CN1303974C - 用于干粉吸入器的载体颗粒 - Google Patents

用于干粉吸入器的载体颗粒 Download PDF

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Publication number
CN1303974C
CN1303974C CNB961926767A CN96192676A CN1303974C CN 1303974 C CN1303974 C CN 1303974C CN B961926767 A CNB961926767 A CN B961926767A CN 96192676 A CN96192676 A CN 96192676A CN 1303974 C CN1303974 C CN 1303974C
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CN
China
Prior art keywords
powder
particles
additional material
carrier
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB961926767A
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English (en)
Chinese (zh)
Other versions
CN1179097A (zh
Inventor
J·N·斯塔尼福思
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vectura Ltd
Vectura Group PLC
Original Assignee
Coordinated Drug Development Ltd
Vectura Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10768844&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1303974(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Coordinated Drug Development Ltd, Vectura Ltd filed Critical Coordinated Drug Development Ltd
Publication of CN1179097A publication Critical patent/CN1179097A/zh
Application granted granted Critical
Publication of CN1303974C publication Critical patent/CN1303974C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
CNB961926767A 1995-01-31 1996-01-31 用于干粉吸入器的载体颗粒 Expired - Lifetime CN1303974C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9501841.2A GB9501841D0 (en) 1995-01-31 1995-01-31 Improvements in and relating to carrier particles for use in dry powder inhalers
GB9501841.2 1995-01-31
GBGB9521937.4A GB9521937D0 (en) 1995-01-31 1995-10-26 Improvementsin and relating to carrier particles for use in dry powder inhailers
GB9521937.4 1995-10-26
PCT/GB1996/000215 WO1996023485A1 (en) 1995-01-31 1996-01-31 Carrier particles for use in dry powder inhalers

Publications (2)

Publication Number Publication Date
CN1179097A CN1179097A (zh) 1998-04-15
CN1303974C true CN1303974C (zh) 2007-03-14

Family

ID=10768844

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB961926767A Expired - Lifetime CN1303974C (zh) 1995-01-31 1996-01-31 用于干粉吸入器的载体颗粒

Country Status (32)

Country Link
US (5) US6153224A (enExample)
EP (6) EP0806938B1 (enExample)
JP (1) JP4042867B2 (enExample)
KR (1) KR100500694B1 (enExample)
CN (1) CN1303974C (enExample)
AT (3) ATE256450T1 (enExample)
AU (1) AU699131B2 (enExample)
BG (1) BG101858A (enExample)
BR (3) BR9612950B1 (enExample)
CA (1) CA2211874C (enExample)
CZ (1) CZ294259B6 (enExample)
DE (2) DE69636961T2 (enExample)
DK (3) DK0806938T3 (enExample)
EA (1) EA000352B1 (enExample)
EE (1) EE9700176A (enExample)
ES (3) ES2375007T3 (enExample)
FI (1) FI119676B (enExample)
GB (2) GB9501841D0 (enExample)
GE (1) GEP19991687B (enExample)
HU (1) HU229965B1 (enExample)
IS (1) IS4531A (enExample)
MX (1) MX9705847A (enExample)
NO (1) NO324037B1 (enExample)
NZ (1) NZ300654A (enExample)
PL (1) PL186757B1 (enExample)
PT (3) PT1232745E (enExample)
SI (2) SI1232745T1 (enExample)
SK (1) SK282630B6 (enExample)
TR (1) TR199700722T1 (enExample)
UA (1) UA61051C2 (enExample)
WO (1) WO1996023485A1 (enExample)
ZA (1) ZA96721B (enExample)

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