ECSP045503A - Derivados de 1-[(indol-3-il)carbonil]piperazina - Google Patents

Derivados de 1-[(indol-3-il)carbonil]piperazina

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Publication number
ECSP045503A
ECSP045503A EC2004005503A ECSP045503A ECSP045503A EC SP045503 A ECSP045503 A EC SP045503A EC 2004005503 A EC2004005503 A EC 2004005503A EC SP045503 A ECSP045503 A EC SP045503A EC SP045503 A ECSP045503 A EC SP045503A
Authority
EC
Ecuador
Prior art keywords
rent
halogen
pain
optionally replaced
carbonil
Prior art date
Application number
EC2004005503A
Other languages
English (en)
Inventor
Phillip Martin Cowley
Wilson Caulfield
Jason Tierney
James Cairns
Julia Adam-Worrall
Mark York
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of ECSP045503A publication Critical patent/ECSP045503A/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN DERIVADO DE 1-[(INDOL-3-IL)CARBONIL]PIPERAZINA, DE ACUERDO CON LA FÓRMULA GENERAL (I), EN DONDE R REPRESENTA A SUSTITUYENTES 1-4 INDEPENDIENTEMENTE SELECCIONADOS DE H, (C1-4)ALQUILO (SUSTITUIDO OPCIONALMENTE CON HALÓGENO), (C1-4)ALQUILOXI (SUSTITUIDO OPCIONALMENTE CON HALÓGENO), HALÓGENO, OH, NH2, CN Y NO2; R1 ES (C5-8)CICLOALQUILO O (C5-8)CICLOALQUENILO; R2 ES H, METILO O ETILO; R3, R3', R4' R4', R5, R5' Y R6' SON INDEPENDIENTEMENTE HIDRÓGENO O (C1-4)ALQUILO, SUSTITUIDO OPCIONALMENTE CON (C1-4)ALQUILOXI, HALÓGENO U OH; R6 ES HIDRÓGENO O (C1-4)ALQUILO, SUSTITUIDO OPCIONALMENTE CON (C1-4)ALQUILOXI, HALÓGENO U OH; O R6 FORMA JUNTO CON R7 UN ANILLO HETEROCÍCLICO SATURADO DE 4-7 MIEMBROS, QUE CONTIENE OPCIONALMENTE OTRO HETEROÁTOMO SELECCIONADO DE O Y S; R7 FORMA JUNTO CON R6 UN ANILLO HETEROCÍCLICO SATURADO DE 4-7 MIEMBROS, QUE CONTIENE OPCIONALMENTE OTRO HETEROÁTOMO SELECCIONADO DE O Y S; O R7 ES H, (C1-4)ALQUILO O (C3-5)CICLOALQUILO, SIENDO LOS GRUPOS ALQUILO SUSTITUIDOS OPCIONALMENTE CON OH, HALÓGENO O (C1-4)ALQUILOXI; O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO. LA INVENCIÓN TAMBIÉN SE REFIERE A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHOS DERIVADOS DE 1-[(INDOL-3-IL)CARBONIL]PIPERAZINA Y AL USO DE ESTOS DERIVADOS EN EL TRATAMIENTO DEL DOLOR, TALES COMO DOLOR PERI-OPERATORIO, DOLOR CRÓNICO, DOLOR NEUROPÁTICO, DOLOR CANCEROSO Y DOLOR Y ESPASTICIDAD ASOCIADOS CON LA ESCLEROSIS MÚLTIPLE.
EC2004005503A 2002-06-21 2004-12-21 Derivados de 1-[(indol-3-il)carbonil]piperazina ECSP045503A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02077505 2002-06-21

Publications (1)

Publication Number Publication Date
ECSP045503A true ECSP045503A (es) 2005-03-10

Family

ID=29797228

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005503A ECSP045503A (es) 2002-06-21 2004-12-21 Derivados de 1-[(indol-3-il)carbonil]piperazina

Country Status (33)

Country Link
US (1) US7304064B2 (es)
EP (1) EP1549637B1 (es)
JP (1) JP4408804B2 (es)
KR (1) KR20050009755A (es)
CN (1) CN1298716C (es)
AR (1) AR040274A1 (es)
AT (1) ATE361290T1 (es)
AU (1) AU2003250245B2 (es)
BR (1) BR0311960A (es)
CA (1) CA2490141C (es)
CO (1) CO5680419A2 (es)
CY (1) CY1107677T1 (es)
DE (1) DE60313640T2 (es)
DK (1) DK1549637T3 (es)
EC (1) ECSP045503A (es)
ES (1) ES2285183T3 (es)
HK (1) HK1076630A1 (es)
HR (1) HRP20041186A2 (es)
IL (1) IL165572A0 (es)
IS (1) IS2443B (es)
MX (1) MXPA04012856A (es)
NO (1) NO20045351L (es)
NZ (1) NZ537143A (es)
PE (1) PE20040578A1 (es)
PL (1) PL375152A1 (es)
PT (1) PT1549637E (es)
RS (1) RS111104A (es)
RU (1) RU2318821C2 (es)
SI (1) SI1549637T1 (es)
TW (1) TW200402417A (es)
UA (1) UA78317C2 (es)
WO (1) WO2004000832A1 (es)
ZA (1) ZA200410057B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
JP4667867B2 (ja) 2002-08-02 2011-04-13 メルク・シャープ・エンド・ドーム・コーポレイション 置換フロ[2,3−b]ピリジン誘導体
DE10253426B4 (de) * 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
MXPA06006928A (es) * 2003-12-17 2006-09-04 Akzo Nobel Nv Derivados de 1-[(3-indol-3-il)carbonil] piperazina ciclica como agonistas del receptor canabinoide cb1.
TWI330635B (en) 2004-03-05 2010-09-21 Organon Nv (indol-3-yl)-heterocycle derivatives
EP1904068A1 (en) * 2005-07-11 2008-04-02 N.V. Organon Synergistic combination for the treatment of pain (cannabioid receptor agonist and opiod receptor agonist)
KR101020351B1 (ko) * 2005-07-29 2011-03-08 에프. 호프만-라 로슈 아게 인돌-3-일-카본일-피페리딘 및 피페라진 유도체
TW200745096A (en) * 2005-08-23 2007-12-16 Organon Nv Indole derivatives
US7763732B2 (en) 2005-08-24 2010-07-27 N.V. Organon Indole derivatives
CN101312724A (zh) * 2005-09-23 2008-11-26 詹森药业有限公司 四氢-吲唑基大麻素调节剂
TW200848417A (en) 2007-02-22 2008-12-16 Organon Nv Indole derivatives
RU2387642C2 (ru) 2007-10-31 2010-04-27 Общество С Ограниченной Ответственностью "Бинатех" Производные 5-замещенных индол-3-карбоновой кислоты, обладающие противовирусной активностью, способ их получения и применение
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
AU2014369446C1 (en) 2013-12-20 2020-03-12 Astex Therapeutics Limited Bicyclic heterocycle compounds and their uses in therapy
CN111566105A (zh) 2018-01-08 2020-08-21 豪夫迈·罗氏有限公司 作为MAGL抑制剂的八氢吡啶并[1,2-α]吡嗪类化合物
CN108752342A (zh) * 2018-08-17 2018-11-06 西安瑞联新材料股份有限公司 1-H-吡啶并[1,2-a]-6-氢吡嗪-1,4-二酮的制备方法
CN111100063B (zh) * 2018-10-25 2022-05-17 南京药石科技股份有限公司 一种合成2-氟甲基取代的吡咯烷、哌啶以及哌嗪衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0922042A1 (en) 1996-08-09 1999-06-16 Smithkline Beecham Corporation Novel piperazine containing compounds
WO2001043746A1 (fr) * 1999-12-14 2001-06-21 Nippon Shinyaku Co., Ltd. Composition medicinale
JP2004502642A (ja) * 2000-02-11 2004-01-29 ブリストル−マイヤーズ スクイブ カンパニー カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用

Also Published As

Publication number Publication date
AU2003250245A1 (en) 2004-01-06
WO2004000832A1 (en) 2003-12-31
PT1549637E (pt) 2007-05-31
RU2005101349A (ru) 2005-06-27
EP1549637A1 (en) 2005-07-06
CO5680419A2 (es) 2006-09-29
TW200402417A (en) 2004-02-16
CY1107677T1 (el) 2013-04-18
US7304064B2 (en) 2007-12-04
CA2490141C (en) 2011-01-25
DK1549637T3 (da) 2007-07-16
ATE361290T1 (de) 2007-05-15
PE20040578A1 (es) 2004-09-15
SI1549637T1 (sl) 2007-10-31
DE60313640D1 (de) 2007-06-14
UA78317C2 (en) 2007-03-15
NO20045351L (no) 2005-01-20
US20050250760A1 (en) 2005-11-10
CN1298716C (zh) 2007-02-07
EP1549637B1 (en) 2007-05-02
JP2005533801A (ja) 2005-11-10
HRP20041186A2 (en) 2005-06-30
HK1076630A1 (en) 2006-01-20
DE60313640T2 (de) 2007-12-27
IS7590A (is) 2004-12-09
AR040274A1 (es) 2005-03-23
JP4408804B2 (ja) 2010-02-03
MXPA04012856A (es) 2005-03-31
RU2318821C2 (ru) 2008-03-10
CA2490141A1 (en) 2003-12-31
PL375152A1 (en) 2005-11-28
IS2443B (is) 2008-11-15
NZ537143A (en) 2005-05-27
IL165572A0 (en) 2006-01-15
CN1668611A (zh) 2005-09-14
BR0311960A (pt) 2005-03-22
ES2285183T3 (es) 2007-11-16
RS111104A (en) 2007-02-05
AU2003250245B2 (en) 2008-07-03
KR20050009755A (ko) 2005-01-25
ZA200410057B (en) 2005-10-20

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