CN112955139B - 用于制备α-酮戊二酸钙的方法 - Google Patents

用于制备α-酮戊二酸钙的方法 Download PDF

Info

Publication number
CN112955139B
CN112955139B CN201980073655.2A CN201980073655A CN112955139B CN 112955139 B CN112955139 B CN 112955139B CN 201980073655 A CN201980073655 A CN 201980073655A CN 112955139 B CN112955139 B CN 112955139B
Authority
CN
China
Prior art keywords
ketoglutarate
water
ketoglutaric acid
calcium
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980073655.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN112955139A (zh
Inventor
D·E·佩雷拉
K·迪欧
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poncci Leon Health Specific Events
Original Assignee
Poncci Leon Health Specific Events
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poncci Leon Health Specific Events filed Critical Poncci Leon Health Specific Events
Publication of CN112955139A publication Critical patent/CN112955139A/zh
Application granted granted Critical
Publication of CN112955139B publication Critical patent/CN112955139B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/418—Preparation of metal complexes containing carboxylic acid moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201980073655.2A 2018-09-25 2019-09-23 用于制备α-酮戊二酸钙的方法 Active CN112955139B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862736320P 2018-09-25 2018-09-25
US62/736,320 2018-09-25
PCT/US2019/052498 WO2020068705A1 (en) 2018-09-25 2019-09-23 Process of making calcium alpha-ketoglutarate

Publications (2)

Publication Number Publication Date
CN112955139A CN112955139A (zh) 2021-06-11
CN112955139B true CN112955139B (zh) 2025-04-18

Family

ID=69952136

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980073655.2A Active CN112955139B (zh) 2018-09-25 2019-09-23 用于制备α-酮戊二酸钙的方法

Country Status (18)

Country Link
US (1) US11802103B2 (enExample)
EP (1) EP3856166A4 (enExample)
JP (1) JP7499259B2 (enExample)
KR (1) KR102833111B1 (enExample)
CN (1) CN112955139B (enExample)
AU (1) AU2019350699B2 (enExample)
BR (1) BR112021005668A2 (enExample)
CA (1) CA3112205A1 (enExample)
CL (1) CL2021000728A1 (enExample)
CO (1) CO2021004529A2 (enExample)
IL (1) IL281761B2 (enExample)
MX (1) MX2021003482A (enExample)
MY (1) MY203278A (enExample)
PE (1) PE20211816A1 (enExample)
PH (1) PH12021550403A1 (enExample)
SG (1) SG11202102204PA (enExample)
TW (1) TWI863930B (enExample)
WO (1) WO2020068705A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102833111B1 (ko) 2018-09-25 2025-07-10 폰세 드 리온 헬스 데지그네이티드 액티비티 컴퍼니 칼슘 알파-케토글루타레이트의 제조 방법
CN112941116B (zh) * 2021-01-04 2022-12-02 上海朴颐化学科技有限公司 一种酶法制备α-酮戊二酸钙的方法
CN114105761B (zh) * 2021-11-19 2024-06-21 广东派特埃尔生物科技有限公司 一种α-酮戊二酸钠盐的合成工艺
CN115974679A (zh) * 2022-12-20 2023-04-18 绍兴市精益生物化工有限公司 α-酮戊二酸钙盐制备方法
CN119977789A (zh) * 2025-02-12 2025-05-13 江苏惠利生物科技有限公司 一种离子交换树脂制备高纯度α-酮戊二酸钙的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112941116A (zh) * 2021-01-04 2021-06-11 上海朴颐化学科技有限公司 一种酶法制备α-酮戊二酸钙的方法
CN114126601A (zh) * 2019-06-10 2022-03-01 庞塞迪利昂健康特定活动公司 α-酮戊二酸类化合物的持续释放组合物
CN115974679A (zh) * 2022-12-20 2023-04-18 绍兴市精益生物化工有限公司 α-酮戊二酸钙盐制备方法

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776926A (en) 1955-08-04 1957-01-08 Eugene S Sharpe Preparation of alpha-ketoglutaric acid by serratia marcescens
US2917528A (en) 1956-08-24 1959-12-15 Victor Chemical Works Alkanolaminealkanephosphonic acids and salts thereof
US2841616A (en) * 1956-10-30 1958-07-01 Campbell Soup Co Process for the recovery of alpha-ketoglutaric acid
US3875304A (en) 1970-04-24 1975-04-01 Schlitz Brewing Co J Livestock feed composition and method of preparing the same
US4045585A (en) 1976-05-19 1977-08-30 Decel Corporation Flavored animal food compositions
DE3151196A1 (de) * 1981-12-23 1983-06-30 Kurt Heinz Prof. Dr. 7800 Freiburg Bauer Verfahren zur herstellung von gut loeslichen 5-aminosalicylsaeure-arzneimittelzubereitungen
US6451341B1 (en) 1990-02-05 2002-09-17 Thomas J. Slaga Time release formulation of vitamins, minerals and other beneficial supplements
US5646187A (en) 1992-05-20 1997-07-08 Ab Erik Vinnars Use of alpha-ketoglutarate
US6306430B1 (en) 1998-04-16 2001-10-23 The Iams Company Process for decreasing adiposity using vitamin a as a dietary supplement
US6905707B2 (en) 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
CO5140079A1 (es) 1998-10-14 2002-03-22 Novartis Ag Composicion farmaceutica de liberacion sostenida y metodo para liberar un agente farmaceuticamente activo de liberacion sostenida y metodo para liberar un agente far- maceuticamente activo
US6649654B1 (en) 1999-11-23 2003-11-18 The Regents Of The University Of California Methods for identifying and using IKK inhibitors
AU2002228955B2 (en) 2000-12-20 2005-09-29 Alcon Inc. Solution for removing cataracts via liquefracture
AU2004237437B2 (en) * 2003-05-07 2011-01-20 Osteologix A/S Controlled release composition containing a strontium salt
US7589235B2 (en) 2004-05-06 2009-09-15 Osteologix, A/S High yield and rapid synthesis methods for producing metallo-organic salts
PL368572A1 (en) 2004-06-17 2005-12-27 Sgp & Sons Ab Pharmaceutical compound for prevention and therapy of increased level of cholesterol, ldl and triglycerides as well as application of the pharmaceutical compound as an agent acting against atherosclerosis and used in circulatory system affections
EP1778616A1 (en) 2004-08-09 2007-05-02 Cancer Research Technology Limited Alpha-ketoglutarates and their use as therapeutic agents
DK1824470T3 (da) 2004-12-17 2014-08-18 Cash Alan Brian Fremgangsmåde til forlængelse af levetiden og forsinke starttidspunktet for alders-relateret sygdom
US20060234250A1 (en) 2005-04-15 2006-10-19 Powers Ralph W Iii Methods of screening and compositions for life span modulators
EP1915144A4 (en) 2005-06-20 2009-08-19 Accera Inc METHOD FOR REDUCING OXIDATIVE DAMAGE AND IMPROVING MITOCHONDRIA EFFICIENCY
WO2007053943A1 (en) 2005-11-08 2007-05-18 Multi Formulations Ltd. The use of compositions comprising ketoacids and amino acids for increasing muscle mass and muscle performance
US8367121B2 (en) 2005-11-23 2013-02-05 Florida A & M University Nutraceutical agent for attenuating the neurodegenerative process associated with Parkinson's disease
PL379512A1 (pl) 2006-04-21 2007-10-29 Sgp & Sons Ab Nowe metody i ich zastosowanie
PL226695B1 (pl) 2006-07-03 2017-08-31 Danuta Kruszewska Środek do zastosowania w zapobieganiu i/lub hamowaniu kolonizacji Helicobacter pylori, zastosowanie soli kwasu alfa‑ketoglutarowego z metalami alkalicznymi i ziem alkalicznych do wytwarzania środka leczniczego oraz dodatku do żywności do zapobiegania i/lub hamowania kolonizacji Helicobacter pylori
JP2010522190A (ja) 2007-03-19 2010-07-01 メタプロテオミクス， エルエルシー 骨及び関節の健康を助成するための方法と組成物
MX2009013937A (es) 2007-07-02 2010-04-30 Entress Ab Nuevo uso de compuestos quimicos farmacologicamente activos conocidos.
EP2033623A1 (en) 2007-09-07 2009-03-11 Cutech S.R.L. Compositions comprising ornithine ketoglutarate (OKG)
JP5406643B2 (ja) 2008-09-22 2014-02-05 日本合成化学工業株式会社 α−オキソカルボン酸の金属塩の製造方法
CN101759553A (zh) 2008-11-21 2010-06-30 扬子江药业集团北京海燕药业有限公司 α-酮酸钙的制备方法
DE102009016119A1 (de) 2009-04-03 2010-10-14 Evonik Degussa Gmbh Nahrungsergänzungsmittel enthaltend alpha-Ketosäuren zur Unterstützung der Diabetestherapie
BRPI1010655A2 (pt) 2009-04-10 2019-09-03 Qi Haiyan novos agentes antienvelhecimento e métodos para identificá-los
CN102481271A (zh) 2009-05-11 2012-05-30 博格生物系统有限责任公司 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法
EP3120709A1 (en) 2009-05-28 2017-01-25 IAMS Europe B.V. Pet food in the form of a coated kibble
EP2440212A4 (en) 2009-06-12 2013-03-20 Generex Pharm Inc COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CORONARY DISEASE
JP6159084B2 (ja) 2009-06-30 2017-07-05 デルマン バイオメディシン カンパニー リミテッド 酒さまたは赤面に関連する皮膚疾患を治療するための、ベルベリンまたはその類似体を含有する組成物
WO2011060305A1 (en) 2009-11-12 2011-05-19 Nox Technologies, Inc. Potato skin compositions that lower cytosolic nadh level to mimic calorie restriction
WO2012114204A2 (en) 2011-02-15 2012-08-30 Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto Methods of treating mitochondrial dysfunction
JP2014511890A (ja) 2011-04-18 2014-05-19 ネステク ソシエテ アノニム α−ＨＩＣＡ及びα−ケトグルタル酸を含有する栄養組成物
WO2012174537A2 (en) 2011-06-16 2012-12-20 President And Fellows Of Harvard College Small molecule screening for mouse satellite cell proliferation
CN102586347B (zh) * 2012-03-06 2014-04-09 江南大学 一种两阶段pH控制高产a-酮戊二酸的方法
US9532997B2 (en) 2012-04-03 2017-01-03 Whitehead Institute For Biomedical Research Compositions and methods for promoting intestinal stem cell function
ITBO20120226A1 (it) 2012-04-24 2013-10-25 Alfa Wassermann Spa Composizioni comprendenti ornitina alfa-chetoglutarato, processi per il loro ottenimento e il loro uso.
JP6029058B2 (ja) 2012-09-14 2016-11-24 国立研究開発法人農業・食品産業技術総合研究機構 シュウ酸カルシウムを含む氷核活性剤
CA2884592C (en) 2012-09-19 2021-08-31 Grespo Ab Compositions for improvement of brain function
CN102976927A (zh) * 2012-12-26 2013-03-20 天津天成制药有限公司 α-酮戊二酸钙的制备方法
CA2896646A1 (en) 2012-12-27 2014-07-03 Hayashibara Co., Ltd. Skin-exterior anti-ageing composition and production method therefor
US20150328176A1 (en) 2013-01-25 2015-11-19 Winning The Fight Inc. Composition for treatment of neurodegenerative disease
US9511057B2 (en) 2013-03-15 2016-12-06 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating denervation-induced muscle atrophy
KR102499654B1 (ko) 2013-03-19 2023-02-13 유니버시티 오브 사우스 플로리다 상승되고 지속되는 케톤증을 생성하기 위한 조성물 및 방법
US20160263092A1 (en) 2013-12-19 2016-09-15 Twi Biotechnology, Inc. Therapeutic uses of berberine formulations
KR20160111529A (ko) 2014-02-12 2016-09-26 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 노화 및 연령 관련 질환 및 증상의 치료를 위한 조성물 및 방법
WO2015171723A1 (en) 2014-05-06 2015-11-12 Research Development Foundation Methods for treating insulin resistance and for sensitizing patients to glp1 agonist therapy
CN106659701B (zh) 2014-06-30 2021-04-27 加尼福尼亚大学董事会 用于治疗年龄相关性症状和疾病的酮基丁酸酯化合物和组合物
IL282156B (en) 2014-07-29 2022-07-01 Shenzhen Hightide Biopharmaceutical Ltd Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof
WO2016019224A1 (en) 2014-07-31 2016-02-04 Indiana University Research And Technology Corporation Antithetical regulation of endothelial ace and ace2 by brg1-foxm1 complex underlies pathological cardiac hypertrophy
CN104529755B (zh) * 2014-12-29 2016-01-06 精晶药业股份有限公司 一种从转化液中分离α-酮戊二酸的方法
SG11201708030XA (en) 2015-04-06 2017-10-30 Shenzhen Hightide Biopharmaceutical Ltd Conjugate compounds of ursodeoxycholic, berberine or l-carnitine, and compositions and methods thereof
JP2018517774A (ja) 2015-06-10 2018-07-05 エリジウム・ヘルス・インコーポレイテッド ニコチンアミドリボシドおよびプテロスチルベン組成物ならびに皮膚障害の処置のための方法
US20180193458A1 (en) 2015-07-08 2018-07-12 Unity Biotechnology, Inc. Compositions and methods for treating senescence-associated diseases and disorders
EP3518915A4 (en) 2016-09-30 2020-04-15 The Regents of the University of California ALPHA KETOBUTYRATE, ALPHA KETOGLUTARATE AND 2-HYDROXYBUTYRATE FOR STIMULATING HAIR GROWTH
PL231635B1 (pl) 2017-01-03 2019-03-29 Politechnika Poznanska Sposób produkcji kwasu alfa-ketoglutarowego (AKG) z jednoskładnikowych roztworów wodnych
MX2017004010A (es) 2017-03-27 2018-02-09 Antonio Hernandez Miramontes Jorge Mezcla de oxalacetato, alfacetoglutarato, ácido tartánico y sales de lactato de calcio y sodio, para tratar pacientes con insuficiencia renal crónica.
SG10202107237SA (en) 2017-04-25 2021-08-30 Buck Inst Res Aging Formulations for extending lifespan and healthspan
US20200253907A1 (en) 2017-08-21 2020-08-13 The Regents Of The University Of California Compositions and Methods for Treating Neurodegenerative Diseases
KR102833111B1 (ko) 2018-09-25 2025-07-10 폰세 드 리온 헬스 데지그네이티드 액티비티 컴퍼니 칼슘 알파-케토글루타레이트의 제조 방법
WO2020086733A1 (en) 2018-10-24 2020-04-30 Ponce De Leon Health Designated Activity Company Nicotinamide riboside compositions for healthspan extension
CN114126599A (zh) 2019-06-10 2022-03-01 巴克老龄化研究所 改变衰老相关分泌表型的方法和组合物
CA3188646A1 (en) 2020-07-02 2022-01-06 Ponce De Leon Health Designated Activity Company Compositions and methods for treating crp-mediated diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114126601A (zh) * 2019-06-10 2022-03-01 庞塞迪利昂健康特定活动公司 α-酮戊二酸类化合物的持续释放组合物
CN112941116A (zh) * 2021-01-04 2021-06-11 上海朴颐化学科技有限公司 一种酶法制备α-酮戊二酸钙的方法
CN115974679A (zh) * 2022-12-20 2023-04-18 绍兴市精益生物化工有限公司 α-酮戊二酸钙盐制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
丙酮酸钠合成工艺研究;潘春，等;精细与专用化学品.;20190228;第27卷(第02期);42-44 *

Also Published As

Publication number Publication date
US11802103B2 (en) 2023-10-31
JP2022502489A (ja) 2022-01-11
BR112021005668A2 (pt) 2021-06-22
AU2019350699B2 (en) 2024-05-23
TWI863930B (zh) 2024-12-01
US20210371368A1 (en) 2021-12-02
PE20211816A1 (es) 2021-09-14
SG11202102204PA (en) 2021-04-29
MY203278A (en) 2024-06-21
IL281761A (en) 2021-05-31
IL281761B2 (en) 2025-09-01
EP3856166A4 (en) 2022-06-22
IL281761B1 (en) 2025-05-01
CA3112205A1 (en) 2020-04-02
CL2021000728A1 (es) 2021-10-22
CO2021004529A2 (es) 2021-04-30
KR20210065120A (ko) 2021-06-03
JP7499259B2 (ja) 2024-06-13
MX2021003482A (es) 2021-06-18
AU2019350699A1 (en) 2021-04-08
TW202024013A (zh) 2020-07-01
PH12021550403A1 (en) 2021-10-04
CN112955139A (zh) 2021-06-11
KR102833111B1 (ko) 2025-07-10
WO2020068705A1 (en) 2020-04-02
EP3856166A1 (en) 2021-08-04

Similar Documents

Publication Publication Date Title
CN112955139B (zh) 用于制备α-酮戊二酸钙的方法
US8969563B2 (en) Calcium salt of pyrroloquinoline quinone
KR102405650B1 (ko) 트레프로스티닐의 염
JP2006515338A (ja) クロピドグレルのベンゼンスルホン酸塩および医薬製剤を製造するためのその使用
KR100958156B1 (ko) 실질적으로 순수한 ｏ-데스메틸벤라팍신 및 이의 제조 방법
EP1671937A1 (en) Method for producing nitrile compound, carboxylic acid compound or carboxylate compound
MX2007014913A (es) Proceso para perparar clorhidrato de memantina sustancialmente libre de impurezas.
EP0647229B1 (en) Diamine salts of clavulanic acid
HK40053335A (en) Process of making calcium alpha-ketoglutarate
Bates et al. Structures of eurycomalactone and related terpenoids
JP6974788B2 (ja) イミダゾピロロキノリン塩及びその製造方法、並びに、医薬品、化粧品及び食品
US8258298B2 (en) Synthesis of morphine-6-glucuronide or one of the derivatives thereof
HK40053335B (zh) 用於制备α-酮戊二酸钙的方法
US20070185352A1 (en) New process for the dimerisation of alkyl glyoxals
EP0433848B1 (en) Crystalline magnesium valproate and a method for the preparation thereof
KR100536750B1 (ko) 시부트라민 메탄술폰산염의 결정성 반수화물을 포함하는약학 조성물
JP2000510486A (ja) α−トコフェロール−４−アミノ安息香酸エステル化合物及びその製造方法
CN121609631A (zh) 一种维奈克拉联苯杂质及其制备方法
KR100187333B1 (ko) 클라불란산의 디아민염
CN116143674A (zh) 一种高纯度羧甲司坦的合成方法
JP2022074008A (ja) トレプロスチニル一水和物結晶およびその製造方法
KR20110103711A (ko) 신규 결정형의 자나미비어 수화물 및 이의 제조방법
JPS58134085A (ja) 新規オキサチンカルボン酸およびその製造法
CZ278017B6 (en) Process for preparing crotonbetaine hydrochloride

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40053335

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant