CN1283223A - 用于生产生物制品的细胞的制备 - Google Patents
用于生产生物制品的细胞的制备 Download PDFInfo
- Publication number
- CN1283223A CN1283223A CN98812635A CN98812635A CN1283223A CN 1283223 A CN1283223 A CN 1283223A CN 98812635 A CN98812635 A CN 98812635A CN 98812635 A CN98812635 A CN 98812635A CN 1283223 A CN1283223 A CN 1283223A
- Authority
- CN
- China
- Prior art keywords
- cell
- production lot
- bio
- production
- reactor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Sustainable Development (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
天 | 3升母发酵罐 | 3升发酵罐 | 3升发酵罐 |
细胞×100.000/ml | 细胞×100.000/ml | 细胞×100.000/ml | |
0 | NOD | ||
1 | 6.6 | ||
2 | 14 | ||
3 | 15.5 | ||
4 | 30 | ||
5 | 5.5 | 10 | 10 |
出菌率 | 85% | 85% | 85% |
天 | 50升培养物 | 250升培养物 |
细胞×100.000/ml | 细胞×100.000/ml | |
0 | 8(400×108个总细胞) | 1.1(275×108个存活细胞) |
1 | 0.8 | |
2 | 2.9 | |
3 | 3.4 | |
4 | 8.9 | |
5 | 18.0 |
天 | 细胞密度(×106/1) | |
10升发酵罐 | 50升发酵罐 | |
0 | 1.0 | |
1/2 | 0.45 | |
3/4 | 1.3 | |
5 | 2.6 | |
6 | 2.8(280×108总量) | |
6 | 0.6(60×108总量) | 0.28(140×108总量) |
7 | 0.4(200×108总量) |
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97204110 | 1997-12-24 | ||
EP97204110.7 | 1997-12-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1283223A true CN1283223A (zh) | 2001-02-07 |
CN1185339C CN1185339C (zh) | 2005-01-19 |
Family
ID=8229133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB988126354A Expired - Fee Related CN1185339C (zh) | 1997-12-24 | 1998-12-17 | 用于生产生物制品的细胞的制备 |
Country Status (26)
Country | Link |
---|---|
US (1) | US20070148753A1 (zh) |
EP (2) | EP1801201B1 (zh) |
JP (1) | JP4478328B2 (zh) |
KR (1) | KR100683429B1 (zh) |
CN (1) | CN1185339C (zh) |
AT (2) | ATE507284T1 (zh) |
AU (1) | AU758209B2 (zh) |
BR (1) | BR9814490A (zh) |
CA (1) | CA2316739C (zh) |
CZ (1) | CZ299719B6 (zh) |
DE (2) | DE69837287T3 (zh) |
DK (2) | DK1801201T3 (zh) |
ES (2) | ES2281148T5 (zh) |
HK (1) | HK1030628A1 (zh) |
HU (1) | HUP0100538A3 (zh) |
ID (1) | ID26784A (zh) |
IL (1) | IL136736A (zh) |
NO (1) | NO329385B1 (zh) |
NZ (1) | NZ505371A (zh) |
PL (1) | PL196042B1 (zh) |
PT (2) | PT1060241E (zh) |
RU (1) | RU2230784C2 (zh) |
SK (1) | SK285971B6 (zh) |
TR (1) | TR200001960T2 (zh) |
UA (1) | UA72732C2 (zh) |
WO (1) | WO1999033955A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112204127A (zh) * | 2018-06-01 | 2021-01-08 | 龙沙有限公司 | 用于有机生长和分阶段的中等规模模型 |
WO2021008571A1 (zh) * | 2019-07-16 | 2021-01-21 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011077035A1 (fr) | 2009-12-23 | 2011-06-30 | Sanofi Pasteur | Procede de culture de cellules adherentes |
WO2019139891A1 (en) | 2018-01-09 | 2019-07-18 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
EP3773686B1 (en) | 2018-03-20 | 2023-06-07 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
EP3768302A4 (en) | 2018-03-20 | 2021-12-15 | Synthetic Biologics, Inc. | INTESTINAL ALKALINE PHOSPHATASE FORMULATIONS |
EP4339274A1 (en) | 2022-09-13 | 2024-03-20 | Sartorius Stedim Biotech GmbH | Method for operating a bioprocess installation for production of a bioproduct |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60151458A (ja) | 1984-01-20 | 1985-08-09 | Nippon Piston Ring Co Ltd | カムシヤフト |
US4664912A (en) * | 1984-10-01 | 1987-05-12 | Wiktor Tadeusz J | Process for the large scale production of rabies vaccine |
DE3833925A1 (de) * | 1988-03-11 | 1989-09-21 | Inst Angewandte Biotechnologie | Verfahren und herstellung von virus und viralem antigen und vorrichtung hierzu |
US5017490A (en) | 1989-03-10 | 1991-05-21 | Baxter International Inc. | Method for in vitro reproduction and growth of cells in culture medium |
DE3930140A1 (de) * | 1989-09-09 | 1991-03-21 | Bayer Ag | Verfahren zur herstellung von biologischen materialien in zellkulturen und vorrichtungen |
WO1992010564A1 (en) * | 1990-12-13 | 1992-06-25 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy |
DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
US8188315B2 (en) * | 2004-04-02 | 2012-05-29 | Samsung Mobile Display Co., Ltd. | Organic light emitting device and flat panel display device comprising the same |
KR100573137B1 (ko) * | 2004-04-02 | 2006-04-24 | 삼성에스디아이 주식회사 | 플루오렌계 화합물 및 이를 이용한 유기 전계 발광 소자 |
KR100787425B1 (ko) * | 2004-11-29 | 2007-12-26 | 삼성에스디아이 주식회사 | 페닐카바졸계 화합물 및 이를 이용한 유기 전계 발광 소자 |
KR100669716B1 (ko) * | 2004-07-14 | 2007-01-16 | 삼성에스디아이 주식회사 | 페닐카르바졸 화합물 및 이를 이용한 유기 전계 발광 소자 |
JP4184332B2 (ja) * | 2004-11-22 | 2008-11-19 | 本田技研工業株式会社 | 可変気筒式内燃機関の制御装置 |
-
1998
- 1998-12-17 IL IL13673698A patent/IL136736A/en not_active IP Right Cessation
- 1998-12-17 PT PT98966693T patent/PT1060241E/pt unknown
- 1998-12-17 DE DE69837287T patent/DE69837287T3/de not_active Expired - Lifetime
- 1998-12-17 HU HU0100538A patent/HUP0100538A3/hu not_active Application Discontinuation
- 1998-12-17 AT AT07103139T patent/ATE507284T1/de active
- 1998-12-17 UA UA2000074455A patent/UA72732C2/uk unknown
- 1998-12-17 CZ CZ20002343A patent/CZ299719B6/cs not_active IP Right Cessation
- 1998-12-17 ES ES98966693T patent/ES2281148T5/es not_active Expired - Lifetime
- 1998-12-17 CA CA2316739A patent/CA2316739C/en not_active Expired - Fee Related
- 1998-12-17 KR KR1020007007068A patent/KR100683429B1/ko not_active IP Right Cessation
- 1998-12-17 SK SK965-2000A patent/SK285971B6/sk not_active IP Right Cessation
- 1998-12-17 DK DK07103139.7T patent/DK1801201T3/da active
- 1998-12-17 TR TR2000/01960T patent/TR200001960T2/xx unknown
- 1998-12-17 ID IDW20001431A patent/ID26784A/id unknown
- 1998-12-17 PL PL98341401A patent/PL196042B1/pl not_active IP Right Cessation
- 1998-12-17 PT PT07103139T patent/PT1801201E/pt unknown
- 1998-12-17 AU AU24179/99A patent/AU758209B2/en not_active Ceased
- 1998-12-17 AT AT98966693T patent/ATE356197T1/de active
- 1998-12-17 EP EP07103139A patent/EP1801201B1/en not_active Expired - Lifetime
- 1998-12-17 WO PCT/EP1998/008522 patent/WO1999033955A1/en active IP Right Grant
- 1998-12-17 RU RU2000119783/13A patent/RU2230784C2/ru not_active IP Right Cessation
- 1998-12-17 BR BR9814490-1A patent/BR9814490A/pt not_active IP Right Cessation
- 1998-12-17 JP JP2000526613A patent/JP4478328B2/ja not_active Expired - Fee Related
- 1998-12-17 DE DE69842245T patent/DE69842245D1/de not_active Expired - Lifetime
- 1998-12-17 ES ES07103139T patent/ES2365631T3/es not_active Expired - Lifetime
- 1998-12-17 DK DK98966693.8T patent/DK1060241T4/da active
- 1998-12-17 NZ NZ505371A patent/NZ505371A/en not_active IP Right Cessation
- 1998-12-17 CN CNB988126354A patent/CN1185339C/zh not_active Expired - Fee Related
- 1998-12-17 EP EP98966693A patent/EP1060241B2/en not_active Expired - Lifetime
-
2000
- 2000-06-21 NO NO20003215A patent/NO329385B1/no not_active IP Right Cessation
-
2001
- 2001-03-06 HK HK01101591A patent/HK1030628A1/xx not_active IP Right Cessation
-
2007
- 2007-01-18 US US11/654,556 patent/US20070148753A1/en not_active Abandoned
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112204127A (zh) * | 2018-06-01 | 2021-01-08 | 龙沙有限公司 | 用于有机生长和分阶段的中等规模模型 |
WO2021008571A1 (zh) * | 2019-07-16 | 2021-01-21 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
CN114127260A (zh) * | 2019-07-16 | 2022-03-01 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Beshay | Production of alkaline protease by Teredinobacter turnirae cells immobilized in Ca-alginate beads | |
CN1043659C (zh) | 生产纳他霉素的发酵方法 | |
CN1483805A (zh) | 一种用于动物细胞扩大接种的消化反应器 | |
CN1185339C (zh) | 用于生产生物制品的细胞的制备 | |
CN103898041A (zh) | 杂交瘤细胞的培养方法 | |
CN103255123B (zh) | 菌丝球吸附光合细菌形成混合菌丝球的方法 | |
Roukas | Production of citric acid from beet molasses by immobilized cells of Aspergillus niger | |
CN115261374B (zh) | 改性生物炭负载微生物的复合体及其在强化厌氧发酵中的应用 | |
CN210506365U (zh) | 一种梯度温度控制发酵系统 | |
Kong et al. | High cell density and productivity culture of Chinese hamster ovary cells in a fluidized bed bioreactor | |
CN1169941C (zh) | 半无菌培养异养小球藻的方法 | |
Griffiths et al. | Fixed immobilized beds for the cultivation of animal cells | |
CN1212392C (zh) | 一种以滤纸为唯一固体介质的粘细菌子实体规模制备方法 | |
CN106755142A (zh) | 米根霉菌体全细胞催化制备l‑乳酸的方法 | |
Kuek | Immobilized living fungal mycelia for the growth-dissociated synthesis of chemicals | |
CN116162666A (zh) | 一种提高l-酪氨酸产量及转化率的方法 | |
CN114717218A (zh) | 一种高效产角蛋白酶的方法 | |
CN114752592A (zh) | 一种用于菌糠饲料化的菌剂及制备方法 | |
CN111088223A (zh) | 一种df-1细胞的微载体悬浮培养方法及应用 | |
Fujii et al. | Citric Acid Fermentation by Immobilized Aspergillus niger in Cellulose Carrier | |
RU97112880A (ru) | Новый мутант e.coli с супрессированной продукцией органической кислоты | |
CN1017452B (zh) | 庆大霉素的发酵生产方法 | |
MXPA00006339A (en) | Preparation of cells for production of biologicals |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1065259 Country of ref document: HK |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20090320 Address after: Holland Weesp Patentee after: Solvay Pharm BV Address before: Holland Weesp Patentee before: Duphar International Research B. V. |
|
ASS | Succession or assignment of patent right |
Owner name: SOLVAN BIOLOGY CO., LTD. Free format text: FORMER OWNER: DUFEIER INTERNATIONAL DEVELOPMENT CO., LTD. Effective date: 20090320 |
|
C56 | Change in the name or address of the patentee |
Owner name: ABBOTT BIOLOGY CO., LTD. Free format text: FORMER NAME: SOLVAY PHARM BV |
|
CP01 | Change in the name or title of a patent holder |
Address after: Holland Weesp Patentee after: Abbott Biologicals B.V. Address before: Holland Weesp Patentee before: Solvay Pharm BV |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050119 Termination date: 20131217 |