PT1296935E - Processo para a preparação de octanoil amidas substituídas - Google Patents

Processo para a preparação de octanoil amidas substituídas Download PDF

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Publication number
PT1296935E
PT1296935E PT01940047T PT01940047T PT1296935E PT 1296935 E PT1296935 E PT 1296935E PT 01940047 T PT01940047 T PT 01940047T PT 01940047 T PT01940047 T PT 01940047T PT 1296935 E PT1296935 E PT 1296935E
Authority
PT
Portugal
Prior art keywords
preparation
substituted
formula
azide
converted
Prior art date
Application number
PT01940047T
Other languages
English (en)
Inventor
Stefan Stutz
Peter Herold
Felix Spindler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT1296935E publication Critical patent/PT1296935E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT01940047T 2000-07-05 2001-06-26 Processo para a preparação de octanoil amidas substituídas PT1296935E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH13292000 2000-07-05
CH24502000 2000-12-15

Publications (1)

Publication Number Publication Date
PT1296935E true PT1296935E (pt) 2009-05-15

Family

ID=25738979

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01940047T PT1296935E (pt) 2000-07-05 2001-06-26 Processo para a preparação de octanoil amidas substituídas

Country Status (24)

Country Link
US (1) US6730798B2 (pt)
EP (1) EP1296935B1 (pt)
JP (1) JP4900755B2 (pt)
KR (1) KR100690471B1 (pt)
CN (1) CN100482636C (pt)
AR (1) AR029564A1 (pt)
AT (1) ATE426592T1 (pt)
AU (2) AU7376301A (pt)
BR (1) BR0112362B1 (pt)
CA (1) CA2414847C (pt)
CY (1) CY1109110T1 (pt)
DE (1) DE60138099D1 (pt)
DK (1) DK1296935T3 (pt)
ES (1) ES2322547T3 (pt)
HK (1) HK1093201A1 (pt)
HU (1) HU228526B1 (pt)
IL (4) IL153717A0 (pt)
MX (1) MXPA02012628A (pt)
NO (1) NO328105B1 (pt)
NZ (1) NZ523088A (pt)
PL (1) PL212898B1 (pt)
PT (1) PT1296935E (pt)
TW (1) TWI289551B (pt)
WO (1) WO2002002508A1 (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
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AU2003238007A1 (en) * 2002-06-11 2003-12-22 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease using aryl alkanoic acid amides
GB0419361D0 (en) 2004-08-31 2004-10-06 Novartis Ag Organic compounds
GB0511686D0 (en) 2005-06-08 2005-07-13 Novartis Ag Organic compounds
RU2470018C2 (ru) * 2005-07-11 2012-12-20 Новартис Аг Новые производные пирокатехина
GB0519764D0 (en) 2005-09-28 2005-11-09 Novartis Ag Organic compounds
GB2431645A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431649A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
DE102005052195A1 (de) 2005-10-28 2007-05-03 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von chiralen Octensäurederivaten
GB0605688D0 (en) 2006-03-21 2006-05-03 Novartis Ag Organic compounds
BRPI0718546A2 (pt) * 2006-11-07 2013-11-19 Novartis Ag Formas cristalinas de hemifumarato de alisquireno
CN101528672A (zh) * 2006-11-09 2009-09-09 诺瓦提斯公司 阿利吉仑乳清酸盐
EP1958666A1 (en) 2007-02-13 2008-08-20 Speedel Experimenta AG Heterocyclic-substituted alkanamides as therapeutic compounds
DE102007049039A1 (de) 2007-10-11 2009-04-16 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung
EP2220031A1 (en) 2007-11-13 2010-08-25 Teva Pharmaceutical Industries Ltd. Polymorphic forms of aliskiren hemifumarate and process for preparation thereof
EP2062874B1 (en) 2007-11-20 2014-12-17 KRKA, tovarna zdravil, d.d., Novo mesto Process and intermediates for the preparation of aliskiren
WO2009143423A1 (en) * 2008-05-23 2009-11-26 Teva Pharmaceutical Industries Ltd. Aliskiren monofumarate and processes for preparation thereof
SI2189442T1 (sl) 2008-11-20 2015-03-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek in intermediati za pripravo aliskirena
CA2724152A1 (en) * 2009-02-05 2010-08-12 Teva Pharmaceutical Industries Ltd. Solid state forms of aliskiren compounds
WO2010089105A2 (en) 2009-02-05 2010-08-12 Krka, Tovarna Zdravil, D.D., Novo Mesto Moisture-activated granulation process
WO2011028919A2 (en) 2009-09-03 2011-03-10 Teva Pharmaceutical Industries Ltd. Solid forms of aliskiren hemifumarate and processes for preparation thereof
US8203005B2 (en) 2009-10-29 2012-06-19 Carbo Design Llc Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren
US20110113995A1 (en) * 2009-11-13 2011-05-19 Lindsay Corporation Method and apparatus for planting and irrigation
WO2011148392A1 (en) * 2010-05-28 2011-12-01 Msn Laboratories Limited Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof
US9187409B2 (en) 2010-10-19 2015-11-17 Mylan Laboratories Limited Synthesis of Aliskiren
ITMI20110893A1 (it) * 2011-05-19 2012-11-20 Chemelectiva S R L Processi ed intermedi per la sintesi di aliskiren
EP2551260A1 (en) 2011-07-28 2013-01-30 Chemo Ibérica, S.A. Chemical process for opening ring compounds
US8703976B2 (en) 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren
WO2013118138A1 (en) 2011-12-13 2013-08-15 Laboratories Ltd Mylan Novel process for the preparation of renin inhibitors
EP2814806B1 (en) 2012-02-17 2016-05-25 Mylan Laboratories Ltd. An improved process for the preparation of aliskiren
WO2013124868A2 (en) 2012-02-21 2013-08-29 Mylan Laboratories Limited Solid form of aliskiren intermediate
WO2013144979A1 (en) 2012-03-28 2013-10-03 Maylan Laboratories Ltd Process for the preparation of aliskiren
WO2013171767A1 (en) 2012-05-18 2013-11-21 Mylan Laboratories Limited An improved process for the preparation of aliskiren
CN106220528B (zh) * 2014-02-28 2018-05-08 华润双鹤药业股份有限公司 阿利吉仑的4-位差向异构体、其制备方法及用途
CN106146339B (zh) * 2015-04-23 2018-02-23 华润双鹤药业股份有限公司 阿利吉仑的5‑位差向异构体、其制备方法及用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492799A (en) * 1979-07-02 1985-01-08 Union Carbide Corporation Halo-4-alkenoic acids and their use as pesticidal intermediates
FR2666757B1 (fr) * 1990-09-14 1992-12-18 Usinor Sacilor Virole pour cylindre de coulee continue des metaux, notamment de l'acier, entre cylindres ou sur un cylindre.
US5659065A (en) 1994-04-18 1997-08-19 Novartis Corporation Alpha-aminoalkanoic acids and reduction products
US5606078A (en) * 1994-04-18 1997-02-25 Ciba-Geigy Corporation 3,5-Disubstituted tetrahydrofuran-2-ones
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
DE59504502D1 (de) * 1994-07-18 1999-01-21 Siemens Ag Giesswalzen-verschleissschutzschicht
WO1998052706A1 (de) * 1997-05-23 1998-11-26 Voest-Alpine Industrieanlagenbau Gmbh Giesswalze für eine dünnband-stranggiessanlage
PT1200390E (pt) * 1999-07-29 2008-12-05 Speedel Pharma Ag Produção de 2,7-dialquil-4-hidroxi-5-amino-8-ariloctanoilamidas n-substituídas

Also Published As

Publication number Publication date
JP2004502667A (ja) 2004-01-29
IL153717A (en) 2008-11-03
IL187795A0 (en) 2008-03-20
KR20030017543A (ko) 2003-03-03
WO2002002508A1 (en) 2002-01-10
MXPA02012628A (es) 2004-09-10
CN100482636C (zh) 2009-04-29
HUP0301463A3 (en) 2008-03-28
BR0112362A (pt) 2003-05-13
IL187795A (en) 2009-05-04
US20030149303A1 (en) 2003-08-07
HU228526B1 (hu) 2013-03-28
PL212898B1 (pl) 2012-12-31
CY1109110T1 (el) 2014-07-02
NO328105B1 (no) 2009-12-07
CA2414847C (en) 2009-06-16
EP1296935A1 (en) 2003-04-02
IL187796A (en) 2009-05-04
US6730798B2 (en) 2004-05-04
ES2322547T3 (es) 2009-06-23
AU2001273763B2 (en) 2006-07-13
TWI289551B (en) 2007-11-11
CA2414847A1 (en) 2002-01-10
IL153717A0 (en) 2003-07-06
JP4900755B2 (ja) 2012-03-21
NO20030012L (no) 2003-03-03
BR0112362B1 (pt) 2013-12-31
HUP0301463A2 (hu) 2003-09-29
KR100690471B1 (ko) 2007-03-09
HK1093201A1 (en) 2007-02-23
NO20030012D0 (no) 2003-01-02
DE60138099D1 (de) 2009-05-07
CN1440381A (zh) 2003-09-03
NZ523088A (en) 2004-06-25
IL187796A0 (en) 2008-03-20
AR029564A1 (es) 2003-07-02
PL358887A1 (en) 2004-08-23
AU7376301A (en) 2002-01-14
DK1296935T3 (da) 2009-06-22
ATE426592T1 (de) 2009-04-15
EP1296935B1 (en) 2009-03-25

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