ES2189697B1 - Procedimiento para obtener nuevas formulaciones a base de luteina. - Google Patents
Procedimiento para obtener nuevas formulaciones a base de luteina.Info
- Publication number
- ES2189697B1 ES2189697B1 ES200102917A ES200102917A ES2189697B1 ES 2189697 B1 ES2189697 B1 ES 2189697B1 ES 200102917 A ES200102917 A ES 200102917A ES 200102917 A ES200102917 A ES 200102917A ES 2189697 B1 ES2189697 B1 ES 2189697B1
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- lutein
- formulations
- luteine
- formulations based
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 235000012680 lutein Nutrition 0.000 title abstract 3
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- FKUISVKPMQSWTN-UHFFFAOYSA-N Kesselringine Natural products C1CC(C2=C34)N(C)CCC2=CC(O)=C4OC2(OC)C(O)CCC31C2 FKUISVKPMQSWTN-UHFFFAOYSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 4
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 abstract 2
- 229960005375 lutein Drugs 0.000 abstract 2
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 abstract 2
- 239000001656 lutein Substances 0.000 abstract 2
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 239000003086 colorant Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 229940107604 lutein esters Drugs 0.000 abstract 1
- 150000002658 luteins Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Obesity (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedimiento para obtener nuevas formulaciones a base de luteína. La presente invención describe un procedimiento de preparación de formulaciones de luteína microcristalina, particularmente en forma de ésteres, estables a la oxidación y solubles en medios hidrofílicos y/o lipofílicos. Para ellos los ésteres de luteína se mezclan con antioxidantes, aceites vegetales y/o disolventes orgánicos, siendo esta mezcla inicial sometida a diversas etapas según el tipo de formulación que finalmente se desee obtener. Estas formulaciones son de aplicación directa como colorantes tanto en los campos farmacéutico, alimentario y en cosmética. Asimismo pueden utilizarse como suplementos nutricionales.
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200102917A ES2189697B1 (es) | 2001-12-28 | 2001-12-28 | Procedimiento para obtener nuevas formulaciones a base de luteina. |
JP2003556387A JP4437041B2 (ja) | 2001-12-28 | 2002-12-20 | ルテインを基本とする新規処方物を得る方法 |
DE60227838T DE60227838D1 (de) | 2001-12-28 | 2002-12-20 | Verfahren zum erhalten neuer formulierungen auf luteinbasis |
AT02796800T ATE402143T1 (de) | 2001-12-28 | 2002-12-20 | Verfahren zum erhalten neuer formulierungen auf luteinbasis |
AU2002361273A AU2002361273B2 (en) | 2001-12-28 | 2002-12-20 | Method of obtaining novel lutein-based formulations |
CA2471418A CA2471418C (en) | 2001-12-28 | 2002-12-20 | Method of obtaining novel lutein-based formulations |
MXPA04006282A MXPA04006282A (es) | 2001-12-28 | 2002-12-20 | Procedimiento para obtener nuevas formulaciones a base de luteina. |
US10/498,434 US7045643B2 (en) | 2001-12-28 | 2002-12-20 | Method for obtaining novel lutein-based formulations |
BRPI0215447A BRPI0215447B1 (pt) | 2001-12-28 | 2002-12-20 | método de obtenção de novas formulações à base de luteína |
ES02796800T ES2310618T5 (es) | 2001-12-28 | 2002-12-20 | Procedimiento para obtener nuevas formulaciones a base de luteína. |
PCT/ES2002/000609 WO2003055855A1 (es) | 2001-12-28 | 2002-12-20 | Procedimiento para obtener nuevas formulaciones a base de luteina |
RU2004123095/04A RU2303028C2 (ru) | 2001-12-28 | 2002-12-20 | Способ получения композиции лютеина, композиции, их применение |
CNB028264215A CN1285574C (zh) | 2001-12-28 | 2002-12-20 | 一种获得基于黄体素的新制剂的方法 |
EP02796800A EP1460060B2 (en) | 2001-12-28 | 2002-12-20 | Method of obtaining novel lutein-based formulations |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200102917A ES2189697B1 (es) | 2001-12-28 | 2001-12-28 | Procedimiento para obtener nuevas formulaciones a base de luteina. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2189697A1 ES2189697A1 (es) | 2003-07-01 |
ES2189697B1 true ES2189697B1 (es) | 2005-02-01 |
Family
ID=8499898
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200102917A Expired - Fee Related ES2189697B1 (es) | 2001-12-28 | 2001-12-28 | Procedimiento para obtener nuevas formulaciones a base de luteina. |
ES02796800T Expired - Lifetime ES2310618T5 (es) | 2001-12-28 | 2002-12-20 | Procedimiento para obtener nuevas formulaciones a base de luteína. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02796800T Expired - Lifetime ES2310618T5 (es) | 2001-12-28 | 2002-12-20 | Procedimiento para obtener nuevas formulaciones a base de luteína. |
Country Status (13)
Country | Link |
---|---|
US (1) | US7045643B2 (es) |
EP (1) | EP1460060B2 (es) |
JP (1) | JP4437041B2 (es) |
CN (1) | CN1285574C (es) |
AT (1) | ATE402143T1 (es) |
AU (1) | AU2002361273B2 (es) |
BR (1) | BRPI0215447B1 (es) |
CA (1) | CA2471418C (es) |
DE (1) | DE60227838D1 (es) |
ES (2) | ES2189697B1 (es) |
MX (1) | MXPA04006282A (es) |
RU (1) | RU2303028C2 (es) |
WO (1) | WO2003055855A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1300394B1 (en) * | 2000-07-13 | 2004-02-11 | Vitatene, S.A. | Method for the production of a water-dispersible formulation containing carotenoids |
DE20319249U1 (de) * | 2003-12-10 | 2004-12-30 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Lutein-Konzentrat |
ATE501644T1 (de) | 2007-01-16 | 2011-04-15 | Basf Se | Flüssige formulierungen enthaltend carotinoide |
JP2010518829A (ja) * | 2007-02-23 | 2010-06-03 | ビーエーエスエフ ソシエタス・ヨーロピア | 味覚変容物質としての水分散性カロテノイドナノ粒子の使用、水分散性カロテノイドナノ粒子を含む味覚変容物質、および味覚変容方法 |
US20100047426A1 (en) * | 2007-02-23 | 2010-02-25 | Basf Se | Method for modulating the taste of material compositions containing at least one high intensity sweetener (his) |
EP1967081A1 (en) | 2007-03-05 | 2008-09-10 | DSMIP Assets B.V. | Process for the manufacture of a powder containing carotenoids |
JP2008280281A (ja) * | 2007-05-10 | 2008-11-20 | Hokkaido Univ | 抗肥満活性剤 |
US8158185B2 (en) * | 2007-10-04 | 2012-04-17 | Bunge Oils, Inc. | Controlled viscosity oil composition and method of making |
US20090118228A1 (en) * | 2007-11-07 | 2009-05-07 | Bristol-Myers Squibb Company | Carotenoid-containing compositions and methods |
CN105077203A (zh) * | 2007-11-29 | 2015-11-25 | 巴斯夫欧洲公司 | 用于饮料着色的粉状类胡萝卜素制剂 |
CN101461450B (zh) * | 2007-12-18 | 2011-12-28 | 浙江医药股份有限公司新昌制药厂 | 通过饮水补充动物体内类胡萝卜素的方法 |
EP2343986B2 (de) | 2008-10-07 | 2021-04-21 | Basf Se | Gebrauchfertige, stabile emulsion |
WO2010094986A1 (en) * | 2009-02-18 | 2010-08-26 | Innova Andina S.A | Micronized carotenoid preparation as immunostimulant for crustaceans |
CN101921495B (zh) * | 2009-06-12 | 2013-04-24 | 中国中化股份有限公司 | 一种制备叶黄素油树脂微胶囊的方法 |
BR112012004009B1 (pt) * | 2009-08-28 | 2021-05-11 | Chr. Hansen Natural Colors A/S | substâncias colorantes dispersíveis em água, seu método de preparação e uso, bem como produtos comestível e farmacêutico |
CN102329520B (zh) * | 2011-07-08 | 2013-06-12 | 中国热带农业科学院农产品加工研究所 | 一种叶黄素纳米液的制备方法 |
KR101493564B1 (ko) * | 2012-03-26 | 2015-02-16 | 우석대학교 산학협력단 | 루테인을 함유한 복합제제의 제조 방법 |
AU2013311059B2 (en) * | 2012-08-26 | 2017-04-06 | Lycored Ltd. | Hue-controlled beta-carotene formulations |
EP2934184A4 (en) * | 2012-12-19 | 2016-06-01 | Novus Int Inc | XANTHOPHYLL COMPOSITIONS AND METHODS OF USE |
CN105072926B (zh) * | 2013-03-28 | 2019-04-05 | 帝斯曼知识产权资产管理有限公司 | 适合婴幼儿食品制剂的叶黄素组合物 |
WO2015173603A1 (en) | 2014-05-16 | 2015-11-19 | Omniactive Health Technologies Limited | Hydrophilic matrix beadlet compositions with enhanced bioavailability |
CN105663082B (zh) * | 2016-01-21 | 2018-06-22 | 江苏怀仁生物科技有限公司 | 一种强抗氧化性叶黄素微胶囊及其制备方法 |
CN108324699A (zh) * | 2017-01-20 | 2018-07-27 | 浙江医药股份有限公司新昌制药厂 | 稳定的脂溶性活性成分组合物、微囊及其制备方法和应用 |
US11197493B2 (en) | 2017-09-12 | 2021-12-14 | Omniactive Health Technologies Limited | Stabilized fat soluble nutrient compositions and process for the preparation thereof |
DE102017009186A1 (de) | 2017-09-25 | 2019-03-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Lutein und -derivate enthaltende Zusammensetzung sowie Verfahren zur Herstellung |
CN108378112A (zh) * | 2018-02-09 | 2018-08-10 | 云南瑞宝生物科技股份有限公司 | 含叶黄素酯的水果保健月饼及其制备方法 |
CN108077367A (zh) * | 2018-02-09 | 2018-05-29 | 云南瑞宝生物科技股份有限公司 | 叶黄素酯饼干及其制备方法 |
EP3784055B1 (en) * | 2018-04-27 | 2024-05-01 | DSM IP Assets B.V. | Apparatus and process for manufacturing of powders with a fat-soluble component |
KR20220082812A (ko) * | 2019-10-15 | 2022-06-17 | 옴니액티브 헬스 테크놀로지스 리미티드 | 루테인 및 제아잔틴을 포함하는 생체이용가능성이 증강된 크산토필 조성물 |
CN112704739A (zh) * | 2020-12-29 | 2021-04-27 | 佛山市南海东方澳龙制药有限公司 | 一种叶黄素制剂的制备方法及叶黄素制剂 |
CN115153032B (zh) * | 2022-05-25 | 2022-12-06 | 北京东方红航天生物技术股份有限公司 | 一种促进运动人群健康的组合物及其制备方法 |
KR20240034947A (ko) | 2022-09-07 | 2024-03-15 | 전북대학교산학협력단 | 크립토캅신과 루테인을 주성분으로 하는 복합 추출물 및 그의 제조방법 |
CN116059386A (zh) * | 2023-03-27 | 2023-05-05 | 山东理工大学 | 一种水溶性叶黄素复合纳米颗粒及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3523138A (en) * | 1965-03-01 | 1970-08-04 | Eastman Kodak Co | Treatment of marigold petal meal to obtain a xanthophyll product |
US5382714A (en) * | 1994-03-17 | 1995-01-17 | The Catholic University Of America | Process for isolation, purification, and recrystallization of lutein from saponified marigold oleoresin and uses thereof |
US5648564A (en) * | 1995-12-21 | 1997-07-15 | Kemin Industries, Inc. | Process for the formation, isolation and purification of comestible xanthophyll crystals from plants |
DE19637517A1 (de) * | 1996-09-13 | 1998-03-19 | Basf Ag | Herstellung von pulverförmigen, kaltwasserdispergierbaren Carotinoid-Zubereitungen und die Verwendung der neuen Carotinoid-Zubereitungen |
CA2261456A1 (en) * | 1998-02-23 | 1999-08-23 | F. Hoffmann-La Roche Ag | Preparation of a finely divided pulverous carotenoid preparation |
-
2001
- 2001-12-28 ES ES200102917A patent/ES2189697B1/es not_active Expired - Fee Related
-
2002
- 2002-12-20 EP EP02796800A patent/EP1460060B2/en not_active Expired - Lifetime
- 2002-12-20 AU AU2002361273A patent/AU2002361273B2/en not_active Ceased
- 2002-12-20 AT AT02796800T patent/ATE402143T1/de not_active IP Right Cessation
- 2002-12-20 RU RU2004123095/04A patent/RU2303028C2/ru active
- 2002-12-20 BR BRPI0215447A patent/BRPI0215447B1/pt not_active IP Right Cessation
- 2002-12-20 ES ES02796800T patent/ES2310618T5/es not_active Expired - Lifetime
- 2002-12-20 DE DE60227838T patent/DE60227838D1/de not_active Expired - Lifetime
- 2002-12-20 CN CNB028264215A patent/CN1285574C/zh not_active Expired - Fee Related
- 2002-12-20 MX MXPA04006282A patent/MXPA04006282A/es active IP Right Grant
- 2002-12-20 WO PCT/ES2002/000609 patent/WO2003055855A1/es active IP Right Grant
- 2002-12-20 US US10/498,434 patent/US7045643B2/en not_active Expired - Lifetime
- 2002-12-20 CA CA2471418A patent/CA2471418C/en not_active Expired - Lifetime
- 2002-12-20 JP JP2003556387A patent/JP4437041B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1460060A1 (en) | 2004-09-22 |
AU2002361273B2 (en) | 2008-06-12 |
WO2003055855A1 (es) | 2003-07-10 |
ES2310618T5 (es) | 2012-01-25 |
CN1285574C (zh) | 2006-11-22 |
AU2002361273A1 (en) | 2003-07-15 |
CA2471418A1 (en) | 2003-07-10 |
MXPA04006282A (es) | 2005-02-24 |
ES2189697A1 (es) | 2003-07-01 |
US20050079223A1 (en) | 2005-04-14 |
RU2004123095A (ru) | 2005-05-10 |
EP1460060B1 (en) | 2008-07-23 |
BR0215447A (pt) | 2005-04-05 |
CN1610662A (zh) | 2005-04-27 |
DE60227838D1 (de) | 2008-09-04 |
ATE402143T1 (de) | 2008-08-15 |
RU2303028C2 (ru) | 2007-07-20 |
BRPI0215447B1 (pt) | 2015-12-22 |
CA2471418C (en) | 2012-04-24 |
ES2310618T3 (es) | 2009-01-16 |
US7045643B2 (en) | 2006-05-16 |
JP4437041B2 (ja) | 2010-03-24 |
EP1460060B2 (en) | 2011-08-31 |
JP2005512587A (ja) | 2005-05-12 |
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