MXPA04001113A - Formacion de imagenes simultaneas de perfusion cardiaca y agente formador de imagenes dirigido al receptor de vitronectina. - Google Patents

Formacion de imagenes simultaneas de perfusion cardiaca y agente formador de imagenes dirigido al receptor de vitronectina.

Info

Publication number
MXPA04001113A
MXPA04001113A MXPA04001113A MXPA04001113A MXPA04001113A MX PA04001113 A MXPA04001113 A MX PA04001113A MX PA04001113 A MXPA04001113 A MX PA04001113A MX PA04001113 A MXPA04001113 A MX PA04001113A MX PA04001113 A MXPA04001113 A MX PA04001113A
Authority
MX
Mexico
Prior art keywords
imaging agent
vitronectin receptor
imaging
receptor targeted
cardiac perfusion
Prior art date
Application number
MXPA04001113A
Other languages
English (en)
Inventor
P Carpenter Alan Jr
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of MXPA04001113A publication Critical patent/MXPA04001113A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acoustics & Sound (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

La presente invencion describe un metodo de formacion de imagen concurrente, que comprende: a) administrar al mamifero un agente formador de imagenes dirigido con un receptor de vitronectina y un agente formador de imagenes de perfusion; y b) detectar concurrentemente el agente formador de imagenes dirigido con el receptor de vitronectina enlazado en el receptor de vitronectina y el agente formador de imagenes de perfusion; y c) formar una imagen de la deteccion del agente formador de imagenes dirigido con vitronectina y el agente formador de imagenes de perfusion.
MXPA04001113A 2001-08-08 2002-08-07 Formacion de imagenes simultaneas de perfusion cardiaca y agente formador de imagenes dirigido al receptor de vitronectina. MXPA04001113A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31085901P 2001-08-08 2001-08-08
PCT/US2002/025375 WO2003013346A2 (en) 2001-08-08 2002-08-07 Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent

Publications (1)

Publication Number Publication Date
MXPA04001113A true MXPA04001113A (es) 2004-07-08

Family

ID=23204402

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04001113A MXPA04001113A (es) 2001-08-08 2002-08-07 Formacion de imagenes simultaneas de perfusion cardiaca y agente formador de imagenes dirigido al receptor de vitronectina.

Country Status (10)

Country Link
US (1) US7138104B2 (es)
EP (1) EP1423152A4 (es)
JP (1) JP2004537573A (es)
CN (1) CN1298390C (es)
AU (1) AU2002331042B2 (es)
CA (1) CA2452478A1 (es)
HU (1) HUP0401904A3 (es)
MX (1) MXPA04001113A (es)
NO (1) NO20040555L (es)
WO (1) WO2003013346A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2427911A1 (en) * 2000-11-03 2002-05-10 Bristol Myers Squibb Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
JP2005506952A (ja) * 2000-11-27 2005-03-10 ブリストル−マイヤーズ・スクイブ・メディカル・イメージング・インコーポレイテッド 心臓潅流およびビトロネクチンレセプター標的造影剤の同時造影
US6838074B2 (en) * 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
EP1572639A4 (en) 2002-01-24 2006-08-09 Barnes Jewish Hospital IMAGING AGENTS TARGETING INTEGRINS
US6813333B2 (en) * 2002-11-27 2004-11-02 Ge Medical Systems Global Technology Company, Llc Methods and apparatus for detecting structural, perfusion, and functional abnormalities
FR2848750B1 (fr) * 2002-12-13 2007-02-09 Centre Nat Rech Scient Procede d'acquisition de signaux electromagnetiques et produit de contraste pour une telle acquisition
ATE449614T1 (de) * 2003-05-12 2009-12-15 Lantheus Medical Imaging Inc Vitronectin rezeptorantagonisten und ihre verwendung als radiopharmazeutika
WO2008059489A2 (en) 2006-11-13 2008-05-22 Spectrum Dynamics Llc Radioimaging applications of and novel formulations of teboroxime
US8926945B2 (en) 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
EP2721045B1 (en) * 2011-06-20 2017-04-12 Radiomedix Inc. Compositions, methods of synthesis and use of carbohydrate targeted agents
US10034614B2 (en) 2012-02-29 2018-07-31 General Electric Company Fractional flow reserve estimation
CN109907856A (zh) * 2017-12-13 2019-06-21 深圳先进技术研究院 超声装置及动物固定装置

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248802A (en) 1975-06-20 1981-02-03 Rhone-Poulenc Industries Catalytic hydroformylation of olefins
US4859777A (en) 1981-07-01 1989-08-22 Eastman Kodak Company Terpyridine chelating agents
US4452774A (en) 1982-04-30 1984-06-05 President And Fellows Of Harvard College Isonitrile radionuclide complexes for labelling and imaging agents
US4765971A (en) 1985-05-31 1988-08-23 Mallinckrodt, Inc. Technetium (Tc-99m)-arene complexes useful in myocardial imaging
DE3688613T2 (de) 1985-11-18 1994-01-13 Access Pharma Inc Polychelierende stoffe für abbildung- und spektralerhöhung (und spektrale verschiebung).
CA1305160C (en) 1985-12-23 1992-07-14 Paul Louis Bergstein Ether isonitriles and radiolabeled complexes thereof
US5252317A (en) 1986-11-10 1993-10-12 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for diagnosis and therapy derived from 3,5-bis[1-(3-amino-2,2-bis (aminomethyl)-propyl) oxymethyl] benzoic acid
US5567411A (en) 1986-11-10 1996-10-22 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group
US5064956A (en) 1987-06-24 1991-11-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
US5028699A (en) 1987-09-11 1991-07-02 E. I. Du Pont De Nemours And Company Process for preparing Tc-99m tris(isonitrile) copper complexes
US5087440A (en) 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
GB8923843D0 (en) 1989-10-23 1989-12-13 Salutar Inc Compounds
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5679810A (en) 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
WO1992017215A1 (en) 1990-03-28 1992-10-15 Nycomed Salutar, Inc. Contrast media
GB9006977D0 (en) 1990-03-28 1990-05-23 Nycomed As Compositions
US5382654A (en) 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
GB9209641D0 (en) 1992-05-02 1992-06-17 Johnson Matthey Plc Improvements in radiolabelling
US5650134A (en) 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
US5760191A (en) 1993-02-05 1998-06-02 Nycomed Imaging As Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods
US5750088A (en) 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5744120A (en) 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
US5417959A (en) 1993-10-04 1995-05-23 Mallinckrodt Medical, Inc. Functionalized aza-crytand ligands for diagnostic imaging applications
US5556939A (en) 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5520904A (en) 1995-01-27 1996-05-28 Mallinckrodt Medical, Inc. Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging
EP0727225A3 (en) 1995-02-14 1997-01-15 Sonus Pharma Inc Compositions and methods for directed ultrasonic imaging
US5801228A (en) 1995-06-07 1998-09-01 Nycomed Imaging As Polymeric contrast agents for medical imaging
ES2201284T3 (es) 1996-03-13 2004-03-16 Bristol-Myers Squibb Pharma Company Nuevos complejos radiofarmaceuticos ternarios.
US5879659A (en) 1996-03-13 1999-03-09 Dupont Pharmaceuticals Company Ternary radiopharmaceutical complexes
US5804161A (en) 1996-05-14 1998-09-08 Nycomed Salutar Inc. Contrast agents
EP0946202B1 (en) * 1996-10-28 2003-09-10 Amersham Health AS Contrast agents
JP2001527527A (ja) 1996-11-27 2001-12-25 デュポン ファーマシューティカルズ カンパニー 新規インテグリン受容体拮抗薬
US6026317A (en) 1998-02-06 2000-02-15 Baylor College Of Medicine Myocardial perfusion imaging during coronary vasodilation with selective adenosine A2 receptor agonists
US6524553B2 (en) * 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
WO1999049899A2 (en) * 1998-03-31 1999-10-07 Nycomed Imaging As Diagnostic imaging of vascular abnormalities using vasomodification
BR9909420A (pt) * 1998-03-31 2001-09-25 Du Pont Pharm Co Composto, kit, composição metalofarmacêutica de diagnóstico ou terapêutica, composição de agente de contraste de ultrassom, composição radiofarmacêutica terapêutica e composição radiofarmacêutica de diagnóstico
CN1356913A (zh) * 1998-12-18 2002-07-03 杜邦药品公司 玻连蛋白受体拮抗剂药物
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US6838074B2 (en) * 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent

Also Published As

Publication number Publication date
CN1541115A (zh) 2004-10-27
EP1423152A4 (en) 2006-12-27
WO2003013346A3 (en) 2003-08-14
CN1298390C (zh) 2007-02-07
CA2452478A1 (en) 2003-02-20
AU2002331042B2 (en) 2007-10-25
NO20040555L (no) 2004-03-23
EP1423152A2 (en) 2004-06-02
JP2004537573A (ja) 2004-12-16
US7138104B2 (en) 2006-11-21
US20030103898A1 (en) 2003-06-05
HUP0401904A2 (hu) 2004-12-28
HUP0401904A3 (en) 2009-01-28
WO2003013346A2 (en) 2003-02-20

Similar Documents

Publication Publication Date Title
WO2002055111A3 (en) Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
MXPA04001113A (es) Formacion de imagenes simultaneas de perfusion cardiaca y agente formador de imagenes dirigido al receptor de vitronectina.
SG152254A1 (en) Contrast agents for myocardial perfusion imaging
SG149895A1 (en) Contrast agents for myocardial perfusion imaging
ATE387142T1 (de) Multimodales abbildungssytem und -verfahren mit trennbaren detektoren
DK0907379T3 (da) Bioaktiveret diagnostisk billeddannelseskontrastmiddel
EP1713395A4 (en) ULTRASONIC IMAGING SYSTEM AND IMAGE FORMING METHODS USING THE SAME
EP1572639A4 (en) IMAGING AGENTS TARGETING INTEGRINS
DE602004022229D1 (de) Bildlesegerät und Bilderzeugungssystem mittels Röntgenstrahlen
EP1594404A4 (en) ULTRASONIC IMAGING DEVICE, SYSTEM AND METHOD FOR USING SAME
NO20052265D0 (no) Etylendicystein (EC)-medikament konjugater og fremgangsmater for vevsspesifik sykdomsbilleddannelse
WO2008075040A3 (en) Radioactive pet agents for imaging ccr5 in vivo
GB0326546D0 (en) Inhibitor imaging agents
MX2007003518A (es) Agentes formadores de imagenes de inhibidor de metaloproteinasa.
EP1501524A4 (en) INTERNAL IMAGE ANTIBODIES FOR OPTICAL PRESENTATION AND THERAPY
PT1237559E (pt) Combinacoes farmaceuticas compreendendo um antagonista do receptor p2t e megalatrano
IL153183A0 (en) Agents for imaging and diagnostic methods using them
EP1463526A4 (en) EARLY DETECTION OF MYCOBACTERIAL DISEASES USING PEPTIDES
BR0104345A (pt) Tratamento combinado para a depressão e ansiedade
EP1309346A4 (en) TREATMENT OF HIV-1 INFECTION AND INFLAMMATORY DISEASES USING CYCLOPHILINE RECEPTOR ANTAGONISTS
AU2003210266A8 (en) Treatment, diagnosis and imaging of disease
DK1548027T3 (da) Forbindelse, som bindes til leukocytter, og lægemiddel indeholdende forbindelsen i mærket tilstand som den aktive bestanddel
ITMI20011706A0 (it) Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l'indagine diagnostica combinata tramite raggi-x e risonanza magnetic
AU4418400A (en) Treatment, imaging and diagnosis of disease using an agent which binds alfa5-integrin
AU2003245589A8 (en) System and method for noninvasive diagnostic imaging

Legal Events

Date Code Title Description
FG Grant or registration