CY1107047T1 - Παραγωγα δολαστατινης 15 - Google Patents

Παραγωγα δολαστατινης 15

Info

Publication number
CY1107047T1
CY1107047T1 CY20061100348T CY061100348T CY1107047T1 CY 1107047 T1 CY1107047 T1 CY 1107047T1 CY 20061100348 T CY20061100348 T CY 20061100348T CY 061100348 T CY061100348 T CY 061100348T CY 1107047 T1 CY1107047 T1 CY 1107047T1
Authority
CY
Cyprus
Prior art keywords
mammal
formula
present
amino group
dolastatine
Prior art date
Application number
CY20061100348T
Other languages
English (en)
Inventor
Bernd Janssen
Teresa Barlozzari
Andreas Haupt
Thomas Zierke
Andreas Kling
Original Assignee
Abbott Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co. Kg filed Critical Abbott Gmbh & Co. Kg
Publication of CY1107047T1 publication Critical patent/CY1107047T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Οι ενώσεις της παρούσας εφεύρεσης συμπεριλαμβάνουν αναστολείς κυτταρικής αύξησης οι οποίοι είναι πεπτίδια του χημικού τύπου (I): A-B-D-E-F-(G)r-(K)s-L και τα άλατα οξέων εξ αυτών, στα οποία τα Α, Β, D, Ε, F, G, και Κ είναι κατάλοιπα α-αμινοξέων, και τα s και r είναι το κάθε ένα ανεξαρτήτως το 0 ή το 1. To L είναι μια μονοσθενής ρίζα, όπως είναι, για παράδειγμα, μια αμινομάδα, μια Ν-υποκατεστημένη αμινομάδα, μια β-υδροξυλαμινομάδα, μια υδραζιδομάδα, μια αλκοξυομάδα, μια θειοαλκοξυομάδα, μια αμινοξυομάδα ή μια οξιματοομάδα. Η παρούσα εφεύρεση συμπεριλαμβάνει επίσης μια μέθοδο για την θεραπεία του καρκίνου σε ένα θηλαστικό, όπως είναι ένας άνθρωπος, περιλαμβάνοντας την χορήγηση στο θηλαστικό μιας αποτελεσματικής ποσότητας μιας ένωσης του Χημικού τύπου (Ι) σε μια φαρμακευτικώς αποδεκτή σύνθεση.
CY20061100348T 1997-07-18 2006-03-13 Παραγωγα δολαστατινης 15 CY1107047T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/896,394 US6143721A (en) 1997-07-18 1997-07-18 Dolastatin 15 derivatives
EP98935531A EP0991658B1 (en) 1997-07-18 1998-07-07 Dolastatin 15 derivatives

Publications (1)

Publication Number Publication Date
CY1107047T1 true CY1107047T1 (el) 2012-09-26

Family

ID=25406130

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100348T CY1107047T1 (el) 1997-07-18 2006-03-13 Παραγωγα δολαστατινης 15

Country Status (33)

Country Link
US (6) US6143721A (el)
EP (1) EP0991658B1 (el)
JP (4) JP4508413B2 (el)
KR (1) KR100579748B1 (el)
CN (1) CN1268636C (el)
AR (1) AR018501A1 (el)
AT (1) ATE314387T1 (el)
AU (1) AU750120B2 (el)
BG (1) BG65212B1 (el)
BR (1) BR9810911A (el)
CA (1) CA2296036C (el)
CO (1) CO4990967A1 (el)
CY (1) CY1107047T1 (el)
CZ (1) CZ303045B6 (el)
DE (1) DE69832982T2 (el)
DK (1) DK0991658T3 (el)
ES (1) ES2258819T3 (el)
HK (1) HK1029125A1 (el)
HR (1) HRP980397A2 (el)
HU (1) HU228996B1 (el)
ID (1) ID24669A (el)
IL (1) IL133784A (el)
MY (1) MY135057A (el)
NO (1) NO326827B1 (el)
NZ (1) NZ502296A (el)
PL (1) PL197884B1 (el)
PT (1) PT991658E (el)
RU (1) RU2195462C2 (el)
SK (1) SK286581B6 (el)
TR (2) TR200000132T2 (el)
TW (1) TW533217B (el)
WO (1) WO1999003879A1 (el)
ZA (1) ZA986358B (el)

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US20010009901A1 (en) 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
AU2001227375A1 (en) * 2000-02-08 2001-08-20 Herbert T. Nagasawa N-terminal d(-)-penicillamine peptides as aldehyde sequestration agents
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
JP5042444B2 (ja) * 2002-03-22 2012-10-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 癌の処置におけるヘミアスタリン誘導体およびその利用法
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
PT1545613E (pt) * 2002-07-31 2011-09-27 Seattle Genetics Inc Conjugados de auristatina e sua utilização para tratamento do cancro, de uma doença autoimune ou de uma doença infecciosa
SG10201701737XA (en) 2003-11-06 2017-04-27 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
WO2006063135A2 (en) * 2004-12-09 2006-06-15 Eisai R & D Management Co., Ltd. Tubulin isotype screnning in cancer therapy using hemiasterlin analogs
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
EP2024362A4 (en) 2006-05-16 2012-01-25 Pharmascience Inc IAP BIR DOMAIN BINDING COMPOUNDS
SG183023A1 (en) 2007-07-16 2012-08-30 Genentech Inc Anti-cd79b antibodies and immunoconjugates and methods of use
RU2557319C2 (ru) 2007-07-16 2015-07-20 Дженентек, Инк. ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА ПРОТИВ CD79b И ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ПРИМЕНЕНИЯ
DE102007039706A1 (de) 2007-08-22 2009-02-26 Erhard Prof. Dr.-Ing. Kohn Chemischer Sensor auf Diamantschichten
WO2009099728A1 (en) 2008-01-31 2009-08-13 Genentech, Inc. Anti-cd79b antibodies and immunoconjugates and methods of use
NZ600608A (en) * 2009-12-18 2015-01-30 Idenix Pharmaceuticals Inc 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors
MX341687B (es) 2010-02-10 2016-08-30 Immunogen Inc "anticuerpos cd20 y su utilización".
US9284350B2 (en) 2010-02-12 2016-03-15 Pharmascience Inc. IAP BIR domain binding compounds
CA2891280C (en) 2012-11-24 2018-03-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
PT3122757T (pt) 2014-02-28 2023-11-03 Hangzhou Dac Biotech Co Ltd Ligantes carregados e as suas utilizações em conjugação
AU2015320678B2 (en) 2014-09-23 2021-07-22 Genentech, Inc. Method of using anti-CD79b immunoconjugates
EP3319936A4 (en) 2015-07-12 2019-02-06 Suzhou M-conj Biotech Co., Ltd. PLACES OF CONDUCT FOR THE CONJUGATION OF CELL BINDING MOLECULES
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
JP7138350B2 (ja) 2016-11-14 2022-09-16 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． 共役連結体、該連結体を含有する細胞結合分子－薬物共役体、並びに該共役体及び連結体の使用及び製造方法
JPWO2023033129A1 (el) 2021-09-03 2023-03-09

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US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
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Also Published As

Publication number Publication date
NZ502296A (en) 2002-02-01
EP0991658A1 (en) 2000-04-12
BG65212B1 (bg) 2007-07-31
WO1999003879A1 (en) 1999-01-28
SK286581B6 (sk) 2009-01-07
KR100579748B1 (ko) 2006-05-15
US7084110B2 (en) 2006-08-01
CN1264388A (zh) 2000-08-23
US7662786B2 (en) 2010-02-16
JP2012211164A (ja) 2012-11-01
JP4508413B2 (ja) 2010-07-21
JP2001515010A (ja) 2001-09-18
TR200000132T2 (tr) 2000-05-22
NO20000231L (no) 2000-01-17
US20130046077A1 (en) 2013-02-21
BG104089A (en) 2000-12-29
IL133784A (en) 2005-09-25
PL197884B1 (pl) 2008-05-30
US20030153505A1 (en) 2003-08-14
HRP980397A2 (en) 1999-04-30
HK1029125A1 (en) 2001-03-23
AU8475898A (en) 1999-02-10
US6458765B1 (en) 2002-10-01
IL133784A0 (en) 2001-04-30
CA2296036A1 (en) 1999-01-28
ID24669A (id) 2000-07-27
CZ2000176A3 (en) 2001-06-13
TR200103545T2 (tr) 2002-06-21
US6143721A (en) 2000-11-07
SK187999A3 (en) 2000-09-12
TW533217B (en) 2003-05-21
ATE314387T1 (de) 2006-01-15
PT991658E (pt) 2006-05-31
BR9810911A (pt) 2000-08-01
PL338144A1 (en) 2000-09-25
DE69832982D1 (de) 2006-02-02
DK0991658T3 (da) 2006-05-15
AR018501A1 (es) 2001-11-28
ES2258819T3 (es) 2006-09-01
CZ303045B6 (cs) 2012-03-07
CN1268636C (zh) 2006-08-09
KR20010021998A (ko) 2001-03-15
US20100099843A1 (en) 2010-04-22
CO4990967A1 (es) 2000-12-26
US20060270606A1 (en) 2006-11-30
US8163698B2 (en) 2012-04-24
MY135057A (en) 2008-01-31
ZA986358B (en) 2000-01-17
RU2195462C2 (ru) 2002-12-27
HUP0004234A3 (en) 2001-08-28
NO326827B1 (no) 2009-02-23
JP5047935B2 (ja) 2012-10-10
HU228996B1 (hu) 2013-07-29
AU750120B2 (en) 2002-07-11
CA2296036C (en) 2007-05-01
NO20000231D0 (no) 2000-01-17
HUP0004234A2 (hu) 2001-05-28
JP2009137968A (ja) 2009-06-25
DE69832982T2 (de) 2006-08-24
EP0991658B1 (en) 2005-12-28
JP2009137967A (ja) 2009-06-25
JP5122429B2 (ja) 2013-01-16

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