CN1192733A - 制备放射性药物的稳定试剂 - Google Patents

制备放射性药物的稳定试剂 Download PDF

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Publication number
CN1192733A
CN1192733A CN96196141A CN96196141A CN1192733A CN 1192733 A CN1192733 A CN 1192733A CN 96196141 A CN96196141 A CN 96196141A CN 96196141 A CN96196141 A CN 96196141A CN 1192733 A CN1192733 A CN 1192733A
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China
Prior art keywords
replaces
independently
group
alkyl
hydrogen
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Pending
Application number
CN96196141A
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English (en)
Chinese (zh)
Inventor
M·斯沃林
M·拉乔帕耶
T·D·哈尔里斯
D·S·爱德华
E·H·赤斯曼
刘爽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
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DuPont Merck Pharmaceutical Co
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Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of CN1192733A publication Critical patent/CN1192733A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN96196141A 1995-06-07 1996-06-07 制备放射性药物的稳定试剂 Pending CN1192733A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/476,296 US5750088A (en) 1993-03-30 1995-06-07 Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US08/476,296 1995-06-07

Publications (1)

Publication Number Publication Date
CN1192733A true CN1192733A (zh) 1998-09-09

Family

ID=23891282

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96196141A Pending CN1192733A (zh) 1995-06-07 1996-06-07 制备放射性药物的稳定试剂

Country Status (29)

Country Link
US (2) US5750088A (enExample)
EP (1) EP0832068B1 (enExample)
JP (1) JPH11507364A (enExample)
KR (1) KR19990022573A (enExample)
CN (1) CN1192733A (enExample)
AR (1) AR003959A1 (enExample)
AT (1) ATE233241T1 (enExample)
AU (1) AU718683B2 (enExample)
BR (1) BR9609003A (enExample)
CA (1) CA2222183A1 (enExample)
CZ (1) CZ380197A3 (enExample)
DE (1) DE69626392T2 (enExample)
EA (1) EA000742B1 (enExample)
EE (1) EE9700313A (enExample)
ES (1) ES2193245T3 (enExample)
HR (1) HRP960250A2 (enExample)
HU (1) HUP9901469A3 (enExample)
IL (1) IL118468A0 (enExample)
LT (1) LT4380B (enExample)
LV (1) LV12044B (enExample)
MX (1) MX9709126A (enExample)
MY (1) MY133974A (enExample)
NO (1) NO975678L (enExample)
NZ (1) NZ310799A (enExample)
PL (1) PL323995A1 (enExample)
SI (1) SI9620076B (enExample)
SK (1) SK163497A3 (enExample)
WO (1) WO1996040637A1 (enExample)
ZA (1) ZA964854B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112999369A (zh) * 2021-03-03 2021-06-22 江苏元本生物科技有限公司 一种her2亲合体放射性核素标记物组合物及其应用

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112999369A (zh) * 2021-03-03 2021-06-22 江苏元本生物科技有限公司 一种her2亲合体放射性核素标记物组合物及其应用

Also Published As

Publication number Publication date
EA199800025A1 (ru) 1998-06-25
LV12044A (lv) 1998-05-20
DE69626392D1 (de) 2003-04-03
LV12044B (en) 1998-09-20
EE9700313A (et) 1998-06-15
NO975678D0 (no) 1997-12-05
NZ310799A (en) 2000-01-28
PL323995A1 (en) 1998-04-27
AU718683B2 (en) 2000-04-20
LT4380B (lt) 1998-09-25
AR003959A1 (es) 1998-09-30
AU6166196A (en) 1996-12-30
IL118468A0 (en) 1996-09-12
ES2193245T3 (es) 2003-11-01
EP0832068B1 (en) 2003-02-26
MY133974A (en) 2007-11-30
HRP960250A2 (en) 1997-12-31
WO1996040637A1 (en) 1996-12-19
HUP9901469A3 (en) 2000-02-28
DE69626392T2 (de) 2004-04-22
US5750088A (en) 1998-05-12
NO975678L (no) 1998-02-06
EP0832068A1 (en) 1998-04-01
EA000742B1 (ru) 2000-02-28
MX9709126A (es) 1998-03-31
SI9620076B (sl) 2000-02-29
CA2222183A1 (en) 1996-12-19
LT97191A (en) 1998-04-27
US6015904A (en) 2000-01-18
SK163497A3 (en) 1998-10-07
CZ380197A3 (cs) 1998-07-15
ATE233241T1 (de) 2003-03-15
ZA964854B (en) 1997-12-08
KR19990022573A (ko) 1999-03-25
BR9609003A (pt) 1999-12-14
HUP9901469A2 (hu) 1999-08-30
SI9620076A (sl) 1998-08-31
JPH11507364A (ja) 1999-06-29

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