CN1268636C - 多拉司他汀15衍生物 - Google Patents

多拉司他汀15衍生物 Download PDF

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Publication number
CN1268636C
CN1268636C CNB988073595A CN98807359A CN1268636C CN 1268636 C CN1268636 C CN 1268636C CN B988073595 A CNB988073595 A CN B988073595A CN 98807359 A CN98807359 A CN 98807359A CN 1268636 C CN1268636 C CN 1268636C
Authority
CN
China
Prior art keywords
methyl
alkyl
ethyl
hydrogen atom
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988073595A
Other languages
English (en)
Chinese (zh)
Other versions
CN1264388A (zh
Inventor
B·杰森
T·巴罗萨里
A·浩普特
T·瑟尔克
A·克林格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ai Bowei Germany & Co KG GmbH
Original Assignee
BASF SE
Abbott GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE, Abbott GmbH and Co KG filed Critical BASF SE
Publication of CN1264388A publication Critical patent/CN1264388A/zh
Application granted granted Critical
Publication of CN1268636C publication Critical patent/CN1268636C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB988073595A 1997-07-18 1998-07-07 多拉司他汀15衍生物 Expired - Fee Related CN1268636C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/896,394 1997-07-18
US08/896,394 US6143721A (en) 1997-07-18 1997-07-18 Dolastatin 15 derivatives

Publications (2)

Publication Number Publication Date
CN1264388A CN1264388A (zh) 2000-08-23
CN1268636C true CN1268636C (zh) 2006-08-09

Family

ID=25406130

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988073595A Expired - Fee Related CN1268636C (zh) 1997-07-18 1998-07-07 多拉司他汀15衍生物

Country Status (32)

Country Link
US (6) US6143721A (enExample)
EP (1) EP0991658B1 (enExample)
JP (4) JP4508413B2 (enExample)
KR (1) KR100579748B1 (enExample)
CN (1) CN1268636C (enExample)
AR (1) AR018501A1 (enExample)
AT (1) ATE314387T1 (enExample)
AU (1) AU750120B2 (enExample)
BG (1) BG65212B1 (enExample)
BR (1) BR9810911A (enExample)
CA (1) CA2296036C (enExample)
CO (1) CO4990967A1 (enExample)
CY (1) CY1107047T1 (enExample)
CZ (1) CZ303045B6 (enExample)
DE (1) DE69832982T2 (enExample)
DK (1) DK0991658T3 (enExample)
ES (1) ES2258819T3 (enExample)
HR (1) HRP980397A2 (enExample)
HU (1) HU228996B1 (enExample)
ID (1) ID24669A (enExample)
IL (1) IL133784A (enExample)
MY (1) MY135057A (enExample)
NO (1) NO326827B1 (enExample)
NZ (1) NZ502296A (enExample)
PL (1) PL197884B1 (enExample)
PT (1) PT991658E (enExample)
RU (1) RU2195462C2 (enExample)
SK (1) SK286581B6 (enExample)
TR (2) TR200103545T2 (enExample)
TW (1) TW533217B (enExample)
WO (1) WO1999003879A1 (enExample)
ZA (1) ZA986358B (enExample)

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US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
AU2001227375A1 (en) * 2000-02-08 2001-08-20 Herbert T. Nagasawa N-terminal d(-)-penicillamine peptides as aldehyde sequestration agents
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
CA2479764C (en) * 2002-03-22 2013-07-30 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
ES2544527T3 (es) 2002-07-31 2015-09-01 Seattle Genetics, Inc. Conjugados de fármacos y su uso para tratar el cáncer, una enfermedad autoinmune o una enfermedad infecciosa
EP3434275A1 (en) 2003-11-06 2019-01-30 Seattle Genetics, Inc. Assay for cancer cells based on the use of auristatin conjugates with antibodies
EP1828776A4 (en) * 2004-12-09 2010-03-17 Eisai R&D Man Co Ltd TUBULINISOTYPE SEARCH IN CANCER THERAPY WITH HEMIASTERLINANALOGES
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
SG10201407457UA (en) 2006-05-16 2014-12-30 Pharmascience Inc Iap bir domain binding compounds
ES2528922T3 (es) 2007-07-16 2015-02-13 Genentech, Inc. Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso
ATE543835T1 (de) 2007-07-16 2012-02-15 Genentech Inc Anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren
DE102007039706A1 (de) 2007-08-22 2009-02-26 Erhard Prof. Dr.-Ing. Kohn Chemischer Sensor auf Diamantschichten
PT2247620T (pt) 2008-01-31 2016-08-23 Genentech Inc Anticorpos e imunoconjugados anti-cd79b e métodos de utilização
SG181797A1 (en) * 2009-12-18 2012-07-30 Idenix Pharmaceuticals Inc 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors
US9173961B2 (en) 2010-02-10 2015-11-03 Immunogen, Inc. CD20 antibodies and uses thereof
MX340870B (es) 2010-02-12 2016-07-27 Pharmascience Inc Compuestos de unión del dominio de repetición de inhibidores de proteínas de apoptosis de baculovirus.
AU2012395148B2 (en) 2012-11-24 2016-10-27 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
FI3122757T3 (fi) 2014-02-28 2023-10-10 Hangzhou Dac Biotech Co Ltd Varautuneita linkkereitä ja niiden konjugointikäyttötapoja
DK3262071T3 (da) 2014-09-23 2020-06-15 Hoffmann La Roche Fremgangsmåde til anvendelse af anti-CD79b-immunkonjugater
CA2989269C (en) 2015-06-15 2020-09-22 Robert Yongxin Zhao Hydrophilic linkers for conjugation of a cytotoxic agent or chromophore molecule to a cell-binding molecule
EP3319936B1 (en) 2015-07-12 2025-12-17 Hangzhou Dac Biotech Co., Ltd. Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
AU2016429272A1 (en) 2016-11-14 2019-05-02 Hangzhou Dac Biotech Co., Ltd. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
EP4400121A1 (en) 2021-09-03 2024-07-17 Toray Industries, Inc. Pharmaceutical composition for treating and/or preventing cancer
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
SG87056A1 (en) * 1991-08-09 2002-03-19 Teikoku Hormone Mfg Co Ltd Novel tetrapeptide derivative
US5448045A (en) 1992-02-26 1995-09-05 Clark; Paul C. System for protecting computers via intelligent tokens or smart cards
US5533097A (en) * 1992-02-26 1996-07-02 Motorola, Inc. Portable communication system comprising a local and wide area communication units which can store a communication when the wide area communication system is not available
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
DE69320339T2 (de) * 1992-05-20 1998-12-17 Basf Ag, 67063 Ludwigshafen Derivate des Dolastatin
AU679479B2 (en) * 1992-12-16 1997-07-03 Basf Aktiengesellschaft Dolostatin analog
US5554993A (en) 1994-01-04 1996-09-10 Panasonic Technologies, Inc. Global position determining system and method
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5618232A (en) 1995-03-23 1997-04-08 Martin; John R. Dual mode gaming device methods and systems
US5970143A (en) 1995-11-22 1999-10-19 Walker Asset Management Lp Remote-auditing of computer generated outcomes, authenticated billing and access control, and software metering system using cryptographic and other protocols
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US6104815A (en) 1997-01-10 2000-08-15 Silicon Gaming, Inc. Method and apparatus using geographical position and universal time determination means to provide authenticated, secure, on-line communication between remote gaming locations
US6143721A (en) 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6554705B1 (en) 1997-08-22 2003-04-29 Blake Cumbers Passive biometric customer identification and tracking system
US6629591B1 (en) 2001-01-12 2003-10-07 Igt Smart token
US6438382B1 (en) 2001-02-14 2002-08-20 Telefonaktiebolaget Lm Ericsson (Publ.) Expedited location determination in analog service areas

Also Published As

Publication number Publication date
DE69832982D1 (de) 2006-02-02
EP0991658B1 (en) 2005-12-28
PT991658E (pt) 2006-05-31
IL133784A (en) 2005-09-25
US20030153505A1 (en) 2003-08-14
ES2258819T3 (es) 2006-09-01
US7084110B2 (en) 2006-08-01
IL133784A0 (en) 2001-04-30
US7662786B2 (en) 2010-02-16
BG65212B1 (bg) 2007-07-31
DE69832982T2 (de) 2006-08-24
BG104089A (en) 2000-12-29
TR200000132T2 (tr) 2000-05-22
NO20000231L (no) 2000-01-17
BR9810911A (pt) 2000-08-01
JP2012211164A (ja) 2012-11-01
MY135057A (en) 2008-01-31
HU228996B1 (hu) 2013-07-29
PL197884B1 (pl) 2008-05-30
NO20000231D0 (no) 2000-01-17
CY1107047T1 (el) 2012-09-26
US20100099843A1 (en) 2010-04-22
NO326827B1 (no) 2009-02-23
US20130046077A1 (en) 2013-02-21
HK1029125A1 (en) 2001-03-23
AU8475898A (en) 1999-02-10
JP2009137968A (ja) 2009-06-25
ZA986358B (en) 2000-01-17
US6143721A (en) 2000-11-07
WO1999003879A1 (en) 1999-01-28
TR200103545T2 (tr) 2002-06-21
KR100579748B1 (ko) 2006-05-15
PL338144A1 (en) 2000-09-25
US8163698B2 (en) 2012-04-24
ATE314387T1 (de) 2006-01-15
JP2009137967A (ja) 2009-06-25
KR20010021998A (ko) 2001-03-15
NZ502296A (en) 2002-02-01
SK187999A3 (en) 2000-09-12
CN1264388A (zh) 2000-08-23
CZ2000176A3 (en) 2001-06-13
AR018501A1 (es) 2001-11-28
CZ303045B6 (cs) 2012-03-07
HUP0004234A3 (en) 2001-08-28
CA2296036C (en) 2007-05-01
AU750120B2 (en) 2002-07-11
ID24669A (id) 2000-07-27
DK0991658T3 (da) 2006-05-15
HRP980397A2 (en) 1999-04-30
US20060270606A1 (en) 2006-11-30
JP4508413B2 (ja) 2010-07-21
EP0991658A1 (en) 2000-04-12
JP5122429B2 (ja) 2013-01-16
TW533217B (en) 2003-05-21
US6458765B1 (en) 2002-10-01
CO4990967A1 (es) 2000-12-26
RU2195462C2 (ru) 2002-12-27
JP5047935B2 (ja) 2012-10-10
HUP0004234A2 (hu) 2001-05-28
CA2296036A1 (en) 1999-01-28
JP2001515010A (ja) 2001-09-18
SK286581B6 (sk) 2009-01-07

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SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: AVECIA BIOLOGY TECHNOLOGY CO., LTD.

Free format text: FORMER OWNER: BASF AKTIENGESELLCHAFT

Effective date: 20030813

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

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Applicant after: Ebert GmbH & Co. KG

Address before: Ludwigshafen, Germany

Applicant before: Basf AG

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ASS Succession or assignment of patent right

Owner name: ABBVIE GERMANY GMBH + CO., KG.

Free format text: FORMER OWNER: EBERT GMBH + CO. KG

Effective date: 20140401

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20140401

Address after: Wiesbaden

Patentee after: Ai Bowei Germany GmbH & Co Kg

Address before: Wiesbaden

Patentee before: Ebert GmbH & Co. KG

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060809

Termination date: 20150707

EXPY Termination of patent right or utility model