CY2404B1 - Use of rapamycin derivatives in vasculopathies andxenotransplantation. - Google Patents

Use of rapamycin derivatives in vasculopathies andxenotransplantation.

Info

Publication number
CY2404B1
CY2404B1 CY0400004A CY0400004A CY2404B1 CY 2404 B1 CY2404 B1 CY 2404B1 CY 0400004 A CY0400004 A CY 0400004A CY 0400004 A CY0400004 A CY 0400004A CY 2404 B1 CY2404 B1 CY 2404B1
Authority
CY
Cyprus
Prior art keywords
andxenotransplantation
vasculopathies
rapamycin derivatives
rapamycin
deoxyspergualine
Prior art date
Application number
CY0400004A
Other languages
English (en)
Inventor
Walter Schuler
Hendrik Schuurman
Gisbert Weckbecker
Hans-Guenter Zerwes
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10791127&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2404(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY2404B1 publication Critical patent/CY2404B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CY0400004A 1996-03-27 2004-01-08 Use of rapamycin derivatives in vasculopathies andxenotransplantation. CY2404B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9606452.2A GB9606452D0 (en) 1996-03-27 1996-03-27 Organic compounds

Publications (1)

Publication Number Publication Date
CY2404B1 true CY2404B1 (en) 2004-09-10

Family

ID=10791127

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0400004A CY2404B1 (en) 1996-03-27 2004-01-08 Use of rapamycin derivatives in vasculopathies andxenotransplantation.

Country Status (30)

Country Link
US (5) US6384046B1 (xx)
EP (3) EP1149581A3 (xx)
JP (2) JP2000507226A (xx)
KR (2) KR20070083654A (xx)
CN (1) CN1124135C (xx)
AT (1) ATE224194T1 (xx)
AU (1) AU716514B2 (xx)
BR (1) BR9708358A (xx)
CA (1) CA2247275C (xx)
CY (1) CY2404B1 (xx)
CZ (1) CZ292483B6 (xx)
DE (1) DE69715611T2 (xx)
DK (2) DK2008657T3 (xx)
ES (2) ES2421455T3 (xx)
GB (1) GB9606452D0 (xx)
HK (1) HK1018688A1 (xx)
HU (1) HU226422B1 (xx)
ID (1) ID17195A (xx)
IL (1) IL125812A (xx)
MY (1) MY117798A (xx)
NO (1) NO316667B1 (xx)
NZ (1) NZ331463A (xx)
PL (1) PL187732B1 (xx)
PT (2) PT893996E (xx)
RU (1) RU2214247C2 (xx)
SI (1) SI2008657T1 (xx)
SK (1) SK284343B6 (xx)
TR (1) TR199801919T2 (xx)
WO (1) WO1997035575A1 (xx)
ZA (1) ZA972719B (xx)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606452D0 (en) * 1996-03-27 1996-06-05 Sandoz Ltd Organic compounds
ATE222502T1 (de) 1996-07-30 2002-09-15 Novartis Ag Kombinationspräparat mit hemmender wirkung auf die abstossung von transplantaten, autoimmunerkrankungen und entzündungen, welches cyclosporin a und 40-0-(2-hydroxyethyl)-rapamycin enthält
US6890546B2 (en) 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
DE60044717D1 (de) * 1999-05-10 2010-09-02 Paolo Brenner Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen
US7807211B2 (en) 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
US20070032853A1 (en) † 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US8460367B2 (en) * 2000-03-15 2013-06-11 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US20070141107A1 (en) * 2000-03-15 2007-06-21 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
AU2001245734A1 (en) 2000-03-15 2001-09-24 Orbus Medical Technologies Inc. Coating that promotes endothelial cell adherence
US20070055367A1 (en) * 2000-03-15 2007-03-08 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence and differentiation
US20030229393A1 (en) * 2001-03-15 2003-12-11 Kutryk Michael J. B. Medical device with coating that promotes cell adherence and differentiation
US8236048B2 (en) 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US6670355B2 (en) 2000-06-16 2003-12-30 Wyeth Method of treating cardiovascular disease
US20020013335A1 (en) * 2000-06-16 2002-01-31 American Home Products Corporation Method of treating cardiovascular disease
EP1709974A3 (en) * 2000-06-16 2006-12-06 Wyeth Method of treating cardiovascular disease using rapamycin
MXPA03002871A (es) 2000-09-29 2004-12-06 Johnson & Johnson Dispositivos medicos recubiertos.
ES2728739T3 (es) * 2001-02-19 2019-10-28 Novartis Pharma Ag Derivado de rapamicina para el tratamiento de un tumor sólido asociado con angiogénesis desregulada
US8741378B1 (en) 2001-06-27 2014-06-03 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device
US6939376B2 (en) 2001-11-05 2005-09-06 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US7682387B2 (en) * 2002-04-24 2010-03-23 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US20040024450A1 (en) * 2002-04-24 2004-02-05 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
WO2003099169A1 (en) * 2002-05-20 2003-12-04 Orbus Medical Technologies Inc. Drug eluting implantable medical device
US8109987B2 (en) 2003-04-14 2012-02-07 Tryton Medical, Inc. Method of treating a lumenal bifurcation
US7279174B2 (en) 2003-05-08 2007-10-09 Advanced Cardiovascular Systems, Inc. Stent coatings comprising hydrophilic additives
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
US7220755B2 (en) 2003-11-12 2007-05-22 Biosensors International Group, Ltd. 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
US9114198B2 (en) 2003-11-19 2015-08-25 Advanced Cardiovascular Systems, Inc. Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
KR20070008714A (ko) * 2004-04-30 2007-01-17 오르버스네이치 메디칼 인코포레이티드 유전적으로-변형된 세포 포획용 코팅을 갖는 의료 장치 및이의 사용 방법
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
US8709469B2 (en) 2004-06-30 2014-04-29 Abbott Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US7901451B2 (en) 2004-09-24 2011-03-08 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
EP1838288A4 (en) * 2004-12-20 2010-08-04 Ariad Pharma Inc THERAPEUTIC MATERIALS AND METHODS
CN102579467A (zh) 2005-11-14 2012-07-18 阿里亚德医药股份有限公司 雷帕霉素衍生物在治疗癌症中的用途
WO2007058399A1 (en) * 2005-11-17 2007-05-24 Access Plus Co., Ltd A tube for connecting marteriovenous and interposition for medical operation
US20070173923A1 (en) * 2006-01-20 2007-07-26 Savage Douglas R Drug reservoir stent
CN104906087A (zh) 2006-09-13 2015-09-16 万能医药公司 大环内酯化合物及它们的使用方法
US8067055B2 (en) * 2006-10-20 2011-11-29 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method of use
US20080097591A1 (en) * 2006-10-20 2008-04-24 Biosensors International Group Drug-delivery endovascular stent and method of use
US20080103584A1 (en) 2006-10-25 2008-05-01 Biosensors International Group Temporal Intraluminal Stent, Methods of Making and Using
KR100930167B1 (ko) * 2007-09-19 2009-12-07 삼성전기주식회사 초광각 광학계
US8661630B2 (en) 2008-05-21 2014-03-04 Abbott Cardiovascular Systems Inc. Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer
KR101587522B1 (ko) 2007-11-14 2016-01-21 바이오센서스 인터내셔널 그룹, 리미티드 자동화된 코팅장치 및 방법
WO2009089549A1 (en) * 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
EP2352459A4 (en) * 2008-10-03 2013-09-25 Elixir Medical Corp MACROCYCLIC LACTONE COMPOUNDS AND METHODS OF USE
US8366763B2 (en) 2009-07-02 2013-02-05 Tryton Medical, Inc. Ostium support for treating vascular bifurcations
US8685433B2 (en) 2010-03-31 2014-04-01 Abbott Cardiovascular Systems Inc. Absorbable coating for implantable device
UA104738C2 (ru) 2011-05-18 2014-03-11 Олег Миколайович Лазаренко Композиция для повышения биосовместимости имплантатов и клеток для трансплантации с организмом реципиента и способ ее приготовления
CN102268015B (zh) * 2011-08-30 2013-08-28 成都摩尔生物医药有限公司 一种依维莫司的合成方法
US10682415B2 (en) 2013-07-22 2020-06-16 Wisconsin Alumni Research Foundation Thermogel formulation for combination drug delivery
KR101723265B1 (ko) 2013-08-16 2017-04-04 가톨릭대학교 산학협력단 mTOR/STAT3 신호억제제 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물
AU2014326794B2 (en) 2013-09-24 2019-03-21 Giner, Inc. System for gas treatment of a cell implant
CA2926719C (en) 2013-10-08 2020-11-24 Lam Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
US10307371B2 (en) 2014-02-11 2019-06-04 AI Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
CA2939342A1 (en) 2014-02-11 2015-08-20 Lam Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
EP4218742A1 (en) 2014-04-04 2023-08-02 AI Therapeutics, Inc. An inhalable rapamycin formulation for treating age-related conditions
EP3209330B1 (en) 2014-10-07 2022-02-23 AI Therapeutics, Inc. An inhalable sirolimus formulation for the treatment of pulmonary hypertension
MA40910A (fr) 2014-11-07 2017-09-12 Civitas Therapeutics Inc Poudres de rapamycine pour administration pulmonaire
WO2016130645A1 (en) 2015-02-10 2016-08-18 Lam Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
WO2018031789A1 (en) 2016-08-10 2018-02-15 The Board Of Regents Of The University Of Texas System Topical rapamycin therapy
CN109715224B (zh) 2016-09-19 2022-02-22 百多力股份公司 无聚合物的药物洗脱血管支架
BR112019009712A2 (pt) 2016-11-15 2019-08-13 Giner Life Sciences Inc dispositivo de difusão gasosa percutânea adequado para uso com um implante subcutâneo
US20190358369A1 (en) 2016-12-22 2019-11-28 Biotronik Ag Drug releasing coatings for medical devices and methods of making same
JP7199632B2 (ja) 2017-05-04 2023-01-06 ガイナー，インク． 堅牢なインプラント可能なガス送達装置ならびにそれを含む方法、システムおよび装置
AR112834A1 (es) 2017-09-26 2019-12-18 Novartis Ag Derivados de rapamicina
TW202045165A (zh) 2019-02-20 2020-12-16 美商Ａｉ治療公司 局部雷帕黴素調配物以及其於治療臉部血管纖維瘤和其他皮膚疾病中的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
CA2086642C (en) * 1992-01-09 2004-06-15 Randall E. Morris Method of treating hyperproliferative vascular disease
US5516781A (en) * 1992-01-09 1996-05-14 American Home Products Corporation Method of treating restenosis with rapamycin
CA2094858C (en) * 1992-04-28 2004-06-15 Robert D. Mitchell Method of treating hyperproliferative vascular disease
US5747034A (en) * 1992-07-09 1998-05-05 Chiron Corporation Methods and materials for the induction of T cell anergy
US5283257A (en) * 1992-07-10 1994-02-01 The Board Of Trustees Of The Leland Stanford Junior University Method of treating hyperproliferative vascular disease
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
CN1046944C (zh) * 1993-12-17 1999-12-01 山道士有限公司 雷怕霉素类衍生物
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US6265427B1 (en) * 1995-06-07 2001-07-24 The Proctor & Gamble Company Pharmaceutical composition for the method of treating leukemia
RU2158267C2 (ru) * 1995-06-09 2000-10-27 Новартис Аг Производные рапамицина и фармацевтическая композиция на их основе
GB9606452D0 (en) * 1996-03-27 1996-06-05 Sandoz Ltd Organic compounds

Also Published As

Publication number Publication date
DK2008657T3 (da) 2013-07-22
DK0893996T3 (da) 2002-12-09
PL187732B1 (pl) 2004-09-30
DE69715611T2 (de) 2003-05-22
AU2291897A (en) 1997-10-17
IL125812A (en) 2001-12-23
US20100152105A1 (en) 2010-06-17
US20120177690A1 (en) 2012-07-12
EP0893996B1 (en) 2002-09-18
IL125812A0 (en) 1999-04-11
EP1149581A3 (en) 2003-12-03
CZ292483B6 (cs) 2003-09-17
ATE224194T1 (de) 2002-10-15
PT893996E (pt) 2002-12-31
HUP0001267A3 (en) 2002-01-28
US20020127248A1 (en) 2002-09-12
EP1149581A2 (en) 2001-10-31
GB9606452D0 (en) 1996-06-05
JP2000507226A (ja) 2000-06-13
ES2184078T3 (es) 2003-04-01
SK132798A3 (en) 1999-03-12
MY117798A (en) 2004-08-30
US20140187574A1 (en) 2014-07-03
KR20070083654A (ko) 2007-08-24
ES2421455T3 (es) 2013-09-02
HK1018688A1 (en) 1999-12-30
HU226422B1 (en) 2008-12-29
CA2247275A1 (en) 1997-10-02
JP5124431B2 (ja) 2013-01-23
NZ331463A (en) 2001-10-26
CZ307098A3 (cs) 1999-01-13
AU716514B2 (en) 2000-02-24
CN1214631A (zh) 1999-04-21
EP0893996A1 (en) 1999-02-03
US6384046B1 (en) 2002-05-07
BR9708358A (pt) 1999-08-03
TR199801919T2 (xx) 1999-02-22
EP2008657A2 (en) 2008-12-31
KR20050038656A (ko) 2005-04-27
PT2008657E (pt) 2013-07-12
EP2008657B1 (en) 2013-04-24
EP2008657A3 (en) 2009-02-04
ID17195A (id) 1997-12-11
CA2247275C (en) 2011-10-11
DE69715611D1 (de) 2002-10-24
SI2008657T1 (sl) 2013-07-31
CN1124135C (zh) 2003-10-15
HUP0001267A2 (hu) 2000-11-28
PL328659A1 (en) 1999-02-15
RU2214247C2 (ru) 2003-10-20
KR100836971B1 (ko) 2008-06-10
NO316667B1 (no) 2004-03-29
NO984340L (no) 1998-09-18
ZA972719B (en) 1998-09-28
NO984340D0 (no) 1998-09-18
SK284343B6 (sk) 2005-02-04
WO1997035575A1 (en) 1997-10-02
JP2009102349A (ja) 2009-05-14

Similar Documents

Publication Publication Date Title
CY2404B1 (en) Use of rapamycin derivatives in vasculopathies andxenotransplantation.
EA200000848A1 (ru) Способ селективного снижения числа или активности макрофагов (варианты), способ лечения или профилактики заболевания субъекта (варианты), способ диагностики заболевания у субъекта
IL140137A (en) Receptor bodies specifically binding tie-2 ligands
TW249198B (en) Stents for autologous tissue heart valve
DE69205845T2 (de) Katalysatorträger, zusammensetzung und Verfahren zu seiner Herstellung.
MX9603479A (es) Derivados de 4-amino de acido micofenolico con actividad inmunosupresora.
ES2184800T3 (es) Uso de agentes anti-vegf en el tratamiento de la endometriosis.
PT922071E (pt) Copolimeros reticulados a base de polimeros policarboxilicos
DE69112007D1 (de) Ferritischer, hitzebeständiger Gussstahl und Verfahren zu seiner Herstellung.
Giakas Risperidone treatment for a Tourette's disorder patient with comorbid obsessive-compulsive disorder.
DE69522564D1 (de) Alkalibeständiges proteinadsorbens
IL112666A0 (en) 4-amino derivatives of 5-substituted mycophenolic acid, their preparation and pharmaceutical compositions containing them
Pioli Reactivation failure in infants: A processing analysis.
RU2000124058A (ru) Способ лечения миопии
IT1241270B (it) Procedimento per realizzare vaschette di contenimento per cuscini, particolarmente cuscini di sedili per autoveicoli.
RU96119633A (ru) Способ лечения аметропий и разницы в функциональных показателях правого и левого глаза по святковской т.я.
UA36539A (uk) Спосіб проведення тренувань, що засновані на переміщеннях пацієнта, та комплекс засобів для його здійснення
ES1022409U (es) Soporte para ceniceros, posavasos y similares desechables o no desechables.
IT9053024U1 (it) Sedile per tazza di w. c. dotato di dispositivo di riscaldamento, di as pirazione e filtrazione