CN1545508B - 1,2,4-三噁茂烷抗疟药 - Google Patents

1,2,4-三噁茂烷抗疟药 Download PDF

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Publication number
CN1545508B
CN1545508B CN028164539A CN02816453A CN1545508B CN 1545508 B CN1545508 B CN 1545508B CN 028164539 A CN028164539 A CN 028164539A CN 02816453 A CN02816453 A CN 02816453A CN 1545508 B CN1545508 B CN 1545508B
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CN
China
Prior art keywords
nmr
mmol
cdcl
trioxa
spiro
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Expired - Lifetime
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CN028164539A
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English (en)
Chinese (zh)
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CN1545508A (zh
Inventor
乔纳森·L·文纳斯特罗姆
雅克·肖莱
董玉湘
于格·马蒂勒
马尼扬·帕德马尼拉炎
唐元清
威廉·N·查曼
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MMV Medicines for Malaria Venture
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MMV Medicines for Malaria Venture
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Dental Preparations (AREA)
CN028164539A 2001-06-21 2002-06-21 1,2,4-三噁茂烷抗疟药 Expired - Lifetime CN1545508B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/886,666 US6486199B1 (en) 2001-06-21 2001-06-21 Spiro and dispiro 1,2,4-trioxolane antimalarials
US09/886,666 2001-06-21
PCT/US2002/019767 WO2003000676A1 (en) 2001-06-21 2002-06-21 1,2,4-trioxolane antimalarials

Publications (2)

Publication Number Publication Date
CN1545508A CN1545508A (zh) 2004-11-10
CN1545508B true CN1545508B (zh) 2012-06-06

Family

ID=25389491

Family Applications (1)

Application Number Title Priority Date Filing Date
CN028164539A Expired - Lifetime CN1545508B (zh) 2001-06-21 2002-06-21 1,2,4-三噁茂烷抗疟药

Country Status (24)

Country Link
US (1) US6486199B1 (https=)
EP (1) EP1414813B1 (https=)
JP (1) JP4303585B2 (https=)
KR (1) KR100759144B1 (https=)
CN (1) CN1545508B (https=)
AT (1) ATE339411T1 (https=)
AU (1) AU2002327183B2 (https=)
BR (1) BRPI0210549B8 (https=)
CA (1) CA2451006C (https=)
CY (1) CY1106214T1 (https=)
DE (1) DE60214733T8 (https=)
DK (1) DK1414813T3 (https=)
ES (1) ES2271323T3 (https=)
HU (1) HUP0400246A3 (https=)
IL (1) IL159474A0 (https=)
MX (1) MXPA03011915A (https=)
NO (1) NO20035721L (https=)
PL (1) PL226418B1 (https=)
PT (1) PT1414813E (https=)
RU (1) RU2271357C2 (https=)
SI (1) SI1414813T1 (https=)
UA (1) UA78709C2 (https=)
WO (1) WO2003000676A1 (https=)
YU (1) YU100703A (https=)

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US6825230B2 (en) * 2002-06-21 2004-11-30 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trixolane antimalarials
US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6906205B2 (en) * 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
FR2862304A1 (fr) * 2003-11-14 2005-05-20 Centre Nat Rech Scient Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques
EP1789380A1 (de) * 2004-07-23 2007-05-30 Justus-Liebig-Universität Giessen Aminoadamantan-derivate, verfahren zu ihrer herstellung und ihre verwendung
US20060040761A1 (en) * 2004-08-23 2006-02-23 Sam-Kyu Shin Scale mark mat for putting practice
US8067620B2 (en) 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
US20090042821A1 (en) * 2005-05-18 2009-02-12 Arno Appavoo Enose Stable dosage forms of spiro and dispiro 1,2,4-trioxolane antimalarials
WO2007036947A1 (en) * 2005-09-30 2007-04-05 Ipca Laboratories Limited Delayed release anti-malarial composition
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US20070231300A1 (en) * 2006-03-28 2007-10-04 Washington, University Of Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents
AR060404A1 (es) 2006-04-11 2008-06-11 Novartis Ag Compuestos organicos utiles como inhibidores de dipeptidil-peptidasa iv
US20090306091A1 (en) * 2006-05-17 2009-12-10 Vyas Madhavrao Shingatgeri Antimalarial therapy using a combination of synthetic artemisinin derivative and bisquinoline derivative
US8569519B2 (en) * 2006-05-24 2013-10-29 Ranbaxy Laboratories Limited Process for the preparation of dispiro 1,2,4-trioxolane antimalarials (OZ277)
FR2902100A1 (fr) * 2006-06-13 2007-12-14 Sanofi Aventis Sa Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique
GB0619333D0 (en) * 2006-09-30 2006-11-08 Univ Liverpool Dispiro tetraoxane compounds
WO2008046109A2 (en) * 2006-10-13 2008-04-17 University Of Washington Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer
FR2924343A1 (fr) * 2007-12-04 2009-06-05 Palumed Sa Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique.
WO2010001824A1 (ja) 2008-07-01 2010-01-07 国立大学法人 岡山大学 新規抗住血吸虫剤
WO2010011684A2 (en) 2008-07-21 2010-01-28 The Regents Of The University Of California Prodrug and fluoregenic compositions and methods for using the same
AP2014007413A0 (en) 2011-07-14 2014-02-28 Ranbaxy Lab Ltd Stable dosage forms of arterolane and piperaquine
WO2015123595A1 (en) 2014-02-14 2015-08-20 The Regents Of The University Of California Cyclic peroxides as prodrugs for selective delivery of agents
CA2971763A1 (en) * 2014-12-23 2016-06-30 Bergenbio Asa Inhibitors of akt kinase
RU2601315C1 (ru) * 2015-06-10 2016-11-10 Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук Способ получения пентаоксаспироалканов
WO2019005977A1 (en) * 2017-06-27 2019-01-03 The Regents Of The University Of California Trioxolane agents
CN108424371B (zh) * 2018-01-19 2021-07-16 北京理工大学 2-(4-氨基环己基)-乙酸乙酯的制备方法
US20210386814A1 (en) * 2020-05-20 2021-12-16 Amanuel Tesfazion Methods and compound for the treatment of malaria
US20240101584A1 (en) * 2021-02-01 2024-03-28 Westlake University Targeted delivery of 1,2,4,5 tetraoxane compounds and their uses
CN117085004A (zh) * 2023-09-27 2023-11-21 赣南师范大学 一种2,6-二苯亚甲基环己酮类似物在制备抗血吸虫药物中的应用

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Also Published As

Publication number Publication date
CA2451006A1 (en) 2003-01-03
SI1414813T1 (sl) 2006-12-31
US6486199B1 (en) 2002-11-26
EP1414813B1 (en) 2006-09-13
RU2271357C2 (ru) 2006-03-10
AU2002327183C1 (en) 2003-01-08
PL367158A1 (en) 2005-02-21
CY1106214T1 (el) 2011-06-08
EP1414813A1 (en) 2004-05-06
BRPI0210549B8 (pt) 2021-05-25
HUP0400246A3 (en) 2009-12-28
YU100703A (sh) 2006-03-03
DK1414813T3 (da) 2007-01-02
UA78709C2 (en) 2007-04-25
JP4303585B2 (ja) 2009-07-29
KR20040030697A (ko) 2004-04-09
ATE339411T1 (de) 2006-10-15
MXPA03011915A (es) 2004-05-21
WO2003000676A1 (en) 2003-01-03
ES2271323T3 (es) 2007-04-16
PT1414813E (pt) 2006-12-29
NO20035721L (no) 2004-02-23
DE60214733T2 (de) 2007-09-13
RU2004101409A (ru) 2005-06-10
HUP0400246A2 (hu) 2004-08-30
AU2002327183B2 (en) 2006-03-09
BR0210549A (pt) 2005-01-11
CN1545508A (zh) 2004-11-10
JP2004535436A (ja) 2004-11-25
DE60214733D1 (de) 2006-10-26
IL159474A0 (en) 2004-06-01
PL226418B1 (pl) 2017-07-31
BRPI0210549B1 (pt) 2020-11-10
KR100759144B1 (ko) 2007-09-14
NO20035721D0 (no) 2003-12-19
CA2451006C (en) 2011-08-23
DE60214733T8 (de) 2008-02-21

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