CN1240374C - 快速崩解的甲基纤维素片剂 - Google Patents
快速崩解的甲基纤维素片剂 Download PDFInfo
- Publication number
- CN1240374C CN1240374C CNB988102935A CN98810293A CN1240374C CN 1240374 C CN1240374 C CN 1240374C CN B988102935 A CNB988102935 A CN B988102935A CN 98810293 A CN98810293 A CN 98810293A CN 1240374 C CN1240374 C CN 1240374C
- Authority
- CN
- China
- Prior art keywords
- tablet
- methylcellulose
- starch
- grain
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229920000609 methyl cellulose Polymers 0.000 title claims abstract description 91
- 239000001923 methylcellulose Substances 0.000 title claims abstract description 90
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims description 88
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 76
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 54
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 54
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 54
- 239000000203 mixture Substances 0.000 claims description 45
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 45
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 45
- 235000019359 magnesium stearate Nutrition 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 35
- 229920002472 Starch Polymers 0.000 claims description 34
- 239000008187 granular material Substances 0.000 claims description 34
- 229940032147 starch Drugs 0.000 claims description 34
- 239000008107 starch Substances 0.000 claims description 34
- 235000019698 starch Nutrition 0.000 claims description 34
- 239000003085 diluting agent Substances 0.000 claims description 33
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 31
- 238000002360 preparation method Methods 0.000 claims description 31
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 30
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 30
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 30
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 30
- 229920002261 Corn starch Polymers 0.000 claims description 29
- 239000008120 corn starch Substances 0.000 claims description 29
- 239000003795 chemical substances by application Substances 0.000 claims description 24
- 229940080313 sodium starch Drugs 0.000 claims description 23
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 18
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims description 18
- 239000000080 wetting agent Substances 0.000 claims description 14
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 11
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 11
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 11
- 229920003084 Avicel® PH-102 Polymers 0.000 claims description 10
- 239000000314 lubricant Substances 0.000 claims description 10
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 241000416162 Astragalus gummifer Species 0.000 claims description 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 7
- 229920001615 Tragacanth Polymers 0.000 claims description 7
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 7
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 7
- 235000010487 tragacanth Nutrition 0.000 claims description 7
- 239000000196 tragacanth Substances 0.000 claims description 7
- 229940116362 tragacanth Drugs 0.000 claims description 7
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 6
- 229920001817 Agar Polymers 0.000 claims description 6
- 229920002907 Guar gum Polymers 0.000 claims description 6
- 229920000161 Locust bean gum Polymers 0.000 claims description 6
- 239000008272 agar Substances 0.000 claims description 6
- 235000010419 agar Nutrition 0.000 claims description 6
- 229940023476 agar Drugs 0.000 claims description 6
- 229940072056 alginate Drugs 0.000 claims description 6
- 235000010443 alginic acid Nutrition 0.000 claims description 6
- 229920000615 alginic acid Polymers 0.000 claims description 6
- HZVVJJIYJKGMFL-UHFFFAOYSA-N almasilate Chemical compound O.[Mg+2].[Al+3].[Al+3].O[Si](O)=O.O[Si](O)=O HZVVJJIYJKGMFL-UHFFFAOYSA-N 0.000 claims description 6
- 235000010417 guar gum Nutrition 0.000 claims description 6
- 239000000665 guar gum Substances 0.000 claims description 6
- 229960002154 guar gum Drugs 0.000 claims description 6
- 235000010420 locust bean gum Nutrition 0.000 claims description 6
- 239000000711 locust bean gum Substances 0.000 claims description 6
- 235000010987 pectin Nutrition 0.000 claims description 6
- 239000001814 pectin Substances 0.000 claims description 6
- 229920001277 pectin Polymers 0.000 claims description 6
- -1 Syloid Chemical compound 0.000 claims description 5
- 206010010774 Constipation Diseases 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 239000011230 binding agent Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000007916 tablet composition Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 235000021355 Stearic acid Nutrition 0.000 claims description 3
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 3
- 239000008116 calcium stearate Substances 0.000 claims description 3
- 235000013539 calcium stearate Nutrition 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 claims description 3
- 239000008117 stearic acid Substances 0.000 claims description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 229960000913 crospovidone Drugs 0.000 claims 5
- 238000004132 cross linking Methods 0.000 claims 5
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 5
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 5
- 239000004605 External Lubricant Substances 0.000 claims 3
- 229960002900 methylcellulose Drugs 0.000 claims 1
- 239000007898 rapid-disintegration tablet Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 41
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract description 24
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920003108 Methocel™ A4M Polymers 0.000 description 16
- 239000003086 colorant Substances 0.000 description 14
- 239000008367 deionised water Substances 0.000 description 14
- 229910021641 deionized water Inorganic materials 0.000 description 14
- 229920003086 cellulose ether Polymers 0.000 description 12
- 239000000975 dye Substances 0.000 description 12
- 235000000346 sugar Nutrition 0.000 description 12
- 239000000843 powder Substances 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- 239000011248 coating agent Substances 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 239000008141 laxative Substances 0.000 description 7
- 230000002475 laxative effect Effects 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 210000003608 fece Anatomy 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 229940099112 cornstarch Drugs 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007968 orange flavor Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 241001550224 Apha Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940081970 citrucel Drugs 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000009478 high shear granulation Methods 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5689997P | 1997-08-22 | 1997-08-22 | |
| US60/056,899 | 1997-08-22 | ||
| US60/056899 | 1997-08-22 | ||
| US8164498P | 1998-04-14 | 1998-04-14 | |
| US60/081,644 | 1998-04-14 | ||
| US60/081644 | 1998-04-14 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510113769 Division CN1762335A (zh) | 1997-08-22 | 1998-08-21 | 快速崩解的甲基纤维素片剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1276718A CN1276718A (zh) | 2000-12-13 |
| CN1240374C true CN1240374C (zh) | 2006-02-08 |
Family
ID=26735830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB988102935A Expired - Fee Related CN1240374C (zh) | 1997-08-22 | 1998-08-21 | 快速崩解的甲基纤维素片剂 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6372253B1 (es) |
| EP (1) | EP1014949A4 (es) |
| JP (1) | JP2001513546A (es) |
| KR (1) | KR20010023198A (es) |
| CN (1) | CN1240374C (es) |
| AR (3) | AR016827A1 (es) |
| AU (1) | AU745682B2 (es) |
| BR (1) | BR9811987A (es) |
| CA (1) | CA2301132C (es) |
| CO (1) | CO4960646A1 (es) |
| EA (1) | EA003663B1 (es) |
| HU (1) | HUP0003186A3 (es) |
| MY (1) | MY137768A (es) |
| NZ (1) | NZ502890A (es) |
| PL (1) | PL338786A1 (es) |
| TW (1) | TWI228421B (es) |
| UA (1) | UA70926C2 (es) |
| WO (1) | WO1999009959A1 (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| AR016827A1 (es) * | 1997-08-22 | 2001-08-01 | Smithkline Beecham Corp | PROCEDIMIENTO PARA LA PREPARACIoN DE UNA TABLETA FARMACÉUTICA |
| AR017512A1 (es) * | 1997-08-22 | 2001-09-12 | Smithkline Beecham Corp | Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas |
| US6348264B1 (en) | 1998-04-27 | 2002-02-19 | Roquette Freres | Process for producing low de starch hydrolysates by nanofiltration fractionation, products obtained thereby, and use of such products |
| WO2000013667A1 (en) | 1998-09-08 | 2000-03-16 | Smithkline Beecham Corporation | Lipstatin derivative-soluble fiber tablets |
| ES2197064T3 (es) * | 2000-10-24 | 2004-01-01 | Fit Gmbh | Granulado de agentes de desintegracion conjuntamente elaborados. |
| CN100509058C (zh) * | 2001-01-26 | 2009-07-08 | 先灵公司 | 过氧化物酶体增殖物激活受体(ppar)活化剂和甾醇吸收抑制剂的组合药以及对于血管适应症的治疗 |
| US9358214B2 (en) * | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| EP1574215B1 (en) | 2002-12-16 | 2015-07-15 | Kissei Pharmaceutical Co., Ltd. | Solid drug for oral use |
| US8367111B2 (en) * | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
| US20050019397A1 (en) * | 2003-07-23 | 2005-01-27 | Jacobs Richard L. | Cellulosic fiber containing composition |
| US7198653B2 (en) | 2003-07-31 | 2007-04-03 | Delavau Llc | Calcium carbonate granulation |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| KR20060126688A (ko) * | 2003-12-09 | 2006-12-08 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 약물-함유 입자 및 그 입자를 함유하는 고형 제제 |
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1998
- 1998-08-18 AR ARP980104077A patent/AR016827A1/es unknown
- 1998-08-19 CO CO98047415A patent/CO4960646A1/es unknown
- 1998-08-20 MY MYPI98003810A patent/MY137768A/en unknown
- 1998-08-21 UA UA2000020918A patent/UA70926C2/uk unknown
- 1998-08-21 BR BR9811987-7A patent/BR9811987A/pt not_active Application Discontinuation
- 1998-08-21 KR KR1020007001826A patent/KR20010023198A/ko not_active IP Right Cessation
- 1998-08-21 AU AU91146/98A patent/AU745682B2/en not_active Ceased
- 1998-08-21 US US09/485,625 patent/US6372253B1/en not_active Expired - Lifetime
- 1998-08-21 WO PCT/US1998/017440 patent/WO1999009959A1/en not_active Application Discontinuation
- 1998-08-21 EP EP98943322A patent/EP1014949A4/en not_active Withdrawn
- 1998-08-21 PL PL98338786A patent/PL338786A1/xx not_active Application Discontinuation
- 1998-08-21 NZ NZ502890A patent/NZ502890A/en unknown
- 1998-08-21 JP JP2000507350A patent/JP2001513546A/ja active Pending
- 1998-08-21 CN CNB988102935A patent/CN1240374C/zh not_active Expired - Fee Related
- 1998-08-21 EA EA200000245A patent/EA003663B1/ru not_active IP Right Cessation
- 1998-08-21 HU HU0003186A patent/HUP0003186A3/hu unknown
- 1998-08-21 TW TW087113822A patent/TWI228421B/zh not_active IP Right Cessation
- 1998-08-21 CA CA002301132A patent/CA2301132C/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| CN1276718A (zh) | 2000-12-13 |
| WO1999009959A1 (en) | 1999-03-04 |
| JP2001513546A (ja) | 2001-09-04 |
| EA200000245A1 (ru) | 2000-08-28 |
| HUP0003186A3 (en) | 2001-04-28 |
| TWI228421B (en) | 2005-03-01 |
| US20030049315A1 (en) | 2003-03-13 |
| AR016827A1 (es) | 2001-08-01 |
| KR20010023198A (ko) | 2001-03-26 |
| CA2301132A1 (en) | 1999-03-04 |
| AU745682B2 (en) | 2002-03-28 |
| EP1014949A1 (en) | 2000-07-05 |
| US7132114B2 (en) | 2006-11-07 |
| AU9114698A (en) | 1999-03-16 |
| EA003663B1 (ru) | 2003-08-28 |
| MY137768A (en) | 2009-03-31 |
| HUP0003186A2 (hu) | 2001-02-28 |
| CO4960646A1 (es) | 2000-09-25 |
| UA70926C2 (uk) | 2004-11-15 |
| AR049057A2 (es) | 2006-06-21 |
| US6372253B1 (en) | 2002-04-16 |
| BR9811987A (pt) | 2000-09-05 |
| NZ502890A (en) | 2002-03-01 |
| EP1014949A4 (en) | 2006-06-21 |
| AR049055A2 (es) | 2006-06-21 |
| CA2301132C (en) | 2007-11-13 |
| PL338786A1 (en) | 2000-11-20 |
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