CN1138765C - 带有硫代羰基功能基的噁唑烷酮抗菌剂 - Google Patents
带有硫代羰基功能基的噁唑烷酮抗菌剂 Download PDFInfo
- Publication number
- CN1138765C CN1138765C CNB98805423XA CN98805423A CN1138765C CN 1138765 C CN1138765 C CN 1138765C CN B98805423X A CNB98805423X A CN B98805423XA CN 98805423 A CN98805423 A CN 98805423A CN 1138765 C CN1138765 C CN 1138765C
- Authority
- CN
- China
- Prior art keywords
- alkyl
- phenyl
- optionally substituted
- methyl
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4834297P | 1997-05-30 | 1997-05-30 | |
| US60/048,342 | 1997-05-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1257486A CN1257486A (zh) | 2000-06-21 |
| CN1138765C true CN1138765C (zh) | 2004-02-18 |
Family
ID=21954059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB98805423XA Expired - Fee Related CN1138765C (zh) | 1997-05-30 | 1998-05-18 | 带有硫代羰基功能基的噁唑烷酮抗菌剂 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6218413B1 (https=) |
| EP (1) | EP0984947B8 (https=) |
| JP (1) | JP2002501530A (https=) |
| KR (1) | KR20010013192A (https=) |
| CN (1) | CN1138765C (https=) |
| AT (1) | ATE293609T1 (https=) |
| AU (1) | AU737995B2 (https=) |
| BR (1) | BR9815518A (https=) |
| CA (1) | CA2288750A1 (https=) |
| DE (1) | DE69829846T2 (https=) |
| ES (1) | ES2242280T3 (https=) |
| FI (1) | FI19992555L (https=) |
| HU (1) | HUP0001393A3 (https=) |
| NO (1) | NO315798B1 (https=) |
| NZ (1) | NZ501412A (https=) |
| PL (1) | PL337329A1 (https=) |
| RU (1) | RU2208613C2 (https=) |
| SK (1) | SK156499A3 (https=) |
| WO (1) | WO1998054161A1 (https=) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2175324C2 (ru) * | 1995-09-01 | 2001-10-27 | Фармация Энд Апджон Компани | Фенилоксазолидиноны, имеющие с-с-связь с 4-8-членными гетероциклическими кольцами |
| US6069141A (en) * | 1998-02-13 | 2000-05-30 | Pharmacia & Upjohn Company | Substituted aminophenyl isoxazoline derivatives useful as antimicrobials |
| AU3180999A (en) * | 1998-02-25 | 1999-09-15 | Pharmacia & Upjohn Company | Substituted aminomethyl isoxazoline derivatives useful as antimicrobials |
| TR200003595T2 (tr) | 1998-06-05 | 2001-07-23 | Astrazeneca Ab | Kimyasal bileşikler |
| JP2000204084A (ja) * | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
| AU1045300A (en) * | 1998-11-17 | 2000-06-05 | Bayer Aktiengesellschaft | Novel heterocyclyl-substituted oxazolidone derivatives |
| WO2000029396A1 (de) * | 1998-11-17 | 2000-05-25 | Bayer Aktiengesellschaft | Neue substituierte phenyloxazolidon-derivate |
| AU764980B2 (en) * | 1998-11-27 | 2003-09-04 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| US6441005B1 (en) | 1999-07-28 | 2002-08-27 | Pharmacia & Upjohn Company | Oxazolidinone compounds and compositions, and methods of using the same |
| US6608081B2 (en) | 1999-08-12 | 2003-08-19 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| US6413981B1 (en) | 1999-08-12 | 2002-07-02 | Ortho-Mcneil Pharamceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| US6297242B1 (en) | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
| MY120189A (en) * | 1999-11-04 | 2005-09-30 | Upjohn Co | Sultam and sultone derived oxazolidinones |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| PE20010851A1 (es) * | 1999-12-14 | 2001-08-17 | Upjohn Co | Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina |
| US6518285B2 (en) | 1999-12-21 | 2003-02-11 | Ortho Mcneil Pharmaceutical, Inc. | Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials |
| HUP0203869A2 (hu) * | 1999-12-21 | 2003-07-28 | Pharmacia & Upjohn Co. | Szulfoximin funkcionalitással rendelkező oxazolidinok és alkalmazásuk mikrobaellenes szerként, a vegyületeket tartalmazó gyógyszerkészítmények |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| US6642238B2 (en) * | 2000-02-10 | 2003-11-04 | Pharmacia And Upjohn Company | Oxazolidinone thioamides with piperazine amide substituents |
| JP2003522763A (ja) * | 2000-02-10 | 2003-07-29 | ファルマシア・アンド・アップジョン・カンパニー | ピペラジンアミド置換基を持つオキサゾリジノンチオアミド |
| AU2001253113B2 (en) * | 2000-04-20 | 2005-02-03 | Pharmacia & Upjohn Company | Use of thioamide oxazolidinones for the treatment of bone resorption and osteoporosis |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| US6562820B2 (en) | 2000-07-05 | 2003-05-13 | Pharmacia & Upjohn Company | Method for treatment and prevention of mastitis |
| BR0112826A (pt) * | 2000-07-17 | 2003-06-24 | Ranbaxy Lab Ltd | Derivados da oxazolidinona como antimicrobianos |
| PE20020689A1 (es) * | 2000-11-17 | 2002-08-03 | Upjohn Co | Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno |
| US6951863B2 (en) | 2001-02-07 | 2005-10-04 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridoarylphenly oxazolidinone antibacterials, and related compositions and methods |
| ES2268011T3 (es) * | 2001-04-07 | 2007-03-16 | Astrazeneca Ab | Oxazolidinonas que contienen un grupo sulfonimida como antibioticos. |
| DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| MXPA05001199A (es) * | 2002-07-29 | 2005-05-16 | Ranbaxy Lab Ltd | Derivados de oxazolidinona como antimicrobianos. |
| ES2258234T3 (es) | 2002-08-12 | 2006-08-16 | PHARMACIA & UPJOHN COMPANY LLC | N-aril-2-oxazolidinonas y sus derivados. |
| US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| WO2004033449A1 (en) * | 2002-10-10 | 2004-04-22 | Pharmacia & Upjohn Company Llc | Antimicrobial 1-aryl dihydropyridone compounds |
| JP2006509035A (ja) | 2002-11-21 | 2006-03-16 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 抗菌剤としてのｎ−（４−（ピペラジン−１−イル）−フェニル−２−オキサゾリジノン−５−カルボキサミド誘導体および関連化合物 |
| GB0229521D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| DE10300111A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| BRPI0409217A (pt) | 2003-04-09 | 2006-03-28 | Pharmacia & Upjohn Co Llc | derivados e análogos antimicrobianos da [3.1.0]bicicloexilfeniloxazolidinona |
| JP5043428B2 (ja) | 2003-06-03 | 2012-10-10 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ビアリール複素環式化合物ならびにその製造および使用方法 |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| BRPI0413838A (pt) * | 2003-08-25 | 2006-10-24 | Warner Lambert Co | compostos de ariloxazolidinona antimicrobianos |
| US7687627B2 (en) * | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
| US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| AR046782A1 (es) * | 2003-12-17 | 2005-12-21 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos. |
| WO2005082900A2 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| EP1874782A1 (en) | 2005-04-15 | 2008-01-09 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| DE602006019870D1 (de) | 2005-06-08 | 2011-03-10 | Rib X Pharmaceuticals Inc | Verfahren zur synthese von triazolen |
| DE102005045518A1 (de) * | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| US8188270B2 (en) | 2005-10-04 | 2012-05-29 | Bayer Schering Pharma Aktiengesellschaft | Polymorphous form of 5-chloro-N-({(5S)-2-oxo-3[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide |
| DE102005047558A1 (de) * | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
| KR20080110877A (ko) | 2006-03-31 | 2008-12-19 | 재단법인 이쯔우 연구소 | 헤테로환을 갖는 신규 화합물 |
| WO2009001192A2 (en) * | 2007-06-22 | 2008-12-31 | Orchid Research Laboratories Limited | Novel compounds and their use |
| WO2009044777A1 (ja) | 2007-10-02 | 2009-04-09 | Research Foundation Itsuu Laboratory | ７員ヘテロ環を有するオキサゾリジノン誘導体 |
| CA2822357A1 (en) | 2010-12-22 | 2012-06-28 | Abbvie Inc. | Hepatitis c inhibitors and uses thereof |
| JP6162704B2 (ja) * | 2011-10-11 | 2017-07-12 | カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ | オキサゾリジノン誘導体のシラアナログ及びその合成 |
| CN103360294B (zh) * | 2012-03-28 | 2015-11-25 | 复旦大学 | 具有抗结核活性的化合物及其制备方法和应用 |
| CN103044341B (zh) * | 2012-12-20 | 2015-07-01 | 郑州大学 | 1,2,3-三唑-氨基二硫代甲酸酯-脲复合体、其制备方法及其应用 |
| WO2015031036A1 (en) * | 2013-08-26 | 2015-03-05 | Purdue Pharma L.P. | Azaspiro[4.5] decane derivatives and use thereof |
| CN108299329A (zh) * | 2018-03-28 | 2018-07-20 | 许传森 | 一种噁唑酮类衍生物及其在抗菌药物中的应用 |
| WO2021184339A1 (en) | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compound and methods of use thereof as an antibacterial agent |
| CN115466253B (zh) * | 2021-06-16 | 2024-08-20 | 沈阳药科大学 | 含二硫代氨基甲酸酯结构的噁唑烷酮类化合物及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8506659A1 (es) | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
| CA1260948A (en) * | 1984-12-05 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents |
| US4948801A (en) | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| AU617871B2 (en) * | 1988-09-15 | 1991-12-05 | Pharmacia & Upjohn Company | In position 3 substituted-5-beta-amidomethyl-oxazolidin-2- ones |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| DE4425612A1 (de) | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
| RU2175324C2 (ru) * | 1995-09-01 | 2001-10-27 | Фармация Энд Апджон Компани | Фенилоксазолидиноны, имеющие с-с-связь с 4-8-членными гетероциклическими кольцами |
| GB9521508D0 (en) * | 1995-10-20 | 1995-12-20 | Zeneca Ltd | Chemical compounds |
| DE19601264A1 (de) | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
| DE19604223A1 (de) * | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| DE69716925T2 (de) * | 1996-08-21 | 2003-09-11 | Pharmacia & Upjohn Co., Kalamazoo | Isoxazoline derivate und ihre verwendung als antimikroben |
-
1998
- 1998-05-18 CN CNB98805423XA patent/CN1138765C/zh not_active Expired - Fee Related
- 1998-05-18 FI FI992555A patent/FI19992555L/fi not_active IP Right Cessation
- 1998-05-18 US US09/080,751 patent/US6218413B1/en not_active Expired - Fee Related
- 1998-05-18 WO PCT/US1998/009889 patent/WO1998054161A1/en not_active Ceased
- 1998-05-18 DE DE69829846T patent/DE69829846T2/de not_active Expired - Fee Related
- 1998-05-18 KR KR19997011178A patent/KR20010013192A/ko not_active Abandoned
- 1998-05-18 AT AT98922303T patent/ATE293609T1/de not_active IP Right Cessation
- 1998-05-18 EP EP98922303A patent/EP0984947B8/en not_active Expired - Lifetime
- 1998-05-18 HU HU0001393A patent/HUP0001393A3/hu unknown
- 1998-05-18 SK SK1564-99A patent/SK156499A3/sk unknown
- 1998-05-18 PL PL98337329A patent/PL337329A1/xx unknown
- 1998-05-18 AU AU74883/98A patent/AU737995B2/en not_active Ceased
- 1998-05-18 NZ NZ501412A patent/NZ501412A/en unknown
- 1998-05-18 BR BR9815518-0A patent/BR9815518A/pt not_active Application Discontinuation
- 1998-05-18 CA CA002288750A patent/CA2288750A1/en not_active Abandoned
- 1998-05-18 ES ES98922303T patent/ES2242280T3/es not_active Expired - Lifetime
- 1998-05-18 RU RU99128083/04A patent/RU2208613C2/ru not_active IP Right Cessation
- 1998-05-18 JP JP50072299A patent/JP2002501530A/ja not_active Withdrawn
-
1999
- 1999-11-29 NO NO19995846A patent/NO315798B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69829846D1 (de) | 2005-05-25 |
| JP2002501530A (ja) | 2002-01-15 |
| ES2242280T3 (es) | 2005-11-01 |
| CA2288750A1 (en) | 1998-12-03 |
| AU737995B2 (en) | 2001-09-06 |
| HUP0001393A2 (hu) | 2001-06-28 |
| WO1998054161A9 (en) | 1999-04-08 |
| HUP0001393A3 (en) | 2001-07-30 |
| NO995846D0 (no) | 1999-11-29 |
| FI19992555A7 (fi) | 1999-11-30 |
| HK1027569A1 (en) | 2001-01-19 |
| NO315798B1 (no) | 2003-10-27 |
| NZ501412A (en) | 2001-11-30 |
| CN1257486A (zh) | 2000-06-21 |
| AU7488398A (en) | 1998-12-30 |
| ATE293609T1 (de) | 2005-05-15 |
| DE69829846T2 (de) | 2006-02-23 |
| SK156499A3 (en) | 2000-06-12 |
| EP0984947B8 (en) | 2005-06-15 |
| EP0984947B1 (en) | 2005-04-20 |
| RU2208613C2 (ru) | 2003-07-20 |
| NO995846L (no) | 2000-01-28 |
| WO1998054161A1 (en) | 1998-12-03 |
| EP0984947A1 (en) | 2000-03-15 |
| KR20010013192A (ko) | 2001-02-26 |
| PL337329A1 (en) | 2000-08-14 |
| US6218413B1 (en) | 2001-04-17 |
| FI19992555L (fi) | 1999-11-30 |
| BR9815518A (pt) | 2000-11-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1138765C (zh) | 带有硫代羰基功能基的噁唑烷酮抗菌剂 | |
| CN1072222C (zh) | 以c－c键连接于4－8元杂环环的苯基噁唑烷酮 | |
| HK1040707A1 (zh) | 具有硫代羰基官能團的噁唑烷酮抗菌劑 | |
| CN1280269C (zh) | 脂肪族含氮五员环化合物 | |
| CN1211384C (zh) | 噻二唑基和噁二唑基苯基噁唑烷酮抗菌剂 | |
| CN1639135A (zh) | N－芳基－2－噁唑烷酮－5－酰胺及其衍生物和它们作为抗菌剂的用途 | |
| CN1221548C (zh) | 含有砜亚氨基官能团的噁唑烷酮 | |
| CN85108556A (zh) | 新型苯并唑基及苯并噻唑基胺类衍生物的制备方法及其应用 | |
| CN1026588C (zh) | 新的1-烷基取代苯并咪唑衍生物的制备方法 | |
| CN1122803A (zh) | 苯并噁唑基-和苯并噻唑基噁唑烷酮类化合物 | |
| CN1053429A (zh) | 吲哚取代五元芳杂环化合物 | |
| CN1714084A (zh) | 嘧啶－2,4,6－三酮类金属蛋白酶抑制剂 | |
| CN1348370A (zh) | 环状蛋白酪氨酸激酶抑制剂 | |
| CN1432015A (zh) | 可用作细胞增殖抑制剂的被1,1－二氧代异噻唑烷取代的吲唑 | |
| CN1582285A (zh) | 用作糖原合酶激酶3β抑制剂(GSK3抑制剂)的杂芳胺化合物 | |
| CN1433413A (zh) | 新的噁唑烷酮衍生物及其制备方法 | |
| CN1703405A (zh) | 用作糖原合酶激酶3β抑制剂的氨基苯甲酰胺衍生物 | |
| CN1312800A (zh) | 治疗用的联芳基衍生物 | |
| CN1152877C (zh) | 哌嗪衍生物 | |
| CN1656083A (zh) | 具有抗菌活性的新的杂环化合物、它们的制备方法和含有它们的药物组合物 | |
| CN101035781A (zh) | 2－吗啉基－4－嘧啶酮化合物 | |
| CN1520412A (zh) | 作为抗菌剂的新噁唑烷酮衍生物 | |
| CN1202096C (zh) | 2－氨基噻唑啉衍生物及其作为no－合酶抑制剂的用途 | |
| CN1098104A (zh) | 2-(2-取代的吡咯烷-4-基)硫代-碳青霉烯类衍生物 | |
| CN87100536A (zh) | 新颖红霉素胺衍生物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |