RU2318821C2 - Производное 1-[(индол-3-ил) карбонил] пиперазина, фармацевтическая композиция на его основе и его применение - Google Patents

Производное 1-[(индол-3-ил) карбонил] пиперазина, фармацевтическая композиция на его основе и его применение Download PDF

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RU2318821C2
RU2318821C2 RU2005101349/04A RU2005101349A RU2318821C2 RU 2318821 C2 RU2318821 C2 RU 2318821C2 RU 2005101349/04 A RU2005101349/04 A RU 2005101349/04A RU 2005101349 A RU2005101349 A RU 2005101349A RU 2318821 C2 RU2318821 C2 RU 2318821C2
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carbonyl
indol
cyclohexylmethyl
methoxy
mmol
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RU2005101349/04A
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Russian (ru)
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RU2005101349A (ru
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Филлип Мартин КОУЛИ
Уилсон КОЛФИЛД
Джэйсон ТИРНИ
Джеймс КЭРНС
Джулия АДАМ-УОРРЕЛЛ
Марк ЙОРК
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Н.В.Органон
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
RU2005101349/04A 2002-06-21 2003-06-13 Производное 1-[(индол-3-ил) карбонил] пиперазина, фармацевтическая композиция на его основе и его применение RU2318821C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02077505.2 2002-06-21
EP02077505 2002-06-21

Publications (2)

Publication Number Publication Date
RU2005101349A RU2005101349A (ru) 2005-06-27
RU2318821C2 true RU2318821C2 (ru) 2008-03-10

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RU2005101349/04A RU2318821C2 (ru) 2002-06-21 2003-06-13 Производное 1-[(индол-3-ил) карбонил] пиперазина, фармацевтическая композиция на его основе и его применение

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US (1) US7304064B2 (enExample)
EP (1) EP1549637B1 (enExample)
JP (1) JP4408804B2 (enExample)
KR (1) KR20050009755A (enExample)
CN (1) CN1298716C (enExample)
AR (1) AR040274A1 (enExample)
AT (1) ATE361290T1 (enExample)
AU (1) AU2003250245B2 (enExample)
BR (1) BR0311960A (enExample)
CA (1) CA2490141C (enExample)
CO (1) CO5680419A2 (enExample)
CY (1) CY1107677T1 (enExample)
DE (1) DE60313640T2 (enExample)
DK (1) DK1549637T3 (enExample)
EC (1) ECSP045503A (enExample)
ES (1) ES2285183T3 (enExample)
HR (1) HRP20041186A2 (enExample)
IL (1) IL165572A0 (enExample)
IS (1) IS2443B (enExample)
MX (1) MXPA04012856A (enExample)
NO (1) NO20045351L (enExample)
NZ (1) NZ537143A (enExample)
PE (1) PE20040578A1 (enExample)
PL (1) PL375152A1 (enExample)
PT (1) PT1549637E (enExample)
RS (1) RS111104A (enExample)
RU (1) RU2318821C2 (enExample)
SI (1) SI1549637T1 (enExample)
TW (1) TW200402417A (enExample)
UA (1) UA78317C2 (enExample)
WO (1) WO2004000832A1 (enExample)
ZA (1) ZA200410057B (enExample)

Cited By (1)

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RU2662827C2 (ru) * 2011-04-21 2018-07-31 Астекс Терапьютикс Лимитед Бициклические гетероциклические соединения и их применения в терапии

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TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
ATE375349T1 (de) 2002-08-02 2007-10-15 Merck & Co Inc Substituierte furo(2,3-b)pyridin derivate
DE10253426B4 (de) 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
ES2284076T3 (es) 2003-12-17 2007-11-01 N.V. Organon Derivados triciclicos de 1-(indol-3-il)carbonil)piperazina como agonistas del receptor de cannabinoides cb1.
TWI330635B (en) 2004-03-05 2010-09-21 Organon Nv (indol-3-yl)-heterocycle derivatives
JP2009500439A (ja) * 2005-07-11 2009-01-08 ナームローゼ・フエンノートチヤツプ・オルガノン 疼痛の治療のための相乗的組み合わせ（カンナビノイド受容体アゴニスト及びオピオイド受容体アゴニスト）
WO2007014851A2 (en) * 2005-07-29 2007-02-08 F. Hoffmann-La Roche Ag Indol-3-yl-carbonyl-piperidin and piperazin derivatives
TW200745096A (en) * 2005-08-23 2007-12-16 Organon Nv Indole derivatives
US7763732B2 (en) 2005-08-24 2010-07-27 N.V. Organon Indole derivatives
US20070117857A1 (en) * 2005-09-23 2007-05-24 Fina Liotta Substituted 3-amido-tetrahydro-indazolyl cannabinoid modulators
TW200848417A (en) 2007-02-22 2008-12-16 Organon Nv Indole derivatives
RU2387642C2 (ru) 2007-10-31 2010-04-27 Общество С Ограниченной Ответственностью "Бинатех" Производные 5-замещенных индол-3-карбоновой кислоты, обладающие противовирусной активностью, способ их получения и применение
TWI649319B (zh) 2013-12-20 2019-02-01 英商阿斯迪克治療公司 雙環雜環化合物及其治療用途
CN111566105A (zh) 2018-01-08 2020-08-21 豪夫迈·罗氏有限公司 作为MAGL抑制剂的八氢吡啶并[1,2-α]吡嗪类化合物
CN108752342A (zh) * 2018-08-17 2018-11-06 西安瑞联新材料股份有限公司 1-H-吡啶并[1,2-a]-6-氢吡嗪-1,4-二酮的制备方法
CN111100063B (zh) * 2018-10-25 2022-05-17 南京药石科技股份有限公司 一种合成2-氟甲基取代的吡咯烷、哌啶以及哌嗪衍生物的制备方法

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RU2099335C1 (ru) * 1989-12-28 1997-12-20 Дзе Апджон Компани Диароматические соединения
WO2001058869A2 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases

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Publication number Priority date Publication date Assignee Title
RU2099335C1 (ru) * 1989-12-28 1997-12-20 Дзе Апджон Компани Диароматические соединения
WO2001058869A2 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases

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MEDICINAL CHEMISTRY LETTERS, vol.4, №4, 1994, 563-566, abstracts. YORNAL OF MEDICINAL CHEMISTRY, v.38, №16, 1995, 3094-3105, abstracts. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2662827C2 (ru) * 2011-04-21 2018-07-31 Астекс Терапьютикс Лимитед Бициклические гетероциклические соединения и их применения в терапии

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UA78317C2 (en) 2007-03-15
PE20040578A1 (es) 2004-09-15
WO2004000832A1 (en) 2003-12-31
TW200402417A (en) 2004-02-16
HK1076630A1 (en) 2006-01-20
US7304064B2 (en) 2007-12-04
ZA200410057B (en) 2005-10-20
NO20045351L (no) 2005-01-20
EP1549637A1 (en) 2005-07-06
EP1549637B1 (en) 2007-05-02
CY1107677T1 (el) 2013-04-18
CA2490141C (en) 2011-01-25
ES2285183T3 (es) 2007-11-16
CO5680419A2 (es) 2006-09-29
DK1549637T3 (da) 2007-07-16
JP4408804B2 (ja) 2010-02-03
ECSP045503A (es) 2005-03-10
IS2443B (is) 2008-11-15
IS7590A (is) 2004-12-09
NZ537143A (en) 2005-05-27
US20050250760A1 (en) 2005-11-10
MXPA04012856A (es) 2005-03-31
IL165572A0 (en) 2006-01-15
AU2003250245A1 (en) 2004-01-06
BR0311960A (pt) 2005-03-22
CA2490141A1 (en) 2003-12-31
JP2005533801A (ja) 2005-11-10
HRP20041186A2 (en) 2005-06-30
AR040274A1 (es) 2005-03-23
RS111104A (sr) 2007-02-05
CN1298716C (zh) 2007-02-07
KR20050009755A (ko) 2005-01-25
AU2003250245B2 (en) 2008-07-03
SI1549637T1 (sl) 2007-10-31
ATE361290T1 (de) 2007-05-15
DE60313640D1 (de) 2007-06-14
PT1549637E (pt) 2007-05-31
DE60313640T2 (de) 2007-12-27
PL375152A1 (en) 2005-11-28
RU2005101349A (ru) 2005-06-27
CN1668611A (zh) 2005-09-14

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