CN1276784A - 作为药物的环状氨基酸及其生物 - Google Patents
作为药物的环状氨基酸及其生物 Download PDFInfo
- Publication number
- CN1276784A CN1276784A CN98810346A CN98810346A CN1276784A CN 1276784 A CN1276784 A CN 1276784A CN 98810346 A CN98810346 A CN 98810346A CN 98810346 A CN98810346 A CN 98810346A CN 1276784 A CN1276784 A CN 1276784A
- Authority
- CN
- China
- Prior art keywords
- acetate
- amino methyl
- cyclopentyl
- methyl
- cyclobutyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
- C07C205/51—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
- C07C205/53—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/417—Saturated compounds containing a keto group being part of a ring polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/50—Spiro compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (18)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6364497P | 1997-10-27 | 1997-10-27 | |
US60/063,644 | 1997-10-27 | ||
US9768598P | 1998-08-24 | 1998-08-24 | |
US60/097,685 | 1998-08-24 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2003101209321A Division CN1303059C (zh) | 1997-10-27 | 1998-09-23 | 作为药物的环状氨基酸及其衍生物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1276784A true CN1276784A (zh) | 2000-12-13 |
CN1138755C CN1138755C (zh) | 2004-02-18 |
Family
ID=26743626
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2003101209321A Expired - Fee Related CN1303059C (zh) | 1997-10-27 | 1998-09-23 | 作为药物的环状氨基酸及其衍生物 |
CNB98810346XA Expired - Fee Related CN1138755C (zh) | 1997-10-27 | 1998-09-23 | 作为药物的环状氨基酸及其衍生物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2003101209321A Expired - Fee Related CN1303059C (zh) | 1997-10-27 | 1998-09-23 | 作为药物的环状氨基酸及其衍生物 |
Country Status (31)
Country | Link |
---|---|
US (3) | US6635673B1 (zh) |
EP (1) | EP1032555B1 (zh) |
JP (2) | JP3756761B2 (zh) |
KR (1) | KR100589066B1 (zh) |
CN (2) | CN1303059C (zh) |
AR (1) | AR013726A1 (zh) |
AT (1) | ATE323067T1 (zh) |
AU (1) | AU755800B2 (zh) |
BR (1) | BR9813284B1 (zh) |
CA (1) | CA2303244C (zh) |
CO (1) | CO5280097A1 (zh) |
CU (1) | CU23048A3 (zh) |
CY (1) | CY1105062T1 (zh) |
DE (1) | DE69834204T2 (zh) |
DK (1) | DK1032555T3 (zh) |
ES (1) | ES2260850T3 (zh) |
GE (1) | GEP20094817B (zh) |
HK (2) | HK1030768A1 (zh) |
HU (1) | HUP0004310A3 (zh) |
IL (1) | IL134732A (zh) |
IS (1) | IS2489B (zh) |
NO (1) | NO327671B1 (zh) |
NZ (1) | NZ503651A (zh) |
PE (1) | PE122799A1 (zh) |
PL (2) | PL199794B1 (zh) |
PT (1) | PT1032555E (zh) |
SI (1) | SI1032555T1 (zh) |
TR (1) | TR200001170T2 (zh) |
UY (1) | UY25223A1 (zh) |
WO (1) | WO1999021824A1 (zh) |
ZA (1) | ZA989740B (zh) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU225502B1 (en) * | 1998-12-29 | 2007-01-29 | Richter Gedeon Vegyeszet | Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates |
PT1180094E (pt) * | 1999-05-26 | 2004-10-29 | Warner Lambert Co | Aminoacidos policiclicos fundidos como agentes farmaceuticos |
OA11962A (en) * | 1999-06-10 | 2006-04-17 | Warner Lambert Co | Mono-and disubstituted 3-propyl gamma-aminobutyricacids. |
US7164034B2 (en) | 1999-06-10 | 2007-01-16 | Pfizer Inc. | Alpha2delta ligands for fibromyalgia and other disorders |
EP1840117A1 (en) * | 1999-06-10 | 2007-10-03 | Warner-Lambert Company LLC | Mono- and disubstituted 3-propyl gamma-aminobutyric acids |
US6642398B2 (en) | 1999-06-10 | 2003-11-04 | Warner-Lambert Company | Mono-and disubstituted 3-propyl gamma-aminobutyric acids |
HN2000000224A (es) | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
HUP0203812A3 (en) * | 1999-12-08 | 2004-12-28 | Warner Lambert Co | Method for the stereoselective synthesis of cyclic amino acids |
US6864390B2 (en) | 1999-12-08 | 2005-03-08 | Warner-Lambert Company | Method for the stereoselective synthesis of cyclic amino acids |
GB2362646A (en) * | 2000-05-26 | 2001-11-28 | Warner Lambert Co | Cyclic amino acid derivatives useful as pharmaceutical agents |
MXPA02010668A (es) | 2000-06-26 | 2003-03-10 | Warner Lambert Co | Analogos de gabapentina para alteraciones del sueno. |
GB2364049A (en) * | 2000-06-28 | 2002-01-16 | Warner Lambert Co | Cyclic ketones and their use in the synthesis of amino acids |
AU2002230398A1 (en) | 2000-10-06 | 2002-04-29 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
AU2002211863A1 (en) | 2000-10-06 | 2002-04-15 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
EP1226820A1 (en) * | 2001-01-26 | 2002-07-31 | Warner-Lambert Company | Use of bicyclic amino acids for preventing and treating visceral pain and gastrointestinal disorders |
EA006396B1 (ru) * | 2001-04-19 | 2005-12-29 | УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл Эл Си | Конденсированные бициклические аминокислоты |
GB2374595A (en) * | 2001-04-19 | 2002-10-23 | Warner Lambert Co | Fused bicyclic or tricyclic amino acids |
US7420002B2 (en) | 2001-06-11 | 2008-09-02 | Xenoport | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues |
KR20040016882A (ko) | 2001-06-11 | 2004-02-25 | 제노포트 인코포레이티드 | 감소된 독성을 가진 gaba 유사체 프로드러그의 구강투여용 투여 형태물 |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8048917B2 (en) * | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
WO2003077902A1 (en) | 2002-02-19 | 2003-09-25 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
US7026351B2 (en) | 2002-03-20 | 2006-04-11 | Xenoport, Inc. | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof |
AU2003243180A1 (en) | 2002-05-17 | 2003-12-12 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
US7018818B2 (en) | 2002-10-04 | 2006-03-28 | Pfizer Inc. | Intermediates in the preparation of therapeutic fused bicyclic amino acids |
GB0223072D0 (en) * | 2002-10-04 | 2002-11-13 | Pfizer Ltd | Cyclic nitromethyl acetic acid derivatives |
US7025745B2 (en) * | 2002-10-07 | 2006-04-11 | Advanced Cardiovascular Systems, Inc. | Method of making a catheter balloon using a tapered mandrel |
US7060727B2 (en) | 2002-12-11 | 2006-06-13 | Xenoport, Inc. | Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof |
EP1572184A1 (en) * | 2002-12-13 | 2005-09-14 | Warner-Lambert Company | Gabapentin analogues for fibromyalgia and other related disorders |
WO2004054566A1 (en) | 2002-12-13 | 2004-07-01 | Warner-Lambert Company Llc | Pregabalin derivatives for the treatment of fibromyalgia and other disorders |
CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
RU2331438C2 (ru) | 2002-12-13 | 2008-08-20 | Уорнер-Ламберт Компани Ллс | Альфа-2-дельта лиганд для лечения симптомов нижних мочевыводящих путей |
WO2005002585A1 (en) * | 2003-07-02 | 2005-01-13 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor |
WO2005025562A1 (en) | 2003-09-11 | 2005-03-24 | Xenoport, Inc. | Treating and/or preventing urinary incontinence using prodrugs of gaba analogs |
NZ545494A (en) | 2003-09-12 | 2009-10-30 | Pfizer | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
SG146643A1 (en) | 2003-09-17 | 2008-10-30 | Xenoport Inc | Treating or preventing restless legs syndrome using prodrugs of gaba analogs |
DK1677767T3 (da) | 2003-10-14 | 2011-10-24 | Xenoport Inc | Krystallinsk form af gamma-aminobutyrsyre-analog |
AU2004305563C1 (en) | 2003-12-11 | 2011-07-07 | Sunovion Pharmaceuticals Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
UA82292C2 (uk) * | 2004-04-14 | 2008-03-25 | Пфайзер Продактс Инк. | Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти) |
EP1811986B1 (en) | 2004-11-04 | 2014-03-26 | XenoPort, Inc. | Gabapentin prodrug sustained release oral dosage forms |
WO2006092692A1 (en) * | 2005-03-01 | 2006-09-08 | Pfizer Limited | Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain |
EP1912936A2 (en) * | 2005-07-18 | 2008-04-23 | Pharmacia & Upjohn Company LLC | Stereoselective synthesis of 3,4-disubstituted cyclopentanones and related compounds |
EP1820502A1 (en) | 2006-02-10 | 2007-08-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising azolylcarbinol compounds |
MX2008011396A (es) * | 2006-03-06 | 2008-09-18 | Pfizer Prod Inc | Ligandos alfa-2-delta para sueño no reconstituyente. |
AR061728A1 (es) * | 2006-06-30 | 2008-09-17 | Pfizer Prod Inc | Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1 |
WO2008077599A1 (en) | 2006-12-22 | 2008-07-03 | Recordati Ireland Limited | COMBINATION THERAPY OF LOWER URINARY TRACT DISORDERS WITH α2δ LIGANDS AND NSAIDS |
WO2008155619A2 (en) * | 2007-06-21 | 2008-12-24 | Pfizer Inc. | Preparation of optically-active cyclic amino acids |
RU2446148C2 (ru) | 2007-09-28 | 2012-03-27 | Дайити Санкио Компани, Лимитед | Бициклическое производное гамма-аминокислоты |
WO2009094563A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use |
WO2009094569A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates |
WO2009094577A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
ES2589915T3 (es) | 2008-10-08 | 2016-11-17 | Xgene Pharmaceutical Inc | Conjugados de GABA y métodos de utilización de los mismos |
CA2756750C (en) | 2009-03-26 | 2014-05-13 | Daiichi Sankyo Company, Limited | A method for producing bicyclic .gamma.-amino acid derivative |
EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
JP5922118B2 (ja) | 2011-06-08 | 2016-05-24 | 第一三共株式会社 | イミニウム塩を経由する二環性化合物の製造方法 |
WO2012169475A1 (ja) | 2011-06-08 | 2012-12-13 | 第一三共株式会社 | クライゼン転位反応による二環性化合物の製造方法 |
CA2859003C (en) | 2011-12-15 | 2016-11-01 | Daiichi Sankyo Company, Limited | Optical resolution method for bicyclic compound using asymmetric catalyst |
IN2014DN07923A (zh) | 2012-04-10 | 2015-05-01 | Daiichi Sankyo Companyltd | |
US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
HUE047629T2 (hu) | 2013-01-28 | 2020-05-28 | Lopez Hector L | Eljárások ß-alanin tolerancia, farmakodinamika és hatékonyság javítására és azok alkalmazása |
TWI635071B (zh) | 2013-07-08 | 2018-09-11 | 第一三共股份有限公司 | 光學活性二環γ-胺基酸衍生物及其製造方法 |
US20160310501A1 (en) | 2013-12-17 | 2016-10-27 | Laboratorios Del Dr. Esteve, S.A. | Gabapentinoids and sigma receptor ligands combinations |
AU2014364647A1 (en) | 2013-12-17 | 2016-06-23 | Laboratorios Del Dr. Esteve, S.A. | Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) and Sigma receptor ligands combinations |
BR112020022885A2 (pt) | 2018-05-14 | 2021-03-23 | Xgene Pharmaceutical Inc. | formas cristalinas de conjugados de fármacos de carbamato de 1-(aciloxi)-alquila de naproxeno e pregabalina |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
US4087544A (en) | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
DE2611690A1 (de) | 1976-03-19 | 1977-09-22 | Goedecke Ag | Cyclische sulfonyloxyimide |
CA1085420A (en) | 1977-03-24 | 1980-09-09 | Johannes Hartenstein | 1-aminomethyl-1-cycloalkane-acetic acid |
DE3928184A1 (de) | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte |
US5132451A (en) | 1989-08-25 | 1992-07-21 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
US5319135A (en) | 1989-08-25 | 1994-06-07 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
US5084479A (en) | 1990-01-02 | 1992-01-28 | Warner-Lambert Company | Novel methods for treating neurodegenerative diseases |
EP0458751A1 (en) | 1990-05-25 | 1991-11-27 | Warner-Lambert Company | Delivery system for cyclic amino acids with improved taste, texture and compressibility |
US5025035A (en) | 1990-10-12 | 1991-06-18 | Warner-Lambert Company | Method of treating depression |
EP0482834B1 (en) | 1990-10-20 | 1996-01-17 | Takasago International Corporation | Process for producing alpha-hydroxyketones |
CA2120351A1 (en) | 1991-10-02 | 1993-04-15 | Siegfried B. Christensen, Iv | Cyclopentane and cyclopentene derivatives with antiallergic antiinflammatory and tumor necrosis factor inhibiting activity |
US5631291A (en) | 1992-05-29 | 1997-05-20 | Bayer Aktiengesellschaft | Cyclopentane- and -pentene-β-amino acids |
DE4400749A1 (de) | 1994-01-13 | 1995-07-20 | Bayer Ag | Neues hochenantioselektives Verfahren zur Herstellung von enantiomerenreinen Cyclopentan- und -penten-beta-Aminosäuren |
CZ291757B6 (cs) | 1994-07-27 | 2003-05-14 | Warner-Lambert Company | Léčivo pro léčení úzkosti a panického strachu |
US5510381A (en) | 1995-05-15 | 1996-04-23 | Warner-Lambert Company | Method of treatment of mania and bipolar disorder |
DK0888285T3 (da) * | 1996-03-14 | 2002-04-08 | Warner Lambert Co | Nye broforbundne cycliske aminosyrer som farmaceutiske midler |
HRP980342A2 (en) | 1997-06-25 | 1999-02-28 | Warner Lambert Co | Anti-inflammatory method |
US9858641B2 (en) * | 2014-12-15 | 2018-01-02 | International Business Machines Corporation | Representing a system using viewpoints |
US9419648B1 (en) * | 2015-09-18 | 2016-08-16 | Intel Corporation | Supporting data compression using match scoring |
-
1998
- 1998-09-23 DE DE69834204T patent/DE69834204T2/de not_active Expired - Lifetime
- 1998-09-23 SI SI9830831T patent/SI1032555T1/sl unknown
- 1998-09-23 KR KR1020007004472A patent/KR100589066B1/ko not_active IP Right Cessation
- 1998-09-23 DK DK98950649T patent/DK1032555T3/da active
- 1998-09-23 TR TR2000/01170T patent/TR200001170T2/xx unknown
- 1998-09-23 IL IL13473298A patent/IL134732A/en not_active IP Right Cessation
- 1998-09-23 CU CU20000089A patent/CU23048A3/es not_active IP Right Cessation
- 1998-09-23 GE GEAP199811187A patent/GEP20094817B/en unknown
- 1998-09-23 CN CNB2003101209321A patent/CN1303059C/zh not_active Expired - Fee Related
- 1998-09-23 AU AU96638/98A patent/AU755800B2/en not_active Ceased
- 1998-09-23 PL PL380277A patent/PL199794B1/pl not_active IP Right Cessation
- 1998-09-23 PL PL340285A patent/PL199500B1/pl not_active IP Right Cessation
- 1998-09-23 CN CNB98810346XA patent/CN1138755C/zh not_active Expired - Fee Related
- 1998-09-23 CA CA002303244A patent/CA2303244C/en not_active Expired - Fee Related
- 1998-09-23 WO PCT/US1998/019876 patent/WO1999021824A1/en active IP Right Grant
- 1998-09-23 EP EP98950649A patent/EP1032555B1/en not_active Expired - Lifetime
- 1998-09-23 AT AT98950649T patent/ATE323067T1/de active
- 1998-09-23 PT PT98950649T patent/PT1032555E/pt unknown
- 1998-09-23 NZ NZ503651A patent/NZ503651A/xx not_active IP Right Cessation
- 1998-09-23 ES ES98950649T patent/ES2260850T3/es not_active Expired - Lifetime
- 1998-09-23 US US09/485,382 patent/US6635673B1/en not_active Expired - Fee Related
- 1998-09-23 BR BRPI9813284-9A patent/BR9813284B1/pt not_active IP Right Cessation
- 1998-09-23 JP JP2000517936A patent/JP3756761B2/ja not_active Expired - Fee Related
- 1998-09-23 HU HU0004310A patent/HUP0004310A3/hu unknown
- 1998-10-26 UY UY25223A patent/UY25223A1/es not_active IP Right Cessation
- 1998-10-26 ZA ZA989740A patent/ZA989740B/xx unknown
- 1998-10-26 CO CO98062354A patent/CO5280097A1/es not_active Application Discontinuation
- 1998-10-26 AR ARP980105348A patent/AR013726A1/es active IP Right Grant
- 1998-10-27 PE PE1998001007A patent/PE122799A1/es not_active Application Discontinuation
-
2000
- 2000-03-03 IS IS5395A patent/IS2489B/is unknown
- 2000-04-26 NO NO20002118A patent/NO327671B1/no not_active IP Right Cessation
-
2001
- 2001-03-12 HK HK01101728A patent/HK1030768A1/xx not_active IP Right Cessation
-
2003
- 2003-05-30 US US10/448,834 patent/US6921835B2/en not_active Expired - Fee Related
-
2004
- 2004-07-06 HK HK04104849A patent/HK1061841A1/xx not_active IP Right Cessation
-
2005
- 2005-03-11 US US11/078,961 patent/US7122678B2/en not_active Expired - Fee Related
- 2005-11-02 JP JP2005319009A patent/JP4263717B2/ja not_active Expired - Fee Related
-
2006
- 2006-07-03 CY CY20061100906T patent/CY1105062T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1138755C (zh) | 作为药物的环状氨基酸及其衍生物 | |
CN1165518C (zh) | 作为药学试剂的双环氨基酸类化合物 | |
CN1310872C (zh) | 单和双取代的3-丙基-γ-氨基丁酸 | |
CN1305839C (zh) | 苯基甘氨酸衍生物 | |
CN1279674A (zh) | 1-取代-1-氨基甲基-环烷衍生物(=加巴喷丁类似物)、其制备及其在治疗神经病方面的用途 | |
CN1016778B (zh) | 螺-取代的戊二酸单酰胺 | |
CN1720038A (zh) | 治疗纤维肌痛及其它病症用的加巴喷丁类似物类 | |
CN1279667A (zh) | 4(3)取代-4(3)-氨基甲基-(硫代)吡喃(噻喃)或-哌啶衍生物(=加巴喷丁类似物)、其制备及其在治疗神经病方面的用途 | |
CN1471515A (zh) | 作为β2-肾上腺素受体激动剂及PDE-4抑制剂的有效的化合物 | |
CN1077954A (zh) | 新的苯并吡喃衍生物 | |
CN1068825A (zh) | 四氢吡咯并[1,2-a]吡嗪-4-螺-3′吡咯烷衍生物的制备方法 | |
CN1137889C (zh) | 新三环酰胺化合物,其制法和含它们的药物组合物 | |
CN1068816A (zh) | 吲哚类衍生物 | |
CN1147467C (zh) | 环戊基烷基腈 | |
CN1720219A (zh) | 稠合二环或三环氨基酸 | |
CN1501941A (zh) | 化合物 | |
CN88101674A (zh) | 色酮衍生物 | |
CN1200729A (zh) | 用作止痛剂的旋光苯基嘧啶衍生物 | |
CN87102304A (zh) | 具有抗痴功效的化合物所制药剂及其在预防和治疗认知机能障碍中的应用 | |
CN1407967A (zh) | 立体选择性地合成环状氨基酸的方法 | |
CN1192014C (zh) | Hiv蛋白酶抑制剂的制备方法 | |
CN1216856C (zh) | 具有亚环烷基链的新环状化合物,其制备方法和含有它们的药物组合物 | |
CN1064349C (zh) | 新型三环酰胺、其制备方法及其药物组合物 | |
CN1145622C (zh) | 取代的苯并杂环化合物、其制备方法及包含它们的药物组合物 | |
CN1199960C (zh) | 新的沉香呋喃衍生物,它们的制备方法,含它们的药物组合物及它们作为药物的用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CI01 | Publication of corrected invention patent application |
Correction item: Denomination of Invention Correct: Cyclic amino acids and derivatives thereof False: A cyclic amino acid and its organism as a drug Number: 50 Page: 121 Volume: 16 |
|
CI02 | Correction of invention patent application |
Correction item: Denomination of Invention Correct: Cyclic amino acids and derivatives thereof False: A cyclic amino acid and its organism as a drug Number: 50 Page: The title page Volume: 16 |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTION NAME; FROM: CYCLIC AMINO ACID AND LIVING BEINGS AS THE MEDICINE TO: CYCLIC AMINOACID AND DERIVANT AS THE MEDICINE |
|
ERR | Gazette correction |
Free format text: CORRECT: INVENTION NAME; FROM: CYCLIC AMINO ACID AND LIVING BEINGS AS THE MEDICINE TO: CYCLIC AMINOACID AND DERIVANT AS THE MEDICINE |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CI01 | Publication of corrected invention patent application |
Correction item: Priority Correct: 1997.10.27 US 60/063,644|1997.08.24 US 60/097,685 False: 1997.10.27 US 60/063,644 Number: 7 Page: 394 Volume: 20 |
|
CI03 | Correction of invention patent |
Correction item: Priority Correct: 1997.10.27 US 60/063,644|1997.08.24 US 60/097,685 False: 1997.10.27 US 60/063,644 Number: 7 Page: The title page Volume: 20 |
|
COR | Change of bibliographic data |
Free format text: CORRECT: PRIORITY; FROM: 1997.10.27 US 60/063,644 TO: 1997.10.27 US 60/063,644 1997.8.24 US 60/097,685 |
|
ERR | Gazette correction |
Free format text: CORRECT: PRIORITY; FROM: 1997.10.27 US 60/063,644 TO: 1997.10.27 US 60/063,644 1997.8.24 US 60/097,685 |
|
CI01 | Publication of corrected invention patent application |
Correction item: Priority Correct: 1997.10.27 US 60/063,644|1998.08.24 US 097,685 False: 1997.10.27 US 60/063,644 Number: 7 Volume: 20 |
|
CI03 | Correction of invention patent |
Correction item: Priority Correct: 1997.10.27 US 60/063,644|1998.08.24 US 097,685 False: 1997.10.27 US 60/063,644 Number: 7 Page: The title page Volume: 20 |
|
COR | Change of bibliographic data |
Free format text: CORRECT: PRIORITY; FROM: 1997.10.27 US 60/063,644 TO: 1997.10.27 US 60/063,644 1998.8.24 US 097,685 |
|
ERR | Gazette correction |
Free format text: CORRECT: PRIORITY; FROM: 1997.10.27 US 60/063,644 TO: 1997.10.27 US 60/063,644 1998.8.24 US 097,685 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1030768 Country of ref document: HK |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040218 Termination date: 20130923 |