JP4303585B2 - １，２，４−トリオキソラン抗マラリア物質 - Google Patents

１，２，４−トリオキソラン抗マラリア物質 Download PDF

Info

Publication number
JP4303585B2
JP4303585B2 JP2003507080A JP2003507080A JP4303585B2 JP 4303585 B2 JP4303585 B2 JP 4303585B2 JP 2003507080 A JP2003507080 A JP 2003507080A JP 2003507080 A JP2003507080 A JP 2003507080A JP 4303585 B2 JP4303585 B2 JP 4303585B2
Authority
JP
Japan
Prior art keywords
spiro
mmol
nmr
mhz
decane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2003507080A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004535436A (ja
JP2004535436A5 (https=
Inventor
ヴェナーストローム，ジョナサン，エル．
コレット，ジャック
ドング，ユヒァング
マタイル，ヒューズ
パドマニラヤム，マニャン
タング，ユアンキング
チャーマン，ウィリアム，エヌ．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MMV Medicines for Malaria Venture
Original Assignee
MMV Medicines for Malaria Venture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MMV Medicines for Malaria Venture filed Critical MMV Medicines for Malaria Venture
Publication of JP2004535436A publication Critical patent/JP2004535436A/ja
Publication of JP2004535436A5 publication Critical patent/JP2004535436A5/ja
Application granted granted Critical
Publication of JP4303585B2 publication Critical patent/JP4303585B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Dental Preparations (AREA)
JP2003507080A 2001-06-21 2002-06-21 １，２，４−トリオキソラン抗マラリア物質 Expired - Fee Related JP4303585B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/886,666 US6486199B1 (en) 2001-06-21 2001-06-21 Spiro and dispiro 1,2,4-trioxolane antimalarials
PCT/US2002/019767 WO2003000676A1 (en) 2001-06-21 2002-06-21 1,2,4-trioxolane antimalarials

Publications (3)

Publication Number Publication Date
JP2004535436A JP2004535436A (ja) 2004-11-25
JP2004535436A5 JP2004535436A5 (https=) 2005-09-29
JP4303585B2 true JP4303585B2 (ja) 2009-07-29

Family

ID=25389491

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003507080A Expired - Fee Related JP4303585B2 (ja) 2001-06-21 2002-06-21 １，２，４−トリオキソラン抗マラリア物質

Country Status (24)

Country Link
US (1) US6486199B1 (https=)
EP (1) EP1414813B1 (https=)
JP (1) JP4303585B2 (https=)
KR (1) KR100759144B1 (https=)
CN (1) CN1545508B (https=)
AT (1) ATE339411T1 (https=)
AU (1) AU2002327183B2 (https=)
BR (1) BRPI0210549B8 (https=)
CA (1) CA2451006C (https=)
CY (1) CY1106214T1 (https=)
DE (1) DE60214733T8 (https=)
DK (1) DK1414813T3 (https=)
ES (1) ES2271323T3 (https=)
HU (1) HUP0400246A3 (https=)
IL (1) IL159474A0 (https=)
MX (1) MXPA03011915A (https=)
NO (1) NO20035721L (https=)
PL (1) PL226418B1 (https=)
PT (1) PT1414813E (https=)
RU (1) RU2271357C2 (https=)
SI (1) SI1414813T1 (https=)
UA (1) UA78709C2 (https=)
WO (1) WO2003000676A1 (https=)
YU (1) YU100703A (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003103592A2 (en) * 2002-06-06 2003-12-18 University Of Washington Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use
US6825230B2 (en) * 2002-06-21 2004-11-30 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trixolane antimalarials
US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6906205B2 (en) * 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
FR2862304A1 (fr) * 2003-11-14 2005-05-20 Centre Nat Rech Scient Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques
EP1789380A1 (de) * 2004-07-23 2007-05-30 Justus-Liebig-Universität Giessen Aminoadamantan-derivate, verfahren zu ihrer herstellung und ihre verwendung
US20060040761A1 (en) * 2004-08-23 2006-02-23 Sam-Kyu Shin Scale mark mat for putting practice
US8067620B2 (en) 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
US20090042821A1 (en) * 2005-05-18 2009-02-12 Arno Appavoo Enose Stable dosage forms of spiro and dispiro 1,2,4-trioxolane antimalarials
WO2007036947A1 (en) * 2005-09-30 2007-04-05 Ipca Laboratories Limited Delayed release anti-malarial composition
DE602006013668D1 (de) 2005-10-04 2010-05-27 Director General Defence Res & Aus gomphostemma niveum isolierte verbindung gegen malaria
US20070231300A1 (en) * 2006-03-28 2007-10-04 Washington, University Of Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents
AR060404A1 (es) 2006-04-11 2008-06-11 Novartis Ag Compuestos organicos utiles como inhibidores de dipeptidil-peptidasa iv
US20090306091A1 (en) * 2006-05-17 2009-12-10 Vyas Madhavrao Shingatgeri Antimalarial therapy using a combination of synthetic artemisinin derivative and bisquinoline derivative
US8569519B2 (en) * 2006-05-24 2013-10-29 Ranbaxy Laboratories Limited Process for the preparation of dispiro 1,2,4-trioxolane antimalarials (OZ277)
FR2902100A1 (fr) * 2006-06-13 2007-12-14 Sanofi Aventis Sa Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique
GB0619333D0 (en) * 2006-09-30 2006-11-08 Univ Liverpool Dispiro tetraoxane compounds
WO2008046109A2 (en) * 2006-10-13 2008-04-17 University Of Washington Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer
FR2924343A1 (fr) * 2007-12-04 2009-06-05 Palumed Sa Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique.
WO2010001824A1 (ja) 2008-07-01 2010-01-07 国立大学法人 岡山大学 新規抗住血吸虫剤
WO2010011684A2 (en) 2008-07-21 2010-01-28 The Regents Of The University Of California Prodrug and fluoregenic compositions and methods for using the same
AP2014007413A0 (en) 2011-07-14 2014-02-28 Ranbaxy Lab Ltd Stable dosage forms of arterolane and piperaquine
WO2015123595A1 (en) 2014-02-14 2015-08-20 The Regents Of The University Of California Cyclic peroxides as prodrugs for selective delivery of agents
CA2971763A1 (en) * 2014-12-23 2016-06-30 Bergenbio Asa Inhibitors of akt kinase
RU2601315C1 (ru) * 2015-06-10 2016-11-10 Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук Способ получения пентаоксаспироалканов
WO2019005977A1 (en) * 2017-06-27 2019-01-03 The Regents Of The University Of California Trioxolane agents
CN108424371B (zh) * 2018-01-19 2021-07-16 北京理工大学 2-(4-氨基环己基)-乙酸乙酯的制备方法
US20210386814A1 (en) * 2020-05-20 2021-12-16 Amanuel Tesfazion Methods and compound for the treatment of malaria
US20240101584A1 (en) * 2021-02-01 2024-03-28 Westlake University Targeted delivery of 1,2,4,5 tetraoxane compounds and their uses
CN117085004A (zh) * 2023-09-27 2023-11-21 赣南师范大学 一种2,6-二苯亚甲基环己酮类似物在制备抗血吸虫药物中的应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3621062A (en) 1966-10-25 1971-11-16 Sterling Drug Inc 2-(8-cyclohexyloctanoyl or 7-cyclohexylheptanoyl)-1-naphthol
US3673222A (en) 1969-11-26 1972-06-27 Sydney Archer 2-(8-cyclohexyloctyl or 7-cyclohexylheptyl)-1,4-naphthoquinone and process for preparation and use thereof
US3682991A (en) 1970-10-19 1972-08-08 Sterling Drug Inc 3,3,5-trimethylcyclohexyl-alkyl-carboxylic acids
SU1421743A1 (ru) * 1987-02-18 1988-09-07 Физико-химический институт им.А.В.Богатского Способ получени 11-нитро-12- @ (2-метокси)-этокси @ -бензо-9-краун-3
US4916204A (en) 1987-07-31 1990-04-10 Massachusetts Institute Of Technology Pure polyanhydride from dicarboxylic acid and coupling agent
US4816478A (en) 1987-08-24 1989-03-28 Thornfeldt Carl R Treatment of acquired immunodeficiency syndrome
US5053342A (en) 1987-12-24 1991-10-01 Litmus Concepts, Inc. Fecal occult blood test reagents
US5559145A (en) 1988-06-01 1996-09-24 Oxaco S.A. 1,2,4-trioxane derivatives
US5270344A (en) 1988-06-24 1993-12-14 Stephen Herman Method of treating a systemic disorder using trioxolane and diperoxide compounds
JP2867529B2 (ja) 1990-01-22 1999-03-08 三菱電機株式会社 投写型表示装置
US5216175A (en) 1990-03-23 1993-06-01 Sri International Antimalarial analogs of artemisinin
US5219880A (en) 1991-03-29 1993-06-15 Dermatologic Research Corporation Treatment of viral tumors and hemorrhoids with artemisinin and derivatives
DE4125201C1 (https=) * 1991-07-30 1992-10-01 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De
US5510356A (en) 1991-10-03 1996-04-23 University Of Nebraska Board Of Regents Bisquinolines and processes for their production and use to treat malaria
US5171676A (en) 1991-10-31 1992-12-15 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of introducing hydroxyl groups into artemisinin and its derivatives
US5430148A (en) 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
JP3567990B2 (ja) 1992-07-28 2004-09-22 ザ、プロクター、エンド、ギャンブル、カンパニー 架橋陽イオン重合体とアルコキシ化エーテルとを含有する局所用途用医薬組成物
US5721209A (en) 1995-02-03 1998-02-24 The Regents Of The University Of California Iron chelator and inhibitor of iron-mediated oxidant injury
US5780675A (en) 1995-04-28 1998-07-14 The University Of New Mexico Deoxygossylic compounds
US5578637A (en) 1995-05-03 1996-11-26 University Of Washington Methods of inhibition or killing cancer cells using an endoperoxide
US5817692A (en) 1995-11-22 1998-10-06 The Johns Hopkins University Endoperoxides useful as antiparasitic agents
US5672624A (en) 1995-11-22 1997-09-30 The Johns Hopkins University Endoperoxides useful as antiparasitic agents
US5932591A (en) 1996-12-02 1999-08-03 Johns Hopkins University C3 substituted trioxanes useful as antiparasitic drugs

Also Published As

Publication number Publication date
CA2451006A1 (en) 2003-01-03
SI1414813T1 (sl) 2006-12-31
US6486199B1 (en) 2002-11-26
EP1414813B1 (en) 2006-09-13
RU2271357C2 (ru) 2006-03-10
AU2002327183C1 (en) 2003-01-08
PL367158A1 (en) 2005-02-21
CY1106214T1 (el) 2011-06-08
EP1414813A1 (en) 2004-05-06
BRPI0210549B8 (pt) 2021-05-25
HUP0400246A3 (en) 2009-12-28
YU100703A (sh) 2006-03-03
DK1414813T3 (da) 2007-01-02
UA78709C2 (en) 2007-04-25
KR20040030697A (ko) 2004-04-09
ATE339411T1 (de) 2006-10-15
MXPA03011915A (es) 2004-05-21
CN1545508B (zh) 2012-06-06
WO2003000676A1 (en) 2003-01-03
ES2271323T3 (es) 2007-04-16
PT1414813E (pt) 2006-12-29
NO20035721L (no) 2004-02-23
DE60214733T2 (de) 2007-09-13
RU2004101409A (ru) 2005-06-10
HUP0400246A2 (hu) 2004-08-30
AU2002327183B2 (en) 2006-03-09
BR0210549A (pt) 2005-01-11
CN1545508A (zh) 2004-11-10
JP2004535436A (ja) 2004-11-25
DE60214733D1 (de) 2006-10-26
IL159474A0 (en) 2004-06-01
PL226418B1 (pl) 2017-07-31
BRPI0210549B1 (pt) 2020-11-10
KR100759144B1 (ko) 2007-09-14
NO20035721D0 (no) 2003-12-19
CA2451006C (en) 2011-08-23
DE60214733T8 (de) 2008-02-21

Similar Documents

Publication Publication Date Title
JP4303585B2 (ja) １，２，４−トリオキソラン抗マラリア物質
AU2002327183A1 (en) 1,2,4-trioxolane antimalarials
KR101588468B1 (ko) 디스피로 1,2,4-트리옥솔란 항말라리아제
US6825230B2 (en) Spiro and dispiro 1,2,4-trixolane antimalarials
US20040186168A1 (en) Spiro and dispiro 1,2,4-trioxolane antimalarials
WO2009091433A2 (en) Spiro and dispiro 1,2,4-trioxolane antimalarials
AU2006331676A1 (en) Nitroimidazole compounds
US7371778B2 (en) Spiro and dispiro 1,2,4-trioxolane antimalarials
AU2013273836A1 (en) Dispiro 1,2,4-trioxolane antimalarials
Wu Part A: Antimalarial agents modified at the C-16 position of artemisinin; Part B: Lead optimization of falcipain-2 and falcipain-3 inhibitors
HK1182699A1 (zh) 作为磷酸二酯酶抑制剂的苯并二氧杂环戊烯或苯并二氧杂环庚烯杂环化合物
HK1182699B (en) Benzodioxole or benzodioxepine heterocyclic compounds phosphodiesterase inhibitors

Legal Events

Date Code Title Description
A529 Written submission of copy of amendment under article 34 pct

Free format text: JAPANESE INTERMEDIATE CODE: A529

Effective date: 20040213

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040224

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040224

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040326

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20060330

RD01 Notification of change of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7421

Effective date: 20060330

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20060330

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20070817

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070821

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20071109

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20071116

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080221

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080221

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080826

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081120

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081128

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090224

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090331

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090424

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120501

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 4303585

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120501

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130501

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140501

Year of fee payment: 5

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees