CN1440381A - 取代的辛酰胺的制备方法 - Google Patents
取代的辛酰胺的制备方法 Download PDFInfo
- Publication number
- CN1440381A CN1440381A CN01812281A CN01812281A CN1440381A CN 1440381 A CN1440381 A CN 1440381A CN 01812281 A CN01812281 A CN 01812281A CN 01812281 A CN01812281 A CN 01812281A CN 1440381 A CN1440381 A CN 1440381A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- general formula
- alkoxy
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
Abstract
Description
Claims (12)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1329/00 | 2000-07-05 | ||
CH13292000 | 2000-07-05 | ||
CH1329/2000 | 2000-07-05 | ||
CH2450/2000 | 2000-12-15 | ||
CH2450/00 | 2000-12-15 | ||
CH24502000 | 2000-12-15 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005101088576A Division CN100526304C (zh) | 2000-07-05 | 2001-06-26 | 取代的辛酰胺的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1440381A true CN1440381A (zh) | 2003-09-03 |
CN100482636C CN100482636C (zh) | 2009-04-29 |
Family
ID=25738979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018122817A Expired - Lifetime CN100482636C (zh) | 2000-07-05 | 2001-06-26 | 取代的辛酰胺的制备方法 |
Country Status (24)
Country | Link |
---|---|
US (1) | US6730798B2 (zh) |
EP (1) | EP1296935B1 (zh) |
JP (1) | JP4900755B2 (zh) |
KR (1) | KR100690471B1 (zh) |
CN (1) | CN100482636C (zh) |
AR (1) | AR029564A1 (zh) |
AT (1) | ATE426592T1 (zh) |
AU (2) | AU2001273763B2 (zh) |
BR (1) | BR0112362B1 (zh) |
CA (1) | CA2414847C (zh) |
CY (1) | CY1109110T1 (zh) |
DE (1) | DE60138099D1 (zh) |
DK (1) | DK1296935T3 (zh) |
ES (1) | ES2322547T3 (zh) |
HK (1) | HK1093201A1 (zh) |
HU (1) | HU228526B1 (zh) |
IL (4) | IL153717A0 (zh) |
MX (1) | MXPA02012628A (zh) |
NO (1) | NO328105B1 (zh) |
NZ (1) | NZ523088A (zh) |
PL (1) | PL212898B1 (zh) |
PT (1) | PT1296935E (zh) |
TW (1) | TWI289551B (zh) |
WO (1) | WO2002002508A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011148392A1 (en) * | 2010-05-28 | 2011-12-01 | Msn Laboratories Limited | Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof |
CN106146339A (zh) * | 2015-04-23 | 2016-11-23 | 华润双鹤药业股份有限公司 | 阿利吉仑的5-位差向异构体、其制备方法及用途 |
CN106220528A (zh) * | 2014-02-28 | 2016-12-14 | 华润双鹤药业股份有限公司 | 阿利吉仑的4‑位差向异构体、其制备方法及用途 |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060154926A1 (en) * | 2002-06-11 | 2006-07-13 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease using aryl alkanoic acid amides |
GB0419361D0 (en) | 2004-08-31 | 2004-10-06 | Novartis Ag | Organic compounds |
GB0511686D0 (en) | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
PT1904469E (pt) | 2005-07-11 | 2012-01-06 | Novartis Ag | Novos derivados de pirocatequina |
GB0519764D0 (en) | 2005-09-28 | 2005-11-09 | Novartis Ag | Organic compounds |
GB2431645A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
GB2431649A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
DE102005052195A1 (de) | 2005-10-28 | 2007-05-03 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von chiralen Octensäurederivaten |
GB0605688D0 (en) | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
RU2466982C2 (ru) * | 2006-11-07 | 2012-11-20 | Новартис Аг | Кристаллические формы гемифумарата алискирена |
CA2665073A1 (en) * | 2006-11-09 | 2008-05-15 | Novartis Ag | Salt of aliskiren with orotic acid |
EP1958666A1 (en) | 2007-02-13 | 2008-08-20 | Speedel Experimenta AG | Heterocyclic-substituted alkanamides as therapeutic compounds |
DE102007049039A1 (de) | 2007-10-11 | 2009-04-16 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung |
US20120029083A1 (en) | 2007-11-13 | 2012-02-02 | Teva Pharmaceutical Industries, Ltd. | Polymorphic forms of aliskiren hemifumarate and process for preparation thereof |
EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
CA2724746A1 (en) * | 2008-05-23 | 2009-11-26 | Teva Pharmaceuticals Industries Ltd. | Aliskiren monofumarate and processes for preparation thereof |
SI2189442T1 (sl) | 2008-11-20 | 2015-03-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek in intermediati za pripravo aliskirena |
CA2724152A1 (en) * | 2009-02-05 | 2010-08-12 | Teva Pharmaceutical Industries Ltd. | Solid state forms of aliskiren compounds |
EP2393489B1 (en) | 2009-02-05 | 2014-10-08 | Krka, tovarna zdravil, d.d., Novo mesto | Moisture-activated granulation process |
US20120220663A1 (en) | 2009-09-03 | 2012-08-30 | Teva Pharmaceuticals Usa, Inc. | Solid forms of aliskiren hemifumarate and processes for preparation thereof |
US8203005B2 (en) | 2009-10-29 | 2012-06-19 | Carbo Design Llc | Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren |
US20110113995A1 (en) * | 2009-11-13 | 2011-05-19 | Lindsay Corporation | Method and apparatus for planting and irrigation |
EP2630118B1 (en) * | 2010-10-19 | 2014-11-05 | Mylan Laboratories Limited | Synthesis of aliskiren |
ITMI20110893A1 (it) * | 2011-05-19 | 2012-11-20 | Chemelectiva S R L | Processi ed intermedi per la sintesi di aliskiren |
EP2551260A1 (en) | 2011-07-28 | 2013-01-30 | Chemo Ibérica, S.A. | Chemical process for opening ring compounds |
US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
WO2013118138A1 (en) | 2011-12-13 | 2013-08-15 | Laboratories Ltd Mylan | Novel process for the preparation of renin inhibitors |
EP2814806B1 (en) | 2012-02-17 | 2016-05-25 | Mylan Laboratories Ltd. | An improved process for the preparation of aliskiren |
WO2013124868A2 (en) | 2012-02-21 | 2013-08-29 | Mylan Laboratories Limited | Solid form of aliskiren intermediate |
WO2013144979A1 (en) | 2012-03-28 | 2013-10-03 | Maylan Laboratories Ltd | Process for the preparation of aliskiren |
WO2013171767A1 (en) | 2012-05-18 | 2013-11-21 | Mylan Laboratories Limited | An improved process for the preparation of aliskiren |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4492799A (en) * | 1979-07-02 | 1985-01-08 | Union Carbide Corporation | Halo-4-alkenoic acids and their use as pesticidal intermediates |
FR2666757B1 (fr) * | 1990-09-14 | 1992-12-18 | Usinor Sacilor | Virole pour cylindre de coulee continue des metaux, notamment de l'acier, entre cylindres ou sur un cylindre. |
US5659065A (en) | 1994-04-18 | 1997-08-19 | Novartis Corporation | Alpha-aminoalkanoic acids and reduction products |
US5606078A (en) * | 1994-04-18 | 1997-02-25 | Ciba-Geigy Corporation | 3,5-Disubstituted tetrahydrofuran-2-ones |
MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
EP0773844B1 (de) * | 1994-07-18 | 1998-12-09 | Siemens Aktiengesellschaft | Giesswalzen-verschleissschutzschicht |
AU7418198A (en) * | 1997-05-23 | 1998-12-11 | Voest-Alpine Industrieanlagenbau Gmbh | Casting cylinder for thin-band continuous casting installation |
PT1200384E (pt) | 1999-07-29 | 2004-09-30 | Speedel Pharma Ag | Acidos 2-alquil-5-halogeneo-pent-4-enocarboxilicos e sua producao |
-
2001
- 2001-06-26 HU HU0301463A patent/HU228526B1/hu not_active IP Right Cessation
- 2001-06-26 NZ NZ523088A patent/NZ523088A/en not_active IP Right Cessation
- 2001-06-26 US US10/312,987 patent/US6730798B2/en not_active Expired - Lifetime
- 2001-06-26 AT AT01940047T patent/ATE426592T1/de active
- 2001-06-26 EP EP01940047A patent/EP1296935B1/en not_active Expired - Lifetime
- 2001-06-26 BR BRPI0112362-9B1A patent/BR0112362B1/pt not_active IP Right Cessation
- 2001-06-26 ES ES01940047T patent/ES2322547T3/es not_active Expired - Lifetime
- 2001-06-26 DK DK01940047T patent/DK1296935T3/da active
- 2001-06-26 IL IL15371701A patent/IL153717A0/xx unknown
- 2001-06-26 AU AU2001273763A patent/AU2001273763B2/en not_active Ceased
- 2001-06-26 CA CA002414847A patent/CA2414847C/en not_active Expired - Fee Related
- 2001-06-26 MX MXPA02012628A patent/MXPA02012628A/es active IP Right Grant
- 2001-06-26 PL PL358887A patent/PL212898B1/pl unknown
- 2001-06-26 PT PT01940047T patent/PT1296935E/pt unknown
- 2001-06-26 DE DE60138099T patent/DE60138099D1/de not_active Expired - Lifetime
- 2001-06-26 JP JP2002507765A patent/JP4900755B2/ja not_active Expired - Lifetime
- 2001-06-26 KR KR1020027017207A patent/KR100690471B1/ko active IP Right Grant
- 2001-06-26 AU AU7376301A patent/AU7376301A/xx active Pending
- 2001-06-26 WO PCT/CH2001/000399 patent/WO2002002508A1/en active Application Filing
- 2001-06-26 CN CNB018122817A patent/CN100482636C/zh not_active Expired - Lifetime
- 2001-06-29 TW TW090115929A patent/TWI289551B/zh not_active IP Right Cessation
- 2001-07-04 AR ARP010103194A patent/AR029564A1/es active IP Right Grant
-
2002
- 2002-12-27 IL IL153717A patent/IL153717A/en not_active IP Right Cessation
-
2003
- 2003-01-02 NO NO20030012A patent/NO328105B1/no not_active IP Right Cessation
-
2006
- 2006-12-19 HK HK06113953.2A patent/HK1093201A1/xx not_active IP Right Cessation
-
2007
- 2007-11-29 IL IL187796A patent/IL187796A/en not_active IP Right Cessation
- 2007-11-29 IL IL187795A patent/IL187795A/en not_active IP Right Cessation
-
2009
- 2009-05-28 CY CY20091100571T patent/CY1109110T1/el unknown
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011148392A1 (en) * | 2010-05-28 | 2011-12-01 | Msn Laboratories Limited | Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof |
CN106220528A (zh) * | 2014-02-28 | 2016-12-14 | 华润双鹤药业股份有限公司 | 阿利吉仑的4‑位差向异构体、其制备方法及用途 |
CN106220528B (zh) * | 2014-02-28 | 2018-05-08 | 华润双鹤药业股份有限公司 | 阿利吉仑的4-位差向异构体、其制备方法及用途 |
CN106146339A (zh) * | 2015-04-23 | 2016-11-23 | 华润双鹤药业股份有限公司 | 阿利吉仑的5-位差向异构体、其制备方法及用途 |
CN106146339B (zh) * | 2015-04-23 | 2018-02-23 | 华润双鹤药业股份有限公司 | 阿利吉仑的5‑位差向异构体、其制备方法及用途 |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170509 Address after: Dublin, Ireland Patentee after: Norton pharmaceuticals Address before: Basel, Switzerland Patentee before: Novartis Pharmaceutical Co.,Ltd. Effective date of registration: 20170509 Address after: Basel, Switzerland Patentee after: Novartis Pharmaceutical Co.,Ltd. Address before: Basel, Switzerland Patentee before: Speedel Pharma AG |
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CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20090429 |