RU2318821C2 - Производное 1-[(индол-3-ил) карбонил] пиперазина, фармацевтическая композиция на его основе и его применение - Google Patents

Производное 1-[(индол-3-ил) карбонил] пиперазина, фармацевтическая композиция на его основе и его применение Download PDF

Info

Publication number
RU2318821C2
RU2318821C2 RU2005101349/04A RU2005101349A RU2318821C2 RU 2318821 C2 RU2318821 C2 RU 2318821C2 RU 2005101349/04 A RU2005101349/04 A RU 2005101349/04A RU 2005101349 A RU2005101349 A RU 2005101349A RU 2318821 C2 RU2318821 C2 RU 2318821C2
Authority
RU
Russia
Prior art keywords
carbonyl
indol
cyclohexylmethyl
methoxy
mmol
Prior art date
Application number
RU2005101349/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2005101349A (ru
Inventor
Филлип Мартин КОУЛИ
Уилсон КОЛФИЛД
Джэйсон ТИРНИ
Джеймс КЭРНС
Джулия АДАМ-УОРРЕЛЛ
Марк ЙОРК
Original Assignee
Н.В.Органон
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Н.В.Органон filed Critical Н.В.Органон
Publication of RU2005101349A publication Critical patent/RU2005101349A/ru
Application granted granted Critical
Publication of RU2318821C2 publication Critical patent/RU2318821C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
RU2005101349/04A 2002-06-21 2003-06-13 Производное 1-[(индол-3-ил) карбонил] пиперазина, фармацевтическая композиция на его основе и его применение RU2318821C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02077505 2002-06-21
EP02077505.2 2002-06-21

Publications (2)

Publication Number Publication Date
RU2005101349A RU2005101349A (ru) 2005-06-27
RU2318821C2 true RU2318821C2 (ru) 2008-03-10

Family

ID=29797228

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005101349/04A RU2318821C2 (ru) 2002-06-21 2003-06-13 Производное 1-[(индол-3-ил) карбонил] пиперазина, фармацевтическая композиция на его основе и его применение

Country Status (32)

Country Link
US (1) US7304064B2 (enExample)
EP (1) EP1549637B1 (enExample)
JP (1) JP4408804B2 (enExample)
KR (1) KR20050009755A (enExample)
CN (1) CN1298716C (enExample)
AR (1) AR040274A1 (enExample)
AT (1) ATE361290T1 (enExample)
AU (1) AU2003250245B2 (enExample)
BR (1) BR0311960A (enExample)
CA (1) CA2490141C (enExample)
CO (1) CO5680419A2 (enExample)
CY (1) CY1107677T1 (enExample)
DE (1) DE60313640T2 (enExample)
DK (1) DK1549637T3 (enExample)
EC (1) ECSP045503A (enExample)
ES (1) ES2285183T3 (enExample)
HR (1) HRP20041186A2 (enExample)
IL (1) IL165572A0 (enExample)
IS (1) IS2443B (enExample)
MX (1) MXPA04012856A (enExample)
NO (1) NO20045351L (enExample)
NZ (1) NZ537143A (enExample)
PE (1) PE20040578A1 (enExample)
PL (1) PL375152A1 (enExample)
PT (1) PT1549637E (enExample)
RS (1) RS111104A (enExample)
RU (1) RU2318821C2 (enExample)
SI (1) SI1549637T1 (enExample)
TW (1) TW200402417A (enExample)
UA (1) UA78317C2 (enExample)
WO (1) WO2004000832A1 (enExample)
ZA (1) ZA200410057B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2662827C2 (ru) * 2011-04-21 2018-07-31 Астекс Терапьютикс Лимитед Бициклические гетероциклические соединения и их применения в терапии

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
ATE375349T1 (de) 2002-08-02 2007-10-15 Merck & Co Inc Substituierte furo(2,3-b)pyridin derivate
DE10253426B4 (de) 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
DE602004005893T2 (de) 2003-12-17 2007-09-06 N.V. Organon Trizyklische 1-((3-indol-3-yl)-carbonyl)-piperazin-derivate als cannabinoid-cb1-rezeptoragonisten
TWI330635B (en) * 2004-03-05 2010-09-21 Organon Nv (indol-3-yl)-heterocycle derivatives
US20090029984A1 (en) * 2005-07-11 2009-01-29 N.V. Organon Synergistic combination for the treatment of pain (cannabinoid receptor agonist and opioid receptor agonist)
CN102295636A (zh) * 2005-07-29 2011-12-28 弗·哈夫曼-拉罗切有限公司 吲哚-3-基-羰基-哌啶和哌嗪衍生物
TW200745096A (en) * 2005-08-23 2007-12-16 Organon Nv Indole derivatives
US7763732B2 (en) 2005-08-24 2010-07-27 N.V. Organon Indole derivatives
CA2623525A1 (en) * 2005-09-23 2007-04-05 Janssen Pharmaceutica N.V. Tetrahydro-indazolyl cannabinoid modulators
TW200848417A (en) 2007-02-22 2008-12-16 Organon Nv Indole derivatives
RU2387642C2 (ru) 2007-10-31 2010-04-27 Общество С Ограниченной Ответственностью "Бинатех" Производные 5-замещенных индол-3-карбоновой кислоты, обладающие противовирусной активностью, способ их получения и применение
CN115368356B (zh) 2013-12-20 2025-05-09 阿斯特克斯治疗有限公司 双环杂环化合物及其治疗用途
EP3737680A1 (en) 2018-01-08 2020-11-18 F. Hoffmann-La Roche AG Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors
CN108752342A (zh) * 2018-08-17 2018-11-06 西安瑞联新材料股份有限公司 1-H-吡啶并[1,2-a]-6-氢吡嗪-1,4-二酮的制备方法
CN111100063B (zh) * 2018-10-25 2022-05-17 南京药石科技股份有限公司 一种合成2-氟甲基取代的吡咯烷、哌啶以及哌嗪衍生物的制备方法
CN114072405A (zh) 2019-07-03 2022-02-18 豪夫迈·罗氏有限公司 杂环单酰基甘油脂肪酶(magl)抑制剂
KR20220034104A (ko) 2019-07-09 2022-03-17 에프. 호프만-라 로슈 아게 신규 헤테로고리 화합물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2099335C1 (ru) * 1989-12-28 1997-12-20 Дзе Апджон Компани Диароматические соединения
WO2001058869A2 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006715A1 (en) 1996-08-09 1998-02-19 Smithkline Beecham Corporation Novel piperazine containing compounds
AU1887401A (en) * 1999-12-14 2001-06-25 Nippon Shinyaku Co. Ltd. Medicinal composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2099335C1 (ru) * 1989-12-28 1997-12-20 Дзе Апджон Компани Диароматические соединения
WO2001058869A2 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MEDICINAL CHEMISTRY LETTERS, vol.4, №4, 1994, 563-566, abstracts. YORNAL OF MEDICINAL CHEMISTRY, v.38, №16, 1995, 3094-3105, abstracts. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2662827C2 (ru) * 2011-04-21 2018-07-31 Астекс Терапьютикс Лимитед Бициклические гетероциклические соединения и их применения в терапии

Also Published As

Publication number Publication date
IS7590A (is) 2004-12-09
BR0311960A (pt) 2005-03-22
AR040274A1 (es) 2005-03-23
IS2443B (is) 2008-11-15
AU2003250245B2 (en) 2008-07-03
PT1549637E (pt) 2007-05-31
DK1549637T3 (da) 2007-07-16
PE20040578A1 (es) 2004-09-15
WO2004000832A1 (en) 2003-12-31
SI1549637T1 (sl) 2007-10-31
CN1298716C (zh) 2007-02-07
CO5680419A2 (es) 2006-09-29
DE60313640T2 (de) 2007-12-27
US20050250760A1 (en) 2005-11-10
JP4408804B2 (ja) 2010-02-03
RU2005101349A (ru) 2005-06-27
AU2003250245A1 (en) 2004-01-06
JP2005533801A (ja) 2005-11-10
CN1668611A (zh) 2005-09-14
DE60313640D1 (de) 2007-06-14
US7304064B2 (en) 2007-12-04
ZA200410057B (en) 2005-10-20
RS111104A (sr) 2007-02-05
KR20050009755A (ko) 2005-01-25
CA2490141C (en) 2011-01-25
HRP20041186A2 (en) 2005-06-30
ES2285183T3 (es) 2007-11-16
ATE361290T1 (de) 2007-05-15
PL375152A1 (en) 2005-11-28
CA2490141A1 (en) 2003-12-31
IL165572A0 (en) 2006-01-15
MXPA04012856A (es) 2005-03-31
HK1076630A1 (en) 2006-01-20
TW200402417A (en) 2004-02-16
NZ537143A (en) 2005-05-27
ECSP045503A (es) 2005-03-10
EP1549637B1 (en) 2007-05-02
NO20045351L (no) 2005-01-20
EP1549637A1 (en) 2005-07-06
CY1107677T1 (el) 2013-04-18
UA78317C2 (en) 2007-03-15

Similar Documents

Publication Publication Date Title
JP4408804B2 (ja) １−［（インドル−３−イル）カルボニル］ピペラジン誘導体
JP4776844B2 (ja) 化合物
RU2404972C2 (ru) Ингибиторы сигма-рецептора
KR101623357B1 (ko) 5-ｈｔ6 길항제로서 아릴설포닐 피라졸린 카복스아미딘 유도체
CN101484424A (zh) 治疗化合物
JP2000509723A (ja) インドリン−２−オン誘導体、その製造方法、およびこれを含有する薬学的組成物
WO2007015567A1 (ja) 環状アミン化合物
EP2588458B1 (en) Novel tetrahydroquinoline derivatives
EP1696930B1 (en) Tricyclic 1-((3-indol-3-yl)carbonyl)piperazine derivatives as cannabinoid cb1 receptor agonists
JP2021514372A (ja) デュアルの５−ｈｔ２ａおよび５−ｈｔ６受容体アンタゴニストとしての新しいインドールおよびベンゾイミダゾール誘導体
HK1076630B (en) 1-(indol-3-yl) carbonyl piperazine derivatives
CN101679385A (zh) 作为nk3受体拮抗剂的脯氨酰胺-四唑衍生物
WO2022022364A1 (zh) 一种吡咯烷类整合素调节剂及其用途
JP2007526242A (ja) カンナビノイドｃｂ１受容体アゴニストとしての三環式１−［（３−インドール−３−イル）カルボニル］ピペラジン誘導体
HK1179618A (en) Novel tetrahydroquinoline derivatives

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20090614