CN1131856C - 作为黄体酮受体调节剂的环硫代氨基甲酸酯衍生物 - Google Patents

作为黄体酮受体调节剂的环硫代氨基甲酸酯衍生物 Download PDF

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Publication number
CN1131856C
CN1131856C CN008070997A CN00807099A CN1131856C CN 1131856 C CN1131856 C CN 1131856C CN 008070997 A CN008070997 A CN 008070997A CN 00807099 A CN00807099 A CN 00807099A CN 1131856 C CN1131856 C CN 1131856C
Authority
CN
China
Prior art keywords
dihydro
dimethyl
benzoxazine
alkyl
sulfo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN008070997A
Other languages
English (en)
Chinese (zh)
Other versions
CN1349516A (zh
Inventor
张普文
A·芬森
E·A·捷烈弗柯
J·E·弗罗贝尔
J·P·爱德华兹
T·K·琼斯
C·M·特格利
智林
M·A·柯林斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hui Shi
Original Assignee
Ligand Pharmaceuticals Inc
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,354 external-priority patent/US6436929B1/en
Application filed by Ligand Pharmaceuticals Inc, American Home Products Corp filed Critical Ligand Pharmaceuticals Inc
Publication of CN1349516A publication Critical patent/CN1349516A/zh
Application granted granted Critical
Publication of CN1131856C publication Critical patent/CN1131856C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Detergent Compositions (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN008070997A 1999-05-04 2000-05-01 作为黄体酮受体调节剂的环硫代氨基甲酸酯衍生物 Expired - Fee Related CN1131856C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18301399P 1999-05-04 1999-05-04
US60/183,013 1999-05-04
US09/552,354 2000-04-19
US09/552,354 US6436929B1 (en) 1999-05-04 2000-04-19 Cyclothiocarbamate derivatives as progesterone receptor modulators

Publications (2)

Publication Number Publication Date
CN1349516A CN1349516A (zh) 2002-05-15
CN1131856C true CN1131856C (zh) 2003-12-24

Family

ID=26878649

Family Applications (1)

Application Number Title Priority Date Filing Date
CN008070997A Expired - Fee Related CN1131856C (zh) 1999-05-04 2000-05-01 作为黄体酮受体调节剂的环硫代氨基甲酸酯衍生物

Country Status (24)

Country Link
EP (1) EP1175411B1 (https=)
JP (2) JP4958338B2 (https=)
KR (1) KR100732692B1 (https=)
CN (1) CN1131856C (https=)
AT (1) ATE386729T1 (https=)
AU (1) AU766801B2 (https=)
BG (1) BG65277B1 (https=)
BR (1) BR0010214A (https=)
CA (1) CA2371712C (https=)
CZ (1) CZ20013952A3 (https=)
DE (1) DE60038108T2 (https=)
DK (1) DK1175411T3 (https=)
EA (1) EA004511B1 (https=)
ES (1) ES2301482T3 (https=)
GE (1) GEP20043181B (https=)
HU (1) HUP0203332A3 (https=)
IL (1) IL146298A0 (https=)
MX (1) MXPA01011287A (https=)
NO (1) NO321370B1 (https=)
NZ (1) NZ515353A (https=)
PL (1) PL351083A1 (https=)
SG (1) SG120970A1 (https=)
SK (1) SK15922001A3 (https=)
TR (1) TR200103285T2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101001863B (zh) * 2004-08-13 2012-10-10 惠氏公司 坦普盖特衍生物、代谢物及其用途
CN104208067A (zh) * 2004-07-07 2014-12-17 惠氏公司 周期性黄体酮方案及试剂盒

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG120970A1 (en) * 1999-05-04 2006-04-26 Ligand Pharm Inc Cyclothiocarbamate derivatives as progesterone receptor modulators
US6407101B1 (en) * 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
ES2317223T3 (es) * 2004-04-08 2009-04-16 Wyeth Derivados de tioamida como moduladores del receptor de progesterona.
JP4950027B2 (ja) * 2004-04-08 2012-06-13 ワイス・エルエルシー チオアミド不純物を最小限に抑えるための方法
BRPI0510278A (pt) * 2004-04-27 2007-10-30 Wyeth Corp método para produzir compostos, produto, e, composto
MXPA06012403A (es) 2004-04-27 2007-01-17 Wyeth Corp Purificacion de moduladores de receptor progesterona.
CN101166532B (zh) 2005-04-28 2011-06-22 惠氏公司 微粒化的他那普戈特、组合物及其制备方法
CN101166521A (zh) * 2005-04-28 2008-04-23 惠氏公司 通过湿制粒法制备包含微粒化他那普戈特的组合物
CN101166736B (zh) * 2005-04-28 2013-02-06 惠氏公司 他那普戈特的多晶型ⅱ
AU2006241189B2 (en) * 2005-04-28 2012-01-19 Wyeth Llc Purified form of tanaproget
MX2007013467A (es) 2005-04-28 2008-01-21 Wyeth Corp Tanaproget micronizado y composiciones que contienen el mismo.
CA2610767C (en) * 2005-06-09 2014-09-23 Wyeth Tanaproget compositions containing ethinyl estradiol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510235A1 (en) * 1991-04-26 1992-10-28 Dong-A Pharm. Co., Ltd. Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same
JPH0510235A (ja) * 1991-07-05 1993-01-19 Nippondenso Co Ltd 内燃機関の点火時期制御装置
AU1694295A (en) * 1994-01-28 1995-08-15 Merck & Co., Inc. Benzoxazinones as inhibitors of hiv reverse transcriptase
US5696127A (en) * 1994-12-22 1997-12-09 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
EP1043325B1 (en) * 1994-12-22 2004-06-16 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
DE69724630T2 (de) * 1996-10-02 2004-07-29 Bristol-Myers Squibb Pharma Co. 4,4-disubstituierte 1,4-dihydro-2h-3,1-benzoxazin-2-one die anwendbar sind als hiv-reverstranskriptase-inhibitoren, zwischenprodukte und verfahren zu ihrer herstellung
SG120970A1 (en) * 1999-05-04 2006-04-26 Ligand Pharm Inc Cyclothiocarbamate derivatives as progesterone receptor modulators
MX2007013467A (es) * 2005-04-28 2008-01-21 Wyeth Corp Tanaproget micronizado y composiciones que contienen el mismo.
CA2610767C (en) * 2005-06-09 2014-09-23 Wyeth Tanaproget compositions containing ethinyl estradiol

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104208067A (zh) * 2004-07-07 2014-12-17 惠氏公司 周期性黄体酮方案及试剂盒
CN101001863B (zh) * 2004-08-13 2012-10-10 惠氏公司 坦普盖特衍生物、代谢物及其用途

Also Published As

Publication number Publication date
CN1349516A (zh) 2002-05-15
BG106080A (en) 2002-05-31
CZ20013952A3 (cs) 2002-05-15
EA004511B1 (ru) 2004-04-29
JP5523430B2 (ja) 2014-06-18
HUP0203332A3 (en) 2004-12-28
HUP0203332A2 (hu) 2003-01-28
CA2371712A1 (en) 2000-11-09
JP2002543192A (ja) 2002-12-17
NO20015381D0 (no) 2001-11-02
BG65277B1 (bg) 2007-11-30
GEP20043181B (en) 2004-02-25
EP1175411A1 (en) 2002-01-30
JP2012087129A (ja) 2012-05-10
IL146298A0 (en) 2002-07-25
TR200103285T2 (tr) 2002-02-21
ES2301482T3 (es) 2008-07-01
NO20015381L (no) 2002-01-03
DE60038108D1 (de) 2008-04-03
KR20020000170A (ko) 2002-01-04
NZ515353A (en) 2004-03-26
SK15922001A3 (sk) 2002-09-10
ATE386729T1 (de) 2008-03-15
BR0010214A (pt) 2002-02-13
CA2371712C (en) 2009-12-22
NO321370B1 (no) 2006-05-02
JP4958338B2 (ja) 2012-06-20
PL351083A1 (en) 2003-03-10
AU4811900A (en) 2000-11-17
KR100732692B1 (ko) 2007-06-27
AU766801B2 (en) 2003-10-23
SG120970A1 (en) 2006-04-26
EA200101181A1 (ru) 2002-04-25
DK1175411T3 (da) 2008-06-09
EP1175411B1 (en) 2008-02-20
MXPA01011287A (es) 2003-07-14
DE60038108T2 (de) 2009-02-12

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Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: WYETH CORP.

Free format text: FORMER NAME OR ADDRESS: AMERICAN HOME PRODUCTS CORP.

CP01 Change in the name or title of a patent holder

Address after: New jersey, USA

Co-patentee after: Ligand Pharmaceuticals Inc.

Patentee after: WYETH

Address before: New jersey, USA

Co-patentee before: Ligand Pharmaceuticals Inc.

Patentee before: American Home Products Corp.

ASS Succession or assignment of patent right

Owner name: WYETH(AMERICAN HOME PRODUCTS)

Free format text: FORMER OWNER: WYETH(AMERICAN HOME PRODUCTS); LEGA PHARMACY CO.,LTD.

Effective date: 20061208

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20061208

Address after: New jersey, USA

Patentee after: Hui Shi

Address before: New jersey, USA

Co-patentee before: Ligand Pharmaceuticals Inc.

Patentee before: Hui Shi

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20031224

Termination date: 20150501

EXPY Termination of patent right or utility model