CN1127500C - 抑制细胞增殖的取代双吲哚基马来酰亚胺 - Google Patents
抑制细胞增殖的取代双吲哚基马来酰亚胺 Download PDFInfo
- Publication number
- CN1127500C CN1127500C CN99804045A CN99804045A CN1127500C CN 1127500 C CN1127500 C CN 1127500C CN 99804045 A CN99804045 A CN 99804045A CN 99804045 A CN99804045 A CN 99804045A CN 1127500 C CN1127500 C CN 1127500C
- Authority
- CN
- China
- Prior art keywords
- methyl
- compound
- indol
- nitro
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7833198P | 1998-03-17 | 1998-03-17 | |
| US60/078,331 | 1998-03-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1293671A CN1293671A (zh) | 2001-05-02 |
| CN1127500C true CN1127500C (zh) | 2003-11-12 |
Family
ID=22143350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99804045A Expired - Lifetime CN1127500C (zh) | 1998-03-17 | 1999-03-10 | 抑制细胞增殖的取代双吲哚基马来酰亚胺 |
Country Status (34)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9908882A (pt) * | 1998-03-17 | 2000-11-21 | Hoffmann La Roche | Bisindolimaleimidas substituìdas para a inibição de proliferação de célula |
| US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| KR20020038817A (ko) * | 1999-10-12 | 2002-05-23 | 프리돌린 클라우스너, 롤란드 비. 보레르 | 암 치료를 위한 항세포증식제로서의 치환 피롤 |
| US6559164B1 (en) | 1999-10-12 | 2003-05-06 | Hoffmann-La Roche Inc. | Substituted pyrroles suitable for continuous infusion |
| US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| US7129250B2 (en) * | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| US6469179B1 (en) | 2000-10-03 | 2002-10-22 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
| US6482847B2 (en) | 2000-10-03 | 2002-11-19 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
| US6548531B2 (en) | 2001-02-09 | 2003-04-15 | Hoffmann-La Roche Inc. | Method for cancer therapy |
| WO2002102373A1 (en) * | 2001-06-15 | 2002-12-27 | F. Hoffmann-La Roche Ag | Method for administration of cancer therapeutic |
| US20030139373A1 (en) * | 2001-11-20 | 2003-07-24 | Breimer Lars Holger | Method for cancer therapy |
| WO2008117935A1 (en) * | 2007-03-28 | 2008-10-02 | Industry-Academic Cooperation Foundation, Yonsei University | Nk cell activating molecules, nk cells and pharmaceutical compositons comprising the same |
| CN102924437B (zh) * | 2012-11-19 | 2014-07-02 | 东华大学 | 3-哌嗪基-4-吲哚马来酰亚胺化合物及其制备和应用 |
| WO2019000224A1 (zh) * | 2017-06-27 | 2019-01-03 | 中国海洋大学 | 双吲哚马来酰亚胺衍生物及其制备方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL89167A (en) * | 1988-02-10 | 1994-02-27 | Hoffmann La Roche | Substituted pyrroles, their manufacture and pharmaceutical compositions containing them |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| PT817627E (pt) * | 1993-12-23 | 2005-07-29 | Lilly Co Eli | Inibidores da proteina cinase c |
| PE91598A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| PE91498A1 (es) * | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | Pirroles sustituidos |
| PE91698A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| BR9908882A (pt) * | 1998-03-17 | 2000-11-21 | Hoffmann La Roche | Bisindolimaleimidas substituìdas para a inibição de proliferação de célula |
-
1999
- 1999-03-10 BR BR9908882-7A patent/BR9908882A/pt not_active Application Discontinuation
- 1999-03-10 AU AU34099/99A patent/AU755673B2/en not_active Expired
- 1999-03-10 KR KR1020007010323A patent/KR100659411B1/ko not_active IP Right Cessation
- 1999-03-10 AT AT99915558T patent/ATE243693T1/de active
- 1999-03-10 ES ES99915558T patent/ES2203111T3/es not_active Expired - Lifetime
- 1999-03-10 HU HU0101258A patent/HU228831B1/hu unknown
- 1999-03-10 CN CN99804045A patent/CN1127500C/zh not_active Expired - Lifetime
- 1999-03-10 PT PT99915558T patent/PT1064279E/pt unknown
- 1999-03-10 NZ NZ506476A patent/NZ506476A/en not_active IP Right Cessation
- 1999-03-10 IL IL13824799A patent/IL138247A/xx not_active IP Right Cessation
- 1999-03-10 DE DE69909068T patent/DE69909068T2/de not_active Expired - Lifetime
- 1999-03-10 DK DK99915558T patent/DK1064279T3/da active
- 1999-03-10 PL PL342964A patent/PL195323B1/pl unknown
- 1999-03-10 EP EP99915558A patent/EP1064279B1/en not_active Expired - Lifetime
- 1999-03-10 WO PCT/EP1999/001534 patent/WO1999047518A1/en active IP Right Grant
- 1999-03-10 ID IDW20001730A patent/ID26353A/id unknown
- 1999-03-10 CZ CZ20003384A patent/CZ299068B6/cs not_active IP Right Cessation
- 1999-03-10 CA CA002322689A patent/CA2322689C/en not_active Expired - Lifetime
- 1999-03-10 RS YUP-552/00A patent/RS49965B/sr unknown
- 1999-03-10 JP JP2000536713A patent/JP5026633B2/ja not_active Expired - Lifetime
- 1999-03-10 RU RU2000125889/04A patent/RU2208612C2/ru active
- 1999-03-10 TR TR2000/02580T patent/TR200002580T2/xx unknown
- 1999-03-12 PE PE1999000199A patent/PE20000340A1/es not_active IP Right Cessation
- 1999-03-12 MA MA25492A patent/MA26613A1/fr unknown
- 1999-03-15 AR ARP990101117A patent/AR018162A1/es active IP Right Grant
- 1999-03-15 ZA ZA9902072A patent/ZA992072B/xx unknown
- 1999-03-15 TW TW088103914A patent/TW539676B/zh not_active IP Right Cessation
- 1999-03-15 MY MYPI99000952A patent/MY121046A/en unknown
- 1999-03-15 CO CO99015752A patent/CO5070675A1/es unknown
- 1999-03-16 US US09/268,887 patent/US6048887A/en not_active Expired - Lifetime
- 1999-04-13 SA SA99191295A patent/SA99191295B1/ar unknown
-
2000
- 2000-09-06 HR HR20000585A patent/HRP20000585B1/xx not_active IP Right Cessation
- 2000-09-14 NO NO20004579A patent/NO320306B1/no not_active IP Right Cessation
-
2001
- 2001-10-15 HK HK01107189A patent/HK1036452A1/xx not_active IP Right Cessation
-
2010
- 2010-06-02 JP JP2010126632A patent/JP2010222366A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1127500C (zh) | 抑制细胞增殖的取代双吲哚基马来酰亚胺 | |
| EP1487804B1 (fr) | Derives d'aminoindazoles comme inhibiteurs de proteine-kinase | |
| CN101072759B (zh) | 调节hsp90活性的三唑化合物 | |
| CN112218851A (zh) | 整合应激通路的调节剂 | |
| CN1019806B (zh) | 利拜卡霉素类似物的制备方法 | |
| CN1314904A (zh) | 用作抗癌剂的炔基取代的喹啉－2－酮衍生物 | |
| CA2710224C (fr) | Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| CN1942446A (zh) | 用于治疗癌症的吡唑啉衍生物 | |
| CN1217720A (zh) | 苯并呋喃基衍生物及其应用 | |
| CN103298805A (zh) | 喹唑啉化合物及其使用方法 | |
| CN1495182A (zh) | 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺 | |
| Zhang et al. | Synthesis of glycol nucleic acids | |
| CN100349892C (zh) | 抗菌的吲哚酮唑烷酮、它们的制备中间体和含有它们的药物组合物 | |
| CN101163710B (zh) | 膦过渡金属配位化合物、其制造方法和含有其的抗癌剂 | |
| CN113825757A (zh) | 取代的稠合双环类衍生物、其制备方法及其在医药上的应用 | |
| CN1077572C (zh) | 取代的吡咯 | |
| FR2580642A1 (fr) | 5-pyrimidinecarboxamides et traitement de la leucemie et des tumeurs en les utilisant | |
| CN1330654A (zh) | 4,5－吡咯并羟吲哚 | |
| CN1055739A (zh) | 半水合物 | |
| CN1777586A (zh) | 稳定的无定形樟脑磺酸氨氯地平、其制备工艺以及其口服给药的组合物 | |
| CN1411457A (zh) | 取代的吡咯类化合物 | |
| CN1046285C (zh) | 作为抗增殖剂的稠合杂环谷氨酸衍生物 | |
| CN1051546C (zh) | 新的1,1-双杂唑基烷烃衍生物及其作为神经保护剂的用途 | |
| CN1699385A (zh) | 匹伏阿德福韦的晶型 | |
| CN105085493A (zh) | 作为丙型肝炎抑制剂的螺环化合物及其在药物中的应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20031112 |
|
| CX01 | Expiry of patent term |