KR100732692B1 - 프로게스테론 수용체 조절인자인 시클로티오카르바메이트유도체 - Google Patents

프로게스테론 수용체 조절인자인 시클로티오카르바메이트유도체 Download PDF

Info

Publication number
KR100732692B1
KR100732692B1 KR1020017014085A KR20017014085A KR100732692B1 KR 100732692 B1 KR100732692 B1 KR 100732692B1 KR 1020017014085 A KR1020017014085 A KR 1020017014085A KR 20017014085 A KR20017014085 A KR 20017014085A KR 100732692 B1 KR100732692 B1 KR 100732692B1
Authority
KR
South Korea
Prior art keywords
substituted
alkyl
dihydro
aryl
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020017014085A
Other languages
English (en)
Korean (ko)
Other versions
KR20020000170A (ko
Inventor
장푸웬
펜섬앤드류
테리펜코유진에이.
지린
존즈토드케이.
테글리크리스토퍼엠.
콜린스마크에이.
로벨제이이.
에드워즈제임즈피.
Original Assignee
와이어쓰
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,354 external-priority patent/US6436929B1/en
Application filed by 와이어쓰 filed Critical 와이어쓰
Publication of KR20020000170A publication Critical patent/KR20020000170A/ko
Application granted granted Critical
Publication of KR100732692B1 publication Critical patent/KR100732692B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Detergent Compositions (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020017014085A 1999-05-04 2000-05-01 프로게스테론 수용체 조절인자인 시클로티오카르바메이트유도체 Expired - Fee Related KR100732692B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18301399P 1999-05-04 1999-05-04
US60/183,013 1999-05-04
US09/552,354 2000-04-19
US09/552,354 US6436929B1 (en) 1999-05-04 2000-04-19 Cyclothiocarbamate derivatives as progesterone receptor modulators

Publications (2)

Publication Number Publication Date
KR20020000170A KR20020000170A (ko) 2002-01-04
KR100732692B1 true KR100732692B1 (ko) 2007-06-27

Family

ID=26878649

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017014085A Expired - Fee Related KR100732692B1 (ko) 1999-05-04 2000-05-01 프로게스테론 수용체 조절인자인 시클로티오카르바메이트유도체

Country Status (24)

Country Link
EP (1) EP1175411B1 (https=)
JP (2) JP4958338B2 (https=)
KR (1) KR100732692B1 (https=)
CN (1) CN1131856C (https=)
AT (1) ATE386729T1 (https=)
AU (1) AU766801B2 (https=)
BG (1) BG65277B1 (https=)
BR (1) BR0010214A (https=)
CA (1) CA2371712C (https=)
CZ (1) CZ20013952A3 (https=)
DE (1) DE60038108T2 (https=)
DK (1) DK1175411T3 (https=)
EA (1) EA004511B1 (https=)
ES (1) ES2301482T3 (https=)
GE (1) GEP20043181B (https=)
HU (1) HUP0203332A3 (https=)
IL (1) IL146298A0 (https=)
MX (1) MXPA01011287A (https=)
NO (1) NO321370B1 (https=)
NZ (1) NZ515353A (https=)
PL (1) PL351083A1 (https=)
SG (1) SG120970A1 (https=)
SK (1) SK15922001A3 (https=)
TR (1) TR200103285T2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG120970A1 (en) * 1999-05-04 2006-04-26 Ligand Pharm Inc Cyclothiocarbamate derivatives as progesterone receptor modulators
US6407101B1 (en) * 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
ES2317223T3 (es) * 2004-04-08 2009-04-16 Wyeth Derivados de tioamida como moduladores del receptor de progesterona.
JP4950027B2 (ja) * 2004-04-08 2012-06-13 ワイス・エルエルシー チオアミド不純物を最小限に抑えるための方法
BRPI0510278A (pt) * 2004-04-27 2007-10-30 Wyeth Corp método para produzir compostos, produto, e, composto
MXPA06012403A (es) 2004-04-27 2007-01-17 Wyeth Corp Purificacion de moduladores de receptor progesterona.
US20060009428A1 (en) * 2004-07-07 2006-01-12 Wyeth Cyclic progestin regimens and kits
MX2007001812A (es) * 2004-08-13 2007-03-26 Wyeth Corp Derivados de tanaproget, metabolitos, y usos de los mismos.
CN101166532B (zh) 2005-04-28 2011-06-22 惠氏公司 微粒化的他那普戈特、组合物及其制备方法
CN101166521A (zh) * 2005-04-28 2008-04-23 惠氏公司 通过湿制粒法制备包含微粒化他那普戈特的组合物
CN101166736B (zh) * 2005-04-28 2013-02-06 惠氏公司 他那普戈特的多晶型ⅱ
AU2006241189B2 (en) * 2005-04-28 2012-01-19 Wyeth Llc Purified form of tanaproget
MX2007013467A (es) 2005-04-28 2008-01-21 Wyeth Corp Tanaproget micronizado y composiciones que contienen el mismo.
CA2610767C (en) * 2005-06-09 2014-09-23 Wyeth Tanaproget compositions containing ethinyl estradiol

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510235A1 (en) * 1991-04-26 1992-10-28 Dong-A Pharm. Co., Ltd. Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same
JPH0510235A (ja) * 1991-07-05 1993-01-19 Nippondenso Co Ltd 内燃機関の点火時期制御装置
WO1995020389A1 (en) * 1994-01-28 1995-08-03 Merck & Co., Inc. Benzoxazinones as inhibitors of hiv reverse transcriptase
WO1996019458A2 (en) * 1994-12-22 1996-06-27 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
WO1998014436A1 (en) * 1996-10-02 1998-04-09 Dupont Pharmaceuticals Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696127A (en) * 1994-12-22 1997-12-09 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
SG120970A1 (en) * 1999-05-04 2006-04-26 Ligand Pharm Inc Cyclothiocarbamate derivatives as progesterone receptor modulators
MX2007013467A (es) * 2005-04-28 2008-01-21 Wyeth Corp Tanaproget micronizado y composiciones que contienen el mismo.
CA2610767C (en) * 2005-06-09 2014-09-23 Wyeth Tanaproget compositions containing ethinyl estradiol

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510235A1 (en) * 1991-04-26 1992-10-28 Dong-A Pharm. Co., Ltd. Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same
JPH0510235A (ja) * 1991-07-05 1993-01-19 Nippondenso Co Ltd 内燃機関の点火時期制御装置
WO1995020389A1 (en) * 1994-01-28 1995-08-03 Merck & Co., Inc. Benzoxazinones as inhibitors of hiv reverse transcriptase
WO1996019458A2 (en) * 1994-12-22 1996-06-27 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
WO1998014436A1 (en) * 1996-10-02 1998-04-09 Dupont Pharmaceuticals Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same

Also Published As

Publication number Publication date
CN1349516A (zh) 2002-05-15
BG106080A (en) 2002-05-31
CZ20013952A3 (cs) 2002-05-15
EA004511B1 (ru) 2004-04-29
JP5523430B2 (ja) 2014-06-18
HUP0203332A3 (en) 2004-12-28
HUP0203332A2 (hu) 2003-01-28
CA2371712A1 (en) 2000-11-09
JP2002543192A (ja) 2002-12-17
NO20015381D0 (no) 2001-11-02
BG65277B1 (bg) 2007-11-30
GEP20043181B (en) 2004-02-25
EP1175411A1 (en) 2002-01-30
JP2012087129A (ja) 2012-05-10
IL146298A0 (en) 2002-07-25
TR200103285T2 (tr) 2002-02-21
ES2301482T3 (es) 2008-07-01
NO20015381L (no) 2002-01-03
DE60038108D1 (de) 2008-04-03
KR20020000170A (ko) 2002-01-04
NZ515353A (en) 2004-03-26
SK15922001A3 (sk) 2002-09-10
ATE386729T1 (de) 2008-03-15
BR0010214A (pt) 2002-02-13
CN1131856C (zh) 2003-12-24
CA2371712C (en) 2009-12-22
NO321370B1 (no) 2006-05-02
JP4958338B2 (ja) 2012-06-20
PL351083A1 (en) 2003-03-10
AU4811900A (en) 2000-11-17
AU766801B2 (en) 2003-10-23
SG120970A1 (en) 2006-04-26
EA200101181A1 (ru) 2002-04-25
DK1175411T3 (da) 2008-06-09
EP1175411B1 (en) 2008-02-20
MXPA01011287A (es) 2003-07-14
DE60038108T2 (de) 2009-02-12

Similar Documents

Publication Publication Date Title
JP5523430B2 (ja) プロゲステロン受容体モジュレーターとしてのシクロチオカルバメート誘導体
US6436929B1 (en) Cyclothiocarbamate derivatives as progesterone receptor modulators
US6509334B1 (en) Cyclocarbamate derivatives as progesterone receptor modulators
US6444668B1 (en) Combination regimens using progesterone receptor modulators
JP2002543155A (ja) 抗プロゲスチン及びプロゲスチンを含有する避妊組成物
KR20010114250A (ko) 프로게스테론 수용체 조절인자인 시클로카르바메이트 유도체

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 20130607

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

FPAY Annual fee payment

Payment date: 20140612

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20150621

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20150621

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000