TR200103545T2 - Dolastatin 15-türevleri. - Google Patents

Dolastatin 15-türevleri.

Info

Publication number
TR200103545T2
TR200103545T2 TR2001/03545T TR200103545T TR200103545T2 TR 200103545 T2 TR200103545 T2 TR 200103545T2 TR 2001/03545 T TR2001/03545 T TR 2001/03545T TR 200103545 T TR200103545 T TR 200103545T TR 200103545 T2 TR200103545 T2 TR 200103545T2
Authority
TR
Turkey
Prior art keywords
group
monovalent
mammal
amino
formula
Prior art date
Application number
TR2001/03545T
Other languages
English (en)
Inventor
Janssen Bernd
Barlozzari Teresa
Haupt Andreas
Zierke Thomas
Kling Andreas
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of TR200103545T2 publication Critical patent/TR200103545T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Mevcut bulusun bilesikleri Formül (1): A-B-D-E-F--(G)r-(Ks)-L'nin peptitleri olan hücre büyüme inhibitörleri ve bunlarin asit tuzlarini içerir. Burada A, B, D, E, F, G ve K alfa-amino asit tortularidir ve s ve r' nin her biri ise bagimsiz olarak 0 veya 1' dir. L ise bir amino grup, bir N' nin yerini tutan amino grup, bir beta-hidroksilamino grup, bir hidrozido grup, bir alkoksi grup, bir thioalkoksi grup, bir aminoksi grup veya bir oksimato grup gibi monovalent (tek degerlikli) bir radikaldir. Bu bulus ayni zamanda farmasötik olarak kabul edilebilen bir kompozisyondaki Formül (I)' in bir bilesiginin etkili bir miktarini insan gibi bir memeli hayvana tatbik etmekten olusan ve bir memeli hayvandaki kanser tedavisinde kullanilan bir metodu da ihtiva eder.
TR2001/03545T 1997-07-18 1998-07-07 Dolastatin 15-türevleri. TR200103545T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/896,394 US6143721A (en) 1997-07-18 1997-07-18 Dolastatin 15 derivatives

Publications (1)

Publication Number Publication Date
TR200103545T2 true TR200103545T2 (tr) 2002-06-21

Family

ID=25406130

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2000/00132T TR200000132T2 (tr) 1997-07-18 1998-07-07 Dolastatin 15 türevleri
TR2001/03545T TR200103545T2 (tr) 1997-07-18 1998-07-07 Dolastatin 15-türevleri.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2000/00132T TR200000132T2 (tr) 1997-07-18 1998-07-07 Dolastatin 15 türevleri

Country Status (33)

Country Link
US (6) US6143721A (tr)
EP (1) EP0991658B1 (tr)
JP (4) JP4508413B2 (tr)
KR (1) KR100579748B1 (tr)
CN (1) CN1268636C (tr)
AR (1) AR018501A1 (tr)
AT (1) ATE314387T1 (tr)
AU (1) AU750120B2 (tr)
BG (1) BG65212B1 (tr)
BR (1) BR9810911A (tr)
CA (1) CA2296036C (tr)
CO (1) CO4990967A1 (tr)
CY (1) CY1107047T1 (tr)
CZ (1) CZ303045B6 (tr)
DE (1) DE69832982T2 (tr)
DK (1) DK0991658T3 (tr)
ES (1) ES2258819T3 (tr)
HK (1) HK1029125A1 (tr)
HR (1) HRP980397A2 (tr)
HU (1) HU228996B1 (tr)
ID (1) ID24669A (tr)
IL (1) IL133784A (tr)
MY (1) MY135057A (tr)
NO (1) NO326827B1 (tr)
NZ (1) NZ502296A (tr)
PL (1) PL197884B1 (tr)
PT (1) PT991658E (tr)
RU (1) RU2195462C2 (tr)
SK (1) SK286581B6 (tr)
TR (2) TR200000132T2 (tr)
TW (1) TW533217B (tr)
WO (1) WO1999003879A1 (tr)
ZA (1) ZA986358B (tr)

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US20010009901A1 (en) 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6686336B2 (en) 2000-02-08 2004-02-03 Federal Government As Represented By The Department Of Veterans Affaires N-terminal D(-)-penicillamine peptides as aldehyde sequestration agents
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
CN1633289A (zh) 2002-03-22 2005-06-29 卫材株式会社 半星芒体衍生物及其用途
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
AU2003263964C1 (en) 2002-07-31 2010-08-19 Seagen Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
SI1725249T1 (sl) 2003-11-06 2014-04-30 Seattle Genetics, Inc. Spojine monometilvalina, sposobne konjugacije na ligande
JP2008522624A (ja) * 2004-12-09 2008-07-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘミアスタリン（ｈｅｍｉａｓｔｅｒｌｉｎ）アナログを使用する癌治療におけるチューブリンのアイソタイプのスクリーニング
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics Inc composto de ligação de domìnio bir da iap
DK2474557T3 (da) 2007-07-16 2014-11-10 Genentech Inc Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse
WO2009012256A1 (en) 2007-07-16 2009-01-22 Genentech, Inc. Humanized anti-cd79b antibodies and immunoconjugates and methods of use
DE102007039706A1 (de) 2007-08-22 2009-02-26 Erhard Prof. Dr.-Ing. Kohn Chemischer Sensor auf Diamantschichten
DK2657253T3 (en) 2008-01-31 2017-10-09 Genentech Inc Anti-CD79b antibodies and immune conjugates and methods of use
RU2554087C2 (ru) * 2009-12-18 2015-06-27 Айденикс Фармасьютикалз, Инк. 5,5-конденсированные ариленовые или гетероариленовые ингибиторы вируса гепатита с
TW201129384A (en) 2010-02-10 2011-09-01 Immunogen Inc CD20 antibodies and uses thereof
SG182724A1 (en) 2010-02-12 2012-08-30 Pharmascience Inc Iap bir domain binding compounds
AU2012395148B2 (en) 2012-11-24 2016-10-27 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
ES2960619T3 (es) 2014-02-28 2024-03-05 Hangzhou Dac Biotech Co Ltd Enlazadores cargados y sus usos para la conjugación
PT3262071T (pt) 2014-09-23 2020-06-16 H Hoffnabb La Roche Ag Métodos de utilização de imunoconjugados anti-cd79b
NZ739830A (en) 2015-07-12 2021-12-24 Hangzhou Dac Biotech Co Ltd Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US20210308277A1 (en) 2016-11-14 2021-10-07 Hangzhou Dac Biotech Co., Ltd. Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers
CA3230737A1 (en) 2021-09-03 2023-03-09 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
DE69230824T2 (de) * 1991-08-09 2000-07-27 Teikoku Hormone Mfg Co Ltd Neue tetrapeptidderivate
US5448045A (en) * 1992-02-26 1995-09-05 Clark; Paul C. System for protecting computers via intelligent tokens or smart cards
US5533097A (en) * 1992-02-26 1996-07-02 Motorola, Inc. Portable communication system comprising a local and wide area communication units which can store a communication when the wide area communication system is not available
HUT71398A (en) * 1992-05-20 1995-11-28 Basf Ag Derivatives of dolastatin
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
DE69329425T2 (de) * 1992-12-16 2001-01-18 Basf Ag Dolastatin analog
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US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5618232A (en) * 1995-03-23 1997-04-08 Martin; John R. Dual mode gaming device methods and systems
US5970143A (en) * 1995-11-22 1999-10-19 Walker Asset Management Lp Remote-auditing of computer generated outcomes, authenticated billing and access control, and software metering system using cryptographic and other protocols
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
CA2287379C (en) * 1997-01-10 2005-10-04 Silicon Gaming-Nevada Method and apparatus for providing authenticated, secure on-line communication between remote locations
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6554705B1 (en) * 1997-08-22 2003-04-29 Blake Cumbers Passive biometric customer identification and tracking system
US6629591B1 (en) * 2001-01-12 2003-10-07 Igt Smart token
US6438382B1 (en) * 2001-02-14 2002-08-20 Telefonaktiebolaget Lm Ericsson (Publ.) Expedited location determination in analog service areas

Also Published As

Publication number Publication date
JP2001515010A (ja) 2001-09-18
TR200000132T2 (tr) 2000-05-22
PT991658E (pt) 2006-05-31
AR018501A1 (es) 2001-11-28
KR20010021998A (ko) 2001-03-15
NZ502296A (en) 2002-02-01
US8163698B2 (en) 2012-04-24
AU8475898A (en) 1999-02-10
US20030153505A1 (en) 2003-08-14
CZ2000176A3 (en) 2001-06-13
JP5122429B2 (ja) 2013-01-16
EP0991658A1 (en) 2000-04-12
ID24669A (id) 2000-07-27
CN1264388A (zh) 2000-08-23
WO1999003879A1 (en) 1999-01-28
JP5047935B2 (ja) 2012-10-10
CA2296036C (en) 2007-05-01
HUP0004234A3 (en) 2001-08-28
AU750120B2 (en) 2002-07-11
ATE314387T1 (de) 2006-01-15
JP2009137968A (ja) 2009-06-25
CY1107047T1 (el) 2012-09-26
SK286581B6 (sk) 2009-01-07
US20100099843A1 (en) 2010-04-22
HRP980397A2 (en) 1999-04-30
TW533217B (en) 2003-05-21
ZA986358B (en) 2000-01-17
NO20000231L (no) 2000-01-17
CO4990967A1 (es) 2000-12-26
KR100579748B1 (ko) 2006-05-15
ES2258819T3 (es) 2006-09-01
IL133784A0 (en) 2001-04-30
US20060270606A1 (en) 2006-11-30
US7662786B2 (en) 2010-02-16
JP2012211164A (ja) 2012-11-01
HK1029125A1 (en) 2001-03-23
BR9810911A (pt) 2000-08-01
DE69832982D1 (de) 2006-02-02
US6143721A (en) 2000-11-07
IL133784A (en) 2005-09-25
US7084110B2 (en) 2006-08-01
DK0991658T3 (da) 2006-05-15
RU2195462C2 (ru) 2002-12-27
PL338144A1 (en) 2000-09-25
JP4508413B2 (ja) 2010-07-21
HU228996B1 (hu) 2013-07-29
CA2296036A1 (en) 1999-01-28
US20130046077A1 (en) 2013-02-21
DE69832982T2 (de) 2006-08-24
HUP0004234A2 (hu) 2001-05-28
EP0991658B1 (en) 2005-12-28
SK187999A3 (en) 2000-09-12
MY135057A (en) 2008-01-31
US6458765B1 (en) 2002-10-01
PL197884B1 (pl) 2008-05-30
JP2009137967A (ja) 2009-06-25
CZ303045B6 (cs) 2012-03-07
BG104089A (en) 2000-12-29
CN1268636C (zh) 2006-08-09
BG65212B1 (bg) 2007-07-31
NO326827B1 (no) 2009-02-23
NO20000231D0 (no) 2000-01-17

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