CN110691795A - 包含抗-lag3抗体、pd-1途径抑制剂和免疫治疗剂组合的组合物 - Google Patents

包含抗-lag3抗体、pd-1途径抑制剂和免疫治疗剂组合的组合物 Download PDF

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Publication number
CN110691795A
CN110691795A CN201880036532.7A CN201880036532A CN110691795A CN 110691795 A CN110691795 A CN 110691795A CN 201880036532 A CN201880036532 A CN 201880036532A CN 110691795 A CN110691795 A CN 110691795A
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antibody
antagonist
agonist
cancer
lag
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Chinese (zh)
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A·J·科曼
N·隆伯格
M·J·塞尔比
J·杰克逊
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201880036532.7A 2017-05-30 2018-05-30 包含抗-lag3抗体、pd-1途径抑制剂和免疫治疗剂组合的组合物 Pending CN110691795A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762512618P 2017-05-30 2017-05-30
US62/512,618 2017-05-30
US201762513812P 2017-06-01 2017-06-01
US62/513,812 2017-06-01
PCT/US2018/035125 WO2018222711A2 (en) 2017-05-30 2018-05-30 Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent

Publications (1)

Publication Number Publication Date
CN110691795A true CN110691795A (zh) 2020-01-14

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CN201880036532.7A Pending CN110691795A (zh) 2017-05-30 2018-05-30 包含抗-lag3抗体、pd-1途径抑制剂和免疫治疗剂组合的组合物

Country Status (11)

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US (3) US20210340250A1 (https=)
EP (2) EP4245375A3 (https=)
JP (3) JP2020522495A (https=)
KR (1) KR20200010500A (https=)
CN (1) CN110691795A (https=)
AU (2) AU2018277559A1 (https=)
BR (1) BR112019018759A2 (https=)
CA (1) CA3060989A1 (https=)
IL (1) IL269090A (https=)
MX (1) MX2019012038A (https=)
WO (1) WO2018222711A2 (https=)

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CN111808192A (zh) * 2020-06-05 2020-10-23 北京天广实生物技术股份有限公司 结合lag3的抗体及其用途
CN113616788A (zh) * 2020-05-08 2021-11-09 勤浩医药（苏州）有限公司 抗lag-3抗体与shp-2抑制剂联合治疗肿瘤的用途
CN115845052A (zh) * 2022-12-28 2023-03-28 广州誉衡生物科技有限公司 一种药物组合物和药物制剂及其在治疗结肠癌中的应用
CN116059341A (zh) * 2021-07-23 2023-05-05 中山康方生物医药有限公司 药物组合物及用途
CN116925236A (zh) * 2023-05-12 2023-10-24 上海恩凯细胞技术有限公司 嵌合转换受体及其应用
WO2025195358A1 (zh) * 2024-03-19 2025-09-25 江苏恒瑞医药股份有限公司 Pd-1结合蛋白及医药用途

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KR20250120305A (ko) 2022-12-14 2025-08-08 아스텔라스 파마 유럽 비.브이. Cldn18.2 및 cd3에 결합하는 2중 특이성 결합제와 면역 체크포인트 저해제를 수반한 조합 요법
CN115869399B (zh) * 2022-12-28 2024-01-12 广州誉衡生物科技有限公司 一种药物组合物和药物制剂及其在治疗非小细胞肺癌中的应用
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TW202540189A (zh) 2023-11-30 2025-10-16 德商生物新技術公司 在組合療法中能夠結合ｏｘ４０之抗體
AR134560A1 (es) 2023-12-08 2026-01-28 Astellas Pharma Inc Terapia de combinación que implica agentes de unión biespecíficos que se unen a cldn18.2 y cd3 y agentes que estabilizan o aumentan la expresión de cldn18.2
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