CN1247588C - 腺苷A2a受体拮抗剂 - Google Patents

腺苷A2a受体拮抗剂 Download PDF

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Publication number
CN1247588C
CN1247588C CNB018134491A CN01813449A CN1247588C CN 1247588 C CN1247588 C CN 1247588C CN B018134491 A CNB018134491 A CN B018134491A CN 01813449 A CN01813449 A CN 01813449A CN 1247588 C CN1247588 C CN 1247588C
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China
Prior art keywords
alkyl
alkoxy
mmol
compound
phenyl
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Expired - Lifetime
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CNB018134491A
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Chinese (zh)
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CN1451007A (zh
Inventor
B·R·纽斯塔德特
N·A·林多
W·J·格林李
D·图尔施安
L·S·西尔弗曼
夏岩
C·D·博伊尔
S·查卡拉曼尼尔
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNB018134491A 2000-05-26 2001-05-24 腺苷A2a受体拮抗剂 Expired - Lifetime CN1247588C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20714300P 2000-05-26 2000-05-26
US60/207,143 2000-05-26

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB2006100049297A Division CN100384847C (zh) 2000-05-26 2001-05-24 腺苷A2a受体拮抗剂

Publications (2)

Publication Number Publication Date
CN1451007A CN1451007A (zh) 2003-10-22
CN1247588C true CN1247588C (zh) 2006-03-29

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CNB2006100049297A Expired - Lifetime CN100384847C (zh) 2000-05-26 2001-05-24 腺苷A2a受体拮抗剂
CNB018134491A Expired - Lifetime CN1247588C (zh) 2000-05-26 2001-05-24 腺苷A2a受体拮抗剂

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CNB2006100049297A Expired - Lifetime CN100384847C (zh) 2000-05-26 2001-05-24 腺苷A2a受体拮抗剂

Country Status (31)

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US (4) US6630475B2 (OSRAM)
EP (1) EP1283839B1 (OSRAM)
JP (3) JP4574112B2 (OSRAM)
KR (1) KR100520907B1 (OSRAM)
CN (2) CN100384847C (OSRAM)
AR (1) AR028621A1 (OSRAM)
AT (1) ATE293627T1 (OSRAM)
AU (2) AU2001268089C1 (OSRAM)
BR (1) BRPI0111015B8 (OSRAM)
CA (1) CA2410237C (OSRAM)
CZ (1) CZ303790B6 (OSRAM)
DE (1) DE60110219T2 (OSRAM)
DK (1) DK1283839T3 (OSRAM)
EC (1) ECSP024364A (OSRAM)
ES (1) ES2237576T3 (OSRAM)
HK (1) HK1049007B (OSRAM)
HU (1) HU230420B1 (OSRAM)
IL (3) IL152726A0 (OSRAM)
MX (1) MXPA02011625A (OSRAM)
MY (1) MY132006A (OSRAM)
NO (1) NO325008B1 (OSRAM)
NZ (1) NZ522326A (OSRAM)
PE (1) PE20020062A1 (OSRAM)
PL (1) PL218764B1 (OSRAM)
PT (1) PT1283839E (OSRAM)
RU (1) RU2315053C2 (OSRAM)
SI (1) SI1283839T1 (OSRAM)
SK (1) SK287748B6 (OSRAM)
TW (1) TWI288137B (OSRAM)
WO (1) WO2001092264A1 (OSRAM)
ZA (1) ZA200208898B (OSRAM)

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CN112608330B (zh) 2019-07-30 2021-09-28 杭州阿诺生物医药科技有限公司 A2a和/或a2b受体抑制剂
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