CN1288148C - 作为尾加压素ii受体拮抗剂的1,2,3,4－四氢异喹啉的衍生物 - Google Patents

作为尾加压素ii受体拮抗剂的1,2,3,4－四氢异喹啉的衍生物 Download PDF

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Publication number
CN1288148C
CN1288148C CNB028059417A CN02805941A CN1288148C CN 1288148 C CN1288148 C CN 1288148C CN B028059417 A CNB028059417 A CN B028059417A CN 02805941 A CN02805941 A CN 02805941A CN 1288148 C CN1288148 C CN 1288148C
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China
Prior art keywords
ethyl
dihydro
dimethoxy
urea
isoquinolinyl
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Expired - Fee Related
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CNB028059417A
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Chinese (zh)
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CN1494542A (zh
Inventor
哈米德·艾萨维
克里斯托夫·宾克特
马丁内·克洛泽尔
博里斯·马蒂斯
克劳斯·米勒
奥利弗·内勒
米夏埃尔·舍茨
约尔格·韦尔克
托马斯·韦勒
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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Publication of CN1494542A publication Critical patent/CN1494542A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
CNB028059417A 2001-03-27 2002-03-20 作为尾加压素ii受体拮抗剂的1,2,3,4－四氢异喹啉的衍生物 Expired - Fee Related CN1288148C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP0103422 2001-03-27
EP010342.2 2001-03-27
EP0103422 2001-03-27
EP010984.5 2001-08-27
EP0109845 2001-08-27
EP0109845 2001-08-27

Publications (2)

Publication Number Publication Date
CN1494542A CN1494542A (zh) 2004-05-05
CN1288148C true CN1288148C (zh) 2006-12-06

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CNB028059417A Expired - Fee Related CN1288148C (zh) 2001-03-27 2002-03-20 作为尾加压素ii受体拮抗剂的1,2,3,4－四氢异喹啉的衍生物

Country Status (16)

Country Link
US (2) US6815451B2 (https=)
EP (1) EP1379523B1 (https=)
JP (1) JP2004529132A (https=)
KR (1) KR20040016844A (https=)
CN (1) CN1288148C (https=)
AT (1) ATE300533T1 (https=)
BR (1) BR0207715A (https=)
CA (1) CA2441790A1 (https=)
DE (1) DE60205234T2 (https=)
ES (1) ES2246399T3 (https=)
HU (1) HUP0402508A2 (https=)
IL (1) IL157093A0 (https=)
MX (1) MXPA03008639A (https=)
NO (1) NO20034230D0 (https=)
NZ (1) NZ527276A (https=)
WO (1) WO2002076979A1 (https=)

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JP2006505533A (ja) * 2002-09-17 2006-02-16 アクテリオン　ファマシューティカルズ　リミテッド １−ピリジン−４−イル−尿素誘導体
CN1964630A (zh) 2003-02-13 2007-05-16 耶希瓦大学艾伯塔·爱恩斯坦医学院 通过控制下丘脑的长链脂肪酰基－辅酶A(LC－CoA)的水平来调控食物摄取和葡萄糖产生
WO2004099179A1 (en) * 2003-05-07 2004-11-18 Actelion Pharmaceuticals Ltd Piperazine-alkyl-ureido derivatives
CA2523568A1 (en) * 2003-05-08 2004-11-18 Actelion Pharmaceuticals Ltd Novel piperidine derivatives
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JP4664924B2 (ja) 2003-12-02 2011-04-06 ウーツェーベー ファルマ ゲーエムベーハー 中枢神経因性疼痛の治療のためのペプチド化合物の新規使用
EP1604655A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
EA014055B1 (ru) 2004-08-27 2010-08-30 Шварц Фарма Аг Применение пептидных соединений для лечения боли при раке кости, а также боли, вызванной химиотерапией и нуклеозидами
MX2007004293A (es) 2004-10-12 2007-06-18 Actelion Pharmaceuticals Ltd 1[2-(4-bencil-4-hidroxi-piperidin-1-il)-etil]-3-(2-metil-quinolin -4-il)-urea como la sal de sulfato cristalina.
WO2006126255A1 (ja) * 2005-05-24 2006-11-30 Daito Chemix Corporation Ｎ－（２－ブロモエチル）カルバミン酸ｔｅｒｔ－ブチルの製造方法
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US20070196510A1 (en) * 2006-02-17 2007-08-23 Gerber Michael J Method for treating resistant hypertension
EA019757B1 (ru) 2006-06-15 2014-06-30 ЮСиБи ФАРМА ГМБХ Фармацевтическая композиция с синергетическим противосудорожным эффектом
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WO2008123582A1 (ja) * 2007-04-04 2008-10-16 Kowa Company, Ltd. テトラヒドロイソキノリン化合物
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US9238657B2 (en) 2008-10-31 2016-01-19 Shionogi & Co., Ltd. Cephalosporin having catechol group
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JP5755217B2 (ja) 2009-03-30 2015-07-29 トランステック・ファーマ，エルエルシー 置換アゾアントラセン誘導体、その医薬組成物とその使用の方法
US20100312480A1 (en) * 2009-04-24 2010-12-09 Hansteen Fredrik Method for monitoring fluid flow in a multi-layered system
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
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UA118548C2 (uk) 2012-12-21 2019-02-11 Епізайм, Інк. Тетрагідро- та дигідроізохіноліни як інгібітори prmt5 та їх застосування
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