CO2021004529A2 - Proceso de elaboración de alfa-cetoglutarato de calcio referencia cruzada con solicitudes relacionadas - Google Patents
Proceso de elaboración de alfa-cetoglutarato de calcio referencia cruzada con solicitudes relacionadasInfo
- Publication number
- CO2021004529A2 CO2021004529A2 CONC2021/0004529A CO2021004529A CO2021004529A2 CO 2021004529 A2 CO2021004529 A2 CO 2021004529A2 CO 2021004529 A CO2021004529 A CO 2021004529A CO 2021004529 A2 CO2021004529 A2 CO 2021004529A2
- Authority
- CO
- Colombia
- Prior art keywords
- ketoglutarate
- manufacturing process
- related applications
- cross reference
- process cross
- Prior art date
Links
- LADYPAWUSNPKJF-UHFFFAOYSA-L calcium;2-oxopentanedioate Chemical compound [Ca+2].[O-]C(=O)CCC(=O)C([O-])=O LADYPAWUSNPKJF-UHFFFAOYSA-L 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical class [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/418—Preparation of metal complexes containing carboxylic acid moieties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862736320P | 2018-09-25 | 2018-09-25 | |
| PCT/US2019/052498 WO2020068705A1 (en) | 2018-09-25 | 2019-09-23 | Process of making calcium alpha-ketoglutarate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2021004529A2 true CO2021004529A2 (es) | 2021-04-30 |
Family
ID=69952136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2021/0004529A CO2021004529A2 (es) | 2018-09-25 | 2021-04-11 | Proceso de elaboración de alfa-cetoglutarato de calcio referencia cruzada con solicitudes relacionadas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US11802103B2 (enExample) |
| EP (1) | EP3856166A4 (enExample) |
| JP (1) | JP7499259B2 (enExample) |
| KR (1) | KR102833111B1 (enExample) |
| CN (1) | CN112955139B (enExample) |
| AU (1) | AU2019350699B2 (enExample) |
| BR (1) | BR112021005668A2 (enExample) |
| CA (1) | CA3112205A1 (enExample) |
| CL (1) | CL2021000728A1 (enExample) |
| CO (1) | CO2021004529A2 (enExample) |
| IL (1) | IL281761B2 (enExample) |
| MX (1) | MX2021003482A (enExample) |
| MY (1) | MY203278A (enExample) |
| PE (1) | PE20211816A1 (enExample) |
| PH (1) | PH12021550403A1 (enExample) |
| SG (1) | SG11202102204PA (enExample) |
| TW (1) | TWI863930B (enExample) |
| WO (1) | WO2020068705A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102833111B1 (ko) | 2018-09-25 | 2025-07-10 | 폰세 드 리온 헬스 데지그네이티드 액티비티 컴퍼니 | 칼슘 알파-케토글루타레이트의 제조 방법 |
| CN112941116B (zh) * | 2021-01-04 | 2022-12-02 | 上海朴颐化学科技有限公司 | 一种酶法制备α-酮戊二酸钙的方法 |
| CN114105761B (zh) * | 2021-11-19 | 2024-06-21 | 广东派特埃尔生物科技有限公司 | 一种α-酮戊二酸钠盐的合成工艺 |
| CN115974679A (zh) * | 2022-12-20 | 2023-04-18 | 绍兴市精益生物化工有限公司 | α-酮戊二酸钙盐制备方法 |
| CN119977789A (zh) * | 2025-02-12 | 2025-05-13 | 江苏惠利生物科技有限公司 | 一种离子交换树脂制备高纯度α-酮戊二酸钙的方法 |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2776926A (en) | 1955-08-04 | 1957-01-08 | Eugene S Sharpe | Preparation of alpha-ketoglutaric acid by serratia marcescens |
| US2917528A (en) | 1956-08-24 | 1959-12-15 | Victor Chemical Works | Alkanolaminealkanephosphonic acids and salts thereof |
| US2841616A (en) * | 1956-10-30 | 1958-07-01 | Campbell Soup Co | Process for the recovery of alpha-ketoglutaric acid |
| US3875304A (en) | 1970-04-24 | 1975-04-01 | Schlitz Brewing Co J | Livestock feed composition and method of preparing the same |
| US4045585A (en) | 1976-05-19 | 1977-08-30 | Decel Corporation | Flavored animal food compositions |
| DE3151196A1 (de) * | 1981-12-23 | 1983-06-30 | Kurt Heinz Prof. Dr. 7800 Freiburg Bauer | Verfahren zur herstellung von gut loeslichen 5-aminosalicylsaeure-arzneimittelzubereitungen |
| US6451341B1 (en) | 1990-02-05 | 2002-09-17 | Thomas J. Slaga | Time release formulation of vitamins, minerals and other beneficial supplements |
| US5646187A (en) | 1992-05-20 | 1997-07-08 | Ab Erik Vinnars | Use of alpha-ketoglutarate |
| US6306430B1 (en) | 1998-04-16 | 2001-10-23 | The Iams Company | Process for decreasing adiposity using vitamin a as a dietary supplement |
| US6905707B2 (en) | 1998-05-28 | 2005-06-14 | Medical Research Institute | Controlled release arginine alpha ketoglutarate |
| CO5140079A1 (es) | 1998-10-14 | 2002-03-22 | Novartis Ag | Composicion farmaceutica de liberacion sostenida y metodo para liberar un agente farmaceuticamente activo de liberacion sostenida y metodo para liberar un agente far- maceuticamente activo |
| US6649654B1 (en) | 1999-11-23 | 2003-11-18 | The Regents Of The University Of California | Methods for identifying and using IKK inhibitors |
| AU2002228955B2 (en) | 2000-12-20 | 2005-09-29 | Alcon Inc. | Solution for removing cataracts via liquefracture |
| AU2004237437B2 (en) * | 2003-05-07 | 2011-01-20 | Osteologix A/S | Controlled release composition containing a strontium salt |
| US7589235B2 (en) | 2004-05-06 | 2009-09-15 | Osteologix, A/S | High yield and rapid synthesis methods for producing metallo-organic salts |
| PL368572A1 (en) | 2004-06-17 | 2005-12-27 | Sgp & Sons Ab | Pharmaceutical compound for prevention and therapy of increased level of cholesterol, ldl and triglycerides as well as application of the pharmaceutical compound as an agent acting against atherosclerosis and used in circulatory system affections |
| EP1778616A1 (en) | 2004-08-09 | 2007-05-02 | Cancer Research Technology Limited | Alpha-ketoglutarates and their use as therapeutic agents |
| DK1824470T3 (da) | 2004-12-17 | 2014-08-18 | Cash Alan Brian | Fremgangsmåde til forlængelse af levetiden og forsinke starttidspunktet for alders-relateret sygdom |
| US20060234250A1 (en) | 2005-04-15 | 2006-10-19 | Powers Ralph W Iii | Methods of screening and compositions for life span modulators |
| EP1915144A4 (en) | 2005-06-20 | 2009-08-19 | Accera Inc | METHOD FOR REDUCING OXIDATIVE DAMAGE AND IMPROVING MITOCHONDRIA EFFICIENCY |
| WO2007053943A1 (en) | 2005-11-08 | 2007-05-18 | Multi Formulations Ltd. | The use of compositions comprising ketoacids and amino acids for increasing muscle mass and muscle performance |
| US8367121B2 (en) | 2005-11-23 | 2013-02-05 | Florida A & M University | Nutraceutical agent for attenuating the neurodegenerative process associated with Parkinson's disease |
| PL379512A1 (pl) | 2006-04-21 | 2007-10-29 | Sgp & Sons Ab | Nowe metody i ich zastosowanie |
| PL226695B1 (pl) | 2006-07-03 | 2017-08-31 | Danuta Kruszewska | Środek do zastosowania w zapobieganiu i/lub hamowaniu kolonizacji Helicobacter pylori, zastosowanie soli kwasu alfa‑ketoglutarowego z metalami alkalicznymi i ziem alkalicznych do wytwarzania środka leczniczego oraz dodatku do żywności do zapobiegania i/lub hamowania kolonizacji Helicobacter pylori |
| JP2010522190A (ja) | 2007-03-19 | 2010-07-01 | メタプロテオミクス, エルエルシー | 骨及び関節の健康を助成するための方法と組成物 |
| MX2009013937A (es) | 2007-07-02 | 2010-04-30 | Entress Ab | Nuevo uso de compuestos quimicos farmacologicamente activos conocidos. |
| EP2033623A1 (en) | 2007-09-07 | 2009-03-11 | Cutech S.R.L. | Compositions comprising ornithine ketoglutarate (OKG) |
| JP5406643B2 (ja) | 2008-09-22 | 2014-02-05 | 日本合成化学工業株式会社 | α−オキソカルボン酸の金属塩の製造方法 |
| CN101759553A (zh) | 2008-11-21 | 2010-06-30 | 扬子江药业集团北京海燕药业有限公司 | α-酮酸钙的制备方法 |
| DE102009016119A1 (de) | 2009-04-03 | 2010-10-14 | Evonik Degussa Gmbh | Nahrungsergänzungsmittel enthaltend alpha-Ketosäuren zur Unterstützung der Diabetestherapie |
| BRPI1010655A2 (pt) | 2009-04-10 | 2019-09-03 | Qi Haiyan | novos agentes antienvelhecimento e métodos para identificá-los |
| CN102481271A (zh) | 2009-05-11 | 2012-05-30 | 博格生物系统有限责任公司 | 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法 |
| EP3120709A1 (en) | 2009-05-28 | 2017-01-25 | IAMS Europe B.V. | Pet food in the form of a coated kibble |
| EP2440212A4 (en) | 2009-06-12 | 2013-03-20 | Generex Pharm Inc | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CORONARY DISEASE |
| JP6159084B2 (ja) | 2009-06-30 | 2017-07-05 | デルマン バイオメディシン カンパニー リミテッド | 酒さまたは赤面に関連する皮膚疾患を治療するための、ベルベリンまたはその類似体を含有する組成物 |
| WO2011060305A1 (en) | 2009-11-12 | 2011-05-19 | Nox Technologies, Inc. | Potato skin compositions that lower cytosolic nadh level to mimic calorie restriction |
| WO2012114204A2 (en) | 2011-02-15 | 2012-08-30 | Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto | Methods of treating mitochondrial dysfunction |
| JP2014511890A (ja) | 2011-04-18 | 2014-05-19 | ネステク ソシエテ アノニム | α−HICA及びα−ケトグルタル酸を含有する栄養組成物 |
| WO2012174537A2 (en) | 2011-06-16 | 2012-12-20 | President And Fellows Of Harvard College | Small molecule screening for mouse satellite cell proliferation |
| CN102586347B (zh) * | 2012-03-06 | 2014-04-09 | 江南大学 | 一种两阶段pH控制高产a-酮戊二酸的方法 |
| US9532997B2 (en) | 2012-04-03 | 2017-01-03 | Whitehead Institute For Biomedical Research | Compositions and methods for promoting intestinal stem cell function |
| ITBO20120226A1 (it) | 2012-04-24 | 2013-10-25 | Alfa Wassermann Spa | Composizioni comprendenti ornitina alfa-chetoglutarato, processi per il loro ottenimento e il loro uso. |
| JP6029058B2 (ja) | 2012-09-14 | 2016-11-24 | 国立研究開発法人農業・食品産業技術総合研究機構 | シュウ酸カルシウムを含む氷核活性剤 |
| CA2884592C (en) | 2012-09-19 | 2021-08-31 | Grespo Ab | Compositions for improvement of brain function |
| CN102976927A (zh) * | 2012-12-26 | 2013-03-20 | 天津天成制药有限公司 | α-酮戊二酸钙的制备方法 |
| CA2896646A1 (en) | 2012-12-27 | 2014-07-03 | Hayashibara Co., Ltd. | Skin-exterior anti-ageing composition and production method therefor |
| US20150328176A1 (en) | 2013-01-25 | 2015-11-19 | Winning The Fight Inc. | Composition for treatment of neurodegenerative disease |
| US9511057B2 (en) | 2013-03-15 | 2016-12-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating denervation-induced muscle atrophy |
| KR102499654B1 (ko) | 2013-03-19 | 2023-02-13 | 유니버시티 오브 사우스 플로리다 | 상승되고 지속되는 케톤증을 생성하기 위한 조성물 및 방법 |
| US20160263092A1 (en) | 2013-12-19 | 2016-09-15 | Twi Biotechnology, Inc. | Therapeutic uses of berberine formulations |
| KR20160111529A (ko) | 2014-02-12 | 2016-09-26 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 노화 및 연령 관련 질환 및 증상의 치료를 위한 조성물 및 방법 |
| WO2015171723A1 (en) | 2014-05-06 | 2015-11-12 | Research Development Foundation | Methods for treating insulin resistance and for sensitizing patients to glp1 agonist therapy |
| CN106659701B (zh) | 2014-06-30 | 2021-04-27 | 加尼福尼亚大学董事会 | 用于治疗年龄相关性症状和疾病的酮基丁酸酯化合物和组合物 |
| IL282156B (en) | 2014-07-29 | 2022-07-01 | Shenzhen Hightide Biopharmaceutical Ltd | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof |
| WO2016019224A1 (en) | 2014-07-31 | 2016-02-04 | Indiana University Research And Technology Corporation | Antithetical regulation of endothelial ace and ace2 by brg1-foxm1 complex underlies pathological cardiac hypertrophy |
| CN104529755B (zh) * | 2014-12-29 | 2016-01-06 | 精晶药业股份有限公司 | 一种从转化液中分离α-酮戊二酸的方法 |
| SG11201708030XA (en) | 2015-04-06 | 2017-10-30 | Shenzhen Hightide Biopharmaceutical Ltd | Conjugate compounds of ursodeoxycholic, berberine or l-carnitine, and compositions and methods thereof |
| JP2018517774A (ja) | 2015-06-10 | 2018-07-05 | エリジウム・ヘルス・インコーポレイテッド | ニコチンアミドリボシドおよびプテロスチルベン組成物ならびに皮膚障害の処置のための方法 |
| US20180193458A1 (en) | 2015-07-08 | 2018-07-12 | Unity Biotechnology, Inc. | Compositions and methods for treating senescence-associated diseases and disorders |
| EP3518915A4 (en) | 2016-09-30 | 2020-04-15 | The Regents of the University of California | ALPHA KETOBUTYRATE, ALPHA KETOGLUTARATE AND 2-HYDROXYBUTYRATE FOR STIMULATING HAIR GROWTH |
| PL231635B1 (pl) | 2017-01-03 | 2019-03-29 | Politechnika Poznanska | Sposób produkcji kwasu alfa-ketoglutarowego (AKG) z jednoskładnikowych roztworów wodnych |
| MX2017004010A (es) | 2017-03-27 | 2018-02-09 | Antonio Hernandez Miramontes Jorge | Mezcla de oxalacetato, alfacetoglutarato, ácido tartánico y sales de lactato de calcio y sodio, para tratar pacientes con insuficiencia renal crónica. |
| SG10202107237SA (en) | 2017-04-25 | 2021-08-30 | Buck Inst Res Aging | Formulations for extending lifespan and healthspan |
| US20200253907A1 (en) | 2017-08-21 | 2020-08-13 | The Regents Of The University Of California | Compositions and Methods for Treating Neurodegenerative Diseases |
| KR102833111B1 (ko) | 2018-09-25 | 2025-07-10 | 폰세 드 리온 헬스 데지그네이티드 액티비티 컴퍼니 | 칼슘 알파-케토글루타레이트의 제조 방법 |
| WO2020086733A1 (en) | 2018-10-24 | 2020-04-30 | Ponce De Leon Health Designated Activity Company | Nicotinamide riboside compositions for healthspan extension |
| US20220265586A1 (en) * | 2019-06-10 | 2022-08-25 | Ponce De Leon Health Designated Activity Company | Sustained-release compositions of alpha-ketoglutarate |
| CN114126599A (zh) | 2019-06-10 | 2022-03-01 | 巴克老龄化研究所 | 改变衰老相关分泌表型的方法和组合物 |
| CA3188646A1 (en) | 2020-07-02 | 2022-01-06 | Ponce De Leon Health Designated Activity Company | Compositions and methods for treating crp-mediated diseases |
| CN112941116B (zh) * | 2021-01-04 | 2022-12-02 | 上海朴颐化学科技有限公司 | 一种酶法制备α-酮戊二酸钙的方法 |
| CN115974679A (zh) * | 2022-12-20 | 2023-04-18 | 绍兴市精益生物化工有限公司 | α-酮戊二酸钙盐制备方法 |
-
2019
- 2019-09-23 KR KR1020217010402A patent/KR102833111B1/ko active Active
- 2019-09-23 JP JP2021540377A patent/JP7499259B2/ja active Active
- 2019-09-23 SG SG11202102204PA patent/SG11202102204PA/en unknown
- 2019-09-23 AU AU2019350699A patent/AU2019350699B2/en active Active
- 2019-09-23 US US17/277,752 patent/US11802103B2/en active Active
- 2019-09-23 PE PE2021000354A patent/PE20211816A1/es unknown
- 2019-09-23 MY MYPI2021001576A patent/MY203278A/en unknown
- 2019-09-23 EP EP19866432.8A patent/EP3856166A4/en active Pending
- 2019-09-23 BR BR112021005668-8A patent/BR112021005668A2/pt unknown
- 2019-09-23 CN CN201980073655.2A patent/CN112955139B/zh active Active
- 2019-09-23 MX MX2021003482A patent/MX2021003482A/es unknown
- 2019-09-23 CA CA3112205A patent/CA3112205A1/en active Pending
- 2019-09-23 WO PCT/US2019/052498 patent/WO2020068705A1/en not_active Ceased
- 2019-09-23 IL IL281761A patent/IL281761B2/en unknown
- 2019-09-25 TW TW108134655A patent/TWI863930B/zh active
-
2021
- 2021-02-26 PH PH12021550403A patent/PH12021550403A1/en unknown
- 2021-03-24 CL CL2021000728A patent/CL2021000728A1/es unknown
- 2021-04-11 CO CONC2021/0004529A patent/CO2021004529A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11802103B2 (en) | 2023-10-31 |
| JP2022502489A (ja) | 2022-01-11 |
| BR112021005668A2 (pt) | 2021-06-22 |
| AU2019350699B2 (en) | 2024-05-23 |
| TWI863930B (zh) | 2024-12-01 |
| US20210371368A1 (en) | 2021-12-02 |
| PE20211816A1 (es) | 2021-09-14 |
| SG11202102204PA (en) | 2021-04-29 |
| MY203278A (en) | 2024-06-21 |
| IL281761A (en) | 2021-05-31 |
| IL281761B2 (en) | 2025-09-01 |
| EP3856166A4 (en) | 2022-06-22 |
| IL281761B1 (en) | 2025-05-01 |
| CA3112205A1 (en) | 2020-04-02 |
| CL2021000728A1 (es) | 2021-10-22 |
| KR20210065120A (ko) | 2021-06-03 |
| JP7499259B2 (ja) | 2024-06-13 |
| MX2021003482A (es) | 2021-06-18 |
| AU2019350699A1 (en) | 2021-04-08 |
| TW202024013A (zh) | 2020-07-01 |
| PH12021550403A1 (en) | 2021-10-04 |
| CN112955139B (zh) | 2025-04-18 |
| CN112955139A (zh) | 2021-06-11 |
| KR102833111B1 (ko) | 2025-07-10 |
| WO2020068705A1 (en) | 2020-04-02 |
| EP3856166A1 (en) | 2021-08-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2021004529A2 (es) | Proceso de elaboración de alfa-cetoglutarato de calcio referencia cruzada con solicitudes relacionadas | |
| CO2022002637A2 (es) | Proceso de fabricación de moduladores de cftr | |
| MX2021001542A (es) | Procedimiento para la fabricacion de polietileniminas alcoxiladas. | |
| CL2019002824A1 (es) | Anticuerpos anti-lag3. | |
| CL2020000946A1 (es) | Métodos y composiciones para la producción de trifosfato de nucleosido y ácido ribonucleico | |
| MX2018010427A (es) | Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion. | |
| MX2022016566A (es) | Composiciones que comprenden una caseina y metodos para producir las mismas. | |
| BR112017024691A2 (pt) | ?métodos para produzir biohidrocarbonetos e para produzir um polímero e mistura de biohidrocarbonetos? | |
| EA201891446A1 (ru) | Молекулы полиспецифичных антител, имеющие специфичность к tnf-альфа, il-17a и il-17f | |
| MX2021007245A (es) | Microorganismos para la produccion de putrescina u ornitina y procedimiento para la produccion de putrescina u ornitina usando los mismos. | |
| MX2016013162A (es) | Proceso para la fabricacion de medicamentos. | |
| MX2019014885A (es) | Formas amorfas y cristalinas de inhibidores de indolamina 2,3-dioxigenasa (ido). | |
| BR112019020338A8 (pt) | Composição para produção de tagatose, e, método de produção de tagatose | |
| CL2021001363A1 (es) | Métodos de tratamiento de enfermedades con inhibidores de magl. | |
| CL2020000217A1 (es) | Inhibidores de ror gamma. | |
| CL2020000190A1 (es) | Inhibidores de ror-gamma. | |
| EA202191840A1 (ru) | Способы получения устекинумаба | |
| CO2020006542A2 (es) | Profármacos de creatina, composiciones y métodos de uso de estos | |
| CL2021000902A1 (es) | Método para la fabricación de gemas sintéticas. | |
| BR112017019176A2 (pt) | processos para a preparação de fluorocetolídeos | |
| CL2023001137A1 (es) | Procedimiento para la purificación de pleuromutilinas | |
| BR112019006310A2 (pt) | método para fabricar digliceróxido de cálcio | |
| EA202191779A1 (ru) | Способ получения антраниламидов | |
| MX2022003879A (es) | Proceso para elaborar acidos alcansulfonicos. | |
| MX2019002673A (es) | Composiciones y metodos para tratar demencia. |