BG65277B1 - Циклотиокарбаматни производни като модулатори на прогестеронови рецептори - Google Patents

Info

Publication number

BG65277B1

BG65277B1 BG106080A BG10608001A BG65277B1 BG 65277 B1 BG65277 B1 BG 65277B1 BG 106080 A BG106080 A BG 106080A BG 10608001 A BG10608001 A BG 10608001A BG 65277 B1 BG65277 B1 BG 65277B1

Authority

BG

Bulgaria

Prior art keywords

substituted

alkyl

dihydro

dimethyl

group

Prior art date

1999-05-04

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• 108090000468 progesterone receptors Proteins 0.000 title abstract description 16
• 150000001875 compounds Chemical class 0.000 claims abstract description 144
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 74
• 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 61
• 125000003118 aryl group Chemical group 0.000 claims abstract description 54
• 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 51
• 125000003107 substituted aryl group Chemical group 0.000 claims abstract description 43
• 125000001424 substituent group Chemical group 0.000 claims abstract description 35
• 125000000217 alkyl group Chemical group 0.000 claims abstract description 26
• 125000005842 heteroatom Chemical group 0.000 claims abstract description 25
• 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 22
• 238000002360 preparation method Methods 0.000 claims abstract description 21
• 238000011282 treatment Methods 0.000 claims abstract description 21
• 125000000304 alkynyl group Chemical group 0.000 claims abstract description 18
• 229910052717 sulfur Inorganic materials 0.000 claims abstract description 18
• 150000003839 salts Chemical class 0.000 claims abstract description 17
• 229910052760 oxygen Inorganic materials 0.000 claims abstract description 13
• 125000003342 alkenyl group Chemical group 0.000 claims abstract description 11
• 239000003814 drug Substances 0.000 claims abstract description 11
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 6
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 6
• -1 4- (4,4- dimethyl-2-thioxo-1,4-dihydro-2H-benzo [1,3] oxazin-6-yl) -thiophene-2-carbonitrile Chemical compound 0.000 claims description 104
• 229910052799 carbon Inorganic materials 0.000 claims description 98
• 229910052736 halogen Inorganic materials 0.000 claims description 41
• 150000002367 halogens Chemical class 0.000 claims description 39
• JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 23
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 18
• 229920006395 saturated elastomer Polymers 0.000 claims description 16
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 15
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 10
• 125000000547 substituted alkyl group Chemical group 0.000 claims description 9
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 7
• 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 7
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• WYHOTGLZCWQZME-UHFFFAOYSA-N 6-(3-bromophenyl)-4,4-dimethyl-1h-3,1-benzoxazine-2-thione Chemical compound C1=C2C(C)(C)OC(=S)NC2=CC=C1C1=CC=CC(Br)=C1 WYHOTGLZCWQZME-UHFFFAOYSA-N 0.000 claims description 2
• YBBTTYFZWTXGQD-UHFFFAOYSA-N 6-(3-chlorophenyl)-4-methyl-4-phenyl-1h-3,1-benzoxazine-2-thione Chemical compound C1=C2C(C)(C=3C=CC=CC=3)OC(=S)NC2=CC=C1C1=CC=CC(Cl)=C1 YBBTTYFZWTXGQD-UHFFFAOYSA-N 0.000 claims description 2
• PJOQVYGNJMPLKZ-UHFFFAOYSA-N 6-(3-fluoro-5-methoxyphenyl)-4,4-dimethyl-1h-3,1-benzoxazine-2-thione Chemical compound COC1=CC(F)=CC(C=2C=C3C(C)(C)OC(=S)NC3=CC=2)=C1 PJOQVYGNJMPLKZ-UHFFFAOYSA-N 0.000 claims description 2
• NAQUDAIOMWNXJF-UHFFFAOYSA-N 6-(3-fluorophenyl)-4-methyl-1,4-dihydro-3,1-benzoxazine-2-thione Chemical compound C1=C2C(C)OC(=S)NC2=CC=C1C1=CC=CC(F)=C1 NAQUDAIOMWNXJF-UHFFFAOYSA-N 0.000 claims description 2
• PIVCHRZUHMHWMD-UHFFFAOYSA-N 6-(4-fluorophenyl)-4,4-dimethyl-1h-3,1-benzoxazine-2-thione Chemical compound C1=C2C(C)(C)OC(=S)NC2=CC=C1C1=CC=C(F)C=C1 PIVCHRZUHMHWMD-UHFFFAOYSA-N 0.000 claims description 2
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• 125000005843 halogen group Chemical group 0.000 claims 2
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