CN1436079A - 咪唑并吡啶和咪唑并嘧啶抗病毒剂 - Google Patents

咪唑并吡啶和咪唑并嘧啶抗病毒剂 Download PDF

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Publication number
CN1436079A
CN1436079A CN01811136A CN01811136A CN1436079A CN 1436079 A CN1436079 A CN 1436079A CN 01811136 A CN01811136 A CN 01811136A CN 01811136 A CN01811136 A CN 01811136A CN 1436079 A CN1436079 A CN 1436079A
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China
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compound
nmr
mmol
alkyl
cycloalkyl
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Pending
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CN01811136A
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English (en)
Chinese (zh)
Inventor
游国龙
R·L·茨维洛
K·D·科姆布林克
H·B·古尔格泽
N·辛
王向东
N·A·梅恩维尔
B·L·维纳布勒斯
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of CN1436079A publication Critical patent/CN1436079A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN01811136A 2000-06-13 2001-05-08 咪唑并吡啶和咪唑并嘧啶抗病毒剂 Pending CN1436079A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21144700P 2000-06-13 2000-06-13
US60/211,447 2000-06-13
US26336301P 2001-01-22 2001-01-22
US60/263,363 2001-01-22

Publications (1)

Publication Number Publication Date
CN1436079A true CN1436079A (zh) 2003-08-13

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Family Applications (1)

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CN01811136A Pending CN1436079A (zh) 2000-06-13 2001-05-08 咪唑并吡啶和咪唑并嘧啶抗病毒剂

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Country Link
US (1) US6489338B2 (cg-RX-API-DMAC7.html)
EP (1) EP1311268A4 (cg-RX-API-DMAC7.html)
JP (1) JP2004503501A (cg-RX-API-DMAC7.html)
KR (1) KR20030008151A (cg-RX-API-DMAC7.html)
CN (1) CN1436079A (cg-RX-API-DMAC7.html)
AR (1) AR029128A1 (cg-RX-API-DMAC7.html)
AU (2) AU7290601A (cg-RX-API-DMAC7.html)
BR (1) BR0111569A (cg-RX-API-DMAC7.html)
CA (1) CA2412327A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ20024078A3 (cg-RX-API-DMAC7.html)
HU (1) HUP0400766A2 (cg-RX-API-DMAC7.html)
IL (1) IL152889A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA02012204A (cg-RX-API-DMAC7.html)
NO (1) NO20025977L (cg-RX-API-DMAC7.html)
NZ (1) NZ523566A (cg-RX-API-DMAC7.html)
PE (1) PE20011348A1 (cg-RX-API-DMAC7.html)
PL (1) PL360290A1 (cg-RX-API-DMAC7.html)
RU (1) RU2003100828A (cg-RX-API-DMAC7.html)
UY (1) UY26758A1 (cg-RX-API-DMAC7.html)
WO (1) WO2001095910A1 (cg-RX-API-DMAC7.html)

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CN102690262A (zh) * 2011-03-23 2012-09-26 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
CN103313974A (zh) * 2010-12-16 2013-09-18 爱尔兰詹森研发公司 苯并咪唑呼吸道合胞病毒抑制剂
CN103347875A (zh) * 2010-12-16 2013-10-09 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的吲哚类
CN104470916A (zh) * 2012-06-15 2015-03-25 爱尔兰詹森研发公司 新颖的作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN104507916A (zh) * 2012-06-15 2015-04-08 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的4-取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN104540817A (zh) * 2012-06-15 2015-04-22 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的用杂环取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN105683190A (zh) * 2013-10-29 2016-06-15 美迪维尔公司 基于喹唑啉的呼吸道合胞病毒抑制剂
CN108349940A (zh) * 2015-10-14 2018-07-31 淄博百极常生制药有限公司 布鲁顿酪氨酸激酶抑制剂
CN114630820A (zh) * 2019-10-30 2022-06-14 杨森科学爱尔兰无限公司 3-硝基-n-(2,2,2-三氟乙基)-4-吡啶胺的合成
WO2023143520A1 (en) * 2022-01-28 2023-08-03 Insilico Medicine Ip Limited Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof

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PL369432A1 (en) 2001-12-10 2005-04-18 Bristol-Myers Squibb Company Bis hydrochloride monohydrate salt of rsv fusion inhibitor
WO2004043913A2 (en) * 2002-11-08 2004-05-27 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
JP2007501251A (ja) * 2003-08-05 2007-01-25 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答調節剤化合物を使用する感染予防
EP1682547B1 (en) 2003-10-30 2012-10-24 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
CA2551178C (en) 2003-12-24 2012-11-06 Biota Scientific Management Pty Ltd Polycyclic agents for the treatment of respiratory syncytial virus infections
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
GB0406282D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
KR101238430B1 (ko) 2004-07-27 2013-02-28 길리애드 사이언시즈, 인코포레이티드 이미다조［4,5-ｄ］피리미딘, 그들의 용도 및 제조방법
CA2612264C (en) 2005-06-20 2014-09-23 Tibotec Pharmaceuticals Ltd. Heterocyclylaminoalkyl substituted benzimidazoles
BRPI0612317B8 (pt) 2005-06-20 2021-05-25 Janssen R & D Ireland benzimidazóis 2-substituídos, seu processo de preparação e composição farmacêutica
ATE529424T1 (de) 2005-06-20 2011-11-15 Tibotec Pharm Ltd 1-ää2-amino-3-(substituiertes alkyl)-3h- benzimidazolylümethylü-3-substituierte-1,3- dihydrobenzimidazol-2-one als replikationshemmer des respiratorischen syncytialvirus
TWI423972B (zh) 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑
WO2009084544A1 (ja) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
WO2010103306A1 (en) 2009-03-10 2010-09-16 Astrazeneca Uk Limited Benzimidazole derivatives and their use as antivaral agents
RU2407738C1 (ru) * 2009-07-03 2010-12-27 Общество с ограниченной ответственностью "Интеллектуальный Диалог" Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
TWI508968B (zh) 2010-02-08 2015-11-21 Biota Scient Management 用於治療呼吸道融合性病毒感染的化合物
JPWO2011115150A1 (ja) * 2010-03-18 2013-07-04 興和株式会社 ベンゾチアジン化合物の製造方法
US8796303B2 (en) 2010-11-26 2014-08-05 Biota Scientific Management Pty Ltd. Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
ES2675583T3 (es) * 2012-06-11 2018-07-11 Ucb Biopharma Sprl Bencimidazoles moduladores de TNF-alfa
AU2013276521A1 (en) * 2012-06-15 2014-12-04 Janssen Sciences Ireland Uc 1,3 -dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
EP2909195B1 (en) * 2012-10-16 2017-06-14 Janssen Sciences Ireland UC Rsv antiviral compounds
JP2016145155A (ja) * 2013-04-30 2016-08-12 日本農薬株式会社 フタルアミド誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
WO2019046364A1 (en) * 2017-08-29 2019-03-07 Emory University INHIBITORS OF SYNCYTIAL RESPIRATORY VIRUS (RSV) REPLICATION AND USES THEREOF
CN114630828B (zh) * 2019-10-30 2023-10-31 杨森科学爱尔兰无限公司 一种rsv抑制化合物的合成
US12145933B2 (en) 2020-06-11 2024-11-19 Janssen Sciences Ireland Unlimited Company Hemi (L)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethy)-1,3-dihydro-2H-imidazo[4,5-C]pyridin-2-one and pharmaceutical compositions comprising the same
WO2022184606A1 (en) * 2021-03-01 2022-09-09 Janssen Sciences Ireland Unlimited Company Synthesis of rilematovir
WO2025026383A1 (en) * 2023-08-02 2025-02-06 Insilico Medicine Ip Limited Crytsalline forms of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof

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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103347875B (zh) * 2010-12-16 2016-03-30 爱尔兰詹森科学公司 作为呼吸道合胞病毒抗病毒剂的吲哚类
CN103313974A (zh) * 2010-12-16 2013-09-18 爱尔兰詹森研发公司 苯并咪唑呼吸道合胞病毒抑制剂
CN103347875A (zh) * 2010-12-16 2013-10-09 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的吲哚类
CN107417683A (zh) * 2010-12-16 2017-12-01 爱尔兰詹森科学公司 苯并咪唑呼吸道合胞病毒抑制剂
CN103860538A (zh) * 2011-03-23 2014-06-18 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
CN102690262A (zh) * 2011-03-23 2012-09-26 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
CN102690262B (zh) * 2011-03-23 2014-05-28 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
CN103893173A (zh) * 2011-03-23 2014-07-02 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
CN104540817B (zh) * 2012-06-15 2017-03-01 爱尔兰詹森科学公司 作为呼吸道合胞病毒抗病毒剂的用杂环取代的1，3‑二氢‑2h‑苯并咪唑‑2‑酮衍生物
CN104540817A (zh) * 2012-06-15 2015-04-22 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的用杂环取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN104507916A (zh) * 2012-06-15 2015-04-08 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的4-取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN104470916A (zh) * 2012-06-15 2015-03-25 爱尔兰詹森研发公司 新颖的作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN105683190A (zh) * 2013-10-29 2016-06-15 美迪维尔公司 基于喹唑啉的呼吸道合胞病毒抑制剂
CN108349940A (zh) * 2015-10-14 2018-07-31 淄博百极常生制药有限公司 布鲁顿酪氨酸激酶抑制剂
CN108349940B (zh) * 2015-10-14 2021-08-13 淄博百极常生制药有限公司 布鲁顿酪氨酸激酶抑制剂
CN114630820A (zh) * 2019-10-30 2022-06-14 杨森科学爱尔兰无限公司 3-硝基-n-(2,2,2-三氟乙基)-4-吡啶胺的合成
CN114630820B (zh) * 2019-10-30 2023-10-31 杨森科学爱尔兰无限公司 3-硝基-n-(2,2,2-三氟乙基)-4-吡啶胺的合成
WO2023143520A1 (en) * 2022-01-28 2023-08-03 Insilico Medicine Ip Limited Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof

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Publication number Publication date
MXPA02012204A (es) 2003-10-15
US6489338B2 (en) 2002-12-03
HUP0400766A2 (hu) 2004-07-28
NO20025977L (no) 2003-01-29
JP2004503501A (ja) 2004-02-05
PE20011348A1 (es) 2002-02-07
AU7290601A (en) 2001-12-24
KR20030008151A (ko) 2003-01-24
CZ20024078A3 (cs) 2003-08-13
EP1311268A1 (en) 2003-05-21
CA2412327A1 (en) 2001-12-20
WO2001095910A1 (en) 2001-12-20
IL152889A0 (en) 2003-06-24
NZ523566A (en) 2004-08-27
NO20025977D0 (no) 2002-12-12
RU2003100828A (ru) 2004-06-27
UY26758A1 (es) 2002-01-31
EP1311268A4 (en) 2004-06-30
AU2001272906B2 (en) 2004-08-26
AR029128A1 (es) 2003-06-04
BR0111569A (pt) 2003-04-29
PL360290A1 (en) 2004-09-06
US20020016309A1 (en) 2002-02-07

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