JP2000510486A - α−トコフェロール−4−アミノ安息香酸エステル化合物及びその製造方法 - Google Patents
α−トコフェロール−4−アミノ安息香酸エステル化合物及びその製造方法Info
- Publication number
- JP2000510486A JP2000510486A JP10546842A JP54684298A JP2000510486A JP 2000510486 A JP2000510486 A JP 2000510486A JP 10546842 A JP10546842 A JP 10546842A JP 54684298 A JP54684298 A JP 54684298A JP 2000510486 A JP2000510486 A JP 2000510486A
- Authority
- JP
- Japan
- Prior art keywords
- tocopherol
- aminobenzoic acid
- reaction
- formula
- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.以下の化学式Iに示されるα−トコフェロール−4−アミノ安息香酸化合物。 前記式で、R1及びR2は、同じでも異なっていてもよく、各々は水素原子又は直 鎖若しくは分岐のC1−C4アルキル鎖である。 2.R1及びR2は、それぞれ水素原子である請求項1に記載のα−トコフェロール −4−アミノ安息香酸化合物。 3.R1は水素原子で、R2は直鎖又は分岐のC1−C4アルキル鎖である請求項1に記載 のα−トコフェロール−4−アミノ安息香酸化合物。 4.R1及びR2は、それぞれ直鎖又は分岐のC1−C4アルキル鎖である請求項1に記 載のα−トコフェロール−4−アミノ安息香酸化合物。 5.塩基性触媒の存在下のジクロロメタン中での、下記化学式IIに示される4−ア ミノ安息香酸誘導体と、下記化学式IIIに示されるα−トコフェロールとの反応 を含む、下記化学式Iに示されるα−トコフェロール−4−アミノ安息香酸塩化 合物の製造方法。 前記式で、R1及びR2は、同じでも異なっていてもよく、各々は水素原子又は直 鎖若しくは分岐のC1−C4アルキル鎖である。 6.前記塩基性触媒がピリジン、ピリジン/4−(ジメチルアミノ)ピリジン及び トリエチルアミンからなる群から選ばれる請求項5に記載の方法。 7.α−トコフェロール、4−アミノ安息香酸誘導体及び塩基性触媒は、1.0:1.1 −5.0:2.5−9.0のモル比で存在する請求項5に記載の方法。 8.α−トコフェロール、4−アミノ安息香酸誘導体及び塩基性触媒は、1.0:2.0 −3.0:6.5−8.5のモル比で存在する請求項7に記載の方法。 9.反応は、0−41℃で、36−48時間かけて行われる請求項5に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019970015961A KR100208814B1 (ko) | 1997-04-28 | 1997-04-28 | 알파토코페롤 4-아미노벤조산 에스테르 화합물 및 이의 제조방법 |
KR199715961 | 1997-04-28 | ||
PCT/KR1998/000103 WO1998049154A1 (en) | 1997-04-28 | 1998-04-28 | Alpha-tocopherol 4-aminobenzoic acid ester compounds and method for preparing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000510486A true JP2000510486A (ja) | 2000-08-15 |
JP3264672B2 JP3264672B2 (ja) | 2002-03-11 |
Family
ID=19504157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54684298A Expired - Fee Related JP3264672B2 (ja) | 1997-04-28 | 1998-04-28 | α−トコフェロール−4−アミノ安息香酸エステル化合物及びその製造方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US6222051B1 (ja) |
EP (1) | EP0980365B1 (ja) |
JP (1) | JP3264672B2 (ja) |
KR (1) | KR100208814B1 (ja) |
DE (1) | DE69821755T2 (ja) |
WO (1) | WO1998049154A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002255809A (ja) * | 2001-02-27 | 2002-09-11 | Jiro Takada | 水溶性6−クロマノールカルボン酸エステル誘導体を含む経口投与剤 |
JP2002332231A (ja) * | 2001-03-06 | 2002-11-22 | Jiro Takada | γ−CEHC送達剤 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
CA2580584C (en) | 2003-09-19 | 2015-07-28 | Galileo Pharmaceuticals, Inc. | Use of alpha-tocotrienol for treatment of mitochondrial diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58203982A (ja) * | 1982-05-24 | 1983-11-28 | Shiseido Co Ltd | ビタミンe−アミノ酸エステル類およびその製造方法 |
DE3581435D1 (de) * | 1984-05-29 | 1991-02-28 | Henkel Corp | Sonnenschutzmittel und verfahren zu dessen verwendung. |
KR0157024B1 (ko) * | 1996-04-17 | 1998-11-16 | 이능희 | 양이온성 비타민 e 유도체 및 그의 제조방법, 및 그를 이용하여 형성한 항산화 작용을 갖는 양친매성 고분자 베시클 |
-
1997
- 1997-04-28 KR KR1019970015961A patent/KR100208814B1/ko not_active IP Right Cessation
-
1998
- 1998-04-28 WO PCT/KR1998/000103 patent/WO1998049154A1/en active IP Right Grant
- 1998-04-28 EP EP98917769A patent/EP0980365B1/en not_active Expired - Lifetime
- 1998-04-28 US US09/403,352 patent/US6222051B1/en not_active Expired - Lifetime
- 1998-04-28 DE DE69821755T patent/DE69821755T2/de not_active Expired - Fee Related
- 1998-04-28 JP JP54684298A patent/JP3264672B2/ja not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002255809A (ja) * | 2001-02-27 | 2002-09-11 | Jiro Takada | 水溶性6−クロマノールカルボン酸エステル誘導体を含む経口投与剤 |
JP2002332231A (ja) * | 2001-03-06 | 2002-11-22 | Jiro Takada | γ−CEHC送達剤 |
Also Published As
Publication number | Publication date |
---|---|
DE69821755T2 (de) | 2008-05-15 |
US6222051B1 (en) | 2001-04-24 |
WO1998049154A1 (en) | 1998-11-05 |
EP0980365B1 (en) | 2004-02-18 |
DE69821755D1 (de) | 2004-03-25 |
EP0980365A1 (en) | 2000-02-23 |
KR100208814B1 (ko) | 1999-07-15 |
JP3264672B2 (ja) | 2002-03-11 |
KR19980078436A (ko) | 1998-11-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0797564B1 (en) | Lignans, a process for their production and pharmaceutical compositions and uses thereof | |
CA1325807C (en) | Tetracyclic antidepressants | |
JP3264672B2 (ja) | α−トコフェロール−4−アミノ安息香酸エステル化合物及びその製造方法 | |
US5990322A (en) | Alpha-tocopherol cyclopropylates, the new vitamin E derivatives and method for producing the same | |
CN112479967B (zh) | 胆绿素类化合物及其制备方法和用途 | |
EP0251039B1 (en) | Esters of salsalate with guaiacol, for treating phlogistic bronchopneumopathies | |
GB2036744A (en) | Eburnane derivatives | |
EP1035120B1 (en) | Alpha-tocopherol cyclopropylates, the new vitamin E derivatives, and method for producing the same | |
CN113248465B (zh) | 一种鹰嘴豆芽素a的合成方法 | |
KR100422253B1 (ko) | 알파토코페롤 시클로프로필산 에스테르 화합물 및그 제조방법 | |
JPH03279348A (ja) | 2,4,5―トリフルオロ―3―アルコキシ安息香酸の製造方法 | |
CN112624953B (zh) | 胆绿素或其衍生物的制备方法 | |
JPH04244076A (ja) | ビタミンa酸エステル化合物 | |
JP2000281674A (ja) | 新規ビタミンe誘導体、アルファ−トコフェロールシクロプロピル酸エステル化合物及びその製造方法 | |
JPH0366298B2 (ja) | ||
JP2905931B2 (ja) | 光学活性2―シクロペンテノン類の製造法 | |
FI77648B (fi) | Foerfaranden foer framstaellning av citrat, maleat, fumarat och pamoat av 2-dietylamino-1-metyletyl-cis-1- hydroxi(bicyklohexyl)-2-karboxylat samt vid foerfarandena anvaent fosfatsalt. | |
KR930011040B1 (ko) | 벤조피란 유도체와 그의 제조방법 | |
JPS6330906B2 (ja) | ||
CN116693547A (zh) | 硫代色酮类化合物、制备该类化合物的中间体、其制备方法及应用 | |
JPH04244058A (ja) | ビタミンa酸エステル化合物 | |
EP0298890A2 (en) | New 2-(P-isobutylphenyl)-propionic acid ester and process for the preparation thereof | |
JPS63112579A (ja) | ピペリジン誘導体の製法 | |
KR20040092058A (ko) | 에르도스테인의 제조방법 | |
GB2111477A (en) | Eburnane derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20071228 Year of fee payment: 6 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20081228 Year of fee payment: 7 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20081228 Year of fee payment: 7 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20081228 Year of fee payment: 7 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20081228 Year of fee payment: 7 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20091228 Year of fee payment: 8 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20091228 Year of fee payment: 8 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101228 Year of fee payment: 9 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20111228 Year of fee payment: 10 |
|
LAPS | Cancellation because of no payment of annual fees |