CA2412327A1 - Imidazopyridine and imidazopyrimidine antiviral agents - Google Patents

Imidazopyridine and imidazopyrimidine antiviral agents Download PDF

Info

Publication number
CA2412327A1
CA2412327A1 CA002412327A CA2412327A CA2412327A1 CA 2412327 A1 CA2412327 A1 CA 2412327A1 CA 002412327 A CA002412327 A CA 002412327A CA 2412327 A CA2412327 A CA 2412327A CA 2412327 A1 CA2412327 A1 CA 2412327A1
Authority
CA
Canada
Prior art keywords
compound
nmr
mmol
alkyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002412327A
Other languages
English (en)
French (fr)
Inventor
Kuo-Long Yu
Rita L. Civiello
Keith D. Combrink
Hatice Belgin Gulgeze
Ny Sin
Xiangdong Wang
Nicholas A. Meanwell
Brian Lee Venables
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2412327A1 publication Critical patent/CA2412327A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002412327A 2000-06-13 2001-05-08 Imidazopyridine and imidazopyrimidine antiviral agents Abandoned CA2412327A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21144700P 2000-06-13 2000-06-13
US60/211,447 2000-06-13
US26336301P 2001-01-22 2001-01-22
US60/263,363 2001-01-22
PCT/US2001/014775 WO2001095910A1 (en) 2000-06-13 2001-05-08 Imidazopyridine and imidazopyrimidine antiviral agents

Publications (1)

Publication Number Publication Date
CA2412327A1 true CA2412327A1 (en) 2001-12-20

Family

ID=26906145

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002412327A Abandoned CA2412327A1 (en) 2000-06-13 2001-05-08 Imidazopyridine and imidazopyrimidine antiviral agents

Country Status (20)

Country Link
US (1) US6489338B2 (cg-RX-API-DMAC7.html)
EP (1) EP1311268A4 (cg-RX-API-DMAC7.html)
JP (1) JP2004503501A (cg-RX-API-DMAC7.html)
KR (1) KR20030008151A (cg-RX-API-DMAC7.html)
CN (1) CN1436079A (cg-RX-API-DMAC7.html)
AR (1) AR029128A1 (cg-RX-API-DMAC7.html)
AU (2) AU7290601A (cg-RX-API-DMAC7.html)
BR (1) BR0111569A (cg-RX-API-DMAC7.html)
CA (1) CA2412327A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ20024078A3 (cg-RX-API-DMAC7.html)
HU (1) HUP0400766A2 (cg-RX-API-DMAC7.html)
IL (1) IL152889A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA02012204A (cg-RX-API-DMAC7.html)
NO (1) NO20025977L (cg-RX-API-DMAC7.html)
NZ (1) NZ523566A (cg-RX-API-DMAC7.html)
PE (1) PE20011348A1 (cg-RX-API-DMAC7.html)
PL (1) PL360290A1 (cg-RX-API-DMAC7.html)
RU (1) RU2003100828A (cg-RX-API-DMAC7.html)
UY (1) UY26758A1 (cg-RX-API-DMAC7.html)
WO (1) WO2001095910A1 (cg-RX-API-DMAC7.html)

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PL369432A1 (en) 2001-12-10 2005-04-18 Bristol-Myers Squibb Company Bis hydrochloride monohydrate salt of rsv fusion inhibitor
WO2004043913A2 (en) * 2002-11-08 2004-05-27 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
JP2007501251A (ja) * 2003-08-05 2007-01-25 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答調節剤化合物を使用する感染予防
EP1682547B1 (en) 2003-10-30 2012-10-24 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
CA2551178C (en) 2003-12-24 2012-11-06 Biota Scientific Management Pty Ltd Polycyclic agents for the treatment of respiratory syncytial virus infections
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
GB0406282D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
KR101238430B1 (ko) 2004-07-27 2013-02-28 길리애드 사이언시즈, 인코포레이티드 이미다조［4,5-ｄ］피리미딘, 그들의 용도 및 제조방법
CA2612264C (en) 2005-06-20 2014-09-23 Tibotec Pharmaceuticals Ltd. Heterocyclylaminoalkyl substituted benzimidazoles
BRPI0612317B8 (pt) 2005-06-20 2021-05-25 Janssen R & D Ireland benzimidazóis 2-substituídos, seu processo de preparação e composição farmacêutica
ATE529424T1 (de) 2005-06-20 2011-11-15 Tibotec Pharm Ltd 1-ää2-amino-3-(substituiertes alkyl)-3h- benzimidazolylümethylü-3-substituierte-1,3- dihydrobenzimidazol-2-one als replikationshemmer des respiratorischen syncytialvirus
TWI423972B (zh) 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑
WO2009084544A1 (ja) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
WO2010103306A1 (en) 2009-03-10 2010-09-16 Astrazeneca Uk Limited Benzimidazole derivatives and their use as antivaral agents
RU2407738C1 (ru) * 2009-07-03 2010-12-27 Общество с ограниченной ответственностью "Интеллектуальный Диалог" Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
TWI508968B (zh) 2010-02-08 2015-11-21 Biota Scient Management 用於治療呼吸道融合性病毒感染的化合物
JPWO2011115150A1 (ja) * 2010-03-18 2013-07-04 興和株式会社 ベンゾチアジン化合物の製造方法
US8796303B2 (en) 2010-11-26 2014-08-05 Biota Scientific Management Pty Ltd. Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
TWI530495B (zh) * 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI515187B (zh) * 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
CN103893173B (zh) * 2011-03-23 2016-02-24 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
ES2675583T3 (es) * 2012-06-11 2018-07-11 Ucb Biopharma Sprl Bencimidazoles moduladores de TNF-alfa
KR102092612B1 (ko) * 2012-06-15 2020-03-25 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 호흡기 합포체 바이러스의 항바이러스제로서의 헤테로사이클로 치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체
AU2013276521A1 (en) * 2012-06-15 2014-12-04 Janssen Sciences Ireland Uc 1,3 -dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
AU2013276518A1 (en) * 2012-06-15 2014-12-04 Janssen Sciences Ireland Uc 4 - substituted 1, 3 - dihydro - 2H - benzimidazol - 2 - one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents
EA201590020A1 (ru) * 2012-06-15 2015-03-31 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса
EP2909195B1 (en) * 2012-10-16 2017-06-14 Janssen Sciences Ireland UC Rsv antiviral compounds
JP2016145155A (ja) * 2013-04-30 2016-08-12 日本農薬株式会社 フタルアミド誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法
HK1219482A1 (zh) * 2013-10-29 2017-04-07 美迪维尔公司 基於喹唑啉的呼吸道合胞病毒抑制剂
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
WO2017066014A1 (en) * 2015-10-14 2017-04-20 Sunnylife Pharma Inc. Bruton's tyrosine kinase inhibitors
WO2019046364A1 (en) * 2017-08-29 2019-03-07 Emory University INHIBITORS OF SYNCYTIAL RESPIRATORY VIRUS (RSV) REPLICATION AND USES THEREOF
EP4051663B1 (en) 2019-10-30 2024-02-21 Janssen Sciences Ireland Unlimited Company Synthesis of 3-nitro-n-(2,2,2-trifluoroethyl)-4-pyridinamine
CN114630828B (zh) * 2019-10-30 2023-10-31 杨森科学爱尔兰无限公司 一种rsv抑制化合物的合成
US12145933B2 (en) 2020-06-11 2024-11-19 Janssen Sciences Ireland Unlimited Company Hemi (L)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethy)-1,3-dihydro-2H-imidazo[4,5-C]pyridin-2-one and pharmaceutical compositions comprising the same
WO2022184606A1 (en) * 2021-03-01 2022-09-09 Janssen Sciences Ireland Unlimited Company Synthesis of rilematovir
CA3247162A1 (en) * 2022-01-28 2023-08-03 Insilico Medicine Ip Limited Ectunocleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) inhibitors and their uses
WO2025026383A1 (en) * 2023-08-02 2025-02-06 Insilico Medicine Ip Limited Crytsalline forms of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof

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FI75816C (fi) 1981-02-06 1988-08-08 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid.
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NZ505894A (en) 1998-01-29 2002-12-20 Viropharma Inc Methylenebisbenzaldehyde derivatives, methylidynetrisphenol derivative and pharmaceuticals thereof; useful for treating or preventing pneumovirus infection and associated diseases
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Also Published As

Publication number Publication date
MXPA02012204A (es) 2003-10-15
US6489338B2 (en) 2002-12-03
HUP0400766A2 (hu) 2004-07-28
NO20025977L (no) 2003-01-29
JP2004503501A (ja) 2004-02-05
PE20011348A1 (es) 2002-02-07
AU7290601A (en) 2001-12-24
KR20030008151A (ko) 2003-01-24
CZ20024078A3 (cs) 2003-08-13
EP1311268A1 (en) 2003-05-21
WO2001095910A1 (en) 2001-12-20
IL152889A0 (en) 2003-06-24
NZ523566A (en) 2004-08-27
NO20025977D0 (no) 2002-12-12
RU2003100828A (ru) 2004-06-27
UY26758A1 (es) 2002-01-31
EP1311268A4 (en) 2004-06-30
CN1436079A (zh) 2003-08-13
AU2001272906B2 (en) 2004-08-26
AR029128A1 (es) 2003-06-04
BR0111569A (pt) 2003-04-29
PL360290A1 (en) 2004-09-06
US20020016309A1 (en) 2002-02-07

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued