CN1473035B - 含有口腔内迅速崩解片剂用缓释微粒的组合物及其制造方法 - Google Patents

含有口腔内迅速崩解片剂用缓释微粒的组合物及其制造方法 Download PDF

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Publication number
CN1473035B
CN1473035B CN028028864A CN02802886A CN1473035B CN 1473035 B CN1473035 B CN 1473035B CN 028028864 A CN028028864 A CN 028028864A CN 02802886 A CN02802886 A CN 02802886A CN 1473035 B CN1473035 B CN 1473035B
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sustained
release microparticle
oral cavity
disintegrating tablet
fast disintegrating
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Expired - Lifetime
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CN1473035A (zh
Inventor
篠田达辉
真荣田笃
伊藤直树
水本隆雄
山崎繁
高石勇希
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Yamanouchi Pharmaceutical Co Ltd
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Yamanouchi Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
CN028028864A 2001-07-27 2002-07-25 含有口腔内迅速崩解片剂用缓释微粒的组合物及其制造方法 Expired - Lifetime CN1473035B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30830301P 2001-07-27 2001-07-27
US60/308,303 2001-07-27
PCT/JP2002/007550 WO2003009831A1 (en) 2001-07-27 2002-07-25 Compositions containing sustained-release fine grains for tablets quickly disintegrable in the oral cavity and process for producing the same

Publications (2)

Publication Number Publication Date
CN1473035A CN1473035A (zh) 2004-02-04
CN1473035B true CN1473035B (zh) 2012-07-18

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CN028028864A Expired - Lifetime CN1473035B (zh) 2001-07-27 2002-07-25 含有口腔内迅速崩解片剂用缓释微粒的组合物及其制造方法

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US (2) US7255876B2 (ja)
EP (1) EP1413294B1 (ja)
JP (3) JP4019374B2 (ja)
KR (1) KR100530546B1 (ja)
CN (1) CN1473035B (ja)
AT (1) ATE482692T1 (ja)
AU (1) AU2002355222B2 (ja)
BR (1) BR0205509A (ja)
CA (1) CA2419089A1 (ja)
CZ (1) CZ14921U1 (ja)
DE (2) DE60237826D1 (ja)
ES (1) ES2351249T3 (ja)
HU (1) HUP0302351A3 (ja)
MX (1) MXPA03000985A (ja)
PL (1) PL361452A1 (ja)
RU (1) RU2245136C2 (ja)
WO (1) WO2003009831A1 (ja)
ZA (1) ZA200300647B (ja)

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WO2003009831A1 (en) 2003-02-06
DE20220604U1 (de) 2004-02-26
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ATE482692T1 (de) 2010-10-15
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