JP4958338B2 - プロゲステロン受容体モジュレーターとしてのシクロチオカルバメート誘導体 - Google Patents

プロゲステロン受容体モジュレーターとしてのシクロチオカルバメート誘導体 Download PDF

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Publication number
JP4958338B2
JP4958338B2 JP2000615600A JP2000615600A JP4958338B2 JP 4958338 B2 JP4958338 B2 JP 4958338B2 JP 2000615600 A JP2000615600 A JP 2000615600A JP 2000615600 A JP2000615600 A JP 2000615600A JP 4958338 B2 JP4958338 B2 JP 4958338B2
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JP
Japan
Prior art keywords
substituted
alkyl
dihydro
group
dimethyl
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Expired - Fee Related
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JP2000615600A
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English (en)
Japanese (ja)
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JP2002543192A5 (https=
JP2002543192A (ja
Inventor
ツアング，プエン
フエンサム，アンドリユー
テレフエンコ，ユージン・エイ
ジ，リン
ジヨーンズ，トツド・ケイ
テグリー，クリストフアー・エム
ブローベル，ジエイ・イー
エドワーズ，ジエイムズ・ピー
コリンズ，マーク・エイ
Original Assignee
ワイス・エルエルシー
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Priority claimed from US09/552,354 external-priority patent/US6436929B1/en
Application filed by ワイス・エルエルシー filed Critical ワイス・エルエルシー
Publication of JP2002543192A publication Critical patent/JP2002543192A/ja
Publication of JP2002543192A5 publication Critical patent/JP2002543192A5/ja
Application granted granted Critical
Publication of JP4958338B2 publication Critical patent/JP4958338B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Detergent Compositions (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2000615600A 1999-05-04 2000-05-01 プロゲステロン受容体モジュレーターとしてのシクロチオカルバメート誘導体 Expired - Fee Related JP4958338B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18301399P 1999-05-04 1999-05-04
US60/183,013 1999-05-04
US09/552,354 2000-04-19
US09/552,354 US6436929B1 (en) 1999-05-04 2000-04-19 Cyclothiocarbamate derivatives as progesterone receptor modulators
PCT/US2000/011749 WO2000066570A1 (en) 1999-05-04 2000-05-01 Cyclothiocarbamate derivatives as progesterone receptor modulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011249051A Division JP5523430B2 (ja) 1999-05-04 2011-11-14 プロゲステロン受容体モジュレーターとしてのシクロチオカルバメート誘導体

Publications (3)

Publication Number Publication Date
JP2002543192A JP2002543192A (ja) 2002-12-17
JP2002543192A5 JP2002543192A5 (https=) 2007-06-21
JP4958338B2 true JP4958338B2 (ja) 2012-06-20

Family

ID=26878649

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000615600A Expired - Fee Related JP4958338B2 (ja) 1999-05-04 2000-05-01 プロゲステロン受容体モジュレーターとしてのシクロチオカルバメート誘導体
JP2011249051A Expired - Fee Related JP5523430B2 (ja) 1999-05-04 2011-11-14 プロゲステロン受容体モジュレーターとしてのシクロチオカルバメート誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011249051A Expired - Fee Related JP5523430B2 (ja) 1999-05-04 2011-11-14 プロゲステロン受容体モジュレーターとしてのシクロチオカルバメート誘導体

Country Status (24)

Country Link
EP (1) EP1175411B1 (https=)
JP (2) JP4958338B2 (https=)
KR (1) KR100732692B1 (https=)
CN (1) CN1131856C (https=)
AT (1) ATE386729T1 (https=)
AU (1) AU766801B2 (https=)
BG (1) BG65277B1 (https=)
BR (1) BR0010214A (https=)
CA (1) CA2371712C (https=)
CZ (1) CZ20013952A3 (https=)
DE (1) DE60038108T2 (https=)
DK (1) DK1175411T3 (https=)
EA (1) EA004511B1 (https=)
ES (1) ES2301482T3 (https=)
GE (1) GEP20043181B (https=)
HU (1) HUP0203332A3 (https=)
IL (1) IL146298A0 (https=)
MX (1) MXPA01011287A (https=)
NO (1) NO321370B1 (https=)
NZ (1) NZ515353A (https=)
PL (1) PL351083A1 (https=)
SG (1) SG120970A1 (https=)
SK (1) SK15922001A3 (https=)
TR (1) TR200103285T2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG120970A1 (en) * 1999-05-04 2006-04-26 Ligand Pharm Inc Cyclothiocarbamate derivatives as progesterone receptor modulators
US6407101B1 (en) * 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
ES2317223T3 (es) * 2004-04-08 2009-04-16 Wyeth Derivados de tioamida como moduladores del receptor de progesterona.
JP4950027B2 (ja) * 2004-04-08 2012-06-13 ワイス・エルエルシー チオアミド不純物を最小限に抑えるための方法
BRPI0510278A (pt) * 2004-04-27 2007-10-30 Wyeth Corp método para produzir compostos, produto, e, composto
MXPA06012403A (es) 2004-04-27 2007-01-17 Wyeth Corp Purificacion de moduladores de receptor progesterona.
US20060009428A1 (en) * 2004-07-07 2006-01-12 Wyeth Cyclic progestin regimens and kits
MX2007001812A (es) * 2004-08-13 2007-03-26 Wyeth Corp Derivados de tanaproget, metabolitos, y usos de los mismos.
CN101166532B (zh) 2005-04-28 2011-06-22 惠氏公司 微粒化的他那普戈特、组合物及其制备方法
CN101166521A (zh) * 2005-04-28 2008-04-23 惠氏公司 通过湿制粒法制备包含微粒化他那普戈特的组合物
CN101166736B (zh) * 2005-04-28 2013-02-06 惠氏公司 他那普戈特的多晶型ⅱ
AU2006241189B2 (en) * 2005-04-28 2012-01-19 Wyeth Llc Purified form of tanaproget
MX2007013467A (es) 2005-04-28 2008-01-21 Wyeth Corp Tanaproget micronizado y composiciones que contienen el mismo.
CA2610767C (en) * 2005-06-09 2014-09-23 Wyeth Tanaproget compositions containing ethinyl estradiol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510235A1 (en) * 1991-04-26 1992-10-28 Dong-A Pharm. Co., Ltd. Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same
JPH0510235A (ja) * 1991-07-05 1993-01-19 Nippondenso Co Ltd 内燃機関の点火時期制御装置
AU1694295A (en) * 1994-01-28 1995-08-15 Merck & Co., Inc. Benzoxazinones as inhibitors of hiv reverse transcriptase
US5696127A (en) * 1994-12-22 1997-12-09 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
EP1043325B1 (en) * 1994-12-22 2004-06-16 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
DE69724630T2 (de) * 1996-10-02 2004-07-29 Bristol-Myers Squibb Pharma Co. 4,4-disubstituierte 1,4-dihydro-2h-3,1-benzoxazin-2-one die anwendbar sind als hiv-reverstranskriptase-inhibitoren, zwischenprodukte und verfahren zu ihrer herstellung
SG120970A1 (en) * 1999-05-04 2006-04-26 Ligand Pharm Inc Cyclothiocarbamate derivatives as progesterone receptor modulators
MX2007013467A (es) * 2005-04-28 2008-01-21 Wyeth Corp Tanaproget micronizado y composiciones que contienen el mismo.
CA2610767C (en) * 2005-06-09 2014-09-23 Wyeth Tanaproget compositions containing ethinyl estradiol

Also Published As

Publication number Publication date
CN1349516A (zh) 2002-05-15
BG106080A (en) 2002-05-31
CZ20013952A3 (cs) 2002-05-15
EA004511B1 (ru) 2004-04-29
JP5523430B2 (ja) 2014-06-18
HUP0203332A3 (en) 2004-12-28
HUP0203332A2 (hu) 2003-01-28
CA2371712A1 (en) 2000-11-09
JP2002543192A (ja) 2002-12-17
NO20015381D0 (no) 2001-11-02
BG65277B1 (bg) 2007-11-30
GEP20043181B (en) 2004-02-25
EP1175411A1 (en) 2002-01-30
JP2012087129A (ja) 2012-05-10
IL146298A0 (en) 2002-07-25
TR200103285T2 (tr) 2002-02-21
ES2301482T3 (es) 2008-07-01
NO20015381L (no) 2002-01-03
DE60038108D1 (de) 2008-04-03
KR20020000170A (ko) 2002-01-04
NZ515353A (en) 2004-03-26
SK15922001A3 (sk) 2002-09-10
ATE386729T1 (de) 2008-03-15
BR0010214A (pt) 2002-02-13
CN1131856C (zh) 2003-12-24
CA2371712C (en) 2009-12-22
NO321370B1 (no) 2006-05-02
PL351083A1 (en) 2003-03-10
AU4811900A (en) 2000-11-17
KR100732692B1 (ko) 2007-06-27
AU766801B2 (en) 2003-10-23
SG120970A1 (en) 2006-04-26
EA200101181A1 (ru) 2002-04-25
DK1175411T3 (da) 2008-06-09
EP1175411B1 (en) 2008-02-20
MXPA01011287A (es) 2003-07-14
DE60038108T2 (de) 2009-02-12

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