CN1298716C - 1－[(吲哚－3－基)羰基]哌嗪衍生物及其药物组合物 - Google Patents

1－[(吲哚－3－基)羰基]哌嗪衍生物及其药物组合物 Download PDF

Info

Publication number
CN1298716C
CN1298716C CNB038170906A CN03817090A CN1298716C CN 1298716 C CN1298716 C CN 1298716C CN B038170906 A CNB038170906 A CN B038170906A CN 03817090 A CN03817090 A CN 03817090A CN 1298716 C CN1298716 C CN 1298716C
Authority
CN
China
Prior art keywords
carbonyl
indol
alkyl
cyclohexylmethyl
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB038170906A
Other languages
English (en)
Chinese (zh)
Other versions
CN1668611A (zh
Inventor
P·M·考利
W·考尔菲尔德
J·蒂尔尼
J·凯恩斯
J·亚当-沃勒尔
M·约克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon NV filed Critical Organon NV
Publication of CN1668611A publication Critical patent/CN1668611A/zh
Application granted granted Critical
Publication of CN1298716C publication Critical patent/CN1298716C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CNB038170906A 2002-06-21 2003-06-13 1－[(吲哚－3－基)羰基]哌嗪衍生物及其药物组合物 Expired - Fee Related CN1298716C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02077505.2 2002-06-21
EP02077505 2002-06-21

Publications (2)

Publication Number Publication Date
CN1668611A CN1668611A (zh) 2005-09-14
CN1298716C true CN1298716C (zh) 2007-02-07

Family

ID=29797228

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038170906A Expired - Fee Related CN1298716C (zh) 2002-06-21 2003-06-13 1－[(吲哚－3－基)羰基]哌嗪衍生物及其药物组合物

Country Status (32)

Country Link
US (1) US7304064B2 (enExample)
EP (1) EP1549637B1 (enExample)
JP (1) JP4408804B2 (enExample)
KR (1) KR20050009755A (enExample)
CN (1) CN1298716C (enExample)
AR (1) AR040274A1 (enExample)
AT (1) ATE361290T1 (enExample)
AU (1) AU2003250245B2 (enExample)
BR (1) BR0311960A (enExample)
CA (1) CA2490141C (enExample)
CO (1) CO5680419A2 (enExample)
CY (1) CY1107677T1 (enExample)
DE (1) DE60313640T2 (enExample)
DK (1) DK1549637T3 (enExample)
EC (1) ECSP045503A (enExample)
ES (1) ES2285183T3 (enExample)
HR (1) HRP20041186A2 (enExample)
IL (1) IL165572A0 (enExample)
IS (1) IS2443B (enExample)
MX (1) MXPA04012856A (enExample)
NO (1) NO20045351L (enExample)
NZ (1) NZ537143A (enExample)
PE (1) PE20040578A1 (enExample)
PL (1) PL375152A1 (enExample)
PT (1) PT1549637E (enExample)
RS (1) RS111104A (enExample)
RU (1) RU2318821C2 (enExample)
SI (1) SI1549637T1 (enExample)
TW (1) TW200402417A (enExample)
UA (1) UA78317C2 (enExample)
WO (1) WO2004000832A1 (enExample)
ZA (1) ZA200410057B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
ES2294330T3 (es) 2002-08-02 2008-04-01 MERCK & CO., INC. Derivados de furo(2,3-b)piridina sustituidos.
DE10253426B4 (de) * 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
ES2284076T3 (es) 2003-12-17 2007-11-01 N.V. Organon Derivados triciclicos de 1-(indol-3-il)carbonil)piperazina como agonistas del receptor de cannabinoides cb1.
TWI330635B (en) 2004-03-05 2010-09-21 Organon Nv (indol-3-yl)-heterocycle derivatives
JP2009500439A (ja) * 2005-07-11 2009-01-08 ナームローゼ・フエンノートチヤツプ・オルガノン 疼痛の治療のための相乗的組み合わせ（カンナビノイド受容体アゴニスト及びオピオイド受容体アゴニスト）
KR101020351B1 (ko) * 2005-07-29 2011-03-08 에프. 호프만-라 로슈 아게 인돌-3-일-카본일-피페리딘 및 피페라진 유도체
TW200745096A (en) * 2005-08-23 2007-12-16 Organon Nv Indole derivatives
US7763732B2 (en) 2005-08-24 2010-07-27 N.V. Organon Indole derivatives
AU2006295130A1 (en) * 2005-09-23 2007-04-05 Janssen Pharmaceutica, N.V. Tetrahydro-indazolyl cannabinoid modulators
TW200848417A (en) 2007-02-22 2008-12-16 Organon Nv Indole derivatives
RU2387642C2 (ru) 2007-10-31 2010-04-27 Общество С Ограниченной Ответственностью "Бинатех" Производные 5-замещенных индол-3-карбоновой кислоты, обладающие противовирусной активностью, способ их получения и применение
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
CN105829310B (zh) 2013-12-20 2019-04-12 阿斯特克斯治疗有限公司 双环杂环化合物及其治疗用途
CN111566105A (zh) 2018-01-08 2020-08-21 豪夫迈·罗氏有限公司 作为MAGL抑制剂的八氢吡啶并[1,2-α]吡嗪类化合物
CN108752342A (zh) * 2018-08-17 2018-11-06 西安瑞联新材料股份有限公司 1-H-吡啶并[1,2-a]-6-氢吡嗪-1,4-二酮的制备方法
CN111100063B (zh) * 2018-10-25 2022-05-17 南京药石科技股份有限公司 一种合成2-氟甲基取代的吡咯烷、哌啶以及哌嗪衍生物的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001043746A1 (en) * 1999-12-14 2001-06-21 Nippon Shinyaku Co., Ltd. Medicinal composition
WO2001058869A2 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE142621T1 (de) * 1989-12-28 1996-09-15 Upjohn Co Diaromatische substituierte verbindungen gegen den aids-virus
WO1998006715A1 (en) 1996-08-09 1998-02-19 Smithkline Beecham Corporation Novel piperazine containing compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001043746A1 (en) * 1999-12-14 2001-06-21 Nippon Shinyaku Co., Ltd. Medicinal composition
WO2001058869A2 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases

Also Published As

Publication number Publication date
JP2005533801A (ja) 2005-11-10
AU2003250245A1 (en) 2004-01-06
RU2318821C2 (ru) 2008-03-10
CO5680419A2 (es) 2006-09-29
WO2004000832A1 (en) 2003-12-31
JP4408804B2 (ja) 2010-02-03
CY1107677T1 (el) 2013-04-18
ZA200410057B (en) 2005-10-20
RS111104A (sr) 2007-02-05
UA78317C2 (en) 2007-03-15
TW200402417A (en) 2004-02-16
ATE361290T1 (de) 2007-05-15
HRP20041186A2 (en) 2005-06-30
DE60313640D1 (de) 2007-06-14
EP1549637A1 (en) 2005-07-06
ES2285183T3 (es) 2007-11-16
PE20040578A1 (es) 2004-09-15
AU2003250245B2 (en) 2008-07-03
SI1549637T1 (sl) 2007-10-31
PL375152A1 (en) 2005-11-28
KR20050009755A (ko) 2005-01-25
RU2005101349A (ru) 2005-06-27
HK1076630A1 (en) 2006-01-20
ECSP045503A (es) 2005-03-10
US7304064B2 (en) 2007-12-04
DK1549637T3 (da) 2007-07-16
CA2490141A1 (en) 2003-12-31
BR0311960A (pt) 2005-03-22
IL165572A0 (en) 2006-01-15
NZ537143A (en) 2005-05-27
US20050250760A1 (en) 2005-11-10
AR040274A1 (es) 2005-03-23
IS7590A (is) 2004-12-09
PT1549637E (pt) 2007-05-31
EP1549637B1 (en) 2007-05-02
IS2443B (is) 2008-11-15
MXPA04012856A (es) 2005-03-31
CN1668611A (zh) 2005-09-14
NO20045351L (no) 2005-01-20
DE60313640T2 (de) 2007-12-27
CA2490141C (en) 2011-01-25

Similar Documents

Publication Publication Date Title
CN1298716C (zh) 1－[(吲哚－3－基)羰基]哌嗪衍生物及其药物组合物
CN100351236C (zh) 用作5－羟色胺－6配体的1－杂环基烷基－3－磺酰基－吲哚衍生物，其制备方法和用途
CN1061341C (zh) 1－氨基乙基吲哚衍生物
CN1115336C (zh) 1－苯基－苯并咪唑类化合物及其作为baga－a受体调节剂的用途
CN1224614C (zh) 吲哚满－2－酮衍生物、其制备方法及其作为催产素受体配体的应用
CN1036456C (zh) 氨基取代的吡唑
CN1253449C (zh) 作为蛋白激酶c抑制剂的吲哚基马来酰亚胺衍生物
CN1190432C (zh) 作为5－htib拮抗药的哌嗪衍生物
CN1093127C (zh) 哌嗪衍生物
CN1319973C (zh) 哌啶衍生物
CN1209129A (zh) 促性腺激素释放激素的拮抗药
CN1047385C (zh) 3-吲哚基哌啶和含有它们的药物组合物
CN1816530A (zh) 用于治疗高眼压症的眼用组合物
CN1391564A (zh) 化合物
CN100340562C (zh) 杂环稠合的苯并二噁烷的抗抑郁芳基哌嗪衍生物
CN1356987A (zh) 新型苯并咪唑衍生物和包括这些化合物的药物组合物
CN1668620A (zh) 用于5－羟色胺－6配体的1－杂环基烷基－3－磺酰基氮杂吲哚或－氮杂吲唑衍生物
CN1454211A (zh) 作为Xa因子抑制剂的含氮杂双环化合物
CN1771244A (zh) 作为5－羟色胺－6配体的杂环－3－磺酰基吲唑
CN1620290A (zh) 作为5－羟色胺－6配体的吲哚基烷基胺衍生物
CN1349524A (zh) 血管紧张肽原酶抑制剂
CN1230432C (zh) 取代的苯基－哌嗪衍生物及其制备和用途
CN1681784A (zh) 作为霉蝇碱受体拮抗剂的氮杂二环衍生物
CN1437596A (zh) 苯基哌嗪基衍生物
CN1871242A (zh) 作为mch r1拮抗剂用于治疗肥胖症、糖尿病、抑郁症和焦虑的3－(4－(氨基苯基)噻吩并嘧啶－4－酮衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: MSD OS CO., LTD.

Free format text: FORMER NAME: ORGANON NV

CP01 Change in the name or title of a patent holder

Address after: Dutch Oss

Patentee after: N.V. Organon

Address before: Dutch Oss

Patentee before: N.V. ORGANON

ASS Succession or assignment of patent right

Owner name: MERCK SHARP + DOHME CORP.

Free format text: FORMER OWNER: ORGANON BIOLOGICAL NETHERLANDS CO., LTD.

Effective date: 20131014

Owner name: ORGANON BIOLOGICAL NETHERLANDS CO., LTD.

Free format text: FORMER OWNER: MSD OUSI CO., LTD.

Effective date: 20131014

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20131014

Address after: Haarlem

Patentee after: MERCK SHARP & DOHME B.V.

Address before: Haarlem

Patentee before: Organon biological science Holland Co.,Ltd.

Effective date of registration: 20131014

Address after: Haarlem

Patentee after: Organon biological science Holland Co.,Ltd.

Address before: Holland

Patentee before: N.V. Organon

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070207

Termination date: 20150613

EXPY Termination of patent right or utility model