CN1124135C - 雷帕霉素衍生物在血管病和异种移植中的应用 - Google Patents

雷帕霉素衍生物在血管病和异种移植中的应用 Download PDF

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Publication number
CN1124135C
CN1124135C CN97193278A CN97193278A CN1124135C CN 1124135 C CN1124135 C CN 1124135C CN 97193278 A CN97193278 A CN 97193278A CN 97193278 A CN97193278 A CN 97193278A CN 1124135 C CN1124135 C CN 1124135C
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CN
China
Prior art keywords
rapamycin
compound
formula
rejection
application
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN97193278A
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English (en)
Chinese (zh)
Other versions
CN1214631A (zh
Inventor
W·舒勒
H·舒尔曼
G·伟克比克尔
H－G·泽尔维斯
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Novartis AG
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Novartis AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10791127&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1124135(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1214631A publication Critical patent/CN1214631A/zh
Application granted granted Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
CN97193278A 1996-03-27 1997-03-26 雷帕霉素衍生物在血管病和异种移植中的应用 Expired - Lifetime CN1124135C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9606452.2A GB9606452D0 (en) 1996-03-27 1996-03-27 Organic compounds
GB9606452.2 1996-03-27

Publications (2)

Publication Number Publication Date
CN1214631A CN1214631A (zh) 1999-04-21
CN1124135C true CN1124135C (zh) 2003-10-15

Family

ID=10791127

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97193278A Expired - Lifetime CN1124135C (zh) 1996-03-27 1997-03-26 雷帕霉素衍生物在血管病和异种移植中的应用

Country Status (29)

Country Link
US (5) US6384046B1 (enExample)
EP (3) EP1149581A3 (enExample)
JP (2) JP2000507226A (enExample)
KR (2) KR100836971B1 (enExample)
CN (1) CN1124135C (enExample)
AT (1) ATE224194T1 (enExample)
AU (1) AU716514B2 (enExample)
BR (1) BR9708358A (enExample)
CA (1) CA2247275C (enExample)
CY (1) CY2404B1 (enExample)
CZ (1) CZ292483B6 (enExample)
DE (1) DE69715611T2 (enExample)
DK (2) DK2008657T3 (enExample)
ES (2) ES2184078T3 (enExample)
GB (1) GB9606452D0 (enExample)
HU (1) HU226422B1 (enExample)
ID (1) ID17195A (enExample)
IL (1) IL125812A (enExample)
MY (1) MY117798A (enExample)
NO (1) NO316667B1 (enExample)
NZ (1) NZ331463A (enExample)
PL (1) PL187732B1 (enExample)
PT (2) PT893996E (enExample)
RU (1) RU2214247C2 (enExample)
SI (1) SI2008657T1 (enExample)
SK (1) SK284343B6 (enExample)
TR (1) TR199801919T2 (enExample)
WO (1) WO1997035575A1 (enExample)
ZA (1) ZA972719B (enExample)

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Also Published As

Publication number Publication date
AU2291897A (en) 1997-10-17
ZA972719B (en) 1998-09-28
ES2421455T3 (es) 2013-09-02
US20020127248A1 (en) 2002-09-12
US20120177690A1 (en) 2012-07-12
DK0893996T3 (da) 2002-12-09
KR100836971B1 (ko) 2008-06-10
IL125812A0 (en) 1999-04-11
EP0893996B1 (en) 2002-09-18
AU716514B2 (en) 2000-02-24
CN1214631A (zh) 1999-04-21
PT893996E (pt) 2002-12-31
EP0893996A1 (en) 1999-02-03
EP2008657A3 (en) 2009-02-04
KR20070083654A (ko) 2007-08-24
US6384046B1 (en) 2002-05-07
HUP0001267A3 (en) 2002-01-28
EP1149581A2 (en) 2001-10-31
CA2247275A1 (en) 1997-10-02
JP5124431B2 (ja) 2013-01-23
NO316667B1 (no) 2004-03-29
NO984340L (no) 1998-09-18
US20100152105A1 (en) 2010-06-17
JP2000507226A (ja) 2000-06-13
BR9708358A (pt) 1999-08-03
HK1018688A1 (en) 1999-12-30
ID17195A (id) 1997-12-11
CZ292483B6 (cs) 2003-09-17
EP1149581A3 (en) 2003-12-03
HU226422B1 (en) 2008-12-29
SK284343B6 (sk) 2005-02-04
EP2008657B1 (en) 2013-04-24
PL328659A1 (en) 1999-02-15
PL187732B1 (pl) 2004-09-30
ES2184078T3 (es) 2003-04-01
GB9606452D0 (en) 1996-06-05
WO1997035575A1 (en) 1997-10-02
CA2247275C (en) 2011-10-11
ATE224194T1 (de) 2002-10-15
SK132798A3 (en) 1999-03-12
TR199801919T2 (xx) 1999-02-22
US20140187574A1 (en) 2014-07-03
DE69715611D1 (de) 2002-10-24
NO984340D0 (no) 1998-09-18
MY117798A (en) 2004-08-30
HUP0001267A2 (hu) 2000-11-28
IL125812A (en) 2001-12-23
CZ307098A3 (cs) 1999-01-13
JP2009102349A (ja) 2009-05-14
CY2404B1 (en) 2004-09-10
EP2008657A2 (en) 2008-12-31
DE69715611T2 (de) 2003-05-22
PT2008657E (pt) 2013-07-12
SI2008657T1 (sl) 2013-07-31
DK2008657T3 (da) 2013-07-22
KR20050038656A (ko) 2005-04-27
NZ331463A (en) 2001-10-26
RU2214247C2 (ru) 2003-10-20

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