BRPI0417626A - derivado de 1-[(indol-3-il) carbonil] piperazina tricìclica, composição farmacêutica, uso de um derivado de 1-[(indol-3-il) carbonil] piperazina tricìclica - Google Patents
derivado de 1-[(indol-3-il) carbonil] piperazina tricìclica, composição farmacêutica, uso de um derivado de 1-[(indol-3-il) carbonil] piperazina tricìclicaInfo
- Publication number
- BRPI0417626A BRPI0417626A BRPI0417626-0A BRPI0417626A BRPI0417626A BR PI0417626 A BRPI0417626 A BR PI0417626A BR PI0417626 A BRPI0417626 A BR PI0417626A BR PI0417626 A BRPI0417626 A BR PI0417626A
- Authority
- BR
- Brazil
- Prior art keywords
- indol
- carbonyl
- alkyl
- pain
- tricyclically
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"DERIVADO DE 1-¢(INDOL-3-IL)CARBONIL!PIPERAZINA TRICìCLICA, COMPOSIçãO FARMACêUTICA, USO DE UM DERIVADO DE 1-¢(INDOL-3-IL)CARBONIL!PIPERAZINA TRICìCLICA". A invenção diz respeito a derivado de 1-¢(indol-3-il)carbonil!piperazina tricíclica tendo Fórmula Geral I Fórmula I em que X é CH~ 2~, O ou S; R representa 1 a 3 substituintes independentemente selecionados de H, alquila C~ 1-4~, alquilóxi C~ 1-4~ e halógeno; R~ 1~ é cicloalquila C~ 5-8~; R~ 2~ é H ou alquila C~ 1-4~; R~ 3~, R~ 3~<39>, R~ 4~, R~ 4~<39>, R~ 5~ , R~ 5~<39> e R~ 6~<39> são independentemente hidrogênio ou alquila C~ 1-4~, opcionalmente substituída por alquilóxi C~ 1-4~, OH ou halógeno; R~ 6~ é hidrogênio ou alquila C~ 1-4~, opcionalmente substituída por alquilóxi C~ 1-4~, OH ou halógeno; ou R~ 6~ forma, junto com R~ 7~, um anel heterocíclico saturado de 4 a 7 membros, opcionalmente contendo um outro heteroátomo selecionado de O e S; R~ 7~ forma, junto com R~ 6~, um anel heterocíclico saturado de 4 a 7 membros, opcionalmente contendo um outro heteroátomo selecionado de O e S; ou R~ 7~ é H, alquila C~ 1-4~ ou cicloalquila C~ 3-5~, os grupos alquila sendo opcionalmente substituídos por OH, halógeno ou alquilóxi C~ 1-4~; ou um seu sal farmaceuticamente aceitável. A invenção também diz respeito a composições farmacêuticas que compreendem os referidos derivados de 1-¢(indol-3-il)carbonil!piperazina tricíclica, e ao uso destes derivados no tratamento da dor, tal como a dor perioperatória, a dor crónica, a dor neuropática, a dor do câncer e a dor e a espasticidade associadas com a esclerose múltipla.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53052803P | 2003-12-17 | 2003-12-17 | |
| EP03104768 | 2003-12-17 | ||
| PCT/EP2004/053421 WO2005058327A1 (en) | 2003-12-17 | 2004-12-13 | Tricyclic 1-[(3-indol-3-yl)carbonyl] piperazine derivatives as cannabinoid cb1 receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0417626A true BRPI0417626A (pt) | 2007-03-27 |
Family
ID=34702353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0417626-0A BRPI0417626A (pt) | 2003-12-17 | 2004-12-13 | derivado de 1-[(indol-3-il) carbonil] piperazina tricìclica, composição farmacêutica, uso de um derivado de 1-[(indol-3-il) carbonil] piperazina tricìclica |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7772227B2 (pt) |
| EP (1) | EP1696930B1 (pt) |
| AT (1) | ATE359078T1 (pt) |
| AU (1) | AU2004298782B2 (pt) |
| BR (1) | BRPI0417626A (pt) |
| CA (1) | CA2549147C (pt) |
| DE (1) | DE602004005893T2 (pt) |
| ES (1) | ES2284076T3 (pt) |
| IL (1) | IL175675A0 (pt) |
| MX (1) | MXPA06006928A (pt) |
| WO (1) | WO2005058327A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI330635B (en) | 2004-03-05 | 2010-09-21 | Organon Nv | (indol-3-yl)-heterocycle derivatives |
| US7763732B2 (en) | 2005-08-24 | 2010-07-27 | N.V. Organon | Indole derivatives |
| CN100448849C (zh) * | 2006-02-02 | 2009-01-07 | 深圳市天和医药科技开发有限公司 | 一种4位-酰基取代-2-甲基哌嗪化合物的制备方法 |
| TW200848417A (en) | 2007-02-22 | 2008-12-16 | Organon Nv | Indole derivatives |
| US9353933B2 (en) * | 2009-09-25 | 2016-05-31 | Cree, Inc. | Lighting device with position-retaining element |
| US9216998B2 (en) * | 2012-02-15 | 2015-12-22 | Janssen Pharmaceutica Nv | Tricyclic indole derivatives useful endothelial lipase inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939138A (en) | 1988-12-29 | 1990-07-03 | Sterling Drug Inc. | 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines |
| ZA902794B (en) | 1989-04-18 | 1991-04-24 | Duphar Int Res | New 3-n substituted carbamoyl-indole derivatives |
| WO1998006715A1 (en) | 1996-08-09 | 1998-02-19 | Smithkline Beecham Corporation | Novel piperazine containing compounds |
| CA2340445A1 (en) | 1998-05-04 | 1999-11-11 | The University Of Connecticut | Novel analgesic and immunomodulatory cannabinoids |
| EP1243268A4 (en) | 1999-12-14 | 2003-05-21 | Nippon Shinyaku Co Ltd | MEDICINAL COMPOSITION |
| AU2001234958A1 (en) * | 2000-02-11 | 2001-08-20 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
| TW200402417A (en) * | 2002-06-21 | 2004-02-16 | Akzo Nobel Nv | 1-[(Indol-3-yl)carbonyl]piperazine derivatives |
-
2004
- 2004-12-13 AT AT04804784T patent/ATE359078T1/de not_active IP Right Cessation
- 2004-12-13 BR BRPI0417626-0A patent/BRPI0417626A/pt not_active IP Right Cessation
- 2004-12-13 WO PCT/EP2004/053421 patent/WO2005058327A1/en active IP Right Grant
- 2004-12-13 MX MXPA06006928A patent/MXPA06006928A/es active IP Right Grant
- 2004-12-13 EP EP04804784A patent/EP1696930B1/en not_active Not-in-force
- 2004-12-13 CA CA2549147A patent/CA2549147C/en not_active Expired - Fee Related
- 2004-12-13 ES ES04804784T patent/ES2284076T3/es active Active
- 2004-12-13 AU AU2004298782A patent/AU2004298782B2/en not_active Ceased
- 2004-12-13 US US10/583,013 patent/US7772227B2/en not_active Expired - Fee Related
- 2004-12-13 DE DE602004005893T patent/DE602004005893T2/de active Active
-
2006
- 2006-05-16 IL IL175675A patent/IL175675A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004005893D1 (de) | 2007-05-24 |
| US20070088025A1 (en) | 2007-04-19 |
| EP1696930A1 (en) | 2006-09-06 |
| DE602004005893T2 (de) | 2007-09-06 |
| ATE359078T1 (de) | 2007-05-15 |
| CA2549147C (en) | 2012-04-10 |
| EP1696930B1 (en) | 2007-04-11 |
| WO2005058327A1 (en) | 2005-06-30 |
| US7772227B2 (en) | 2010-08-10 |
| AU2004298782A1 (en) | 2005-06-30 |
| IL175675A0 (en) | 2006-09-05 |
| AU2004298782B2 (en) | 2010-06-17 |
| MXPA06006928A (es) | 2006-09-04 |
| ES2284076T3 (es) | 2007-11-01 |
| CA2549147A1 (en) | 2005-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |