CN1307194C - 大环内酯类化合物 - Google Patents

大环内酯类化合物 Download PDF

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Publication number
CN1307194C
CN1307194C CNB028270452A CN02827045A CN1307194C CN 1307194 C CN1307194 C CN 1307194C CN B028270452 A CNB028270452 A CN B028270452A CN 02827045 A CN02827045 A CN 02827045A CN 1307194 C CN1307194 C CN 1307194C
Authority
CN
China
Prior art keywords
amino
dihydro
oxo
ethyl
cyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028270452A
Other languages
English (en)
Chinese (zh)
Other versions
CN1612888A (zh
Inventor
S·阿利霍德兹克
D·安德雷奥蒂
A·贝尔迪克
I·比恩蒂内斯
S·比安迪
M·茨拉科
F·达米亚尼
M·德耶雷克
M·杜米克
V·埃拉科维克
A·胡蒂内克
G·拉扎雷夫斯基
S·罗丘罗
N·马西克
Z·马鲁西克－伊斯图克
S·穆塔克
A·派奥
D·帕夫罗维克
A·夸格利亚
W·舍恩费尔德
V·斯蒂马克
J·蒂巴斯各
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Pliva Farmaceutika dd
Original Assignee
Glaxo Group Ltd
Pliva Farmaceutika dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Pliva Farmaceutika dd filed Critical Glaxo Group Ltd
Publication of CN1612888A publication Critical patent/CN1612888A/zh
Application granted granted Critical
Publication of CN1307194C publication Critical patent/CN1307194C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
CNB028270452A 2001-11-14 2002-11-13 大环内酯类化合物 Expired - Fee Related CN1307194C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0127349.9 2001-11-14
GBGB0127349.9A GB0127349D0 (en) 2001-11-14 2001-11-14 Macrolides

Publications (2)

Publication Number Publication Date
CN1612888A CN1612888A (zh) 2005-05-04
CN1307194C true CN1307194C (zh) 2007-03-28

Family

ID=9925777

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028270452A Expired - Fee Related CN1307194C (zh) 2001-11-14 2002-11-13 大环内酯类化合物

Country Status (20)

Country Link
US (1) US7202221B2 (enExample)
EP (1) EP1453846B1 (enExample)
JP (1) JP2005515978A (enExample)
CN (1) CN1307194C (enExample)
AR (1) AR037371A1 (enExample)
AT (1) ATE362479T1 (enExample)
BR (1) BR0214132A (enExample)
CA (1) CA2466975A1 (enExample)
DE (1) DE60220180T2 (enExample)
EA (1) EA007433B1 (enExample)
ES (1) ES2287332T3 (enExample)
GB (1) GB0127349D0 (enExample)
HR (1) HRP20040433A2 (enExample)
HU (1) HUP0402225A3 (enExample)
IL (1) IL161710A0 (enExample)
PL (1) PL371472A1 (enExample)
RS (1) RS41904A (enExample)
UA (1) UA77210C2 (enExample)
WO (1) WO2003042228A1 (enExample)
ZA (1) ZA200403684B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US7022679B2 (en) 2002-05-13 2006-04-04 Enanta Pharmaceuticals, Inc. Processes for the preparation of 6-11 bicyclic erythromycin derivatives
US7135573B2 (en) 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US7910558B2 (en) 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
JP4532263B2 (ja) * 2002-05-14 2010-08-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 置換されたキノロンカルボン酸、その誘導体、作用の部位、およびその使用
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
GB0225384D0 (en) * 2002-10-31 2002-12-11 Glaxo Group Ltd Novel compounds
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
CL2004001012A1 (es) * 2003-05-13 2005-03-18 Glaxo Group Ltd Compuestos derivados de macrolidos de 14 o 15 miembros, sustituidos en posicion 4"; procedimiento para su preparacion; composicion farmaceutica que lo comprende; y su uso para el tratamiento o profilaxis de infecciones microbianas sistemicas o topica
GB0310986D0 (en) 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310980D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310979D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310984D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
WO2005070113A2 (en) 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
EP1723159B1 (en) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same
BRPI0510328A (pt) * 2004-05-06 2007-10-23 Glaxosmithkline Zagreb macrolìdeos ligados a éster úteis para o tratamento de infecções microbianas
EP1756134A1 (en) * 2004-05-06 2007-02-28 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Carbamate linked macrolides useful for the treatment of microbial infections
WO2006047167A2 (en) * 2004-10-21 2006-05-04 Janssen Pharmaceutica, N.V. 9 alkyl and 9 alkylidenyl 6-0 alkyl-11, 12 carbamate ketolide antimicrobials
GB0424951D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424961D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424958D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424959D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
KR101239490B1 (ko) * 2006-08-09 2013-03-05 바실리어 파마슈티카 아게 염증성 및 알러지성 질환에 유용한 새로운 마크로라이드
WO2008023248A2 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
MX2010008750A (es) 2008-02-08 2010-08-31 Basilea Pharmaceutica Ag Nuevos macrolidos y su uso.
MX2011012614A (es) 2009-05-27 2012-02-22 Wockhardt Ltd Compuestos de quetolida que tienen actividad antimicrobiana.
RU2601550C2 (ru) 2010-12-09 2016-11-10 Вокхардт Лимитед Кетолидные соединения
BR112013019283A2 (pt) * 2011-01-31 2016-09-13 Meiji Seika Pharma Co Ltd composto, fármaco, composição farmacêutica e uso
JP5718488B2 (ja) 2011-03-01 2015-05-13 ウォックハート リミテッド ケトライド中間体の調製方法
CN119060110A (zh) * 2023-05-30 2024-12-03 北京理工大学 一种红霉素衍生物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0248279A2 (en) * 1986-06-04 1987-12-09 Abbott Laboratories Semisynthetic erythromycin antibiotics
EP0508699A1 (en) * 1991-04-04 1992-10-14 Merck & Co. Inc. 9-Deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and 8a-positions
US6025350A (en) * 1997-08-06 2000-02-15 Pfizer Inc. C-4" substituted macrolide antibiotics

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126344A2 (en) 1983-05-20 1984-11-28 Abbott Laboratories Tripeptide esters of therapeutic agents
AU623764B2 (en) 1989-03-28 1992-05-21 Abbott Laboratories Erythromycin derivatives
WO1997042206A1 (en) 1996-05-07 1997-11-13 Abbott Laboratories 6-o-substituted erythromycin compounds and method for making same
US6262030B1 (en) * 1998-11-03 2001-07-17 Pfizer Inc. Erythromycin derivatives
OA11945A (en) 1999-05-24 2006-04-13 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
AU6748500A (en) 1999-08-24 2001-03-19 Abbott Laboratories 9a-azalides with antibacterial activity
CA2398848C (en) 2000-02-24 2007-09-25 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
US6946446B2 (en) * 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
JP2002173498A (ja) 2000-09-27 2002-06-21 Hokuriku Seiyaku Co Ltd エリスロマイシン誘導体
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0248279A2 (en) * 1986-06-04 1987-12-09 Abbott Laboratories Semisynthetic erythromycin antibiotics
EP0508699A1 (en) * 1991-04-04 1992-10-14 Merck & Co. Inc. 9-Deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and 8a-positions
US6025350A (en) * 1997-08-06 2000-02-15 Pfizer Inc. C-4" substituted macrolide antibiotics

Also Published As

Publication number Publication date
PL371472A1 (en) 2005-06-13
WO2003042228A1 (en) 2003-05-22
JP2005515978A (ja) 2005-06-02
ES2287332T3 (es) 2007-12-16
DE60220180D1 (de) 2007-06-28
DE60220180T2 (de) 2008-01-17
EP1453846B1 (en) 2007-05-16
EA007433B1 (ru) 2006-10-27
US7202221B2 (en) 2007-04-10
ATE362479T1 (de) 2007-06-15
CN1612888A (zh) 2005-05-04
AR037371A1 (es) 2004-11-03
CA2466975A1 (en) 2003-05-22
HUP0402225A3 (en) 2006-01-30
ZA200403684B (en) 2005-09-13
EA200400536A1 (ru) 2004-12-30
IL161710A0 (en) 2004-09-27
RS41904A (sr) 2006-10-27
HUP0402225A2 (hu) 2005-02-28
EP1453846A1 (en) 2004-09-08
GB0127349D0 (en) 2002-01-02
UA77210C2 (en) 2006-11-15
BR0214132A (pt) 2004-09-14
US20050080025A1 (en) 2005-04-14
HRP20040433A2 (en) 2005-04-30

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070328

Termination date: 20091214