNIBRQSA-N 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000009838 combustion analysis Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000010981 drying operation Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000002680 epsilon-carotene Nutrition 0.000 description 1
- QABFXOMOOYWZLZ-UWXQCODUSA-N epsilon-carotene Natural products CC(=CC=CC=C(C)C=CC=C(C)C=C[C@H]1C(=CCCC1(C)C)C)C=CC=C(C)C=C[C@H]2C(=CCCC2(C)C)C QABFXOMOOYWZLZ-UWXQCODUSA-N 0.000 description 1
- UDOUIRSXTJAWOV-UHFFFAOYSA-N ethyl acetate;propyl acetate Chemical compound CCOC(C)=O.CCCOC(C)=O UDOUIRSXTJAWOV-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000011663 gamma-carotene Substances 0.000 description 1
- 235000000633 gamma-carotene Nutrition 0.000 description 1
- HRQKOYFGHJYEFS-RZWPOVEWSA-N gamma-carotene Natural products C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(/C=C/C=1C(C)(C)CCCC=1C)\C)/C)\C)(\C=C\C=C(/CC/C=C(\C)/C)\C)/C HRQKOYFGHJYEFS-RZWPOVEWSA-N 0.000 description 1
- 150000005826 halohydrocarbons Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 235000006486 human diet Nutrition 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- BIPAHAFBQLWRMC-KLCRVCSUSA-N lactucaxanthin Chemical compound C(\[C@@H]1C(C[C@@H](O)C=C1C)(C)C)=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=C[C@H]1C(C)=C[C@H](O)CC1(C)C BIPAHAFBQLWRMC-KLCRVCSUSA-N 0.000 description 1
- 235000004490 lactucaxanthin Nutrition 0.000 description 1
- DYUUPIKEWLHQGQ-FJOIUHRLSA-N lutein 5,6-epoxide Chemical compound C(/[C@]12[C@@](O1)(C)C[C@@H](O)CC2(C)C)=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C DYUUPIKEWLHQGQ-FJOIUHRLSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- OWAAYLVMANNJOG-OAKWGMHJSA-N neoxanthin Natural products CC(=C/C=C(C)/C=C/C=C(C)/C=C=C1C(C)(C)CC(O)CC1(C)O)C=CC=C(/C)C=CC23OC2(C)CC(O)CC3(C)C OWAAYLVMANNJOG-OAKWGMHJSA-N 0.000 description 1
- 238000006864 oxidative decomposition reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000001688 paprika extract Substances 0.000 description 1
- 235000012658 paprika extract Nutrition 0.000 description 1
- 230000000243 photosynthetic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004854 plant resin Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000019245 violaxanthin Nutrition 0.000 description 1
- SZCBXWMUOPQSOX-PSXNNQPNSA-N violaxanthin Chemical compound C(\[C@@]12[C@](O1)(C)C[C@H](O)CC2(C)C)=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/[C@]1(C(C[C@@H](O)C2)(C)C)[C@]2(C)O1 SZCBXWMUOPQSOX-PSXNNQPNSA-N 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 150000003735 xanthophylls Chemical class 0.000 description 1
- 235000008210 xanthophylls Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Obesity (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (22)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ESP0102917 | 2001-12-28 | ||
ES200102917A ES2189697B1 (es) | 2001-12-28 | 2001-12-28 | Procedimiento para obtener nuevas formulaciones a base de luteina. |
Publications (2)
Publication Number | Publication Date |
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CN1610662A true CN1610662A (zh) | 2005-04-27 |
CN1285574C CN1285574C (zh) | 2006-11-22 |
Family
ID=8499898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CNB028264215A Expired - Fee Related CN1285574C (zh) | 2001-12-28 | 2002-12-20 | 一种获得基于黄体素的新制剂的方法 |
Country Status (13)
Country | Link |
---|---|
US (1) | US7045643B2 (zh) |
EP (1) | EP1460060B2 (zh) |
JP (1) | JP4437041B2 (zh) |
CN (1) | CN1285574C (zh) |
AT (1) | ATE402143T1 (zh) |
AU (1) | AU2002361273B2 (zh) |
BR (1) | BRPI0215447B1 (zh) |
CA (1) | CA2471418C (zh) |
DE (1) | DE60227838D1 (zh) |
ES (2) | ES2189697B1 (zh) |
MX (1) | MXPA04006282A (zh) |
RU (1) | RU2303028C2 (zh) |
WO (1) | WO2003055855A1 (zh) |
Cited By (3)
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US20160074456A1 (en) * | 2012-12-19 | 2016-03-17 | Novus International Inc. | Xanthophyll compositions and methods of use |
CN108308616A (zh) * | 2013-03-28 | 2018-07-24 | 帝斯曼知识产权资产管理有限公司 | 适合婴幼儿食品制剂的叶黄素组合物 |
CN108324699A (zh) * | 2017-01-20 | 2018-07-27 | 浙江医药股份有限公司新昌制药厂 | 稳定的脂溶性活性成分组合物、微囊及其制备方法和应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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ES2215696T3 (es) * | 2000-07-13 | 2004-10-16 | Vitatene, S.A. | Metodo para la produccion de una formulacion dispersable en agua que contiene carotenoides. |
DE20319249U1 (de) * | 2003-12-10 | 2004-12-30 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Lutein-Konzentrat |
ATE501644T1 (de) | 2007-01-16 | 2011-04-15 | Basf Se | Flüssige formulierungen enthaltend carotinoide |
WO2008102019A2 (de) * | 2007-02-23 | 2008-08-28 | Basf Se | Verwendung von wasserdispergierbaren carotinoid-nanopartikeln als geschmacksmodulatoren, geschmacksmodulatoren, enthaltend wasserdispergierbare carotinoid-nanopartikel, und verfahren zur geschmacksmodulation |
DE502008002299D1 (de) * | 2007-02-23 | 2011-02-24 | Brain Biotechnology Res & Information Network Ag | Verfahren zur geschmacksmodulation von stofflichen zusammensetzungen, die mindestens einen high intensity sweetener (his) enthalten |
EP1967081A1 (en) * | 2007-03-05 | 2008-09-10 | DSMIP Assets B.V. | Process for the manufacture of a powder containing carotenoids |
JP2008280281A (ja) * | 2007-05-10 | 2008-11-20 | Hokkaido Univ | 抗肥満活性剤 |
US8158185B2 (en) * | 2007-10-04 | 2012-04-17 | Bunge Oils, Inc. | Controlled viscosity oil composition and method of making |
US20090118228A1 (en) * | 2007-11-07 | 2009-05-07 | Bristol-Myers Squibb Company | Carotenoid-containing compositions and methods |
JP2011505125A (ja) * | 2007-11-29 | 2011-02-24 | ビーエーエスエフ ソシエタス・ヨーロピア | 飲料着色用カロテノイド粉末状組成物 |
CN101461450B (zh) * | 2007-12-18 | 2011-12-28 | 浙江医药股份有限公司新昌制药厂 | 通过饮水补充动物体内类胡萝卜素的方法 |
CN102176833B (zh) * | 2008-10-07 | 2018-03-16 | 巴斯夫欧洲公司 | 即用型稳定乳液 |
WO2010094986A1 (en) * | 2009-02-18 | 2010-08-26 | Innova Andina S.A | Micronized carotenoid preparation as immunostimulant for crustaceans |
CN101921495B (zh) * | 2009-06-12 | 2013-04-24 | 中国中化股份有限公司 | 一种制备叶黄素油树脂微胶囊的方法 |
ES2443846T3 (es) * | 2009-08-28 | 2014-02-20 | Chr. Hansen A/S | Sustancias de carbo de alta resistencia |
CN102329520B (zh) * | 2011-07-08 | 2013-06-12 | 中国热带农业科学院农产品加工研究所 | 一种叶黄素纳米液的制备方法 |
KR101493564B1 (ko) * | 2012-03-26 | 2015-02-16 | 우석대학교 산학협력단 | 루테인을 함유한 복합제제의 제조 방법 |
CA2881798A1 (en) * | 2012-08-26 | 2014-03-06 | Lycored Ltd. | Hue-controlled .beta.-carotene formulations |
WO2015173603A1 (en) | 2014-05-16 | 2015-11-19 | Omniactive Health Technologies Limited | Hydrophilic matrix beadlet compositions with enhanced bioavailability |
CN105663082B (zh) * | 2016-01-21 | 2018-06-22 | 江苏怀仁生物科技有限公司 | 一种强抗氧化性叶黄素微胶囊及其制备方法 |
US11197493B2 (en) | 2017-09-12 | 2021-12-14 | Omniactive Health Technologies Limited | Stabilized fat soluble nutrient compositions and process for the preparation thereof |
DE102017009186A1 (de) | 2017-09-25 | 2019-03-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Lutein und -derivate enthaltende Zusammensetzung sowie Verfahren zur Herstellung |
CN108378112A (zh) * | 2018-02-09 | 2018-08-10 | 云南瑞宝生物科技股份有限公司 | 含叶黄素酯的水果保健月饼及其制备方法 |
CN108077367A (zh) * | 2018-02-09 | 2018-05-29 | 云南瑞宝生物科技股份有限公司 | 叶黄素酯饼干及其制备方法 |
US11772007B2 (en) | 2018-04-27 | 2023-10-03 | Dsm Ip Assets B.V. | Evaporator system |
KR20220082812A (ko) * | 2019-10-15 | 2022-06-17 | 옴니액티브 헬스 테크놀로지스 리미티드 | 루테인 및 제아잔틴을 포함하는 생체이용가능성이 증강된 크산토필 조성물 |
CN112704739A (zh) * | 2020-12-29 | 2021-04-27 | 佛山市南海东方澳龙制药有限公司 | 一种叶黄素制剂的制备方法及叶黄素制剂 |
CN115153032B (zh) * | 2022-05-25 | 2022-12-06 | 北京东方红航天生物技术股份有限公司 | 一种促进运动人群健康的组合物及其制备方法 |
KR20240034947A (ko) | 2022-09-07 | 2024-03-15 | 전북대학교산학협력단 | 크립토캅신과 루테인을 주성분으로 하는 복합 추출물 및 그의 제조방법 |
CN116059386A (zh) * | 2023-03-27 | 2023-05-05 | 山东理工大学 | 一种水溶性叶黄素复合纳米颗粒及其制备方法 |
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US3523138A (en) * | 1965-03-01 | 1970-08-04 | Eastman Kodak Co | Treatment of marigold petal meal to obtain a xanthophyll product |
US5382714A (en) * | 1994-03-17 | 1995-01-17 | The Catholic University Of America | Process for isolation, purification, and recrystallization of lutein from saponified marigold oleoresin and uses thereof |
US5648564A (en) * | 1995-12-21 | 1997-07-15 | Kemin Industries, Inc. | Process for the formation, isolation and purification of comestible xanthophyll crystals from plants |
DE19637517A1 (de) * | 1996-09-13 | 1998-03-19 | Basf Ag | Herstellung von pulverförmigen, kaltwasserdispergierbaren Carotinoid-Zubereitungen und die Verwendung der neuen Carotinoid-Zubereitungen |
CA2261456A1 (en) * | 1998-02-23 | 1999-08-23 | F. Hoffmann-La Roche Ag | Preparation of a finely divided pulverous carotenoid preparation |
-
2001
- 2001-12-28 ES ES200102917A patent/ES2189697B1/es not_active Expired - Fee Related
-
2002
- 2002-12-20 ES ES02796800T patent/ES2310618T5/es not_active Expired - Lifetime
- 2002-12-20 RU RU2004123095/04A patent/RU2303028C2/ru active
- 2002-12-20 CN CNB028264215A patent/CN1285574C/zh not_active Expired - Fee Related
- 2002-12-20 CA CA2471418A patent/CA2471418C/en not_active Expired - Lifetime
- 2002-12-20 DE DE60227838T patent/DE60227838D1/de not_active Expired - Lifetime
- 2002-12-20 MX MXPA04006282A patent/MXPA04006282A/es active IP Right Grant
- 2002-12-20 EP EP02796800A patent/EP1460060B2/en not_active Expired - Lifetime
- 2002-12-20 WO PCT/ES2002/000609 patent/WO2003055855A1/es active IP Right Grant
- 2002-12-20 AT AT02796800T patent/ATE402143T1/de not_active IP Right Cessation
- 2002-12-20 JP JP2003556387A patent/JP4437041B2/ja not_active Expired - Fee Related
- 2002-12-20 AU AU2002361273A patent/AU2002361273B2/en not_active Ceased
- 2002-12-20 US US10/498,434 patent/US7045643B2/en not_active Expired - Lifetime
- 2002-12-20 BR BRPI0215447A patent/BRPI0215447B1/pt not_active IP Right Cessation
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160074456A1 (en) * | 2012-12-19 | 2016-03-17 | Novus International Inc. | Xanthophyll compositions and methods of use |
US9827283B2 (en) * | 2012-12-19 | 2017-11-28 | Novus International, Inc. | Xanthophyll compositions and methods of use |
CN105188408B (zh) * | 2012-12-19 | 2019-03-01 | 诺华丝国际股份有限公司 | 叶黄素类组合物和使用方法 |
CN108308616A (zh) * | 2013-03-28 | 2018-07-24 | 帝斯曼知识产权资产管理有限公司 | 适合婴幼儿食品制剂的叶黄素组合物 |
US11730704B2 (en) | 2013-03-28 | 2023-08-22 | Dsm Ip Assets B.V. | Lutein composition suitable for infant food formulations |
CN108324699A (zh) * | 2017-01-20 | 2018-07-27 | 浙江医药股份有限公司新昌制药厂 | 稳定的脂溶性活性成分组合物、微囊及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
BR0215447A (pt) | 2005-04-05 |
AU2002361273A1 (en) | 2003-07-15 |
MXPA04006282A (es) | 2005-02-24 |
ATE402143T1 (de) | 2008-08-15 |
CA2471418C (en) | 2012-04-24 |
JP2005512587A (ja) | 2005-05-12 |
JP4437041B2 (ja) | 2010-03-24 |
EP1460060A1 (en) | 2004-09-22 |
EP1460060B1 (en) | 2008-07-23 |
ES2310618T5 (es) | 2012-01-25 |
CN1285574C (zh) | 2006-11-22 |
ES2310618T3 (es) | 2009-01-16 |
AU2002361273B2 (en) | 2008-06-12 |
US7045643B2 (en) | 2006-05-16 |
DE60227838D1 (de) | 2008-09-04 |
RU2004123095A (ru) | 2005-05-10 |
BRPI0215447B1 (pt) | 2015-12-22 |
WO2003055855A1 (es) | 2003-07-10 |
ES2189697A1 (es) | 2003-07-01 |
RU2303028C2 (ru) | 2007-07-20 |
ES2189697B1 (es) | 2005-02-01 |
US20050079223A1 (en) | 2005-04-14 |
CA2471418A1 (en) | 2003-07-10 |
EP1460060B2 (en) | 2011-08-31 |
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