JP4408804B2 - １−［（インドル−３−イル）カルボニル］ピペラジン誘導体 - Google Patents

１−［（インドル−３−イル）カルボニル］ピペラジン誘導体 Download PDF

Info

Publication number
JP4408804B2
JP4408804B2 JP2004514874A JP2004514874A JP4408804B2 JP 4408804 B2 JP4408804 B2 JP 4408804B2 JP 2004514874 A JP2004514874 A JP 2004514874A JP 2004514874 A JP2004514874 A JP 2004514874A JP 4408804 B2 JP4408804 B2 JP 4408804B2
Authority
JP
Japan
Prior art keywords
carbonyl
indol
methoxy
cyclohexylmethyl
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2004514874A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005533801A (ja
JP2005533801A5 (enExample
Inventor
カウリー，フイリツプ・マーテイン
コールフイールド，ウイルソン
テイアニー，ジエイソン
ケアンズ，ジエイムズ
アダム−ウオラル，ジユリア
ヨーク，マーク
Original Assignee
ナームローゼ・フエンノートチヤツプ・オルガノン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ナームローゼ・フエンノートチヤツプ・オルガノン filed Critical ナームローゼ・フエンノートチヤツプ・オルガノン
Publication of JP2005533801A publication Critical patent/JP2005533801A/ja
Publication of JP2005533801A5 publication Critical patent/JP2005533801A5/ja
Application granted granted Critical
Publication of JP4408804B2 publication Critical patent/JP4408804B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
JP2004514874A 2002-06-21 2003-06-13 １−［（インドル−３−イル）カルボニル］ピペラジン誘導体 Expired - Fee Related JP4408804B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02077505 2002-06-21
PCT/EP2003/050226 WO2004000832A1 (en) 2002-06-21 2003-06-13 1-[(indol-3-yl)carbonyl] piperazine derivatives

Publications (3)

Publication Number Publication Date
JP2005533801A JP2005533801A (ja) 2005-11-10
JP2005533801A5 JP2005533801A5 (enExample) 2006-07-13
JP4408804B2 true JP4408804B2 (ja) 2010-02-03

Family

ID=29797228

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004514874A Expired - Fee Related JP4408804B2 (ja) 2002-06-21 2003-06-13 １−［（インドル−３−イル）カルボニル］ピペラジン誘導体

Country Status (32)

Country Link
US (1) US7304064B2 (enExample)
EP (1) EP1549637B1 (enExample)
JP (1) JP4408804B2 (enExample)
KR (1) KR20050009755A (enExample)
CN (1) CN1298716C (enExample)
AR (1) AR040274A1 (enExample)
AT (1) ATE361290T1 (enExample)
AU (1) AU2003250245B2 (enExample)
BR (1) BR0311960A (enExample)
CA (1) CA2490141C (enExample)
CO (1) CO5680419A2 (enExample)
CY (1) CY1107677T1 (enExample)
DE (1) DE60313640T2 (enExample)
DK (1) DK1549637T3 (enExample)
EC (1) ECSP045503A (enExample)
ES (1) ES2285183T3 (enExample)
HR (1) HRP20041186A2 (enExample)
IL (1) IL165572A0 (enExample)
IS (1) IS2443B (enExample)
MX (1) MXPA04012856A (enExample)
NO (1) NO20045351L (enExample)
NZ (1) NZ537143A (enExample)
PE (1) PE20040578A1 (enExample)
PL (1) PL375152A1 (enExample)
PT (1) PT1549637E (enExample)
RS (1) RS111104A (enExample)
RU (1) RU2318821C2 (enExample)
SI (1) SI1549637T1 (enExample)
TW (1) TW200402417A (enExample)
UA (1) UA78317C2 (enExample)
WO (1) WO2004000832A1 (enExample)
ZA (1) ZA200410057B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
ATE375349T1 (de) 2002-08-02 2007-10-15 Merck & Co Inc Substituierte furo(2,3-b)pyridin derivate
DE10253426B4 (de) 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
DE602004005893T2 (de) 2003-12-17 2007-09-06 N.V. Organon Trizyklische 1-((3-indol-3-yl)-carbonyl)-piperazin-derivate als cannabinoid-cb1-rezeptoragonisten
TWI330635B (en) * 2004-03-05 2010-09-21 Organon Nv (indol-3-yl)-heterocycle derivatives
US20090029984A1 (en) * 2005-07-11 2009-01-29 N.V. Organon Synergistic combination for the treatment of pain (cannabinoid receptor agonist and opioid receptor agonist)
CN102295636A (zh) * 2005-07-29 2011-12-28 弗·哈夫曼-拉罗切有限公司 吲哚-3-基-羰基-哌啶和哌嗪衍生物
TW200745096A (en) * 2005-08-23 2007-12-16 Organon Nv Indole derivatives
US7763732B2 (en) 2005-08-24 2010-07-27 N.V. Organon Indole derivatives
CA2623525A1 (en) * 2005-09-23 2007-04-05 Janssen Pharmaceutica N.V. Tetrahydro-indazolyl cannabinoid modulators
TW200848417A (en) 2007-02-22 2008-12-16 Organon Nv Indole derivatives
RU2387642C2 (ru) 2007-10-31 2010-04-27 Общество С Ограниченной Ответственностью "Бинатех" Производные 5-замещенных индол-3-карбоновой кислоты, обладающие противовирусной активностью, способ их получения и применение
GB201106817D0 (en) * 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
CN115368356B (zh) 2013-12-20 2025-05-09 阿斯特克斯治疗有限公司 双环杂环化合物及其治疗用途
EP3737680A1 (en) 2018-01-08 2020-11-18 F. Hoffmann-La Roche AG Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors
CN108752342A (zh) * 2018-08-17 2018-11-06 西安瑞联新材料股份有限公司 1-H-吡啶并[1,2-a]-6-氢吡嗪-1,4-二酮的制备方法
CN111100063B (zh) * 2018-10-25 2022-05-17 南京药石科技股份有限公司 一种合成2-氟甲基取代的吡咯烷、哌啶以及哌嗪衍生物的制备方法
CN114072405A (zh) 2019-07-03 2022-02-18 豪夫迈·罗氏有限公司 杂环单酰基甘油脂肪酶(magl)抑制剂
KR20220034104A (ko) 2019-07-09 2022-03-17 에프. 호프만-라 로슈 아게 신규 헤테로고리 화합물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9203454A (es) * 1989-12-28 1992-08-01 Upjohn Co Compuestos anti sida diaromaticos substituidos.
WO1998006715A1 (en) 1996-08-09 1998-02-19 Smithkline Beecham Corporation Novel piperazine containing compounds
AU1887401A (en) * 1999-12-14 2001-06-25 Nippon Shinyaku Co. Ltd. Medicinal composition
JP2004502642A (ja) * 2000-02-11 2004-01-29 ブリストル−マイヤーズ　スクイブ　カンパニー カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用

Also Published As

Publication number Publication date
IS7590A (is) 2004-12-09
BR0311960A (pt) 2005-03-22
AR040274A1 (es) 2005-03-23
IS2443B (is) 2008-11-15
AU2003250245B2 (en) 2008-07-03
PT1549637E (pt) 2007-05-31
DK1549637T3 (da) 2007-07-16
PE20040578A1 (es) 2004-09-15
WO2004000832A1 (en) 2003-12-31
SI1549637T1 (sl) 2007-10-31
CN1298716C (zh) 2007-02-07
CO5680419A2 (es) 2006-09-29
DE60313640T2 (de) 2007-12-27
US20050250760A1 (en) 2005-11-10
RU2005101349A (ru) 2005-06-27
AU2003250245A1 (en) 2004-01-06
JP2005533801A (ja) 2005-11-10
RU2318821C2 (ru) 2008-03-10
CN1668611A (zh) 2005-09-14
DE60313640D1 (de) 2007-06-14
US7304064B2 (en) 2007-12-04
ZA200410057B (en) 2005-10-20
RS111104A (sr) 2007-02-05
KR20050009755A (ko) 2005-01-25
CA2490141C (en) 2011-01-25
HRP20041186A2 (en) 2005-06-30
ES2285183T3 (es) 2007-11-16
ATE361290T1 (de) 2007-05-15
PL375152A1 (en) 2005-11-28
CA2490141A1 (en) 2003-12-31
IL165572A0 (en) 2006-01-15
MXPA04012856A (es) 2005-03-31
HK1076630A1 (en) 2006-01-20
TW200402417A (en) 2004-02-16
NZ537143A (en) 2005-05-27
ECSP045503A (es) 2005-03-10
EP1549637B1 (en) 2007-05-02
NO20045351L (no) 2005-01-20
EP1549637A1 (en) 2005-07-06
CY1107677T1 (el) 2013-04-18
UA78317C2 (en) 2007-03-15

Similar Documents

Publication Publication Date Title
RU2318821C2 (ru) Производное 1-[(индол-3-ил) карбонил] пиперазина, фармацевтическая композиция на его основе и его применение
JP6665169B2 (ja) 新規化合物αｖβ６インテグリンアンタゴニスト
EP0345808B1 (en) 1-Indolylalkyl-4-(substituted-pyridinyl)piperazines
US5834493A (en) Indole derivatives as 5-HT1A and/or 5-HT2 ligands
JP2004531506A (ja) 選択的なセロトニン再取り込みインヒビターとしてのシクロプロピルインドール誘導体
JPH07149762A (ja) ピペリジン類およびピペラジン類
HRP20010854A2 (en) INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE
US5693655A (en) 3-indolylpiperidines
JPH0649027A (ja) インドール誘導体
WO2007015567A1 (ja) 環状アミン化合物
US20040132710A1 (en) Lactams as tachkinin antagonists
JP2012518612A (ja) ガンの治療のための新規なオルトアミノアミド類
WO2022170947A1 (zh) 一类作为kras突变体g12c抑制剂的四氢萘啶类衍生物、其制备方法及其应用
JP2013534928A (ja) 新規テトラヒドロキノリン誘導体
JPH09208582A (ja) ３−アザ及び３−オキサピペリドンタキキニン拮抗薬
CA2727669C (fr) Nouveaux derives de (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75
JP2006523626A (ja) ピラゾール化合物
JP2002544223A (ja) 精神病性障害の治療方法
US6562809B1 (en) 3-bicycloindole compounds
JP2021514372A (ja) デュアルの５−ｈｔ２ａおよび５−ｈｔ６受容体アンタゴニストとしての新しいインドールおよびベンゾイミダゾール誘導体
HK1076630B (en) 1-(indol-3-yl) carbonyl piperazine derivatives
WO2022022364A1 (zh) 一种吡咯烷类整合素调节剂及其用途
CN101679385A (zh) 作为nk3受体拮抗剂的脯氨酰胺-四唑衍生物
FR2678270A1 (fr) Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique.
ZA200307464B (en) Cyclopropylindole derivatives as selective serotonin reuptake inhibitors.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060526

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060526

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20070416

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20091020

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20091110

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121120

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121120

Year of fee payment: 3

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313111

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121120

Year of fee payment: 3

R371 Transfer withdrawn

Free format text: JAPANESE INTERMEDIATE CODE: R371

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313111

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121120

Year of fee payment: 3

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131120

Year of fee payment: 4

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313111

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

LAPS Cancellation because of no payment of annual fees