AU766801B2 - Cyclothiocarbamate derivatives as progesterone receptor modulators - Google Patents
Cyclothiocarbamate derivatives as progesterone receptor modulators Download PDFInfo
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- AU766801B2 AU766801B2 AU48119/00A AU4811900A AU766801B2 AU 766801 B2 AU766801 B2 AU 766801B2 AU 48119/00 A AU48119/00 A AU 48119/00A AU 4811900 A AU4811900 A AU 4811900A AU 766801 B2 AU766801 B2 AU 766801B2
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- substituted
- alkyl
- dihydro
- dimethyl
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- 239000002379 progesterone receptor modulator Substances 0.000 title description 2
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 title description 2
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- 238000011282 treatment Methods 0.000 claims abstract description 34
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 25
- 150000003839 salts Chemical class 0.000 claims abstract description 24
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- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 22
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- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- PNQBEPDZQUOCNY-UHFFFAOYSA-N trifluoroacetyl chloride Chemical compound FC(F)(F)C(Cl)=O PNQBEPDZQUOCNY-UHFFFAOYSA-N 0.000 description 1
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- WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical compound COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 description 1
- NHDIQVFFNDKAQU-UHFFFAOYSA-N tripropan-2-yl borate Chemical compound CC(C)OB(OC(C)C)OC(C)C NHDIQVFFNDKAQU-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Detergent Compositions (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
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|---|---|---|---|
| US18301399P | 1999-05-04 | 1999-05-04 | |
| US60/183013 | 1999-05-04 | ||
| US09/552354 | 2000-04-19 | ||
| US09/552,354 US6436929B1 (en) | 1999-05-04 | 2000-04-19 | Cyclothiocarbamate derivatives as progesterone receptor modulators |
| PCT/US2000/011749 WO2000066570A1 (en) | 1999-05-04 | 2000-05-01 | Cyclothiocarbamate derivatives as progesterone receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU4811900A AU4811900A (en) | 2000-11-17 |
| AU766801B2 true AU766801B2 (en) | 2003-10-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU48119/00A Ceased AU766801B2 (en) | 1999-05-04 | 2000-05-01 | Cyclothiocarbamate derivatives as progesterone receptor modulators |
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| EP (1) | EP1175411B1 (https=) |
| JP (2) | JP4958338B2 (https=) |
| KR (1) | KR100732692B1 (https=) |
| CN (1) | CN1131856C (https=) |
| AT (1) | ATE386729T1 (https=) |
| AU (1) | AU766801B2 (https=) |
| BG (1) | BG65277B1 (https=) |
| BR (1) | BR0010214A (https=) |
| CA (1) | CA2371712C (https=) |
| CZ (1) | CZ20013952A3 (https=) |
| DE (1) | DE60038108T2 (https=) |
| DK (1) | DK1175411T3 (https=) |
| EA (1) | EA004511B1 (https=) |
| ES (1) | ES2301482T3 (https=) |
| GE (1) | GEP20043181B (https=) |
| HU (1) | HUP0203332A3 (https=) |
| IL (1) | IL146298A0 (https=) |
| MX (1) | MXPA01011287A (https=) |
| NO (1) | NO321370B1 (https=) |
| NZ (1) | NZ515353A (https=) |
| PL (1) | PL351083A1 (https=) |
| SG (1) | SG120970A1 (https=) |
| SK (1) | SK15922001A3 (https=) |
| TR (1) | TR200103285T2 (https=) |
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| ATE386729T1 (de) * | 1999-05-04 | 2008-03-15 | Wyeth Corp | Cyclothiocarbamatderivate als progesteron- rezeptormodulatoren |
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| ATE409699T1 (de) * | 2004-04-08 | 2008-10-15 | Wyeth Corp | Verfahren zur minimierung von thioamidverunreinigungen |
| ATE413398T1 (de) * | 2004-04-08 | 2008-11-15 | Wyeth Corp | Thioamidderivate als progesteronrezeptormodulatoren |
| EP1756072A2 (en) * | 2004-04-27 | 2007-02-28 | Wyeth | Purification of progesterone receptor modulators |
| CA2562160C (en) * | 2004-04-27 | 2013-05-28 | Wyeth | Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same |
| WO2006014476A1 (en) * | 2004-07-07 | 2006-02-09 | Wyeth | Cyclic progestin regimens and kits |
| SI1778710T1 (sl) | 2004-08-13 | 2012-05-31 | Wyeth Llc | Derivati tanaprogeta metaboliti in njihove uporabe |
| EP1877059B8 (en) | 2005-04-28 | 2010-05-19 | Wyeth a Corporation of the State of Delaware | Micronized tanaproget and compostions containing same |
| JP2008539254A (ja) * | 2005-04-28 | 2008-11-13 | ワイス | タナプロゲットの精製形態 |
| SI1896034T1 (sl) | 2005-04-28 | 2010-07-30 | Wyeth Llc | Mikronizirani sestavki tanaprogeta in postopki priprave le-tega |
| WO2007030153A2 (en) * | 2005-04-28 | 2007-03-15 | Wyeth | Compositions containing micronized tanaproget |
| BRPI0610433A2 (pt) * | 2005-04-28 | 2010-11-23 | Wyeth Corp | forma polimórfica ii de tanaproget, processos para preparar a mesma, e para preparar forma micronizada de um composto, composição farmacêutica, método de preparação de uma composição farmacêutica, e, uso da forma polimórfica ii de tanaproget ou da forma micronizada |
| CN103989687A (zh) * | 2005-06-09 | 2014-08-20 | 惠氏公司 | 含有炔雌醇的tanaproget组合物 |
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| EP0510235A1 (en) * | 1991-04-26 | 1992-10-28 | Dong-A Pharm. Co., Ltd. | Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same |
| JPH0510235A (ja) * | 1991-07-05 | 1993-01-19 | Nippondenso Co Ltd | 内燃機関の点火時期制御装置 |
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| EP1043325B1 (en) * | 1994-12-22 | 2004-06-16 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
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| ATE386729T1 (de) * | 1999-05-04 | 2008-03-15 | Wyeth Corp | Cyclothiocarbamatderivate als progesteron- rezeptormodulatoren |
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2000
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| TC | Change of applicant's name (sec. 104) |
Owner name: LIGAND PHARMACEUTICALS, INC., WYETH Free format text: FORMER NAME: AMERICAN HOME PRODUCTS CORPORATION, LIGAND PHARMACEUTICALS, INC. |
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| FGA | Letters patent sealed or granted (standard patent) |