YU100703A - 1,2,4-trioksolanski antimalarici - Google Patents

1,2,4-trioksolanski antimalarici

Info

Publication number
YU100703A
YU100703A YU100703A YUP100703A YU100703A YU 100703 A YU100703 A YU 100703A YU 100703 A YU100703 A YU 100703A YU P100703 A YUP100703 A YU P100703A YU 100703 A YU100703 A YU 100703A
Authority
YU
Yugoslavia
Prior art keywords
trioxolane
group
spirocyclohexyl
trioxolane antimalarials
antimalarials
Prior art date
Application number
YU100703A
Other languages
English (en)
Inventor
Jonathan L. Vennerstrom
Jacques Chollet
Yuxiang Dong
Hugues Matile
Maniyan Padmanilayam
Yuanqing Tang
William N. Charman
Original Assignee
Medicines For Malaria Venture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicines For Malaria Venture filed Critical Medicines For Malaria Venture
Publication of YU100703A publication Critical patent/YU100703A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dental Preparations (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Opisani su načini i postupci za lečenje malarije, šistozomijaze i kancera, putem korišćenja spiro ili dispiro 1,2,4-trioksolana. Preferirani 1,2,4-trioksolani sadrže spiroadamantansku grupu sa jedne strane trioksolanske grupe i spirocikloheksil grupu sa druge strane trioksolanske grupe, pri čemu je spirocikloheksil prsten poželjno supstituisan na poziciji 4. U poredjenju sa polusintetičkim derivatima artemisinina, jedinjenja predmetnog pronalaska su strukturno jednostavnija, jednostavna za sintezu, netoksična i moćna protiv malarijskih parazita.[A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
YU100703A 2001-06-21 2002-06-21 1,2,4-trioksolanski antimalarici YU100703A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/886,666 US6486199B1 (en) 2001-06-21 2001-06-21 Spiro and dispiro 1,2,4-trioxolane antimalarials

Publications (1)

Publication Number Publication Date
YU100703A true YU100703A (sh) 2006-03-03

Family

ID=25389491

Family Applications (1)

Application Number Title Priority Date Filing Date
YU100703A YU100703A (sh) 2001-06-21 2002-06-21 1,2,4-trioksolanski antimalarici

Country Status (24)

Country Link
US (1) US6486199B1 (sh)
EP (1) EP1414813B1 (sh)
JP (1) JP4303585B2 (sh)
KR (1) KR100759144B1 (sh)
CN (1) CN1545508B (sh)
AT (1) ATE339411T1 (sh)
AU (1) AU2002327183B2 (sh)
BR (1) BRPI0210549B8 (sh)
CA (1) CA2451006C (sh)
CY (1) CY1106214T1 (sh)
DE (1) DE60214733T8 (sh)
DK (1) DK1414813T3 (sh)
ES (1) ES2271323T3 (sh)
HU (1) HUP0400246A3 (sh)
IL (1) IL159474A0 (sh)
MX (1) MXPA03011915A (sh)
NO (1) NO20035721L (sh)
PL (1) PL226418B1 (sh)
PT (1) PT1414813E (sh)
RU (1) RU2271357C2 (sh)
SI (1) SI1414813T1 (sh)
UA (1) UA78709C2 (sh)
WO (1) WO2003000676A1 (sh)
YU (1) YU100703A (sh)

Families Citing this family (29)

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ATE536887T1 (de) * 2002-06-06 2011-12-15 Univ Washington Kovalente konjugate zwischen mit artemisinin verwandten endoperoxiden und eisentragenden proteinen und anwendungsverfahren
US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6825230B2 (en) * 2002-06-21 2004-11-30 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trixolane antimalarials
US6906205B2 (en) * 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
FR2862304A1 (fr) * 2003-11-14 2005-05-20 Centre Nat Rech Scient Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques
EP1789380A1 (de) * 2004-07-23 2007-05-30 Justus-Liebig-Universität Giessen Aminoadamantan-derivate, verfahren zu ihrer herstellung und ihre verwendung
US20060040761A1 (en) * 2004-08-23 2006-02-23 Sam-Kyu Shin Scale mark mat for putting practice
US8067620B2 (en) * 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
CN101272777B (zh) * 2005-05-18 2013-01-30 兰贝克赛实验室有限公司 螺和二螺1,2,4-三氧戊环抗疟药的稳定剂型
WO2007036947A1 (en) * 2005-09-30 2007-04-05 Ipca Laboratories Limited Delayed release anti-malarial composition
DE602006013668D1 (de) 2005-10-04 2010-05-27 Director General Defence Res & Aus gomphostemma niveum isolierte verbindung gegen malaria
US20070231300A1 (en) * 2006-03-28 2007-10-04 Washington, University Of Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents
JP2009533368A (ja) 2006-04-11 2009-09-17 ノバルティス アクチエンゲゼルシャフト 有機化合物
US20090306091A1 (en) * 2006-05-17 2009-12-10 Vyas Madhavrao Shingatgeri Antimalarial therapy using a combination of synthetic artemisinin derivative and bisquinoline derivative
US8569519B2 (en) * 2006-05-24 2013-10-29 Ranbaxy Laboratories Limited Process for the preparation of dispiro 1,2,4-trioxolane antimalarials (OZ277)
FR2902100A1 (fr) * 2006-06-13 2007-12-14 Sanofi Aventis Sa Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique
GB0619333D0 (en) * 2006-09-30 2006-11-08 Univ Liverpool Dispiro tetraoxane compounds
WO2008046109A2 (en) * 2006-10-13 2008-04-17 University Of Washington Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer
FR2924343A1 (fr) * 2007-12-04 2009-06-05 Palumed Sa Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique.
EP2340829B1 (en) * 2008-07-01 2015-08-05 National University Corporation Okayama University Novel antischistosomal agent
US8618096B2 (en) 2008-07-21 2013-12-31 The Regents Of The University Of California Prodrug compositions and methods for using the same in treating cancer and malaria
AU2012282077A1 (en) 2011-07-14 2014-01-30 Sun Pharmaceutical Industries Limited Stable dosage forms of arterolane and piperaquine
WO2015123595A1 (en) 2014-02-14 2015-08-20 The Regents Of The University Of California Cyclic peroxides as prodrugs for selective delivery of agents
WO2016102672A2 (en) * 2014-12-23 2016-06-30 Bergenbio As Pharmaceutically active compounds
RU2601315C1 (ru) * 2015-06-10 2016-11-10 Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук Способ получения пентаоксаспироалканов
US11072594B2 (en) 2017-06-27 2021-07-27 The Regents Of The University Of California Trioxolane agents
CN108424371B (zh) * 2018-01-19 2021-07-16 北京理工大学 2-(4-氨基环己基)-乙酸乙酯的制备方法
US20210386814A1 (en) * 2020-05-20 2021-12-16 Amanuel Tesfazion Methods and compound for the treatment of malaria

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Also Published As

Publication number Publication date
RU2004101409A (ru) 2005-06-10
PL226418B1 (pl) 2017-07-31
SI1414813T1 (sl) 2006-12-31
BRPI0210549B8 (pt) 2021-05-25
CA2451006C (en) 2011-08-23
PT1414813E (pt) 2006-12-29
AU2002327183B2 (en) 2006-03-09
HUP0400246A2 (hu) 2004-08-30
KR100759144B1 (ko) 2007-09-14
US6486199B1 (en) 2002-11-26
CN1545508A (zh) 2004-11-10
JP2004535436A (ja) 2004-11-25
NO20035721D0 (no) 2003-12-19
UA78709C2 (en) 2007-04-25
HUP0400246A3 (en) 2009-12-28
MXPA03011915A (es) 2004-05-21
ES2271323T3 (es) 2007-04-16
CY1106214T1 (el) 2011-06-08
ATE339411T1 (de) 2006-10-15
NO20035721L (no) 2004-02-23
BR0210549A (pt) 2005-01-11
CN1545508B (zh) 2012-06-06
RU2271357C2 (ru) 2006-03-10
WO2003000676A1 (en) 2003-01-03
BRPI0210549B1 (pt) 2020-11-10
DE60214733T8 (de) 2008-02-21
KR20040030697A (ko) 2004-04-09
PL367158A1 (en) 2005-02-21
EP1414813A1 (en) 2004-05-06
IL159474A0 (en) 2004-06-01
CA2451006A1 (en) 2003-01-03
DK1414813T3 (da) 2007-01-02
EP1414813B1 (en) 2006-09-13
JP4303585B2 (ja) 2009-07-29
DE60214733D1 (de) 2006-10-26
AU2002327183C1 (en) 2003-01-08
DE60214733T2 (de) 2007-09-13

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