PT1414813E - Trioxolano como agente anti-malária - Google Patents
Trioxolano como agente anti-malária Download PDFInfo
- Publication number
- PT1414813E PT1414813E PT02763208T PT02763208T PT1414813E PT 1414813 E PT1414813 E PT 1414813E PT 02763208 T PT02763208 T PT 02763208T PT 02763208 T PT02763208 T PT 02763208T PT 1414813 E PT1414813 E PT 1414813E
- Authority
- PT
- Portugal
- Prior art keywords
- trioxolane
- spiro
- group
- substituted
- malaria
- Prior art date
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- RZYIPLSVRHWROD-UHFFFAOYSA-N 1,2,4-trioxolane Chemical compound C1OCOO1 RZYIPLSVRHWROD-UHFFFAOYSA-N 0.000 title claims abstract description 9
- 239000003430 antimalarial agent Substances 0.000 title description 17
- 229940033495 antimalarials Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 64
- 201000004792 malaria Diseases 0.000 claims abstract description 53
- MAAKQSASDHJHIR-UHFFFAOYSA-N trioxolane Chemical group C1COOO1 MAAKQSASDHJHIR-UHFFFAOYSA-N 0.000 claims abstract description 49
- 238000000034 method Methods 0.000 claims abstract description 28
- 125000003003 spiro group Chemical group 0.000 claims abstract description 27
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 12
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- 238000011282 treatment Methods 0.000 claims description 49
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- 230000008569 process Effects 0.000 claims description 17
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
- C07D323/02—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/886,666 US6486199B1 (en) | 2001-06-21 | 2001-06-21 | Spiro and dispiro 1,2,4-trioxolane antimalarials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1414813E true PT1414813E (pt) | 2006-12-29 |
Family
ID=25389491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02763208T PT1414813E (pt) | 2001-06-21 | 2002-06-21 | Trioxolano como agente anti-malária |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6486199B1 (https=) |
| EP (1) | EP1414813B1 (https=) |
| JP (1) | JP4303585B2 (https=) |
| KR (1) | KR100759144B1 (https=) |
| CN (1) | CN1545508B (https=) |
| AT (1) | ATE339411T1 (https=) |
| AU (1) | AU2002327183B2 (https=) |
| BR (1) | BRPI0210549B8 (https=) |
| CA (1) | CA2451006C (https=) |
| CY (1) | CY1106214T1 (https=) |
| DE (1) | DE60214733T8 (https=) |
| DK (1) | DK1414813T3 (https=) |
| ES (1) | ES2271323T3 (https=) |
| HU (1) | HUP0400246A3 (https=) |
| IL (1) | IL159474A0 (https=) |
| MX (1) | MXPA03011915A (https=) |
| NO (1) | NO20035721L (https=) |
| PL (1) | PL226418B1 (https=) |
| PT (1) | PT1414813E (https=) |
| RU (1) | RU2271357C2 (https=) |
| SI (1) | SI1414813T1 (https=) |
| UA (1) | UA78709C2 (https=) |
| WO (1) | WO2003000676A1 (https=) |
| YU (1) | YU100703A (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003103592A2 (en) * | 2002-06-06 | 2003-12-18 | University Of Washington | Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use |
| US6825230B2 (en) * | 2002-06-21 | 2004-11-30 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trixolane antimalarials |
| US20080125441A1 (en) * | 2002-06-21 | 2008-05-29 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US6906205B2 (en) * | 2002-06-21 | 2005-06-14 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US7371778B2 (en) * | 2002-06-21 | 2008-05-13 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| FR2862304A1 (fr) * | 2003-11-14 | 2005-05-20 | Centre Nat Rech Scient | Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
| EP1789380A1 (de) * | 2004-07-23 | 2007-05-30 | Justus-Liebig-Universität Giessen | Aminoadamantan-derivate, verfahren zu ihrer herstellung und ihre verwendung |
| US20060040761A1 (en) * | 2004-08-23 | 2006-02-23 | Sam-Kyu Shin | Scale mark mat for putting practice |
| US8067620B2 (en) | 2005-05-04 | 2011-11-29 | Medicines For Malaria Venture Mmv | Dispiro 1,2,4-trioxolane antimalarials |
| US20090042821A1 (en) * | 2005-05-18 | 2009-02-12 | Arno Appavoo Enose | Stable dosage forms of spiro and dispiro 1,2,4-trioxolane antimalarials |
| WO2007036947A1 (en) * | 2005-09-30 | 2007-04-05 | Ipca Laboratories Limited | Delayed release anti-malarial composition |
| DE602006013668D1 (de) | 2005-10-04 | 2010-05-27 | Director General Defence Res & | Aus gomphostemma niveum isolierte verbindung gegen malaria |
| US20070231300A1 (en) * | 2006-03-28 | 2007-10-04 | Washington, University Of | Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents |
| AR060404A1 (es) | 2006-04-11 | 2008-06-11 | Novartis Ag | Compuestos organicos utiles como inhibidores de dipeptidil-peptidasa iv |
| US20090306091A1 (en) * | 2006-05-17 | 2009-12-10 | Vyas Madhavrao Shingatgeri | Antimalarial therapy using a combination of synthetic artemisinin derivative and bisquinoline derivative |
| US8569519B2 (en) * | 2006-05-24 | 2013-10-29 | Ranbaxy Laboratories Limited | Process for the preparation of dispiro 1,2,4-trioxolane antimalarials (OZ277) |
| FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
| GB0619333D0 (en) * | 2006-09-30 | 2006-11-08 | Univ Liverpool | Dispiro tetraoxane compounds |
| WO2008046109A2 (en) * | 2006-10-13 | 2008-04-17 | University Of Washington | Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer |
| FR2924343A1 (fr) * | 2007-12-04 | 2009-06-05 | Palumed Sa | Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique. |
| WO2010001824A1 (ja) | 2008-07-01 | 2010-01-07 | 国立大学法人 岡山大学 | 新規抗住血吸虫剤 |
| WO2010011684A2 (en) | 2008-07-21 | 2010-01-28 | The Regents Of The University Of California | Prodrug and fluoregenic compositions and methods for using the same |
| AP2014007413A0 (en) | 2011-07-14 | 2014-02-28 | Ranbaxy Lab Ltd | Stable dosage forms of arterolane and piperaquine |
| WO2015123595A1 (en) | 2014-02-14 | 2015-08-20 | The Regents Of The University Of California | Cyclic peroxides as prodrugs for selective delivery of agents |
| CA2971763A1 (en) * | 2014-12-23 | 2016-06-30 | Bergenbio Asa | Inhibitors of akt kinase |
| RU2601315C1 (ru) * | 2015-06-10 | 2016-11-10 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | Способ получения пентаоксаспироалканов |
| WO2019005977A1 (en) * | 2017-06-27 | 2019-01-03 | The Regents Of The University Of California | Trioxolane agents |
| CN108424371B (zh) * | 2018-01-19 | 2021-07-16 | 北京理工大学 | 2-(4-氨基环己基)-乙酸乙酯的制备方法 |
| US20210386814A1 (en) * | 2020-05-20 | 2021-12-16 | Amanuel Tesfazion | Methods and compound for the treatment of malaria |
| US20240101584A1 (en) * | 2021-02-01 | 2024-03-28 | Westlake University | Targeted delivery of 1,2,4,5 tetraoxane compounds and their uses |
| CN117085004A (zh) * | 2023-09-27 | 2023-11-21 | 赣南师范大学 | 一种2,6-二苯亚甲基环己酮类似物在制备抗血吸虫药物中的应用 |
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| US3673222A (en) | 1969-11-26 | 1972-06-27 | Sydney Archer | 2-(8-cyclohexyloctyl or 7-cyclohexylheptyl)-1,4-naphthoquinone and process for preparation and use thereof |
| US3682991A (en) | 1970-10-19 | 1972-08-08 | Sterling Drug Inc | 3,3,5-trimethylcyclohexyl-alkyl-carboxylic acids |
| SU1421743A1 (ru) * | 1987-02-18 | 1988-09-07 | Физико-химический институт им.А.В.Богатского | Способ получени 11-нитро-12- @ (2-метокси)-этокси @ -бензо-9-краун-3 |
| US4916204A (en) | 1987-07-31 | 1990-04-10 | Massachusetts Institute Of Technology | Pure polyanhydride from dicarboxylic acid and coupling agent |
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| DE4125201C1 (https=) * | 1991-07-30 | 1992-10-01 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De | |
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2001
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- 2002-06-21 JP JP2003507080A patent/JP4303585B2/ja not_active Expired - Fee Related
- 2002-06-21 SI SI200230411T patent/SI1414813T1/sl unknown
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- 2002-06-21 WO PCT/US2002/019767 patent/WO2003000676A1/en not_active Ceased
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- 2002-06-21 AT AT02763208T patent/ATE339411T1/de not_active IP Right Cessation
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- 2002-06-21 DK DK02763208T patent/DK1414813T3/da active
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- 2002-06-21 CN CN028164539A patent/CN1545508B/zh not_active Expired - Lifetime
- 2002-06-21 KR KR1020037016719A patent/KR100759144B1/ko not_active Expired - Lifetime
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