CN110198683A - 用于植入假体心脏瓣膜的输送系统、方法和装置的系统、方法和装置 - Google Patents

用于植入假体心脏瓣膜的输送系统、方法和装置的系统、方法和装置 Download PDF

Info

Publication number
CN110198683A
CN110198683A CN201880007705.2A CN201880007705A CN110198683A CN 110198683 A CN110198683 A CN 110198683A CN 201880007705 A CN201880007705 A CN 201880007705A CN 110198683 A CN110198683 A CN 110198683A
Authority
CN
China
Prior art keywords
mitral valve
prosthetic mitral
valve film
film device
delivery conduit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201880007705.2A
Other languages
English (en)
Other versions
CN110198683B (zh
Inventor
杰弗里·W·钱伯斯
格雷戈里·G·布鲁克
约瑟夫·P·希金斯
萨拉瓦纳·B·库玛尔
詹森·S·迪德林
卡尔·A·卡巴罗夫斯基
罗伯特·J·撒切尔
詹姆斯·E·弗莱厄蒂
杰弗里·R·斯通
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
4C Medical Technologies Inc
Original Assignee
4C Medical Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4C Medical Technologies Inc filed Critical 4C Medical Technologies Inc
Priority to CN202210281271.3A priority Critical patent/CN115068170A/zh
Publication of CN110198683A publication Critical patent/CN110198683A/zh
Application granted granted Critical
Publication of CN110198683B publication Critical patent/CN110198683B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/243—Deployment by mechanical expansion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2436—Deployment by retracting a sheath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2439—Expansion controlled by filaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

公开了用于将假体心脏瓣膜装置输送到心脏腔室用于扩张实施的输送系统、装置和方法的实施例。更具体而言，方法、系统和装置被公开，用于将自扩张假体二尖瓣膜装置输送到左心房，在输送期间不接合左心室、原生二尖瓣膜小叶或上环形表面下游的环形组织，并且在一些实施例中，心室、二尖瓣膜小叶和/或位于上环形表面下游的环形组织不被已输送、已定位并且已扩张的假体二尖瓣膜装置接合。

Description

用于植入假体心脏瓣膜的输送系统、方法和装置的系统、方法 和装置
发明人
Jeffrey W.Chambers，梅普尔格罗夫，明尼苏达州，美国公民；
Gregory G.Brucker，明尼阿波利斯，明尼苏达州，美国公民；
Joseph P.Higgins，明尼通卡，明尼苏达州，美国公民；
Saravana B.Kumar，明尼通卡，明尼苏达州，印度公民；
Jason S.Diedering，明尼阿波利斯，明尼苏达州，美国公民；
Karl A.Kabarowski，梅普尔格罗夫，明尼苏达州，美国公民；
Robert J.Thatcher，布莱恩，明尼苏达州，美国公民；
James E.Flaherty，明尼通卡，明尼苏达州，美国公民；以及
Jeffrey R.Stone，明尼通卡，明尼苏达州，美国公民。
相关申请的交叉引用
本申请要求2017年1月19日提交的题为“SYSTEMS,METHODS AND DEVICES FORDELIVERY SYSTEMS,METHODS AND DEVICES FOR IMPLANTING PROSTHETIC HEART VALVES”的美国临时申请No.62/448036的权益，其全部内容通过引用并入本文。
关于联邦资助的研究或开发的声明
不适用
通过引用并入
所有参考文献(包括但不限于本说明书中提及的出版物、专利申请和专利)通过引用并入本文，程度如同于以及效果如同于每个参考文献被具体地和单独地表明通过引用并入一样。
技术领域
本文所描述的发明涉及用于输送和/或定位心脏瓣膜的输送系统、装置和方法。
背景技术
人类心脏包括四个腔室和四个心脏瓣膜，其协助使血液向前(顺行)流动通过心脏。腔室包括左心房、左心室、右心房和左心室。四个心脏瓣膜包括二尖瓣膜、三尖瓣膜、主动脉瓣和肺动脉瓣。
二尖瓣膜位于左心房与左心室之间，并且通过用作防止向左心房中回流的单向瓣膜来帮助控制血液从左心房到左心室的流动。类似地，三尖瓣膜位于右心房与右心室之间，而主动脉瓣和肺动脉瓣是位于供血液流动离开心脏的动脉中的半月瓣。瓣膜均为单向瓣膜，具有小叶，其打开以允许向前(顺行)的血液流动。正常工作的瓣膜小叶在由反流血液施加的压力下关闭，以防止血液回流(逆行)到其刚刚流出的腔室中。
由于各种原因和/或状况(包括但不限于疾病、创伤、先天性畸形和衰老)，原生心脏瓣膜可能是或者变得功能失调。这些类型的状况可能导致瓣膜结构不能正常打开(狭窄故障)和/或不能正常关闭(反流)。
二尖瓣膜反流是由功能失调的二尖瓣膜引起的特定问题。二尖瓣膜反流由允许至少一些逆行血液流从右心房返回到左心房中的二尖瓣膜导致。该血液回流以一定的体积负荷对左心室造成负担，这可能导致一系列左心室代偿性适应和调整，包括重塑心室腔室尺寸和形状，其在二尖瓣膜反流的长期临床过程中显著地变化。
因此，原生心脏瓣膜(例如二尖瓣膜)通常可能需要功能性修复和/或协助，包括部分或完全置换。这种干预可以采取数种形式，包括开心手术和开心植入置换心脏瓣膜。参见例如美国专利No.4,106,129(Carpentier)，来获知一种手术，其是高度创伤性的、充满患者风险，并且不仅需要长期住院治疗，而且还需要非常痛苦的恢复期。
用于置换功能失调的心脏瓣膜的创伤性较小的方法和装置也是已知的，并且涉及经皮进入以及置换瓣膜的导管促进输送。这些解决方案中的大多数都涉及附接至结构支撑件(比如本领域公知的支架)的置换心脏瓣膜，或设计成在从输送导管释放后扩张的其它形式的线网。例如参见美国专利No.3,657,744(Ersek)；美国专利No.5,411,552(Andersen)。支撑支架的自扩张变型协助在对象心脏腔室或血管内定位瓣膜并将已扩张的装置保持就位。当装置在第一次定位尝试中没有恰当地定位(情况往往如此)，并且因此必须被重新捕获并在位置上被调节时，这种自扩张形式也存在问题。该重新捕获过程在已完全或甚至部分扩张的装置的情况下，需要将装置重新收缩到一点，其允许操作者将已收缩的装置缩回到输送护套或导管中，调节用于装置的入进位置，并且随后通过将在位置上已得到调节的装置向远侧重新部署到输送护套或导管外来重新扩张到适当位置。收缩已经扩张的装置是困难的，因为已扩张的支架或线网通常设计成实现扩张状态，其也抵聚缩或收缩力。
除了以上讨论的开心手术途径之外，还经由至少以下公知进入途径中的一种经皮实现进入所关注的瓣膜：经心尖、经股、经心房以及经中隔输送技术。
通常地，本领域专注于这样的系统和方法，其使用上述公知进入途径中的一种来允许收缩的瓣膜装置的部分输送，其中装置的一个端部从输送护套或导管得到释放，并且发生扩张用于初始定位，然后在适当定位得以实现时完全释放和扩张。例如参见美国专利No.8,852,271(Murray,III)；8,747,459(Nguyen)；8,814,931(Wang)；9,402,720(Richter)；8,986,372(Murray,III)；和9,277,991(Salahieh)；以及美国专利公开No.2015/0272731(Racchini)；和2016/0235531(Ciobanu)。
然而，公知的输送系统、装置和方法仍然遭受输送方法的显著缺陷，尤其包括定位和重新捕获能力和效率。
另外，公知的“置换”心脏瓣膜旨在用于完全置换原生心脏瓣膜。因此，这些置换心脏瓣膜物理地接合环形喉部和/或瓣膜小叶，从而消除原生瓣膜的所有剩余功能并使患者完全依赖于置换瓣膜。一般而言，维持和/或保持心脏瓣膜的原生功能是优选的解决方案，因此瓣膜的修补是优选的，而不是完全置换。显然，将存在这样的情况：原生瓣膜在介入植入手术之前已经几乎完全丧失功能，或者原生瓣膜在植入手术后继续丧失功能。优选的解决方案是输送和植入一种瓣膜装置，其将既作为补充功能瓣膜发挥功能，又能完全代替丧失其大部分或全部功能的瓣膜的原生功能。然而，下文描述的创造性解决方案将大体上适用于所有类型和形式的心脏瓣膜装置，除非另有说明。
最后，用于例如二尖瓣膜置换系统、装置和方法的公知解决方案需要两腔室解决方案，即，植入的置换瓣膜装置在左心房和左心室中均有参与和接合。通常地，这些解决方案包括在左心房中的径向扩张支架，其中锚定件或系缚件(设置成向下穿过环形喉部)从支架装置向下穿过环形喉部连接至左心室内的子环形表面、左心室腱索并且甚至到左心室壁表面中。
这种两腔室解决方案是不必要地笨重的，并且因此从严格的结构角度来说更难以输送和定位/重新捕获/重新定位。此外，两腔室解决方案在进行保持位置所需的心室锚定和/或系缚方面存在困难。另外，这些解决方案如上所述干扰原生瓣膜功能，因为设置在左心室内的装置部分必须前行通过瓣环、环形喉部和原生二尖瓣膜，从而破坏原生小叶的任何剩余的对合能力。另外，两腔室解决方案通常需要对一些原生组织进行创伤性锚定，从而导致不必要的创伤和潜在的并发症。
将进一步认识到的是，两腔室二尖瓣膜解决方案需要与锚定件、系绳及类似物精确的子环和/或心室接合，因为装置的心房部分不能充分地将其自身锚定到瓣环的上部和/或心房腔室。再次，本文中描述的创造性解决方案轻松地适用于单腔室或两腔室解决方案，除非另有说明。
本文中公开的数个发明的各个实施例尤其致力于这些问题。
附图说明
图1示出了本发明的一个实施例的侧剖视图。
图2A示出了本发明的一个实施例的侧视图。
图2B示出了本发明的一个实施例的侧剖视图。
图3A示出了本发明的一个实施例的侧剖视图。
图3B示出了本发明的一个实施例的侧剖视图。
图4示出了本发明的一个实施例的侧剖视图。
图5A示出了本发明的一个实施例的侧剖视图。
图5B示出了本发明的一个实施例的侧剖视图。
图6A示出了本发明的一个实施例的侧剖视图。
图6B示出了本发明的一个实施例的侧剖视图。
图6C示出了本发明的一个实施例的侧剖视图。
图7A示出了本发明的一个实施例的侧剖视图。
图7B示出了本发明的一个实施例的侧剖视图。
图8A示出了本发明的一个实施例的顶视图。
图8B示出了本发明的一个实施例的侧视和局部分解视图。
图9A示出了本发明的一个实施例的侧剖视图。
图9B示出了本发明的一个实施例的侧剖视图。
图9C示出了本发明的一个实施例的侧剖视图。
图9D示出了本发明的一个实施例的侧剖视图。
图10A示出了本发明的一个实施例的侧剖视图。
图10B示出了本发明的一个实施例的侧剖视图。
图10C示出了本发明的一个实施例的侧剖视图。
图11示出了本发明的一个实施例的侧剖视图。
图12示出了本发明的一个实施例的侧视图。
具体实施方式
本发明的各种实施例在图中公开，用于经由至少以下公知的进入途径中的一个对所关注的瓣膜提供经皮进入：经心尖、经股、经心房以及经中隔输送技术。这些进入途径中的每个可以用于本文所公开的实施例。
因此，图1示出了具有两部式框架处于收缩构造的假体瓣膜装置100的一个实施例。收缩的装置的远侧部分102包括具有假体小叶具有支撑框架的一部分的瓣膜，并且被纵向可平移地且可旋转地限制在具有第一外径D的外护套104的管腔内。收缩的装置100的近侧部分106包括剩余的支撑框架，其与收缩的装置100的远侧部分102操作连接，并且被纵向可平移地且可旋转地限制在内护套108的管腔中，所述内护套108相对于外护套104至少纵向地可平移，并且其中外护套104相对于内护套108至少纵向地可平移。内和/或外护套108、104也可以相对于另一护套旋转地可平移。内护套108设置在外护套104的管腔内，并且因此内护套108包括小于外护套的外径D的第二外径D'。
图1的装置的优选构造包括收缩的装置100，其由具有近侧部分106和远侧部分102的一个单元组成，如图所示。外护套104可以缩回以首先使远侧部分102从外护套104的远侧端部110释放暴露，以便在心脏的对象腔室中初始扩张和定位。替代地，装置100的远侧部分102可以例如响应于内护套108的远侧平移或响应于抵靠装置100的近侧部分106进行推压的推杆，被向远侧推动以从外护套104的远侧端部110得到释放。在推杆的情况下，近侧部分106将最终被向远侧推出内护套106的较小管腔并进入外护套104的较大管腔中，在这里发生近侧部分106的临时二次扩张，接着在近侧部分106最终从外护套104的远侧端部110得到释放时发生二次定位扩张。
如果在与假体二尖瓣膜相关的左心房内扩张，则远侧部分102的下部可以抵靠左心房内的瓣环的上表面定位。
在该构造中，如果远侧部分102被适当地定位和释放/扩张，则可以根据以上结合远侧部分102的初始释放和扩张所描述的替代方法来开启和实现装置100的近侧部分106的二次释放和扩张。本领域的技术人员将认识到，一旦远侧部分102的初始定位扩张得以完成，则近侧部分106的二次定位扩张也将被适当地寻位和定位。
图1的构造在其各种实施例中允许通过两步框架定位扩张方法来输送装置100，其包括框架，其可以对于腔室(例如心房)尺寸略微过大。处于收缩形式的一些框架可以在纵向长度上高达任何腔室(例如心房)尺寸的2倍。因此，分阶段定位扩张方法对于输送是必要的。
现在转到图2A和2B，提供了假体瓣膜装置200，其包括支撑支架框架，在其中附接和/或支撑假体瓣膜，其中该设计包括具有扩张直径的两个部分(远侧部分202和近侧部分206，其中具有小叶205的假体瓣膜被保持/支撑在远侧部分202内)，这两个部分通过具有比两个部分202、206的扩张直径更小的直径的中央部分203连接。如图所示，两个部分202、206包括未变形且完全扩张的球体形状，但是可以使用其它形状，如本领域技术人员将容易理解的。某些实施例可以包括近侧部分206和远侧部分202中的至少一个具有扩张尺寸，其略大于对象腔室的尺寸(例如左心房尺寸)，以允许扩张锚定。另外，两个部分206、202中的每个的纵横比可以变化。
如图所示，具有瓣膜的收缩支架被保持在输送护套204的管腔内，且在其中保持或支撑装置200的远侧部分从输送护套204的端部210得到释放，随后它在对象腔室(例如左心房)内定位扩张。当适当定位得以确认时，剩余的中央部分203(如果先前未与远侧部分202一起释放)和/或近侧部分206于是可以通过结合图1描述的方法得到释放并在位置上扩张，所述方法包括使用如上所述的内护套和/或推杆，以将装置200平移出外输送护套204的远侧端部210。正如图1，该实施例包括两步或分阶段输送机制。图1和图2A/2B两组的实施例可以包括远侧部分202上的涂层或覆盖物，而近侧部分206可以包括由例如支架网格形成的开放框架。在图2A/2B的情况下，中央部分202也可以包括开放网格构造并且未被覆盖。图2B的虚线示出了一替代实施例，其中已扩张已输送的部分202包括铰接点212，以协助将远侧部分202内的小叶和假体瓣膜向下朝向原生瓣膜定向。
图3A、3B、3C、5A和5B提供了具有支撑手段(例如支架式)的示例性假体瓣膜装置及相关示例性输送方法的进一步公开。因此，图3A示出了收缩的装置300，其处于输送护套304的管腔中，与被装置操作者致动的推/拉杆308操作地连通，所述推/拉杆能够将如图3A中的收缩的装置300向远侧平移出输送护套304的远侧端部310以用于定位扩张，并且相反地，如有必要，将如图3B中所示的已扩张的装置300拉回到输送护套304的远侧端部310中。推/拉杆308还可以在某些实施例中允许收缩的装置300在输送护套310的管腔内旋转，以在释放和扩张之前辅助定位。此外，推/拉杆308与收缩的装置300的操作连通可以包括与收缩的装置300的最近侧部分连接的螺丝或夹具释放机构311。装置300的基部或下部可以被组织或其它生物相容性材料覆盖，而装置的上部可以包括开放网格构造。
通常地，收缩的装置300被装载并定位在输送护套304内，且瓣膜部分305定向在向下位置，如图所示。这允许收缩的瓣膜装置305如图所示沿侧向定向被推出输送护套304，并且允许发生扩张的瓣膜装置300在从输送护套释放后被适当地定向到原生瓣膜和对象腔室，例如二尖瓣膜和左心房。
在某些情况下，对准线315可以从输送护套304平移到肺静脉(例如左上肺静脉PV)中，以协助装置300的定位和输送。
图4示出了在扩张期间且刚从输送护套304的外端部310输送之后的装置300的侧向输送，其中已输送装置大致竖直地定向并且对准，以定位在原生瓣膜上。
因此，如图5A和5B中最佳所示，假体瓣膜装置500可以被不对称地侧向输送(其中瓣膜部分505如图所示定向在底部上)，并且可以包括定位元件515，其与假体瓣膜装置500操作连接，并且其从输送护套503延伸，其中推管或定位元件515的至少远侧端部设置在肺静脉PV(例如，如图所示的左上肺静脉)内。该系统提供自定心系统，其可以在从输送护套504的远侧端部510释放/平移收缩的假体瓣膜装置500后扩张。如图所示，一旦假体瓣膜装置500从输送护套504的远侧端部510被输送后，推管508和相关的连接器511可以用于协助操控假体瓣膜装置500的定向。
现在转到图6A-6C，假体瓣膜装置600的输送使用了输送导管或护套604，其包括预弯曲的远侧部分620或适于能够弯曲的远侧部分620，以在心房内提供大致伸直的远侧部段。图6A提供了预弯曲实施例，其弯曲以允许装载假体瓣膜装置600在一定构造中，其将带瓣底部605在从输送导管或护套的预弯曲远侧部分620的远侧端部610(更具体地从预弯曲远侧部分620的远侧的已伸直远侧部段)释放后放置在适当位置。因此，如图所示，已收缩且可扩张的框架/支架的瓣膜支撑部分605在输送导管/护套604的管腔内是最远侧。预弯曲部分620允许带瓣部分605与示例性二尖瓣膜和/或其瓣环的上表面的轻松定向。
因此，具有如图6A中的弯曲远侧部分的输送系统允许假体瓣膜装置600定位在瓣环和原生瓣膜小叶上。当已定位在瓣环和原生瓣膜小叶上时，弯曲的输送导管或护套604可以向近侧单独地或与假体瓣膜装置600的近侧的推杆608或类似装置一起被取回，以释放并输送假体瓣膜装置600到左心房中并扩张已输送的装置600。值得注意的是，弯曲的输送导管或护套604在一些实施例中包括在左心房内并且位于弯曲部段620的远侧的伸直远侧端部，其中压缩态的假体瓣膜装置600绕着弯曲的输送导管或护套604的弯曲部分620受到平移和操控。压缩态的假体瓣膜装置600可以受助而绕着弯曲的输送导管或护套的弯曲部分620平移，即通过包括附接到植入物的远侧端部的缝合线、附接到植入物的远侧端部的拉线(延伸至输送导管或护套的近侧端部)，或通过利用图1的配置中在假体瓣膜装置的近侧部分和远侧部分之间的自然挠曲点，和/或通过如图2中的铰接点。
图6B和6C包括一种用以建立弯曲部分620的替代途径，其通过沿着护套或导管的底部表面提供一系列切口或锯齿609从而导致易于弯折的薄弱区域，来允许输送护套或导管604的远侧部分的弯曲。如图所示，拉线625沿着该底部薄弱切口或锯齿状区域附接至导管604的远侧端部610，并且设置成穿过导管/护套管腔到操作者，其可以在释放收缩的假体瓣膜结构600之前通过力F向近侧拉动线来实现期望的曲率，所述假体瓣膜结构600定向成如图6A中的收缩形式并且被释放以实际上直接在对象瓣膜或上环形表面上定位扩张。切口609可以完全延伸穿过导管/护套壁，或者可以仅仅是具有比导管/护套壁的其余部分更薄的导管/护套壁的部段。所示的切口609是均匀且大体方形的，但是可以使用其任何深度、形状和均匀或不均匀的间隔来实现弱化区域。
图7A和7B示出了对心脏腔室例如左心房进行示例性假体瓣膜例如二尖瓣膜置换或修补的输送系统，其使用如图7A中所示的输送导管或护套704，经中隔进入并加上附加的引导工具728，其用于在带瓣装置使用本文中描述的方法或装置从导管或护套704的远侧端部710被释放时帮助引导扩张的带瓣装置(未示出)。附加的引导工具728可以设置在例如上肺静脉PV内。引导工具728可以铰接地或旋转地附接至导管或护套704，从而允许工具728旋转就位。类似于图6B和6C中所示的拉线的拉线可以用于连接至工具728并将工具728操控就位。
图7B示出了两个输送系统，即用于对准和部署的第一输送系统800以及用于在必要时重新捕获和重新定位的第二输送系统850。输送系统中的一个，即第一输送系统800或第二输送系统850，可以经由经股进入方法进入对象心脏腔室，而另一输送系统可以经由另一经静脉进入方法进入对象心脏腔室。第一输送系统800因此可以包括如本文中其它地方描述的输送导管或护套804，而第二输送系统可以包括重新捕获和重新定位的导管或护套854，其在结构上类似于输送导管/护套804。
图8A和8B示出了实施例，其设计成促进假体心脏瓣膜在腔室例如左心房内的精确定位，包括但不限于自定心和荧光透视技术。在假体支架式瓣膜装置900的该实施例中，在假体瓣膜和小叶905被支撑在瓣膜装置的底部附近的情况下，装置900的上部909可以分成如图8A中从顶部所示的子部。所示的情况提供了4个子部，但是其它数量的子部当然可以是有用的并且在本发明的范围内。如图所示，相对的子部是开放网格或开放线构造907，或者由呈一种帆908形式的织物构成。在该装置900输送到对象心脏腔室后，织物帆908将捕捉并使用血液流动的自然力来将装置框架900操纵到适当定位，随后在定位被确认时释放和扩张。
图8B是一种相关构思，但还包括瓣环间隔件919，其可以首先经由如本文中在先前所描述的输送导管/护套得到输送，并且在某些实施例中，间隔件可以利用定位在输送导管/护套的管腔内的引导线被引导就位，并且进一步移动出输送导管/护套的远侧端部，并且要么在腔室上环形表面附近(在近侧)，或者可以至少部分地设置在环形喉部内。一旦从输送导管/护套的管腔和远侧端部得到释放，环形间隔件919可以从被输送的收缩形式扩张并定位在上环形表面上，这可以将假体瓣膜和小叶905与上环形表面间隔开。接下来，假体瓣膜装置(如本文中描述的，并且可以或可以不包括如图7A中的帆908)从输送导管/护套得到输送，并且在位置上扩张以与先前定位的间隔件919连接。
我们接下来描述图9A-9D中的位置定向输送结构。通常地，这些假体带瓣装置中的每个被设计成用于左心房，并且利用左心耳(LAA)作为定向机构。图9A因此包括设置在输送护套1004的管腔内的收缩的装置100的侧表面上的左心耳插塞1006，并且在图9B中，左心耳插塞1006至少部分地定位在左心耳内。一旦左心耳被左心耳插塞1006接合，操作者就确认带瓣假体装置1000处于正确位置。该装置可以与任何先前描述的装置和方法结合使用，包括但不限于分阶段的两步输送装置和方法，其中初始定位扩张将导致左心耳插塞定向到左心耳中，然后通过从输送护套的远侧端部释放而开启装置的其余部分的二次定位扩张。
图9A和9B的某些实施例的附加益处是可以采用左心耳插塞1006作为防止左心耳内凝血的装置，其中左心耳插塞1006完全填充左心耳和/或外凸缘1008完全覆盖左心耳开口，以防止任何血凝块形成和/或移出心脏而潜在地引起中风。
图9D示出了稍微不同的机构，其中引导线1020被设置穿过输送护套1004并进入左心耳中，以为输送护套1004的管腔内的收缩的假体带瓣装置(未示出)的定位扩张(一步或分阶段)提供定向引导。护套1004可以被拉回以从护套1004的远侧端部部署/释放带瓣装置(未示出)以用于定位扩张，或者可以如前所述使用推杆来将带瓣装置推出护套的远侧端部。在这些情况下，定位在左心耳内的引导线1020提供关键定向引导参数，使得操作者知晓定位将在扩张时是适当的。引导线1020可以包括无创末端，以防止损坏左心耳的组织。
图9C示出了另一对准/定向系统，其中输送导管/护套1004经由肺静脉PV(例如上肺静脉)引入左心房中，并且引导线1020设置成穿过输送导管/护套1004的管腔并进入或接近瓣环(即，环形喉部)，作为用于待输送的带瓣装置(未示出，但如前面所述呈压缩和自扩张态)的引导件。当护套1004被拉回或者推杆被用于将收缩的带瓣装置推出输送导管或护套1004的远侧端部时，扩张中的带瓣装置可以在预定位的引导线1020上向下滑动，以在完全扩张时到达适当位置。
图10A示出了从输送导管护套释放的部分扩张的支架式带瓣装置1100。示出了至少一根捕获线1030(示出为径向包绕着装置1100，但可以采用其它包绕位置)，并且其限制可扩张装置1100完全扩张，直到适当地定位在对象心脏腔室(例如左心房)内。当适当位置得到确认时，捕获线1030可以被移除，即通过切割并穿过输送护套1004的管腔向远侧取回，或通过断开连接器引脚或闩锁1032或等同者，以允许装置1100在适当定位位置处完全扩张。图10B是类似的，具有对准线1130，其在它与部分地扩张的护套在2个或3个或更多个稳定点1034处连接着的同时进给出输送导管/护套1104的远侧端部时协助位置定向，直到适当位置得到确认。稳定点1134连接可以将部分扩张的装置保持在该状态直到适当位置得到确认，然后连接可以被移除，即通过切割(如在可释放缝合线的情况中那样)或通过断开连接器引脚或闩锁，以允许在适当定位位置处完全扩张，或者通过提供二次线上切割器，其经由输送导管/护套1104引入以剪断对准线1130。
图10C提供了一替代性假体心脏瓣膜装置，其示出为在从输送导管/护套1104的远侧端部释放之后处于位置上的扩张位置，并且包括位于支架式心脏瓣膜装置内的至少一个附接点1032以及两个或更多个拉/推线1130，其具有连接到至少一个附接点1032的第一端部以及附接到围绕支架框架的点1033的第二端部。该配置可以通过数种不同的方式起作用，以促进重新捕获、重新定位和/或重新部署。
首先，一个实施例可以包括两个或更多个拉/推线1130，其长度略小于腔室(例如左心房)尺寸以确保适当定位。一旦位置被确认为适当，拉/推线1130就可以被释放，例如通过二次线上切割器或其它器件来解除至少一个附接点1032与两个或更多个拉/推线1130之间的拉/推线连接，从而允许适当定位的框架在腔室内的完全扩张。与本文中描述的其它实施例一样，完全扩张的框架可以略大于至少一个尺寸以便于锚定。
另一实施例可以进一步包括推杆，其平移地设置在输送导管/护套1104的管腔内，并且其还提供向远侧延伸的可释放连接器，该连接器附接至支架式心脏瓣膜框架内的至少一个附接点1032，以便在适当定位得到确认后，解除至少一个附接点1032与两个或更多个推/拉线1130之间的附接。该实施例提供了进一步的益处，即使用向远侧延伸的可释放连接器工具来在至少一个附接点上向近侧拉动，其中附接点和推/拉线连接至支架框架上的点，这在向近侧的力被施加到附接点时，导致支架框架略微或完全收缩，以允许重新定位。一旦得以重新定位，则向远侧的力被施加到可释放连接器工具，以使假体瓣膜框架完全扩张。
仍另一实施例可以包括附接点1132、推/拉线1130、和/或推/拉线到支架框架的连接由在一短时间周期内溶解的材料形成。
图11示出了假体瓣膜装置1200，其包括支撑框架(窝或部分窝)与设置在其中的假体瓣膜和小叶1253(球或部分球)之间的球窝关系。在该实施例中，外框架1250如图所示是具有圆角和中心点1252的部分球体，且中心点1252大体围绕原生瓣膜和瓣环设置。外框架1250可以包括径向延伸的凸缘1254以与上环形表面连接和密封，并且可以进一步包括壁元件1256，其从径向延伸的凸缘1252的至少一些部分向上延，以与腔室(例如左心房)壁连接并抵靠其密封。径向延伸的凸缘1252可以包括可扩张的支架状构造，以提供径向扩张力来协助锚定该装置1200。替代构造可以包括本文中描述的假体支架瓣膜框架中的任一个，例如且不限于，上部开放式可扩张框架与被组织覆盖的下部可扩张框架。
假体瓣膜进一步包括内部的部分球体1253，其具有与外框架的部分球体1250的圆角匹配或互补的圆角，但是具有比外框架1250更小的半径，因为内部的部分球体1253驻留在外框架的部分球体1250内。假体小叶被支撑在内部的部分球体1253内。内部的部分球体1253可以包括与外框架的部分球体1250的摩擦配合，使得一些移动在所有维度中都是可行的(包括旋转)，而不会失去相对于原生瓣膜和/或瓣环的适当瓣膜位置。替代方案可以允许更宽松的摩擦配合，使得内部的部分球体实质上漂浮在外框架的部分球体内，从而允许比更紧密的摩擦配合更充分的运动范围。
图12示出了一种植入物框架，附接于其上的假体瓣膜装置1300经由连接器元件1302连接至套索结构1304，其进而与操控线1306可操作地连接，所述操控线1306可以包括单根线或两根线，其向近侧延伸到操作者，该操作者于是能够操控套索1304和连接器元件1302。套索结构1304可以包括与连接器元件1302操作连接的两根远侧线W1、W2或多于两根的远侧线。如果操控线1306包括两根线W1、W2，则两根线中的第一根可以与线1连接，并且两根线中的第二根可以与线1连接。通过操作者拉动操控线W1、W2中的一根或两根，可以使线W1、W2与连接器元件1302断开。套索结构1304可以如图所示可扩张到大于导管1305的管腔的内径的直径，并且设置成穿过植入物框架结构，其中与套索1304和装置框架1300操作连接的连接器元件1302大体上处于植入物结构的中部。该构造允许操作者在部署期间以套索结构1304操控装置1300，并且如有必要还允许取回到导管1305的管腔中。连接器元件1302可以与装置1300的框架结构一起构造，以允许装置1300的框架结构收缩，从而允许装置1300的结构被拉回到导管1305的管腔中。连接器元件1302也可以通过操作者从装置1300的框架断开，由此线W1、W2中的一根或两根被断开，并且套索结构1304向近侧穿过导管1305撤回。在其它实施例中，当操作者将线W1、W2与连接器元件1302断开并将套索结构1304向近侧拉动穿过导管护套1305时，连接器元件1302可以保持附接至装置1300的框架结构。
如本文中给出的各种发明、其实施例及应用的描述是说明性的，而并不旨在限制本发明的范围。各个实施例的特征可以在这些发明的构思内与其它实施例组合。本文中公开的实施例的变型和修改是可能的，并且本领域技术人员在研究本专利文件后将理解实施例的各种要素的实际替代方案和等同方案。本文中公开的实施例的这些和其它变型和修改可以被做出，而不背离本发明的范围和精神。

Claims (40)

1.一种将包括假体二尖瓣膜小叶的自扩张假体二尖瓣膜装置输送到患者心脏的左心房内的植入部位的方法，包括：
利用输送导管进入左心房，所述输送导管具有近侧端部、远侧端部以及穿过其中的管腔；
将处于收缩构造的自扩张假体二尖瓣膜装置在所述输送导管的近侧端部处装载到所述输送导管的管腔中，其中假体二尖瓣膜装置的收缩构造包括附接到其上的假体二尖瓣膜；
将收缩的假体瓣膜输送出所述输送导管的远侧端部，并在接近植入部位的位置处进入左心房中；
允许已输送的自扩张假体二尖瓣膜装置在左心房内在植入部位处扩张，其中已扩张的装置的至少一部分接合左心房内的上环形表面的至少一部分；以及
确保原生二尖瓣膜小叶在任何点处都不被已扩张的假体二尖瓣膜装置接触。
2.根据权利要求1所述的方法，进一步包括通过以下进入途径之一获得对左心房的经皮进入：经心尖进入、经股进入、经心房进入和经中隔进入。
3.根据权利要求1所述的方法，进一步包括确保在假体二尖瓣膜装置的输送和扩张期间在任何点处都不接触左心室。
4.根据权利要求2所述的方法，进一步包括确保上环形表面下方和下游的环形组织在任何点处都不被已扩张的假体二尖瓣膜装置接触。
5.根据权利要求2所述的方法，进一步包括确保已扩张的假体瓣膜位于左心房的上环形表面上方。
6.根据权利要求2所述的方法，其中，已扩张的假体二尖瓣膜装置接合左心房内的上环形表面的至少一部分。
7.一种将包括假体二尖瓣膜小叶的自扩张假体二尖瓣膜装置输送到患者心脏的左心房内的植入部位的方法，包括：
利用输送导管进入左心房，所述输送导管具有近侧端部、远侧端部以及穿过其中的管腔；
将处于收缩构造的自扩张假体二尖瓣膜装置在所述输送导管的近侧端部处装载到所述输送导管的管腔中，其中假体二尖瓣膜装置的收缩构造包括附接到其上的假体二尖瓣膜；
将收缩的假体瓣膜输送出所述输送导管的远侧端部，并在接近植入部位的位置处进入左心房中；
允许已输送的自扩张假体二尖瓣膜装置在左心房内在植入部位处扩张，其中已扩张的装置的至少一部分接合左心房内的上环形表面的至少一部分；以及
在已输送的自扩张假体二尖瓣膜装置被允许在左心房内扩张之前，确保左心室、上环形表面下方或下游的环形组织以及心脏的原生二尖瓣膜小叶在自扩张假体二尖瓣膜装置的输送中在任何点处都不被接触。
8.根据权利要求7所述的方法，进一步包括确保左心室和原生二尖瓣膜小叶在任何点处都不被已扩张的假体二尖瓣膜装置接触。
9.根据权利要求7所述的方法，进一步包括确保原生二尖瓣膜小叶在任何点处都不被已扩张的假体二尖瓣膜装置接触。
10.根据权利要求7所述的方法，进一步包括确保上环形表面下方和下游的环形组织在任何点处都不被已扩张的假体二尖瓣膜装置接触。
11.根据权利要求7所述的方法，其中，已扩张的假体二尖瓣膜装置接合左心房内的上环形表面的至少一部分。
12.根据权利要求7所述的方法，其中，通过右心房与左心房之间的中隔进入左心房。
13.根据权利要求7所述的方法，进一步包括：
使对准线平移穿过所述导管的管腔并接合假体二尖瓣膜装置的开放框架部分；以及
在将假体二尖瓣膜装置沿着所述对准线输送到左心房中之前，使左上肺静脉的管腔与所述对准线的远侧端部接合。
14.根据权利要求12所述的方法，进一步包括对准穿过所述导管的管腔设置的引导线并接合左心耳。
15.根据权利要求7所述的方法，其中，所述输送导管包括预弯曲的远侧部分，以便于在植入部位附近定位自扩张假体二尖瓣膜装置。
16.根据权利要求7所述的方法，进一步包括：
提供拉线，其附接至所述输送导管的远侧端部，并向近侧延伸出所述输送导管的近侧端部；
在所述输送导管的远侧部分上在所述拉线到所述输送导管的远侧端部的附接部的近侧和附近提供弱化部段；以及
至少在假体二尖瓣膜装置的输送期间通过向近侧拉动所述拉线来使所述输送导管的远侧端部弯曲；以及
在左心房内在位置上定向假体二尖瓣膜装置。
17.根据权利要求7所述的方法，进一步包括：
提供附接至收缩的自扩张假体二尖瓣膜装置的侧部的插塞；
将所述插塞与左心耳对准；以及
当自扩张假体二尖瓣膜装置已扩张时，使左心耳与所述插塞接合。
18.根据权利要求17所述的方法，其中，所述插塞进一步包括凸缘，其围绕左心耳接合并密封心房壁。
19.根据权利要求7所述的方法，其中，收缩的自扩张假体二尖瓣膜装置进一步包括近侧部分和远侧部分，其中假体二尖瓣膜小叶设置在所述远侧部分内；
将内护套装载到导管管腔中，所述内护套具有与收缩的自扩张假体二尖瓣膜接合的远侧端部，其中所述内护套穿过所述导管管腔的平移导致收缩的自扩张支架式瓣膜平移穿过所述导管管腔。
20.根据权利要求19所述的方法，其中，所述内护套包括穿过其中的管腔，所述管腔定尺寸为接收收缩的自扩张假体二尖瓣膜装置的近侧部分。
21.根据权利要求20所述的方法，其中，所述内护套的远侧端部接合收缩的自扩张假体二尖瓣膜装置的远侧部分，其中所述远侧部分不被接收在所述内护套的管腔内。
22.根据权利要求19所述的方法，其中，在收缩的自扩张假体二尖瓣膜装置的近侧部分被输送并扩张之前，所述远侧部分被输送、在植入部位附近定位并扩张。
23.根据权利要求19所述的方法，进一步包括：
提供附接至收缩的自扩张假体二尖瓣膜装置的远侧部分的侧面上的插塞；
将所述插塞与左心耳对准；以及
当自扩张假体二尖瓣膜装置已扩张时，使左心耳与所述插塞接合。
24.根据权利要求23所述的方法，其中，所述插塞进一步包括凸缘，其围绕左心耳接合并密封心房壁。
25.根据权利要求7所述的方法，进一步包括：
提供连接至收缩的假体二尖瓣膜装置的推杆；以及
利用所述推杆推动收缩的假体二尖瓣膜装置穿过所述输送导管的管腔，以在左心房内输送和扩张。
26.根据权利要求25所述的方法，进一步包括通过在所述推杆上向近侧拉动，使已扩张的假体二尖瓣膜至少部分地收缩在所述输送导管的管腔内。
27.根据权利要求25所述的方法，进一步包括：
使定位元件平移穿过所述导管的管腔；
使假体二尖瓣膜装置的开放框架部分与所述定位元件接合；以及
在将假体二尖瓣膜装置输送到左心房中之前，使左上肺静脉的管腔与所述定位元件的远侧端部接合。
28.根据权利要求27所述的方法，其中，所述定位元件延伸穿过假体二尖瓣膜装置的开放框架部段。
29.根据权利要求19所述的方法，进一步包括中央部分，其设置在所述近侧部分与所述远侧部分之间，所述中央部分具有小于所述近侧部分的最大直径和所述远侧部分的最大直径的最大直径。
30.根据权利要求29所述的方法，进一步包括：
在所述中央部分上提供铰接部；
将所述中央部分输送出输送导管管腔的远侧端部，以使所述铰接部暴露于左心房；以及
使所述远侧部分朝向左心房的上环形表面旋转；以及
将所述近侧部分输送出输送导管管腔的远侧端部并进入左心房中。
31.根据权利要求19所述的方法，进一步包括：
平移通过所述输送导管的管腔设置的对准线；
使假体二尖瓣膜装置的开放框架部分与所述对准线接合；以及
在将假体二尖瓣膜装置沿着所述对准线输送到左心房中之前，使左上肺静脉与所述对准线接合。
32.根据权利要求7所述的方法，进一步包括至少一根捕获线，其延伸穿过输送导管管腔并与自扩张假体二尖瓣膜装置接合，适于将所述装置的扩张限制为部分扩张构造。
33.根据权利要求32所述的方法，进一步包括所述至少一根捕获线进一步适于通过在所述输送导管的近侧端部处操控所述至少一根捕获线来在位置上定向已部分扩张的装置。
34.根据权利要求33所述的方法，进一步包括：
在左心房内在位置上定向已部分扩张的装置；
确认已部分扩张的装置的适当定向；
移除所述至少一根捕获线；以及
允许已部分扩张的装置完全扩张。
35.根据权利要求34所述的方法，进一步包括提供穿过所述输送导管的管腔的推/拉杆，其适于协助在位置上定向已部分扩张的装置。
36.根据权利要求7所述的方法，进一步包括附接至假体二尖瓣膜装置的套索元件，其适于在所述输送导管的近侧端部处被操控；
操控所述套索元件以在位置上定向、防止假体二尖瓣膜装置的完全扩张和/或允许假体二尖瓣膜装置在左心房内完全扩张。
37.根据权利要求7所述的方法，其中，自扩张假体二尖瓣膜装置进一步包括由支架形成的上部，其包括至少两组相对的子部，所述相对的子部中的一组包括织物覆盖物。
38.根据权利要求37所述的方法，进一步包括使用所述织物覆盖物来捕获血液流动，以定位自扩张假体二尖瓣膜装置并使已定位的自扩张假体二尖瓣膜装置扩张。
39.一种用于通过来自左上肺静脉或左下肺静脉中的至少一个的管腔的位置的支撑引导向左心房输送医疗装置的引导工具，包括：
输送导管，其包括近侧端部、远侧端部以及穿过其中的管腔；
引导工具，其在所述远侧端部附近附接至所述输送导管并从所述远侧端部延伸，所述引导工具适于在所述输送导管被设置在左心房内时，接合左肺静脉的管腔的一部分。
40.根据权利要求39所述的引导工具，其中，所述医疗装置包括假体二尖瓣膜装置。
CN201880007705.2A 2017-01-19 2018-01-19 假体二尖瓣膜装置 Active CN110198683B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210281271.3A CN115068170A (zh) 2017-01-19 2018-01-19 假体二尖瓣膜装置

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762448036P 2017-01-19 2017-01-19
US62/448,036 2017-01-19
US15/874,376 US10653523B2 (en) 2017-01-19 2018-01-18 Systems, methods and devices for delivery systems, methods and devices for implanting prosthetic heart valves
US15/874,376 2018-01-18
PCT/US2018/014400 WO2018136726A1 (en) 2017-01-19 2018-01-19 Systems, methods and devices for delivery systems, methods and devices for implanting prosthetic heart valves

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210281271.3A Division CN115068170A (zh) 2017-01-19 2018-01-19 假体二尖瓣膜装置

Publications (2)

Publication Number Publication Date
CN110198683A true CN110198683A (zh) 2019-09-03
CN110198683B CN110198683B (zh) 2022-04-01

Family

ID=62838362

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201880007705.2A Active CN110198683B (zh) 2017-01-19 2018-01-19 假体二尖瓣膜装置
CN202210281271.3A Pending CN115068170A (zh) 2017-01-19 2018-01-19 假体二尖瓣膜装置

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202210281271.3A Pending CN115068170A (zh) 2017-01-19 2018-01-19 假体二尖瓣膜装置

Country Status (7)

Country Link
US (3) US10653523B2 (zh)
EP (1) EP3570783A4 (zh)
JP (1) JP2020505117A (zh)
CN (2) CN110198683B (zh)
AU (2) AU2018210336B2 (zh)
CA (1) CA3050113C (zh)
WO (1) WO2018136726A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113855334A (zh) * 2021-10-26 2021-12-31 金仕生物科技（常熟）有限公司 预压弯远端外管及输送系统

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US10653523B2 (en) 2017-01-19 2020-05-19 4C Medical Technologies, Inc. Systems, methods and devices for delivery systems, methods and devices for implanting prosthetic heart valves
US10561495B2 (en) * 2017-01-24 2020-02-18 4C Medical Technologies, Inc. Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve
ES2890936T3 (es) 2017-03-27 2022-01-25 Truleaf Medical Ltd Elementos de acoplamiento
WO2019028264A1 (en) * 2017-08-03 2019-02-07 The Regents Of The University Of California AURICULAR CAGE FOR THE PLACEMENT, FASTENING AND ANCHORING OF ATRIOVENTRICULAR VALVES
WO2019195860A2 (en) 2018-04-04 2019-10-10 Vdyne, Llc Devices and methods for anchoring transcatheter heart valve
US20190365538A1 (en) * 2018-06-04 2019-12-05 4C Medical Technologies, Inc. Devices, systems and methods for preventing prolapse of native cardiac valve leaflets
US10779937B2 (en) 2018-06-22 2020-09-22 Vdyne, Inc. Transcatheter heart valve with plication window and tissue anchors
US11857441B2 (en) 2018-09-04 2024-01-02 4C Medical Technologies, Inc. Stent loading device
US11071627B2 (en) * 2018-10-18 2021-07-27 Vdyne, Inc. Orthogonally delivered transcatheter heart valve frame for valve in valve prosthesis
US11344413B2 (en) * 2018-09-20 2022-05-31 Vdyne, Inc. Transcatheter deliverable prosthetic heart valves and methods of delivery
US10321995B1 (en) * 2018-09-20 2019-06-18 Vdyne, Llc Orthogonally delivered transcatheter heart valve replacement
WO2020061124A1 (en) * 2018-09-20 2020-03-26 Vdyne, Llc Transcatheter deliverable prosthetic heart valves and methods of delivery
US11278437B2 (en) * 2018-12-08 2022-03-22 Vdyne, Inc. Compression capable annular frames for side delivery of transcatheter heart valve replacement
US10595994B1 (en) * 2018-09-20 2020-03-24 Vdyne, Llc Side-delivered transcatheter heart valve replacement
US11395738B2 (en) 2018-09-25 2022-07-26 Truleaf Medical Ltd. Docking elements
US11109969B2 (en) 2018-10-22 2021-09-07 Vdyne, Inc. Guidewire delivery of transcatheter heart valve
US11253359B2 (en) * 2018-12-20 2022-02-22 Vdyne, Inc. Proximal tab for side-delivered transcatheter heart valves and methods of delivery
US10653522B1 (en) * 2018-12-20 2020-05-19 Vdyne, Inc. Proximal tab for side-delivered transcatheter heart valve prosthesis
US11185409B2 (en) * 2019-01-26 2021-11-30 Vdyne, Inc. Collapsible inner flow control component for side-delivered transcatheter heart valve prosthesis
US11273032B2 (en) 2019-01-26 2022-03-15 Vdyne, Inc. Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis
CA3132162A1 (en) * 2019-03-05 2020-09-10 Vdyne, Inc. Tricuspid regurgitation control devices for orthogonal transcatheter heart valve prosthesis
US11173027B2 (en) 2019-03-14 2021-11-16 Vdyne, Inc. Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same
US11076956B2 (en) * 2019-03-14 2021-08-03 Vdyne, Inc. Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis
US10758346B1 (en) * 2019-03-14 2020-09-01 Vdyne, Inc. A2 clip for side-delivered transcatheter mitral valve prosthesis
CN113747860A (zh) * 2019-03-14 2021-12-03 维迪内股份有限公司 可侧向输送的经导管假体瓣膜以及用于输送和锚定其的方法
AU2020267390A1 (en) * 2019-05-04 2021-11-11 Vdyne, Inc. Cinch device and method for deployment of a side-delivered prosthetic heart valve in a native annulus
EP4017442A4 (en) 2019-08-20 2023-07-26 Vdyne, Inc. INSERTION AND RETRIEVAL DEVICES AND PROCEDURES FOR SIDE-INSERTED TRANSCATHETER PROSTHETIC VALVES
CN114630665A (zh) * 2019-08-26 2022-06-14 维迪内股份有限公司 可侧面输送的经导管假体瓣膜及其输送和锚定方法
US11234813B2 (en) 2020-01-17 2022-02-01 Vdyne, Inc. Ventricular stability elements for side-deliverable prosthetic heart valves and methods of delivery
US11931253B2 (en) 2020-01-31 2024-03-19 4C Medical Technologies, Inc. Prosthetic heart valve delivery system: ball-slide attachment
US11992403B2 (en) 2020-03-06 2024-05-28 4C Medical Technologies, Inc. Devices, systems and methods for improving recapture of prosthetic heart valve device with stent frame having valve support with inwardly stent cells
WO2024081883A1 (en) * 2022-10-14 2024-04-18 Vdyne, Inc. Devices and methods for delivering a prosthetic heart valve using supra-annular support

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020072710A1 (en) * 2000-12-08 2002-06-13 Medtronic, Inc. Medical device delivery catheter with distal locator
US20080234814A1 (en) * 2003-12-23 2008-09-25 Sadra Medical, Inc. Low Profile Heart Valve and Delivery System
CN102985033A (zh) * 2010-02-25 2013-03-20 耶拿阀门科技公司 用于瓣膜假体在病人心脏中的植入部位的定位和锚定的支架
US20130238089A1 (en) * 2006-06-28 2013-09-12 Kardium Inc. Method for anchoring a mitral valve
US20140276395A1 (en) * 2008-06-13 2014-09-18 Cardiosolutions Inc. Steerable Catheter and Dilator and System and Method for Implanting a Heart Implant
CN104302247A (zh) * 2011-11-23 2015-01-21 内奥瓦斯克迪亚拉公司 依次展开的经导管二尖瓣假体
CN104720937A (zh) * 2015-03-26 2015-06-24 杭州启明医疗器械有限公司 减小压缩长度的瓣膜支架及具有该瓣膜支架的瓣膜置换装置
CN105101911A (zh) * 2013-03-15 2015-11-25 托尔福公司 人造心瓣装置、人造二尖瓣以及相关系统和方法
US20160242905A1 (en) * 2015-02-20 2016-08-25 4C Medical Technologies, Inc. Devices, systems and methods for cardiac treatment
WO2016186909A1 (en) * 2015-05-18 2016-11-24 Mayo Foundation For Medical Education And Research Percutaneously-deployable prosthetic tricuspid valve

Family Cites Families (811)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3657744A (en) 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
CA1069652A (en) 1976-01-09 1980-01-15 Alain F. Carpentier Supported bioprosthetic heart valve with compliant orifice ring
US4424833A (en) 1981-10-02 1984-01-10 C. R. Bard, Inc. Self sealing gasket assembly
US4503569A (en) 1983-03-03 1985-03-12 Dotter Charles T Transluminally placed expandable graft prosthesis
US5693083A (en) 1983-12-09 1997-12-02 Endovascular Technologies, Inc. Thoracic graft and delivery catheter
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4878906A (en) 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
DK124690D0 (da) 1990-05-18 1990-05-18 Henning Rud Andersen Klapprotes til implantering i kroppen for erstatning af naturlig klap samt kateter til brug ved implantering af en saadan klapprotese
GB9012716D0 (en) 1990-06-07 1990-08-01 Frater Robert W M Mitral heart valve replacements
US5190528A (en) 1990-10-19 1993-03-02 Boston University Percutaneous transseptal left atrial cannulation system
US5441483A (en) 1992-11-16 1995-08-15 Avitall; Boaz Catheter deflection control
EP0732949B1 (en) 1993-12-17 2003-03-26 Heartport, Inc. System for cardiac procedures
EP0810845A2 (en) 1995-02-22 1997-12-10 Menlo Care Inc. Covered expanding mesh stent
US5693089A (en) 1995-04-12 1997-12-02 Inoue; Kanji Method of collapsing an implantable appliance
ZA964885B (en) 1995-06-07 1997-02-06 St Jude Medical Direct suture orifice for mechanical heart valve.
US5843090A (en) 1996-11-05 1998-12-01 Schneider (Usa) Inc. Stent delivery device
NL1004827C2 (nl) 1996-12-18 1998-06-19 Surgical Innovations Vof Inrichting voor het reguleren van de bloedsomloop.
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
EP0930845B1 (en) 1997-06-27 2009-10-14 The Trustees Of Columbia University In The City Of New York Apparatus for circulatory valve repair
US5954766A (en) 1997-09-16 1999-09-21 Zadno-Azizi; Gholam-Reza Body fluid flow control device
US5928258A (en) 1997-09-26 1999-07-27 Corvita Corporation Method and apparatus for loading a stent or stent-graft into a delivery sheath
US6332893B1 (en) 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
DE69841333D1 (de) 1997-12-29 2010-01-07 Cleveland Clinic Foundation System zur minimalinvasiven einführung einer herzklappen- bioprothese
DK174814B1 (da) 1998-02-25 2003-12-01 Cook William Europ Stentaggregat
US6280467B1 (en) 1998-02-26 2001-08-28 World Medical Manufacturing Corporation Delivery system for deployment and endovascular assembly of a multi-stage stented graft
US6132458A (en) 1998-05-15 2000-10-17 American Medical Systems, Inc. Method and device for loading a stent
US20040088041A1 (en) 1999-07-20 2004-05-06 Stanford Ulf Harry Expandable stent with array of relief cuts
US6152144A (en) * 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6896690B1 (en) 2000-01-27 2005-05-24 Viacor, Inc. Cardiac valve procedure methods and devices
US6425916B1 (en) 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US6319281B1 (en) 1999-03-22 2001-11-20 Kumar R. Patel Artificial venous valve and sizing catheter
AU4203100A (en) 1999-04-05 2000-10-23 Regents Of The University Of California, The Endomyocardial monophasic action potential for early detection of myocardium pathology
US7666204B2 (en) 1999-04-09 2010-02-23 Evalve, Inc. Multi-catheter steerable guiding system and methods of use
US6231602B1 (en) 1999-04-16 2001-05-15 Edwards Lifesciences Corporation Aortic annuloplasty ring
US6319280B1 (en) 1999-08-03 2001-11-20 St. Jude Medical, Inc. Prosthetic ring holder
US6371983B1 (en) 1999-10-04 2002-04-16 Ernest Lane Bioprosthetic heart valve
US6440164B1 (en) 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US8016877B2 (en) 1999-11-17 2011-09-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6821297B2 (en) 2000-02-02 2004-11-23 Robert V. Snyders Artificial heart valve, implantation instrument and method therefor
EP1251803B1 (en) 2000-02-02 2005-06-01 Robert V. Snyders Artificial heart valve
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
ATE381291T1 (de) 2000-06-23 2008-01-15 Viacor Inc Automatische ringförmige faltung zur mitralklappenreparatur
US6409758B2 (en) 2000-07-27 2002-06-25 Edwards Lifesciences Corporation Heart valve holder for constricting the valve commissures and methods of use
US6572652B2 (en) 2000-08-29 2003-06-03 Venpro Corporation Method and devices for decreasing elevated pulmonary venous pressure
US7510572B2 (en) 2000-09-12 2009-03-31 Shlomo Gabbay Implantation system for delivery of a heart valve prosthesis
US6893459B1 (en) 2000-09-20 2005-05-17 Ample Medical, Inc. Heart valve annulus device and method of using same
US7381220B2 (en) 2000-09-20 2008-06-03 Ample Medical, Inc. Devices, systems, and methods for supplementing, repairing, or replacing a native heart valve leaflet
US6461382B1 (en) 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
US6974476B2 (en) 2003-05-05 2005-12-13 Rex Medical, L.P. Percutaneous aortic valve
US6494909B2 (en) 2000-12-01 2002-12-17 Prodesco, Inc. Endovascular valve
US6899727B2 (en) 2001-01-22 2005-05-31 Gore Enterprise Holdings, Inc. Deployment system for intraluminal devices
AU2002243851A1 (en) 2001-02-05 2002-08-19 Viacor, Inc. Apparatus and method for reducing mitral regurgitation
CA2441119A1 (en) 2001-03-08 2002-09-19 Atritech, Inc. Atrial filter implants
US6503272B2 (en) 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
US8219208B2 (en) 2001-04-13 2012-07-10 Greatbatch Ltd. Frequency selective passive component networks for active implantable medical devices utilizing an energy dissipating surface
US6676692B2 (en) 2001-04-27 2004-01-13 Intek Technology L.L.C. Apparatus for delivering, repositioning and/or retrieving self-expanding stents
WO2002098282A2 (en) 2001-06-04 2002-12-12 Albert Einstein Healthcare Network Cardiac stimulating apparatus having a blood clot filter and atrial pacer
US7678128B2 (en) 2001-06-29 2010-03-16 Advanced Cardiovascular Systems, Inc. Delivery and recovery sheaths for medical devices
US8623077B2 (en) 2001-06-29 2014-01-07 Medtronic, Inc. Apparatus for replacing a cardiac valve
FR2826863B1 (fr) 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
US7011671B2 (en) 2001-07-18 2006-03-14 Atritech, Inc. Cardiac implant device tether system and method
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
AU2002362441A1 (en) 2001-10-01 2003-04-14 Am Discovery, Incorporated Devices for treating atrial fibrilation
CN100333704C (zh) 2001-10-01 2007-08-29 安普尔医药公司 心脏瓣膜治疗的方法和装置
US6790237B2 (en) 2001-10-09 2004-09-14 Scimed Life Systems, Inc. Medical stent with a valve and related methods of manufacturing
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US7144363B2 (en) 2001-10-16 2006-12-05 Extensia Medical, Inc. Systems for heart treatment
US20030083730A1 (en) 2001-10-25 2003-05-01 Scimed Life Systems, Inc. Loading cartridge for self-expanding stent
GB0125925D0 (en) 2001-10-29 2001-12-19 Univ Glasgow Mitral valve prosthesis
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
CA2474324C (en) 2002-01-25 2011-09-20 Atritech, Inc. Atrial appendage blood filtration systems
US7125420B2 (en) 2002-02-05 2006-10-24 Viacor, Inc. Method and apparatus for improving mitral valve function
US6797001B2 (en) 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
US20030199971A1 (en) 2002-04-23 2003-10-23 Numed, Inc. Biological replacement valve assembly
US20030225445A1 (en) 2002-05-14 2003-12-04 Derus Patricia M. Surgical stent delivery devices and methods
US20030233141A1 (en) 2002-06-13 2003-12-18 Israel Henry M. Stent coated with stent graft and method therefor
US7041132B2 (en) 2002-08-16 2006-05-09 3F Therapeutics, Inc, Percutaneously delivered heart valve and delivery means thereof
US6875231B2 (en) 2002-09-11 2005-04-05 3F Therapeutics, Inc. Percutaneously deliverable heart valve
US8235844B2 (en) 2010-06-01 2012-08-07 Adams Golf Ip, Lp Hollow golf club head
US6830585B1 (en) 2003-01-14 2004-12-14 3F Therapeutics, Inc. Percutaneously deliverable heart valve and methods of implantation
DE10362223B4 (de) 2003-01-21 2010-02-04 pfm Produkte für die Medizin AG Grundwickelform
US7399315B2 (en) 2003-03-18 2008-07-15 Edwards Lifescience Corporation Minimally-invasive heart valve with cusp positioners
US7175656B2 (en) 2003-04-18 2007-02-13 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
US7201772B2 (en) 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
WO2005011534A1 (en) 2003-07-31 2005-02-10 Cook Incorporated Prosthetic valve devices and methods of making such devices
US20050075713A1 (en) 2003-10-06 2005-04-07 Brian Biancucci Minimally invasive valve replacement system
US9579194B2 (en) 2003-10-06 2017-02-28 Medtronic ATS Medical, Inc. Anchoring structure with concave landing zone
US7566336B2 (en) 2003-11-25 2009-07-28 Cardia, Inc. Left atrial appendage closure device
US8052749B2 (en) 2003-12-23 2011-11-08 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US7445631B2 (en) 2003-12-23 2008-11-04 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US9232948B2 (en) 2003-12-23 2016-01-12 Stryker Corporation Catheter with distal occlusion apparatus
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US7871435B2 (en) 2004-01-23 2011-01-18 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
AU2005213458B2 (en) 2004-02-05 2010-04-22 Children's Medical Center Corporation Transcatheter delivery of a replacement heart valve
US20070073387A1 (en) 2004-02-27 2007-03-29 Forster David C Prosthetic Heart Valves, Support Structures And Systems And Methods For Implanting The Same
AU2005218326A1 (en) 2004-02-27 2005-09-15 Aortx, Inc. Prosthetic heart valve delivery systems and methods
ITTO20040135A1 (it) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa Protesi valvolare cardiaca
WO2005087140A1 (en) 2004-03-11 2005-09-22 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous heart valve prosthesis
WO2005099374A2 (en) 2004-04-05 2005-10-27 Genesee Biomedical, Inc. Method and apparatus for the surgical treatment of congestive heart failure
EP2856949B2 (en) 2004-04-08 2019-09-11 Aga Medical Corporation Flanged occlusion devices
US7641686B2 (en) 2004-04-23 2010-01-05 Direct Flow Medical, Inc. Percutaneous heart valve with stentless support
ES2407684T3 (es) 2004-05-05 2013-06-13 Direct Flow Medical, Inc. Válvula cardiaca sin estent con estructura de soporte formada en el sitio
CN100413471C (zh) 2004-06-25 2008-08-27 深圳市先健科技股份有限公司 输送左心耳闭塞装置的输送器
US7276078B2 (en) 2004-06-30 2007-10-02 Edwards Lifesciences Pvt Paravalvular leak detection, sealing, and prevention
CA2580053C (en) 2004-09-14 2014-07-08 Edwards Lifesciences Ag. Device and method for treatment of heart valve regurgitation
US8052592B2 (en) 2005-09-27 2011-11-08 Evalve, Inc. Methods and devices for tissue grasping and assessment
US20060162731A1 (en) 2004-11-16 2006-07-27 Pulmonx Pulmonary occlusal stent delivery catheter, loading system and methods of use
EP3967269A3 (en) 2005-02-07 2022-07-13 Evalve, Inc. Systems and devices for cardiac valve repair
US20100298929A1 (en) * 2005-02-07 2010-11-25 Thornton Troy L Methods, systems and devices for cardiac valve repair
US7918880B2 (en) 2005-02-16 2011-04-05 Boston Scientific Scimed, Inc. Self-expanding stent and delivery system
DK1850796T3 (en) 2005-02-18 2016-01-18 Cleveland Clinic Foundation DEVICE FOR REPLACEMENT OF A HEART VALVE
US8083793B2 (en) 2005-02-28 2011-12-27 Medtronic, Inc. Two piece heart valves including multiple lobe valves and methods for implanting them
SE531468C2 (sv) 2005-04-21 2009-04-14 Edwards Lifesciences Ag En anordning för styrning av blodflöde
US7833268B2 (en) 2005-04-29 2010-11-16 Delgado Iii Reynolds M Method and apparatus for implanting an aortic valve prosthesis
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
EP3292838A1 (en) 2005-05-24 2018-03-14 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
US8663312B2 (en) 2005-05-27 2014-03-04 Hlt, Inc. Intravascular cuff
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
EP1919397B1 (en) 2005-07-13 2013-01-02 Medtronic, Inc. Two-piece percutaneous prosthetic heart valves
US8790396B2 (en) 2005-07-27 2014-07-29 Medtronic 3F Therapeutics, Inc. Methods and systems for cardiac valve delivery
US7455689B2 (en) 2005-08-25 2008-11-25 Edwards Lifesciences Corporation Four-leaflet stented mitral heart valve
US7611534B2 (en) 2005-08-25 2009-11-03 The Cleveland Clinic Foundation Percutaneous atrioventricular valve and method of use
US8167932B2 (en) 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
DE102005051849B4 (de) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen
US20080275540A1 (en) 2005-11-09 2008-11-06 Ning Wen Artificial Heart Valve Stent and Weaving Method Thereof
US8764820B2 (en) 2005-11-16 2014-07-01 Edwards Lifesciences Corporation Transapical heart valve delivery system and method
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US7947074B2 (en) 2005-12-23 2011-05-24 Attila Meretei Implantable prosthetic valve
US8663674B2 (en) 2006-01-13 2014-03-04 Surmodics, Inc. Microparticle containing matrices for drug delivery
CN2820130Y (zh) 2006-01-16 2006-09-27 孔祥清 能在左心耳内自动定位的左心耳封堵器
CN100444811C (zh) 2006-01-16 2008-12-24 孔祥清 能在左心耳内自动定位的左心耳封堵器
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
US7749266B2 (en) 2006-02-27 2010-07-06 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US8147541B2 (en) 2006-02-27 2012-04-03 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US20070238979A1 (en) 2006-03-23 2007-10-11 Medtronic Vascular, Inc. Reference Devices for Placement in Heart Structures for Visualization During Heart Valve Procedures
CN101045022B (zh) 2006-03-30 2010-08-25 温宁 自扩型支架轴向拉线张紧机构
FR2899096B1 (fr) 2006-04-04 2008-12-05 Perouse Soc Par Actions Simpli Dispositif de traitement d'un conduit de circulation du sang et procede de preparation de ce dispositif
US7524331B2 (en) 2006-04-06 2009-04-28 Medtronic Vascular, Inc. Catheter delivered valve having a barrier to provide an enhanced seal
US20070239254A1 (en) 2006-04-07 2007-10-11 Chris Chia System for percutaneous delivery and removal of a prosthetic valve
US20070239271A1 (en) 2006-04-10 2007-10-11 Than Nguyen Systems and methods for loading a prosthesis onto a minimally invasive delivery system
EP1849440A1 (en) 2006-04-28 2007-10-31 Younes Boudjemline Vascular stents with varying diameter
US8834550B2 (en) 2006-05-19 2014-09-16 Boston Scientific Scimed, Inc. Apparatus and method for loading and delivering a stent using a suture retaining mechanism
US20070293942A1 (en) 2006-06-16 2007-12-20 Daryush Mirzaee Prosthetic valve and deployment method
JP2009540956A (ja) 2006-06-21 2009-11-26 エーオーテックス， インコーポレイテッド 補綴弁移植システム
US20090306768A1 (en) 2006-07-28 2009-12-10 Cardiaq Valve Technologies, Inc. Percutaneous valve prosthesis and system and method for implanting same
US7731717B2 (en) 2006-08-08 2010-06-08 Covidien Ag System and method for controlling RF output during tissue sealing
US20080039928A1 (en) 2006-08-08 2008-02-14 Medlogics Device Corporation Slotted Self-Expanding Stent Delivery System
CA2976839C (en) 2006-09-08 2020-04-28 Edwards Lifesciences Corporation Integrated heart valve delivery system
US8876895B2 (en) 2006-09-19 2014-11-04 Medtronic Ventor Technologies Ltd. Valve fixation member having engagement arms
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
FR2906454B1 (fr) 2006-09-28 2009-04-10 Perouse Soc Par Actions Simpli Implant destine a etre place dans un conduit de circulation du sang.
AU2013201970B2 (en) 2006-09-28 2016-03-03 Hlt, Inc. Delivery tool for percutaneous delivery of a prosthesis
US8029556B2 (en) 2006-10-04 2011-10-04 Edwards Lifesciences Corporation Method and apparatus for reshaping a ventricle
US8163011B2 (en) 2006-10-06 2012-04-24 BioStable Science & Engineering, Inc. Intra-annular mounting frame for aortic valve repair
US7935144B2 (en) 2006-10-19 2011-05-03 Direct Flow Medical, Inc. Profile reduction of valve implant
WO2008051554A2 (en) 2006-10-24 2008-05-02 Beth Israel Deaconess Medical Center Percutaneous aortic valve assembly
US10624621B2 (en) 2006-11-07 2020-04-21 Corvia Medical, Inc. Devices and methods for the treatment of heart failure
US9232997B2 (en) 2006-11-07 2016-01-12 Corvia Medical, Inc. Devices and methods for retrievable intra-atrial implants
WO2008070797A2 (en) 2006-12-06 2008-06-12 Medtronic Corevalve, Inc. System and method for transapical delivery of an annulus anchored self-expanding valve
EP2094194B1 (en) 2006-12-19 2015-09-02 St. Jude Medical, Inc. Prosthetic heart valve including stent structure and tissue leaflets, and related methods
FR2910269B1 (fr) 2006-12-22 2009-02-27 Corevalve Inc Materiel de traitement d'une valve cardiaque,en particulier d'une valve mitrale
ES2425415T3 (es) 2006-12-27 2013-10-15 Posco Composición de resina negra que disipa el calor en forma excelente, método para tratar una lámina de acero recubierta de zinc utilizando esta composición y lámina de acero tratada de este modo
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
US8105375B2 (en) 2007-01-19 2012-01-31 The Cleveland Clinic Foundation Method for implanting a cardiovascular valve
WO2008094894A1 (en) 2007-01-29 2008-08-07 Cook Incorporated Artificial venous valve with discrete shaping members
EP2109417B1 (en) 2007-02-05 2013-11-06 Boston Scientific Limited Percutaneous valve and delivery system
EP2117468A1 (en) 2007-02-05 2009-11-18 Boston Scientific Limited Systems and methods for valve delivery
US8246677B2 (en) 2007-02-16 2012-08-21 Medtronic, Inc. Delivery systems and methods of implantation for replacement prosthetic heart valves
US8070802B2 (en) 2007-02-23 2011-12-06 The Trustees Of The University Of Pennsylvania Mitral valve system
US8187284B2 (en) 2007-04-23 2012-05-29 Boston Scientific Scimed, Inc. Intraluminary stent relocating apparatus
JP5264264B2 (ja) 2007-04-23 2013-08-14 セント ジョセフズ トランスレーショナル リサーチ インスティテュート インコーポレイテッド 交換用心臓弁およびその製造方法
FR2915678B1 (fr) 2007-05-02 2010-04-16 Lapeyre Ind Llc Valve cardiaque prothetique mecanique
US8764816B2 (en) 2007-05-07 2014-07-01 W. L. Gore & Associates, Inc. Stent delivery and deployment system
US7673379B1 (en) 2007-05-11 2010-03-09 Abbott Cardiovascular Systems Inc. Method of producing a stent-balloon assembly
US7766953B2 (en) 2007-05-16 2010-08-03 Med Institute, Inc. Deployment system for an expandable stent
US8403979B2 (en) 2007-05-17 2013-03-26 Cook Medical Technologies Llc Monocuspid prosthetic valve having a partial sinus
ES2788453T3 (es) 2007-06-04 2020-10-21 St Jude Medical Llc Válvulas cardíacas protésicas
US8663318B2 (en) 2007-07-23 2014-03-04 Hocor Cardiovascular Technologies Llc Method and apparatus for percutaneous aortic valve replacement
DE102007043830A1 (de) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Herzklappenstent
US8220121B2 (en) 2007-09-14 2012-07-17 Cook Medical Technologies Llc Device for loading a self-expandable prosthesis into a sheath
US9393137B2 (en) 2007-09-24 2016-07-19 Boston Scientific Scimed, Inc. Method for loading a stent into a delivery system
DE202008018589U1 (de) 2007-09-26 2016-03-14 St. Jude Medical, Inc. Zusammenfaltbare Herzklappenprothesen
WO2009045334A1 (en) 2007-09-28 2009-04-09 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US8454686B2 (en) 2007-09-28 2013-06-04 St. Jude Medical, Inc. Two-stage collapsible/expandable prosthetic heart valves and anchoring systems
AU2008308759B2 (en) 2007-10-01 2014-10-23 Smith & Nephew, Inc. Method and apparatus for preparing bone for a prosthetic device
US9414842B2 (en) 2007-10-12 2016-08-16 St. Jude Medical, Cardiology Division, Inc. Multi-component vascular device
EP2211779B1 (en) 2007-10-15 2014-08-20 Edwards Lifesciences Corporation Transcatheter heart valve with micro-anchors
WO2009052432A2 (en) 2007-10-19 2009-04-23 Coherex Medical, Inc. Medical device for modification of left atrial appendange and related systems and methods
US8597349B2 (en) 2007-11-05 2013-12-03 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with non-expanding stent posts and retrieval features
US20090125096A1 (en) 2007-11-12 2009-05-14 Medtronic Vascular, Inc. Stent Graft With Pins
US8663320B2 (en) 2007-12-04 2014-03-04 Cook Medical Technologies Llc Storage and loading system for implantable medical devices
US10166127B2 (en) 2007-12-12 2019-01-01 Intact Vascular, Inc. Endoluminal device and method
US8679176B2 (en) 2007-12-18 2014-03-25 Cormatrix Cardiovascular, Inc Prosthetic tissue valve
US8257434B2 (en) 2007-12-18 2012-09-04 Cormatrix Cardiovascular, Inc. Prosthetic tissue valve
US8876897B2 (en) 2007-12-20 2014-11-04 Arash Kheradvar Implantable prosthetic valves and methods relating to same
JP2011507657A (ja) 2007-12-26 2011-03-10 メッド・インスティテュート・インコーポレイテッド ステントおよびステントを作製する方法
US20090171456A1 (en) 2007-12-28 2009-07-02 Kveen Graig L Percutaneous heart valve, system, and method
WO2009091811A1 (en) 2008-01-14 2009-07-23 Brenzel Michael P Apparatus and methods for fracture repair
MX2010008171A (es) 2008-01-24 2010-12-07 Medtronic Inc Endoprotesis para valvulas cardiacas protesicas.
US8157853B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
WO2011104269A1 (en) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9241792B2 (en) 2008-02-29 2016-01-26 Edwards Lifesciences Corporation Two-step heart valve implantation
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
WO2009120764A2 (en) 2008-03-25 2009-10-01 Ellipse Technologies, Inc. Systems and methods for adjusting an annuloplasty ring with an integrated magnetic drive
US10456259B2 (en) 2008-04-16 2019-10-29 Heart Repair Technologies, Inc. Transvalvular intraannular band for mitral valve repair
US11013599B2 (en) 2008-04-16 2021-05-25 Heart Repair Technologies, Inc. Percutaneous transvalvular intraannular band for mitral valve repair
WO2009127973A2 (en) 2008-04-18 2009-10-22 Symetis Sa Introducer
BRPI0911351B8 (pt) 2008-04-23 2021-06-22 Medtronic Inc estrutura de stent para uma válvula cardíaca protética, e, prótese de válvula cardíaca
US10813779B2 (en) 2008-04-25 2020-10-27 CARDINAL HEALTH SWITZERLAND 515 GmbH Stent attachment and deployment mechanism
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
US9061119B2 (en) 2008-05-09 2015-06-23 Edwards Lifesciences Corporation Low profile delivery system for transcatheter heart valve
US7993394B2 (en) 2008-06-06 2011-08-09 Ilia Hariton Low profile transcatheter heart valve
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
US9101382B2 (en) 2009-02-18 2015-08-11 Hotspur Technologies, Inc. Apparatus and methods for treating obstructions within body lumens
JP5379853B2 (ja) 2008-07-15 2013-12-25 セント ジュード メディカル インコーポレイテッド 軸線方向に固定する、潰れ可能かつ再膨張可能な多種症状用人工心臓弁
EP3838221A1 (en) 2008-07-15 2021-06-23 St. Jude Medical, LLC Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US20100016095A1 (en) 2008-07-15 2010-01-21 Michael Scott Burnett Golf club head having trip step feature
EP2309949B1 (en) 2008-07-17 2013-07-03 Nvt Ag Cardiac valve prosthesis system
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US20100069948A1 (en) 2008-09-12 2010-03-18 Micrus Endovascular Corporation Self-expandable aneurysm filling device, system and method of placement
US8097926B2 (en) 2008-10-07 2012-01-17 Mc10, Inc. Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy
US8137398B2 (en) 2008-10-13 2012-03-20 Medtronic Ventor Technologies Ltd Prosthetic valve having tapered tip when compressed for delivery
US10166014B2 (en) 2008-11-21 2019-01-01 Percutaneous Cardiovascular Solutions Pty Ltd Heart valve prosthesis and method
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
EP2382336B1 (en) 2008-12-29 2013-03-06 Hille & Müller GmbH Coated product for use in an electrochemical device and a method for producing such a product
US9402720B2 (en) 2009-01-12 2016-08-02 Valve Medical Ltd. Modular percutaneous valve structure and delivery method
US8998982B2 (en) 2009-01-12 2015-04-07 Valve Medical Ltd. Method and apparatus for fine adjustment of a percutaneous valve structure
US8500733B2 (en) * 2009-02-20 2013-08-06 Boston Scientific Scimed, Inc. Asymmetric dual directional steerable catheter sheath
US20100217268A1 (en) 2009-02-20 2010-08-26 University Of Utah Intervertebral milling instrument
EP2221014B1 (en) 2009-02-23 2015-05-20 Inion Oy Implant, implantation tool and kit
US8394101B2 (en) 2009-02-23 2013-03-12 Globus Medical, Inc. Discectomy instrument
TW201031381A (en) 2009-02-24 2010-09-01 Univ Nat Yang Ming The anti-subsidence dynamic coupling fixation plate for proximal femoral fracture
US20100217382A1 (en) 2009-02-25 2010-08-26 Edwards Lifesciences Mitral valve replacement with atrial anchoring
US20100217263A1 (en) 2009-02-26 2010-08-26 Thane International, Inc. Automated hair removal device
US8876812B2 (en) 2009-02-26 2014-11-04 Megadyne Medical Products, Inc. Self-limiting electrosurgical return electrode with pressure sore reduction and heating capabilities
US8021420B2 (en) 2009-03-12 2011-09-20 Medtronic Vascular, Inc. Prosthetic valve delivery system
CA2759242A1 (en) 2009-03-17 2010-09-23 Mitrassist Medical Ltd. Heart valve prosthesis with collapsible valve and method of delivery thereof
US20140057734A1 (en) 2009-03-25 2014-02-27 Clive S. Lu Grip for sporting equipment
CN101919750A (zh) 2009-03-30 2010-12-22 卡迪万蒂奇医药公司 无缝合肺动脉瓣膜或二尖瓣膜的移植方法
US9980818B2 (en) 2009-03-31 2018-05-29 Edwards Lifesciences Corporation Prosthetic heart valve system with positioning markers
US9066785B2 (en) 2009-04-06 2015-06-30 Medtronic Vascular, Inc. Packaging systems for percutaneously deliverable bioprosthetic valves
US9011522B2 (en) 2009-04-10 2015-04-21 Lon Sutherland ANNEST Device and method for temporary or permanent suspension of an implantable scaffolding containing an orifice for placement of a prosthetic or bio-prosthetic valve
US20100262157A1 (en) 2009-04-14 2010-10-14 Medtronic Vascular, Inc. Methods and Systems for Loading a Stent
WO2010121076A2 (en) 2009-04-15 2010-10-21 Cardiaq Valve Technologies, Inc. Vascular implant and delivery system
WO2010148246A2 (en) 2009-06-17 2010-12-23 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US8657870B2 (en) 2009-06-26 2014-02-25 Biosensors International Group, Ltd. Implant delivery apparatus and methods with electrolytic release
US8348998B2 (en) 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
DE102009037739A1 (de) 2009-06-29 2010-12-30 Be Innovative Gmbh Perkutan implantierbarer Klappenstent, Vorrichtung zu seiner Applizierung sowie Verfahren zur Herstellung des Klappenstents
WO2011004925A1 (ko) 2009-07-10 2011-01-13 (주)태웅메디칼 스텐트
US8439970B2 (en) 2009-07-14 2013-05-14 Edwards Lifesciences Corporation Transapical delivery system for heart valves
US8845722B2 (en) 2009-08-03 2014-09-30 Shlomo Gabbay Heart valve prosthesis and method of implantation thereof
EP2467104B1 (en) 2009-08-20 2016-11-02 Cook Medical Technologies LLC Loading apparatus and system for expandable intraluminal medical devices
US20110054515A1 (en) 2009-08-25 2011-03-03 John Bridgeman Device and method for occluding the left atrial appendage
EP2470119B1 (en) 2009-08-27 2017-05-10 Medtronic Inc. Transcatheter valve delivery systems
IN2012DN02041A (zh) 2009-08-28 2015-08-21 3F Therapeutics Inc
US9757107B2 (en) 2009-09-04 2017-09-12 Corvia Medical, Inc. Methods and devices for intra-atrial shunts having adjustable sizes
EP2633821B1 (en) 2009-09-15 2016-04-06 Evalve, Inc. Device for cardiac valve repair
CN102548508B (zh) 2009-09-21 2015-06-03 麦德托尼克公司 带支架的经导管假体心脏瓣膜输送系统及方法
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US8808369B2 (en) 2009-10-05 2014-08-19 Mayo Foundation For Medical Education And Research Minimally invasive aortic valve replacement
JP4891379B2 (ja) 2009-10-27 2012-03-07 Ｓｒｉスポーツ株式会社 ゴルフクラブ
WO2011057087A1 (en) 2009-11-05 2011-05-12 The Trustees University Of Pennsylvania Valve prosthesis
US20130190861A1 (en) 2012-01-23 2013-07-25 Tendyne Holdings, Inc. Prosthetic Valve for Replacing Mitral Valve
US8449599B2 (en) * 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
JP2013512765A (ja) 2009-12-08 2013-04-18 アヴァロン メディカル リミテッド 経カテーテル僧帽弁置換術のためのデバイスおよびシステム
AU2015230879B2 (en) 2009-12-08 2017-06-15 Avalon Medical Ltd. Device and system for transcatheter mitral valve replacement
US9504562B2 (en) 2010-01-12 2016-11-29 Valve Medical Ltd. Self-assembling modular percutaneous valve and methods of folding, assembly and delivery
US10959840B2 (en) 2010-01-20 2021-03-30 Micro Interventional Devices, Inc. Systems and methods for affixing a prosthesis to tissue
AU2011207550B2 (en) 2010-01-20 2016-03-10 Conventus Orthopaedics, Inc. Apparatus and methods for bone access and cavity preparation
US8518106B2 (en) 2010-02-17 2013-08-27 Medtronic, Inc. Catheter assembly with valve crimping accessories
US20110208293A1 (en) 2010-02-23 2011-08-25 Medtronic, Inc. Catheter-Based Heart Valve Therapy System with Sizing Balloon
US9072603B2 (en) 2010-02-24 2015-07-07 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US9522062B2 (en) 2010-02-24 2016-12-20 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
EP4129238A1 (en) 2010-03-05 2023-02-08 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
AU2011224441B2 (en) 2010-03-08 2016-02-18 Conventus Orthopaedics, Inc. Apparatus and methods for bone repair
CA2829193A1 (en) 2010-03-08 2011-09-15 Conventus Orthopaedics, Inc. Apparatus and methods for securing a bone implant
US9320597B2 (en) 2010-03-30 2016-04-26 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8652204B2 (en) 2010-04-01 2014-02-18 Medtronic, Inc. Transcatheter valve with torsion spring fixation and related systems and methods
US8491650B2 (en) 2010-04-08 2013-07-23 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with stretchable stability tube
US8926692B2 (en) 2010-04-09 2015-01-06 Medtronic, Inc. Transcatheter prosthetic heart valve delivery device with partial deployment and release features and methods
US8512400B2 (en) * 2010-04-09 2013-08-20 Medtronic, Inc. Transcatheter heart valve delivery system with reduced area moment of inertia
US8998980B2 (en) * 2010-04-09 2015-04-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8512401B2 (en) 2010-04-12 2013-08-20 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with funnel recapturing feature and method
US20110251676A1 (en) 2010-04-12 2011-10-13 Medtronic Vascular, Inc. Sheath for Controlled Delivery of a Heart Valve Prosthesis
US8579963B2 (en) 2010-04-13 2013-11-12 Medtronic, Inc. Transcatheter prosthetic heart valve delivery device with stability tube and method
US10512537B2 (en) 2010-04-16 2019-12-24 Abiomed, Inc. Flow optimized polymeric heart valve
CN101953724B (zh) 2010-04-19 2012-10-10 杭州启明医疗器械有限公司 用于装载人造瓣膜置换装置的支架固定头
CN101961273B (zh) 2010-04-19 2012-11-21 杭州启明医疗器械有限公司 带有缓冲作用的人造瓣膜置换装置及支架
CN101953725B (zh) 2010-04-19 2013-06-19 杭州启明医疗器械有限公司 人造瓣膜置换装置及支架
CN101953728B (zh) 2010-04-19 2012-09-05 杭州启明医疗器械有限公司 一种方便植入的人造瓣膜置换装置及支架
US8465541B2 (en) 2010-04-19 2013-06-18 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with expandable stability tube
CN101953723B (zh) 2010-04-19 2013-02-27 杭州启明医疗器械有限公司 一种定位稳固的人造瓣膜置换装置及支架
CN101953729B (zh) 2010-04-19 2012-10-17 杭州启明医疗器械有限公司 一种使用安全的人造瓣膜置换装置及支架
CN101961269B (zh) 2010-04-19 2012-09-05 杭州启明医疗器械有限公司 用于输送人造瓣膜置换装置的输送装置
US8740976B2 (en) 2010-04-21 2014-06-03 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with flush report
US8623075B2 (en) 2010-04-21 2014-01-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with controlled expansion of prosthetic heart valve
CN102917668B (zh) 2010-04-27 2015-01-28 美敦力公司 具有偏置释放结构的经导管假体心脏瓣膜输送装置
JP5688865B2 (ja) 2010-04-27 2015-03-25 メドトロニック，インコーポレイテッド 受動的トリガリリースを備える経カテーテル補綴心臓弁送達装置
US8579964B2 (en) * 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
AU2014203064B2 (en) 2010-05-05 2015-06-11 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
EP2569043B1 (en) 2010-05-10 2023-12-13 Edwards Lifesciences Corporation Stentless support structure
WO2011143238A2 (en) 2010-05-10 2011-11-17 Edwards Lifesciences Corporation Prosthetic heart valve
US20130204311A1 (en) 2010-05-12 2013-08-08 Helical Solutions, Inc. Implants and methods for treating cardiac arrhythmias
WO2011143468A2 (en) 2010-05-12 2011-11-17 Shifamed, Llc Low profile electrode assembly
US9603708B2 (en) 2010-05-19 2017-03-28 Dfm, Llc Low crossing profile delivery catheter for cardiovascular prosthetic implant
US11278406B2 (en) 2010-05-20 2022-03-22 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
DE102010021345A1 (de) 2010-05-22 2011-11-24 Acoredis Gmbh Occlusionsinstrument zum Verschließen des linken Herzohrs
US9561102B2 (en) 2010-06-02 2017-02-07 Medtronic, Inc. Transcatheter delivery system and method with controlled expansion and contraction of prosthetic heart valve
WO2011156714A2 (en) 2010-06-10 2011-12-15 Chambers Dr Jeffrey W Systems and methods for preventing formation of blood clots in the left atrium
US8828051B2 (en) 2010-07-02 2014-09-09 Pfm Medical Ag Left atrial appendage occlusion device
US9119717B2 (en) 2010-07-15 2015-09-01 St. Jude Medical, Inc. Retainers for transcatheter heart valve delivery systems
US9132009B2 (en) 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
US9326853B2 (en) 2010-07-23 2016-05-03 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US8696737B2 (en) 2010-08-11 2014-04-15 Hlt, Inc. Reinforced commissural support structure
US10130470B2 (en) 2010-08-17 2018-11-20 St. Jude Medical, Llc Sleeve for facilitating movement of a transfemoral catheter
JP5891228B2 (ja) 2010-08-24 2016-03-22 セント・ジュード・メディカル，インコーポレイテッド 経カテーテル心臓弁送達システム用の段階的展開装置および方法
US9039759B2 (en) 2010-08-24 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Repositioning of prosthetic heart valve and deployment
EP2444030A1 (en) 2010-08-31 2012-04-25 Biotronik AG Medical valve implant for implantation in an animal body and/or human body
WO2012031141A2 (en) 2010-09-01 2012-03-08 Maurice Buchbinder Cardiac valve support structure
US10105224B2 (en) 2010-09-01 2018-10-23 Mvalve Technologies Ltd. Cardiac valve support structure
EP4119107A3 (en) 2010-09-10 2023-02-15 Boston Scientific Limited Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device
US8641757B2 (en) 2010-09-10 2014-02-04 Edwards Lifesciences Corporation Systems for rapidly deploying surgical heart valves
EP2428189A1 (en) 2010-09-10 2012-03-14 Symetis Sa Catheter delivery system for stent valve
WO2012036744A2 (en) 2010-09-17 2012-03-22 St. Jude Medical, Cardiology Division, Inc. Improved preparation methods for transcatheter heart valve delivery systems
US9439795B2 (en) 2010-09-17 2016-09-13 St. Jude Medical, Cardiology Division, Inc. Retainers for transcatheter heart valve delivery systems
US8973234B2 (en) 2010-09-17 2015-03-10 St. Jude Medical, Cardiology Division, Inc. Assembly and method for loading a self-expanding collapsible heart valve
EP2618780B1 (en) 2010-09-20 2017-11-15 St. Jude Medical, Cardiology Division, Inc. Delivery device having a curved shaft and a straightening member for transcatheter aortic valve implantation
USD660967S1 (en) 2010-09-20 2012-05-29 St. Jude Medical, Inc. Surgical stent
USD653341S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Surgical stent
USD653342S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Stent connections
JP2013540484A (ja) 2010-09-20 2013-11-07 セント・ジュード・メディカル，カーディオロジー・ディヴィジョン，インコーポレイテッド 折畳み可能な人工弁における弁尖の取付装置
USD660433S1 (en) 2010-09-20 2012-05-22 St. Jude Medical, Inc. Surgical stent assembly
USD648854S1 (en) 2010-09-20 2011-11-15 St. Jude Medical, Inc. Commissure points
US9579193B2 (en) 2010-09-23 2017-02-28 Transmural Systems Llc Methods and systems for delivering prostheses using rail techniques
SG188528A1 (en) 2010-09-23 2013-04-30 Colibri Heart Valve Llc Percutaneously deliverable heart or blood vessel valve with frame having abluminally situated tissue membrane
EP3001978B2 (en) 2010-09-23 2023-03-01 Edwards Lifesciences CardiAQ LLC Replacement heart valve delivery device
US10321998B2 (en) 2010-09-23 2019-06-18 Transmural Systems Llc Methods and systems for delivering prostheses using rail techniques
US9161835B2 (en) 2010-09-30 2015-10-20 BioStable Science & Engineering, Inc. Non-axisymmetric aortic valve devices
EP3494928B1 (en) 2010-10-05 2020-06-17 Edwards Lifesciences Corporation Prosthetic heart valve
WO2012054776A1 (en) 2010-10-21 2012-04-26 Medtronic Inc Mitral bioprosthesis with low ventricular profile
US9072872B2 (en) * 2010-10-29 2015-07-07 Medtronic, Inc. Telescoping catheter delivery system for left heart endocardial device placement
US9186152B2 (en) 2010-11-12 2015-11-17 W. L. Gore & Associates, Inc. Left atrial appendage occlusive devices
GB201019354D0 (en) 2010-11-16 2010-12-29 Vascutek Ltd Prothesis
CN201870772U (zh) 2010-11-30 2011-06-22 孔祥清 带瓣膜定位功能的经皮主动脉瓣置换手术用输送装置
US9078750B2 (en) 2010-11-30 2015-07-14 Edwards Lifesciences Corporation Ergonomic mitral heart valve holders
CA3027755C (en) 2010-12-14 2021-05-11 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
US9579197B2 (en) 2010-12-15 2017-02-28 Medtronic Vascular, Inc. Systems and methods for positioning a heart valve using visual markers
JP6010545B2 (ja) 2010-12-23 2016-10-19 トゥエルヴ， インコーポレイテッド 僧帽弁の修復および置換のためのシステム
US8790196B2 (en) 2011-01-04 2014-07-29 Karsten Manufacturing Corporation Golf club heads with apertures and methods to manufacture golf club heads
WO2013037505A1 (en) 2011-01-11 2013-03-21 Symetis Sa Method and apparatus useful for transcatheter aortic valve implantation
EP2663258B1 (de) 2011-01-11 2018-11-21 Hans Reiner Figulla Klappenprothese zum ersatz einer artrioventrikularklappe des herzens
EP2478868A1 (en) 2011-01-25 2012-07-25 The Provost, Fellows, Foundation Scholars, and the other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Implant device
US9101808B2 (en) 2011-01-27 2015-08-11 Nike, Inc. Golf club head or other ball striking device having impact-influencing body features
US9717593B2 (en) 2011-02-01 2017-08-01 St. Jude Medical, Cardiology Division, Inc. Leaflet suturing to commissure points for prosthetic heart valve
US8932343B2 (en) 2011-02-01 2015-01-13 St. Jude Medical, Cardiology Division, Inc. Blunt ended stent for prosthetic heart valve
US20120209375A1 (en) 2011-02-11 2012-08-16 Gilbert Madrid Stability device for use with percutaneous delivery systems
EP2486894B1 (en) 2011-02-14 2021-06-09 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
GB2488530A (en) 2011-02-18 2012-09-05 David J Wheatley Heart valve
CN103687574B (zh) 2011-02-25 2015-11-25 康涅狄格州大学 人工心脏瓣膜
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US9498370B2 (en) 2011-03-07 2016-11-22 Conventus Orthopaedics, Inc. Apparatus and methods for bone repair preparation
US8602903B2 (en) 2011-04-12 2013-12-10 Kids Ii, Inc. Child support repositioning mechanism
WO2012147028A1 (en) 2011-04-28 2012-11-01 Koninklijke Philips Electronics N.V. Guided delivery of prosthetic valve
EP2520251A1 (en) 2011-05-05 2012-11-07 Symetis SA Method and Apparatus for Compressing Stent-Valves
EP2522307B1 (en) 2011-05-08 2020-09-30 ITSO Medical AB Device for delivery of medical devices to a cardiac valve
US9144494B2 (en) 2011-05-12 2015-09-29 Medtronic, Inc. Delivery catheter system with micro and macro movement control
US8945209B2 (en) 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
US20120303048A1 (en) 2011-05-24 2012-11-29 Sorin Biomedica Cardio S.R.I. Transapical valve replacement
US9289282B2 (en) 2011-05-31 2016-03-22 Edwards Lifesciences Corporation System and method for treating valve insufficiency or vessel dilatation
PL2529701T3 (pl) * 2011-06-01 2014-04-30 Nvt Ag Układ do instalowania protezy zastawki serca
CN102805654B (zh) 2011-06-01 2014-04-02 先健科技(深圳)有限公司 左心耳封堵器
US9101471B2 (en) 2011-06-13 2015-08-11 Edwards Lifesciences Corporation Systems and delivery handles for delivering prosthetic heart valves disposed on valve holders
WO2012173995A2 (en) 2011-06-15 2012-12-20 St. Jude Medical, Inc. Multi-layer stent
US8764793B2 (en) 2011-06-17 2014-07-01 Northwestern University Left atrial appendage occluder
US9011523B2 (en) 2011-06-20 2015-04-21 Jacques Seguin Prosthetic leaflet assembly for repairing a defective cardiac valve and methods of using the same
EP3964176A1 (en) 2011-06-21 2022-03-09 Twelve, Inc. Prosthetic heart valve devices
US8795357B2 (en) 2011-07-15 2014-08-05 Edwards Lifesciences Corporation Perivalvular sealing for transcatheter heart valve
CA2841952C (en) 2011-07-20 2018-07-03 Boston Scientific Scimed, Inc. Heart valve replacement
US20130023852A1 (en) 2011-07-22 2013-01-24 William Joseph Drasler Flow Protection Device
US9339384B2 (en) 2011-07-27 2016-05-17 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
EP2736450A1 (en) 2011-07-28 2014-06-04 St. Jude Medical, Inc. Expandable radiopaque marker for transcatheter aortic valve implantation
US8931159B2 (en) 2011-07-28 2015-01-13 St. Jude Medical, Cardiology Division, Inc. System for loading a collapsible heart valve
WO2013017359A1 (en) 2011-08-03 2013-02-07 Aeeg Ab Delivery device for medical implant and medical procedure
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
EP4289398A3 (en) 2011-08-11 2024-03-13 Tendyne Holdings, Inc. Improvements for prosthetic valves and related inventions
US20140288634A1 (en) 2011-09-01 2014-09-25 Endospan Ltd. Double-layer stent
US9364637B2 (en) 2011-09-06 2016-06-14 Medtronic, Inc. Transcatheter balloon-assisted mitral valve navigation device and method
US9387075B2 (en) 2011-09-12 2016-07-12 Highlife Sas Transcatheter valve prosthesis
US8956404B2 (en) 2011-09-12 2015-02-17 Highlife Sas Transcatheter valve prosthesis
US9549817B2 (en) 2011-09-22 2017-01-24 Transmural Systems Llc Devices, systems and methods for repairing lumenal systems
US9554904B2 (en) 2011-09-28 2017-01-31 Medtronic CV Luxembourg S.a.r.l. Distal tip assembly for a heart valve delivery catheter
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9039757B2 (en) 2011-10-19 2015-05-26 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
CN114903657A (zh) 2011-10-19 2022-08-16 托尔福公司 人工心脏瓣膜装置、人工二尖瓣和相关系统及方法
CA2848334C (en) 2011-10-19 2020-10-20 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9827093B2 (en) 2011-10-21 2017-11-28 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
IN2014CN03396A (zh) 2011-10-27 2015-10-09 Occlutech Holding Ag
US8858623B2 (en) 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
WO2013070896A1 (en) 2011-11-08 2013-05-16 Boston Scientific Scimed Inc. Replacement heart valve leaflet stitching method and device
WO2013071115A1 (en) 2011-11-09 2013-05-16 Boston Scientific Scimed, Inc. Occlusion device
US9592099B2 (en) 2011-11-15 2017-03-14 St. Jude Medical, Cardiology Division, Inc. Transapical collapsible valve reference fixture
EP2596754A1 (en) 2011-11-23 2013-05-29 Occlutech Holding AG Medical implant and manufacturing method thereof
EP2757962B1 (en) 2011-11-23 2017-06-07 Occlutech Holding AG Medical occlusion device
US9480558B2 (en) 2011-12-05 2016-11-01 Medtronic, Inc. Transcatheter valve having reduced seam exposure
US20130144328A1 (en) 2011-12-06 2013-06-06 Boston Scientific Scimed, Inc. Expanding distal sheath with combined embolic protection
US9168131B2 (en) 2011-12-09 2015-10-27 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
US20150018933A1 (en) 2011-12-29 2015-01-15 Beijing Percutek Therapeutics Co., Ltd. Aortic stent-graft
US20130184811A1 (en) 2012-01-13 2013-07-18 Tendyne Holdings, Inc. Device and Method for Replacing Mitral Valve
FR2985659B1 (fr) 2012-01-13 2015-03-06 Assist Publ Hopitaux De Paris Dispositif d'ancrage d'une valve cardiaque prothetique.
JP6049761B2 (ja) * 2012-01-31 2016-12-21 マイトラル・ヴァルヴ・テクノロジーズ・エス・アー・エール・エル 僧帽弁ドッキングデバイス、システム、および方法
CA2863503A1 (en) 2012-02-01 2013-08-08 Hlt, Inc. Invertible tissue valve and method
US20130304197A1 (en) 2012-02-28 2013-11-14 Mvalve Technologies Ltd. Cardiac valve modification device
US20150094802A1 (en) 2012-02-28 2015-04-02 Mvalve Technologies Ltd. Single-ring cardiac valve support
US20130274873A1 (en) 2012-03-22 2013-10-17 Symetis Sa Transcatheter Stent-Valves and Methods, Systems and Devices for Addressing Para-Valve Leakage
US11207176B2 (en) 2012-03-22 2021-12-28 Boston Scientific Scimed, Inc. Transcatheter stent-valves and methods, systems and devices for addressing para-valve leakage
GB2500432A (en) 2012-03-22 2013-09-25 Stephen Brecker Replacement heart valve with resiliently deformable securing means
US9066800B2 (en) 2012-03-28 2015-06-30 Medtronic, Inc. Dual valve prosthesis for transcatheter valve implantation
US9295547B2 (en) 2012-03-28 2016-03-29 Medtronic Vascular Galway Prosthesis for transcatheter valve implantation
US9101467B2 (en) 2012-03-30 2015-08-11 Medtronic CV Luxembourg S.a.r.l. Valve prosthesis
US9301839B2 (en) 2012-04-17 2016-04-05 Medtronic CV Luxembourg S.a.r.l. Transcatheter prosthetic heart valve delivery device with release features
US9427315B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US9011515B2 (en) 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
ITTO20120372A1 (it) 2012-04-27 2013-10-28 Marcio Scorsin Protesi valvolare cardiaca monocuspide
US9445897B2 (en) 2012-05-01 2016-09-20 Direct Flow Medical, Inc. Prosthetic implant delivery device with introducer catheter
US9532871B2 (en) 2012-05-04 2017-01-03 St. Jude Medical, Cardiology Division, Inc. Delivery system deflection mechanism
AU2013261169B2 (en) 2012-05-15 2016-05-26 Valve Medical Ltd System and method for assembling a folded percutaneous valve
US10292816B2 (en) 2012-05-20 2019-05-21 Tel Hashomer Medical Research Infrastructure And Services Ltd. Prosthetic mitral valve
EP2856972B1 (en) 2012-05-24 2019-01-16 Shanghai Cingular Biotech Corp Artificial heart valve
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
DE102012010798A1 (de) 2012-06-01 2013-12-05 Universität Duisburg-Essen Implantierbare Vorrichtung zur Verbesserung oder Behebung einer Herzklappeninsuffizienz
CZ2012376A3 (cs) 2012-06-05 2013-12-18 Institut Klinické A Experimentální Medicíny Způsob výroby perikardiální náhrady srdeční chlopně, perikardiální náhrada srdeční chlopně vyrobená tímto způsobem, zařízení pro kondicioning a modifikaci tkáně autologního perikardu pro perikardiální náhradu srdeční chlopně
US9883941B2 (en) 2012-06-19 2018-02-06 Boston Scientific Scimed, Inc. Replacement heart valve
US10413402B2 (en) 2012-06-22 2019-09-17 Pierre Squara Heart valve prostheses
US9289292B2 (en) 2012-06-28 2016-03-22 St. Jude Medical, Cardiology Division, Inc. Valve cuff support
US9615920B2 (en) 2012-06-29 2017-04-11 St. Jude Medical, Cardiology Divisions, Inc. Commissure attachment feature for prosthetic heart valve
US20140005776A1 (en) 2012-06-29 2014-01-02 St. Jude Medical, Cardiology Division, Inc. Leaflet attachment for function in various shapes and sizes
US9241791B2 (en) 2012-06-29 2016-01-26 St. Jude Medical, Cardiology Division, Inc. Valve assembly for crimp profile
US10004597B2 (en) 2012-07-03 2018-06-26 St. Jude Medical, Cardiology Division, Inc. Stent and implantable valve incorporating same
CA2875669C (en) 2012-07-12 2017-02-14 Boston Scientific Scimed, Inc. Low profile heart valve delivery system and method
CA2878167C (en) 2012-07-13 2018-03-13 Boston Scientific Scimed, Inc. Occlusion device for an atrial appendage
CN104427956B (zh) 2012-07-13 2016-09-28 波士顿科学国际有限公司 用于经导管递送的可收缩笼球人工瓣膜
US9271856B2 (en) 2012-07-25 2016-03-01 Medtronic Vascular Galway Delivery catheter with distal moving capsule for transapical prosthetic heart valve delivery
US9283072B2 (en) 2012-07-25 2016-03-15 W. L. Gore & Associates, Inc. Everting transcatheter valve and methods
US20140046436A1 (en) 2012-07-27 2014-02-13 The Regents Of The University Of California Implantable prosthetic valves and methods
US20140031951A1 (en) 2012-07-27 2014-01-30 Cook Medical Technologies Llc Two-Way Valve
WO2014022124A1 (en) 2012-07-28 2014-02-06 Tendyne Holdings, Inc. Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly
WO2014021905A1 (en) 2012-07-30 2014-02-06 Tendyne Holdings, Inc. Improved delivery systems and methods for transcatheter prosthetic valves
US9232995B2 (en) 2013-01-08 2016-01-12 Medtronic, Inc. Valve prosthesis and method for delivery
US9468525B2 (en) 2012-08-13 2016-10-18 Medtronic, Inc. Heart valve prosthesis
CN102805676B (zh) 2012-08-14 2015-06-17 杭州启明医疗器械有限公司 人造瓣膜置换装置的压缩装置
US20140057735A1 (en) 2012-08-21 2014-02-27 Ruey J. Yu Scientific golf and equipment
DE102012215108A1 (de) 2012-08-24 2014-02-27 Gewa Music Gmbh Verbindungsgelenk für eine Verbindungswelle und Verbindungswelle mit einem derartigen Verbindungsgelenk
US20140057731A1 (en) 2012-08-24 2014-02-27 Gregory N. Stephens Threaded Structures with Solder Control Features
US9717595B2 (en) 2012-09-05 2017-08-01 Medtronic Vascular Galway Trans-aortic delivery system with containment capsule centering device
EP2895108B1 (en) 2012-09-12 2017-05-31 Boston Scientific Scimed, Inc. Fixation anchor design for an occlusion device
US9610156B2 (en) 2012-09-14 2017-04-04 Millipede, Inc. Mitral valve inversion prostheses
DE102012216742A1 (de) 2012-09-19 2014-03-20 Hans-Hinrich Sievers Herzklappenprothese
EP2710985A3 (de) 2012-09-20 2016-01-13 Biotronik AG Implantat, System aus einem Implantat und einem Katheter sowie Verfahren zur Herstellung eines solchen Systems
US9295549B2 (en) 2012-10-12 2016-03-29 St. Jude Medical, Cardiology Division, Inc. Valve holder and loading integration
ES2617182T3 (es) 2012-10-19 2017-06-15 Boston Scientific Scimed, Inc. Elemento antitrómbico para dispositivos médicos implantados
US9717592B2 (en) 2012-10-29 2017-08-01 Aneumed, Inc. Personalized aortic valve prosthesis
US9023099B2 (en) 2012-10-31 2015-05-05 Medtronic Vascular Galway Limited Prosthetic mitral valve and delivery method
US9675456B2 (en) 2012-11-02 2017-06-13 Medtronic, Inc. Transcatheter valve prosthesis delivery system with recapturing feature and method
US20140135907A1 (en) 2012-11-09 2014-05-15 Medtronic CV Luxembourg S.a.r.l. Medical Device Delivery System and Methods of Delivering Medical Devices
US9408951B2 (en) 2012-11-13 2016-08-09 Boston Scientific Scimed, Inc. Nanoparticle implantation in medical devices
US20140135817A1 (en) 2012-11-14 2014-05-15 Boston Scientific Scimed, Inc. Left atrial appendage closure implant
US9144493B2 (en) 2012-11-14 2015-09-29 Medtronic Vascular Galway Limited Valve prosthesis deployment assembly and method
US20140142688A1 (en) 2012-11-20 2014-05-22 Medtronic CV Luxembourg S.a.r.l. Medical Device Delivery System and Methods of Delivering a Medical Device
EP2732796A1 (en) 2012-11-20 2014-05-21 Nakostech Sarl Mitral valve replacement system
ES2931210T3 (es) 2012-11-21 2022-12-27 Edwards Lifesciences Corp Mecanismos de retención para válvulas cardiacas protésicas
US10039638B2 (en) 2012-12-19 2018-08-07 W. L. Gore & Associates, Inc. Geometric prosthetic heart valves
US9968443B2 (en) 2012-12-19 2018-05-15 W. L. Gore & Associates, Inc. Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet
WO2014105873A1 (en) 2012-12-26 2014-07-03 Stryker Corporation Multilayer stent
WO2014106239A1 (en) 2012-12-31 2014-07-03 Boston Scientific Scimed, Inc. Medical devices having fixation anchor
US9066801B2 (en) 2013-01-08 2015-06-30 Medtronic, Inc. Valve prosthesis and method for delivery
BR112015017206A2 (pt) 2013-01-25 2017-07-11 Medtentia Int Ltd Oy sistema para reparo de válvula cardíaca
EP2948099B1 (en) 2013-01-25 2018-05-23 Medtentia International Ltd Oy Temporary atrium support device
US10105217B2 (en) 2013-01-25 2018-10-23 Medtentia International Ltd. Oy Valve for short time replacement, for taking over the function of and/or for temporary or partial support of a native valve in a heart and a method for delivery therefor
US10413401B2 (en) 2013-02-01 2019-09-17 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage component for a transcatheter valve prosthesis
US9675451B2 (en) 2013-02-01 2017-06-13 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage component for a transcatheter valve prosthesis
EP2950752B1 (en) 2013-02-04 2022-07-27 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
CN104968300A (zh) 2013-02-06 2015-10-07 西美蒂斯股份公司 人工瓣膜、输送装置和输送方法
US9168129B2 (en) 2013-02-12 2015-10-27 Edwards Lifesciences Corporation Artificial heart valve with scalloped frame design
US9456897B2 (en) 2013-02-21 2016-10-04 Medtronic, Inc. Transcatheter valve prosthesis and a concurrently delivered sealing component
CN104000672B (zh) 2013-02-25 2016-06-15 上海微创心通医疗科技有限公司 心脏瓣膜假体
US20140243954A1 (en) 2013-02-27 2014-08-28 Donald Shannon Transcatheter mitral valve prosthesis
US9387106B2 (en) 2013-02-28 2016-07-12 Medtronic Vascular, Inc. Medical device delivery systems and methods of use thereof
US9155616B2 (en) 2013-02-28 2015-10-13 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with expandable microspheres
US9844435B2 (en) 2013-03-01 2017-12-19 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve replacement
US9901470B2 (en) 2013-03-01 2018-02-27 St. Jude Medical, Cardiology Division, Inc. Methods of repositioning a transcatheter heart valve after full deployment
US10080657B2 (en) 2013-03-07 2018-09-25 Cedars-Sinai Medical Center Catheter based apical approach heart prostheses delivery system
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US9119713B2 (en) 2013-03-11 2015-09-01 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve replacement
US8986375B2 (en) 2013-03-12 2015-03-24 Medtronic, Inc. Anti-paravalvular leakage component for a transcatheter valve prosthesis
US20140277388A1 (en) 2013-03-12 2014-09-18 Aga Medical Corporation Biocompatible foam occlusion device for self-expanding heart valves
US20140277408A1 (en) 2013-03-12 2014-09-18 Boston Scientific Scimed, Inc. Prosthetic Heart Valve System
EP2967853B1 (en) * 2013-03-12 2019-11-06 Medtronic Inc. Heart valve prosthesis
US9744034B2 (en) 2013-03-12 2017-08-29 St. Jude Medical, Cardiology Division, Inc. Radiopaque transcatheter valve and anatomical markers
US10271949B2 (en) 2013-03-12 2019-04-30 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak occlusion device for self-expanding heart valves
US9339274B2 (en) 2013-03-12 2016-05-17 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak occlusion device for self-expanding heart valves
US9636222B2 (en) 2013-03-12 2017-05-02 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak protection
US9867697B2 (en) 2013-03-12 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for a paravalvular leak protection
US9333077B2 (en) 2013-03-12 2016-05-10 Medtronic Vascular Galway Limited Devices and methods for preparing a transcatheter heart valve system
JP6423851B2 (ja) 2013-03-13 2018-11-14 アーロン・ヴィ・カプラン 左心耳に空置術を行うためのデバイス
CA2910753A1 (en) 2013-03-13 2014-10-09 Aortic Innovations, Llc Dual frame stent and valve devices and implantation
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9326856B2 (en) 2013-03-14 2016-05-03 St. Jude Medical, Cardiology Division, Inc. Cuff configurations for prosthetic heart valve
EP2967855B1 (en) * 2013-03-14 2023-04-26 JC Medical, Inc. Sutureless valve prosthesis delivery device
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9439796B2 (en) 2013-03-15 2016-09-13 Cook Medical Technologies Llc Prosthesis delivery device
US10149757B2 (en) 2013-03-15 2018-12-11 Edwards Lifesciences Corporation System and method for transaortic delivery of a prosthetic heart valve
KR20220104302A (ko) 2013-03-15 2022-07-26 네비게이트 카디악 스트럭쳐스, 인크. 카테터 안내된 치환 판막 장치 및 방법
EP3357456A1 (en) 2013-03-15 2018-08-08 Symetis SA Improvements relating to transcatheter stent-valves
AU2014227955A1 (en) 2013-03-15 2015-11-12 Hlt, Inc. Low-profile prosthetic valve structure
US9993339B2 (en) 2013-03-15 2018-06-12 The Charlotte-Mecklenburg Hospital Authority Method and apparatus for therapy of mitral valve
EP2967862A4 (en) 2013-03-15 2017-05-17 Endoluminal Sciences Pty Ltd Means for controlled sealing of endovascular devices
CN114534102A (zh) 2013-03-15 2022-05-27 伊姆普兰蒂卡专利有限公司 包括电动马达和齿轮系统的可操作的植入物
CN103190968B (zh) 2013-03-18 2015-06-17 杭州启明医疗器械有限公司 一种支架以及具有该支架的安装稳固的人造瓣膜置换装置
WO2015065646A1 (en) 2013-10-28 2015-05-07 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US9486306B2 (en) 2013-04-02 2016-11-08 Tendyne Holdings, Inc. Inflatable annular sealing device for prosthetic mitral valve
US20140296969A1 (en) 2013-04-02 2014-10-02 Tendyne Holdlings, Inc. Anterior Leaflet Clip Device for Prosthetic Mitral Valve
US20140296970A1 (en) 2013-04-02 2014-10-02 Tendyne Holdings, Inc. Positioning Tool for Transcatheter Valve Delivery
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
FR3004336A1 (fr) 2013-04-12 2014-10-17 St George Medical Inc Prothese de valve cardiaque mitrale et catheter de largage associe
FR3004638B1 (fr) 2013-04-19 2015-05-29 Invalv Lab Implant, notamment destine a etre place dans une valve auriculo-ventriculaire cardiaque, comportant un systeme d'ecartement des bras proximaux
BR112015026425B1 (pt) 2013-04-19 2021-11-23 Strait Access Technologies Holdings (Pty) Ltd Prótese de válvula cardíaca, stent e folheto
WO2014178971A1 (en) 2013-05-03 2014-11-06 Cormatrix Cardiovascular, Inc. Prosthetic tissue valves and methods for anchoring same to cardiovascular structures
EP2991586A1 (en) 2013-05-03 2016-03-09 Medtronic Inc. Valve delivery tool
EP2991599A4 (en) 2013-05-03 2016-12-21 Cormatrix Cardiovascular Inc RELEASE OF A FLAP PROSTHESIS AS WELL AS MOUNTING DEVICE AND SYSTEM
US20140330373A1 (en) 2013-05-03 2014-11-06 Robert G. Matheny Reinforced Prosthetic Tissue Valves
CA2910751C (en) 2013-05-09 2021-02-23 Mitrassist Medical Ltd. Heart valve assistive prosthesis
US10188515B2 (en) 2013-05-13 2019-01-29 Medtronic Vascular Inc. Devices and methods for crimping a medical device
CN108294846A (zh) 2013-05-20 2018-07-20 托尔福公司 可植入心脏瓣膜装置、二尖瓣修复装置以及相关系统和方法
ES2908132T3 (es) 2013-05-20 2022-04-27 Edwards Lifesciences Corp Aparato de suministro de válvula cardiaca protésica
EP2999433B1 (en) 2013-05-22 2019-07-10 ValCare, Inc. Transcatheter prosthetic valve for mitral or tricuspid valve replacement
US20160120642A1 (en) 2013-05-24 2016-05-05 Valcare, Inc. Heart and peripheral vascular valve replacement in conjunction with a support ring
CN105578991B (zh) 2013-05-29 2017-11-14 M阀门技术有限公司 装配有瓣膜瓣叶心脏瓣膜支撑装置
US20140358224A1 (en) 2013-05-30 2014-12-04 Tendyne Holdlings, Inc. Six cell inner stent device for prosthetic mitral valves
US9326854B2 (en) 2013-06-13 2016-05-03 Medtronic Vascular Galway Delivery system with pacing element
US9968445B2 (en) 2013-06-14 2018-05-15 The Regents Of The University Of California Transcatheter mitral valve
US20140371844A1 (en) 2013-06-18 2014-12-18 St. Jude Medical, Cardiology Division, Inc. Transcatheter mitral valve and delivery system
CN203290964U (zh) 2013-06-19 2013-11-20 孔祥清 心内辅助定位下经心外膜套扎封闭左心耳的装置
WO2014209232A1 (en) 2013-06-25 2014-12-31 National University Of Singapore Stent member, artificial valve, and method of implanting the same
CN103431931B (zh) 2013-06-25 2015-10-28 杭州启明医疗器械有限公司 肺动脉支架及具有该肺动脉支架的肺动脉瓣膜置换装置
CN203379235U (zh) 2013-06-25 2014-01-08 杭州启明医疗器械有限公司 肺动脉支架及具有该肺动脉支架的肺动脉瓣膜置换装置
CA2914856C (en) 2013-06-25 2021-03-09 Chad Perrin Thrombus management and structural compliance features for prosthetic heart valves
US9138574B2 (en) 2013-06-26 2015-09-22 Medtronic, Inc. Anchor deployment for implantable medical devices
US9668856B2 (en) 2013-06-26 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Puckering seal for reduced paravalvular leakage
WO2014210299A1 (en) 2013-06-27 2014-12-31 Bridges Charles R Device, system, and method for implanting a prosthetic heart valve
WO2015002832A1 (en) 2013-07-01 2015-01-08 St. Jude Medical, Cardiology Division, Inc. Hybrid orientation pravalvular sealing stent
WO2015004173A1 (en) 2013-07-11 2015-01-15 Jenavalve Technology Gmbh Delivery system for transcatheter aortic valve implantation
US9414916B2 (en) 2013-07-17 2016-08-16 Medtronic Vascular Galway Adapter to actuate a delivery system
US9861474B2 (en) 2013-07-18 2018-01-09 The Trustees Of The University Of Pennsylvania Cardiac repair prosthesis sets and methods
EP2918245B1 (en) 2014-03-14 2017-05-03 Venus MedTech (HangZhou), Inc. Heart valve comprising a crown piece interconnected to leaflets, a top cuff and a bottom cuff; and a medical implant
US9895219B2 (en) 2013-07-31 2018-02-20 Medtronic Vascular Galway Mitral valve prosthesis for transcatheter valve implantation
EP2918246B1 (en) 2014-03-14 2018-08-08 Venus MedTech (HangZhou), Inc. Heart valve assembly comprising twofold sealing
CN105873545B (zh) 2013-07-31 2018-09-11 杭州启明医疗器械有限公司 包括导管及支承瓣膜的植入体的套组
EP2835112B1 (en) 2013-08-08 2021-01-27 Sorin Group Italia S.r.l. Heart valve prosthesis
SG10201805117UA (en) 2013-08-12 2018-07-30 Mitral Valve Tech Sarl Apparatus and methods for implanting a replacement heart valve
ES2782876T3 (es) 2013-08-29 2020-09-16 St Jude Medical Cardiology Div Inc Válvula transcatéter con tejido liofilizado
US20160193045A1 (en) 2013-08-29 2016-07-07 Mayo Foundation For Medical Education And Research Self-assembling percutaneously implantable heart valve
US10070857B2 (en) 2013-08-31 2018-09-11 Mitralign, Inc. Devices and methods for locating and implanting tissue anchors at mitral valve commissure
USD730521S1 (en) 2013-09-04 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Stent with commissure attachments
US9968448B2 (en) 2013-09-04 2018-05-15 St. Jude Medical, Cardiology Division, Inc. Commissure attachment features for improved delivery flexibility and tracking
USD730520S1 (en) 2013-09-04 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Stent with commissure attachments
US10195028B2 (en) 2013-09-10 2019-02-05 Edwards Lifesciences Corporation Magnetic retaining mechanisms for prosthetic valves
US9737399B2 (en) 2013-09-11 2017-08-22 Cormatrix Cardiovascular, Inc. Systems, apparatus and methods for sealing perivalvular leaks
EP3043745B1 (en) 2013-09-12 2020-10-21 St. Jude Medical, Cardiology Division, Inc. Stent designs for prosthetic heart valves
WO2015036617A2 (en) 2013-09-16 2015-03-19 Symetis Sa Method and apparatus for compressing/loading stent-valves
US9414917B2 (en) 2013-09-17 2016-08-16 Medtronic, Inc. Systems and methods for loading a valve prosthesis onto a catheter
US20150088251A1 (en) 2013-09-26 2015-03-26 San Diego State University Research Foundation Cardiac valve prosthesis
US9393111B2 (en) 2014-01-15 2016-07-19 Sino Medical Sciences Technology Inc. Device and method for mitral valve regurgitation treatment
CN105658179B (zh) 2013-10-05 2018-06-12 赛诺医疗科学技术有限公司 用于二尖瓣反流方法的装置和方法
EP2856946A1 (en) 2013-10-07 2015-04-08 Occlutech Holding AG A medical implant for occluding an opening in a body and a method of producing such a medical implant
CA2926531A1 (en) 2013-10-08 2015-04-16 Medical Research, Infrastructure And Health Services Fund Of The Tel Aviv Medical Center Cardiac prostheses and their deployment
CN203619728U (zh) 2013-10-17 2014-06-04 杭州启明医疗器械有限公司 提高安全性的肺动脉支架及肺动脉瓣膜置换装置
CN103598939A (zh) 2013-10-17 2014-02-26 杭州启明医疗器械有限公司 提高安全性的肺动脉支架及肺动脉瓣膜置换装置
US9788944B2 (en) 2013-10-21 2017-10-17 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve implantation access sheaths
US9925045B2 (en) 2013-10-21 2018-03-27 Medtronic Vascular Galway Systems, devices and methods for transcatheter valve delivery
US9050188B2 (en) 2013-10-23 2015-06-09 Caisson Interventional, LLC Methods and systems for heart valve therapy
US10646333B2 (en) 2013-10-24 2020-05-12 Medtronic, Inc. Two-piece valve prosthesis with anchor stent and valve component
US9662202B2 (en) 2013-10-24 2017-05-30 Medtronic, Inc. Heart valve prosthesis
US9414913B2 (en) 2013-10-25 2016-08-16 Medtronic, Inc. Stented prosthetic heart valve
WO2015063118A1 (en) 2013-10-28 2015-05-07 Symetis Sa Stent-valve, delivery apparatus and method of use
US9526611B2 (en) 2013-10-29 2016-12-27 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US9629653B2 (en) 2013-11-01 2017-04-25 Cook Medical Technologies Llc Looped wire catheter and method
CN105873633B (zh) 2013-11-06 2019-08-27 贝克顿·迪金森有限公司 用于医疗设备的连接装置
WO2015069683A1 (en) 2013-11-06 2015-05-14 St. Jude Medical, Cardiology Division, Inc. Reduced profile prosthetic heart valve
US9913715B2 (en) 2013-11-06 2018-03-13 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
WO2015073287A1 (en) 2013-11-12 2015-05-21 St. Jude Medical, Cardiology Division, Inc. Pneumatically power-assisted tavi delivery system
US9839765B2 (en) 2013-11-12 2017-12-12 St. Jude Medical, Cardiology Division, Inc. Transfemoral mitral valve repair delivery device
WO2015077274A1 (en) 2013-11-19 2015-05-28 St. Jude Medical, Cardiology Division, Inc. Sealing structures for paravalvular leak protection
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
US20150173898A1 (en) 2013-12-03 2015-06-25 William Joseph Drasler Transcatheter Mitral Valve Replacement Apparatus
US10098734B2 (en) 2013-12-05 2018-10-16 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
CN103610520B (zh) 2013-12-05 2016-08-17 杭州启明医疗器械有限公司 一种人工心脏瓣膜持握器
CN203677318U (zh) 2013-12-05 2014-07-02 杭州启明医疗器械有限公司 一种人工心脏瓣膜持握器
EP3079633B1 (en) 2013-12-11 2023-01-18 Cedars-Sinai Medical Center Devices for transcatheter mitral valve replacement in a double-orifice mitral valve
WO2015089357A2 (en) 2013-12-12 2015-06-18 Conventus Orthopaedics, Inc. Tissue displacement tools and methods
US9901444B2 (en) 2013-12-17 2018-02-27 Edwards Lifesciences Corporation Inverted valve structure
ES2771900T3 (es) 2013-12-19 2020-07-07 St Jude Medical Cardiology Div Inc Fijaciones de valva-manguito para válvula cardíaca protésica
CN106456182B (zh) 2013-12-20 2021-04-09 泰尔茂株式会社 血管闭塞装置
US9730701B2 (en) 2014-01-16 2017-08-15 Boston Scientific Scimed, Inc. Retrieval wire centering device
EP2896387A1 (en) 2014-01-20 2015-07-22 Mitricares Heart valve anchoring device
US9820852B2 (en) 2014-01-24 2017-11-21 St. Jude Medical, Cardiology Division, Inc. Stationary intra-annular halo designs for paravalvular leak (PVL) reduction—active channel filling cuff designs
US9750603B2 (en) 2014-01-27 2017-09-05 Medtronic Vascular Galway Stented prosthetic heart valve with variable stiffness and methods of use
US10258343B2 (en) 2014-01-27 2019-04-16 Lifetech Scientific (Shenzhen) Co. Ltd. Left atrial appendage occluder
US9867556B2 (en) 2014-02-07 2018-01-16 St. Jude Medical, Cardiology Division, Inc. System and method for assessing dimensions and eccentricity of valve annulus for trans-catheter valve implantation
US10292711B2 (en) * 2014-02-07 2019-05-21 St. Jude Medical, Cardiology Division, Inc. Mitral valve treatment device having left atrial appendage closure
US9986993B2 (en) 2014-02-11 2018-06-05 Tendyne Holdings, Inc. Adjustable tether and epicardial pad system for prosthetic heart valve
US9072604B1 (en) 2014-02-11 2015-07-07 Gilberto Melnick Modular transcatheter heart valve and implantation method
JP2017506118A (ja) 2014-02-20 2017-03-02 マイトラル・ヴァルヴ・テクノロジーズ・エス・アー・エール・エル 人工心臓弁を支持するためのコイル状アンカー、人工心臓弁、および展開デバイス
MX2016010303A (es) 2014-02-21 2017-04-27 Mitral Valve Tech Sarl Dispositivos, sistemas y metodos de suministro de valvula mitral prostetica y dispositivo de anclaje.
US9763779B2 (en) 2014-03-11 2017-09-19 Highlife Sas Transcatheter valve prosthesis
US10064719B2 (en) 2014-03-11 2018-09-04 Highlife Sas Transcatheter valve prosthesis
US9889003B2 (en) 2014-03-11 2018-02-13 Highlife Sas Transcatheter valve prosthesis
US9687343B2 (en) 2014-03-11 2017-06-27 Highlife Sas Transcatheter valve prosthesis
EP2918248A1 (en) 2014-03-11 2015-09-16 Epygon Sasu An expandable stent-valve and a delivery device
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
EP2921139B1 (en) 2014-03-18 2018-11-21 Nvt Ag Heartvalve implant
WO2015143103A1 (en) 2014-03-21 2015-09-24 St. Jude Medical, Cardiology Division, Inc. Leaflet abrasion mitigation
US20150272737A1 (en) 2014-03-26 2015-10-01 St. Jude Medical, Cardiology Division, Inc. Transcatheter mitral valve stent frames
WO2015152980A1 (en) 2014-03-31 2015-10-08 St. Jude Medical, Cardiology Division, Inc. Paravalvular sealing via extended cuff mechanisms
US10149758B2 (en) 2014-04-01 2018-12-11 Medtronic, Inc. System and method of stepped deployment of prosthetic heart valve
PL2929860T3 (pl) 2014-04-07 2018-01-31 Nvt Ag Urządzenie do wszczepiania w serce ssaka
GB2525005B (en) 2014-04-09 2016-03-09 Cook Medical Technologies Llc Delivery system for implantable medical device
EP3131504B1 (en) 2014-04-14 2023-03-15 St. Jude Medical, Cardiology Division, Inc. Leaflet abrasion mitigation in prosthetic heart valves
CN106170270B (zh) 2014-04-17 2019-09-17 美敦力瓦斯科尔勒戈尔韦公司 铰接的经导管假体关节心脏瓣膜递送系统
US10321987B2 (en) 2014-04-23 2019-06-18 Medtronic, Inc. Paravalvular leak resistant prosthetic heart valve system
US9585752B2 (en) 2014-04-30 2017-03-07 Edwards Lifesciences Corporation Holder and deployment system for surgical heart valves
EP3714839B1 (en) 2014-05-06 2024-06-12 DSM IP Assets B.V. Prosthetic valve and method of making a prosthetic valve
US10195025B2 (en) 2014-05-12 2019-02-05 Edwards Lifesciences Corporation Prosthetic heart valve
EP3142604B1 (en) 2014-05-16 2024-01-10 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve with paravalvular leak sealing ring
EP3257473A1 (en) 2014-05-16 2017-12-20 St. Jude Medical, Cardiology Division, Inc. Stent assembly for use in prosthetic heart valves
US10130467B2 (en) 2014-05-16 2018-11-20 St. Jude Medical, Cardiology Division, Inc. Subannular sealing for paravalvular leak protection
CA2986584A1 (en) 2014-05-21 2015-11-26 The Royal Institution For The Advancement Of Learning/Mcgill University Methods and systems for anatomical structure and transcatheter device visualization
EP3145450B1 (en) 2014-05-22 2019-07-17 St. Jude Medical, Cardiology Division, Inc. Stents with anchoring sections
FR3021208B1 (fr) 2014-05-23 2021-03-12 Thomas Modine Prothese de valve cardiaque mitrale ou tricuspide
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
EP2954875B1 (en) 2014-06-10 2017-11-15 St. Jude Medical, Cardiology Division, Inc. Stent cell bridge for cuff attachment
US10111749B2 (en) 2014-06-11 2018-10-30 Medtronic Vascular, Inc. Prosthetic valve with flow director
WO2015189307A1 (en) 2014-06-11 2015-12-17 Occlutech Holding Ag Left atrial appendage occluder
US9974647B2 (en) 2014-06-12 2018-05-22 Caisson Interventional, LLC Two stage anchor and mitral valve assembly
US20150366690A1 (en) 2014-06-23 2015-12-24 Abbott Cardiovascular Systems Inc. Stent delivery system with anchoring guide wire and method for deploying a self-expanding stent
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
US10195026B2 (en) 2014-07-22 2019-02-05 Edwards Lifesciences Corporation Mitral valve anchoring
US10524910B2 (en) 2014-07-30 2020-01-07 Mitraltech Ltd. 3 Ariel Sharon Avenue Articulatable prosthetic valve
EP2982336A1 (en) 2014-08-04 2016-02-10 Alvimedica Tibb Ürünler San. Ve Dis Tic. A.S. Mitral valve prosthesis, particularly suitable for transcatheter implantation
US20160038283A1 (en) 2014-08-06 2016-02-11 The University Of Iowa Research Foundation Systems and methods utilizing expandable transcatheter valve
JP2017525534A (ja) 2014-08-15 2017-09-07 ディーエフエム、 エルエルシー 人工インプラント送出デバイス
US20160045306A1 (en) 2014-08-18 2016-02-18 Boston Scientific Scimed, Inc. Cut pattern transcatheter valve frame
US10058424B2 (en) 2014-08-21 2018-08-28 Edwards Lifesciences Corporation Dual-flange prosthetic valve frame
US9877832B2 (en) 2014-08-22 2018-01-30 Medtronic Vascular, Inc. Rapid exchange transcatheter valve delivery system
US20170281193A1 (en) 2014-08-26 2017-10-05 Mayo Foundation For Medical Education And Research Closure and ablation of body viscera and conduits
US10016272B2 (en) 2014-09-12 2018-07-10 Mitral Valve Technologies Sarl Mitral repair and replacement devices and methods
US9827094B2 (en) 2014-09-15 2017-11-28 W. L. Gore & Associates, Inc. Prosthetic heart valve with retention elements
TWI789782B (zh) 2014-09-17 2023-01-11 美商亞提歐醫藥公司 醫療系統
ES2676060T3 (es) 2014-09-26 2018-07-16 Nvt Ag Dispositivo implantable para el tratamiento de la regurgitación de la válvula mitral
CN204133530U (zh) 2014-09-29 2015-02-04 上海形状记忆合金材料有限公司 左心耳封堵器
US10390950B2 (en) 2014-10-03 2019-08-27 St. Jude Medical, Cardiology Division, Inc. Flexible catheters and methods of forming same
US20160095701A1 (en) 2014-10-07 2016-04-07 St. Jude Medical, Cardiology Division, Inc. Bi-Leaflet Mitral Valve Design
CN104352261B (zh) 2014-10-13 2017-11-03 深圳市科奕顿生物医疗科技有限公司 左心耳封堵器
US9999504B2 (en) 2014-10-13 2018-06-19 Hlt, Inc. Inversion delivery device and method for a prosthesis
CN204181679U (zh) 2014-10-13 2015-03-04 陈奕龙 左心耳封堵器
US10507101B2 (en) 2014-10-13 2019-12-17 W. L. Gore & Associates, Inc. Valved conduit
EP3009104B1 (en) 2014-10-14 2019-11-20 St. Jude Medical, Cardiology Division, Inc. Flexible catheter and methods of forming same
US9750607B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9750605B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
CN104287804B (zh) 2014-10-27 2017-02-22 梁巧英 一种生物腔体封堵装置
US10213307B2 (en) 2014-11-05 2019-02-26 Medtronic Vascular, Inc. Transcatheter valve prosthesis having an external skirt for sealing and preventing paravalvular leakage
US20160120643A1 (en) 2014-11-05 2016-05-05 Tara Kupumbati Transcatheter cardiac valve prosthetic
WO2016077783A1 (en) 2014-11-14 2016-05-19 Cedars-Sinai Medical Center Cardiovascular access and device delivery system
US9901445B2 (en) 2014-11-21 2018-02-27 Boston Scientific Scimed, Inc. Valve locking mechanism
CN105596052A (zh) 2014-11-22 2016-05-25 常州乐奥医疗科技有限公司 一种笼式左心耳封堵器
CN105615936A (zh) 2014-11-22 2016-06-01 常州乐奥医疗科技有限公司 一种新型左心耳封堵器
CN204318826U (zh) 2014-11-22 2015-05-13 常州乐奥医疗科技有限公司 一种新型笼式左心耳封堵器
CN204246182U (zh) 2014-11-22 2015-04-08 常州乐奥医疗科技有限公司 一种新型伞状左心耳封堵器
CN106999281B (zh) 2014-11-26 2020-05-05 爱德华兹生命科学公司 经导管人工心脏瓣膜和递送系统
US20190069949A1 (en) 2014-12-03 2019-03-07 Metavention, Inc. Systems and methods for modulatng nerves or other tissue
EP3028668A1 (en) 2014-12-05 2016-06-08 Nvt Ag Prosthetic heart valve system and delivery system therefor
AU2015361260B2 (en) 2014-12-09 2020-04-23 Cephea Valve Technologies, Inc. Replacement cardiac valves and methods of use and manufacture
US20160158011A1 (en) 2014-12-09 2016-06-09 Didier De Canniere Intracardiac device to correct mitral regurgitation
US9517131B2 (en) 2014-12-12 2016-12-13 Than Nguyen Cardiac valve repair device
WO2016100799A1 (en) 2014-12-18 2016-06-23 Medtronic Inc. Transcatheter prosthetic heart valve delivery system with clinician feedback
US9937037B2 (en) 2014-12-18 2018-04-10 W. L. Gore & Associates, Inc. Prosthetic valved conduits with mechanically coupled leaflets
AU2016205371B2 (en) 2015-01-07 2019-10-10 Tendyne Holdings, Inc. Prosthetic mitral valves and apparatus and methods for delivery of same
US10383726B2 (en) 2015-01-13 2019-08-20 George Kramer Implantable transcatheter intracardiac devices and methods for treating incompetent atrioventricular valves
US9579195B2 (en) 2015-01-13 2017-02-28 Horizon Scientific Corp. Mitral bileaflet valve
US9861477B2 (en) 2015-01-26 2018-01-09 Boston Scientific Scimed Inc. Prosthetic heart valve square leaflet-leaflet stitch
US10478297B2 (en) 2015-01-27 2019-11-19 Medtronic Vascular, Inc. Delivery system having an integral centering mechanism for positioning a valve prosthesis in situ
CA3162308A1 (en) 2015-02-05 2016-08-11 Cardiovalve Ltd. Prosthetic valve with axially-sliding frames
EP3253331B1 (en) 2015-02-05 2021-04-07 Tendyne Holdings, Inc. Prosthetic heart valve with tether and expandable epicardial pad
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
US10231834B2 (en) 2015-02-09 2019-03-19 Edwards Lifesciences Corporation Low profile transseptal catheter and implant system for minimally invasive valve procedure
US10039637B2 (en) 2015-02-11 2018-08-07 Edwards Lifesciences Corporation Heart valve docking devices and implanting methods
US10251748B2 (en) 2015-02-12 2019-04-09 Medtronic Vascular, Inc. Centering devices for use with a valve prosthesis delivery system and methods of use thereof
US20160235525A1 (en) 2015-02-12 2016-08-18 Medtronic, Inc. Integrated valve assembly and method of delivering and deploying an integrated valve assembly
CN204683686U (zh) 2015-02-15 2015-10-07 上海形状记忆合金材料有限公司 一种左心耳封堵装置及封堵系统
CN104688292B (zh) 2015-02-15 2017-08-25 上海形状记忆合金材料有限公司 一种左心耳封堵装置及封堵系统
EP3258886B1 (en) 2015-02-17 2023-03-29 Medtronic Vascular Inc. Catheter for anchoring a heart valve prosthesis
US20160235530A1 (en) 2015-02-18 2016-08-18 St. Jude Medical, Cardiology Division, Inc. Introducer sheath for transcatheter heart valve delivery
US10285809B2 (en) 2015-03-06 2019-05-14 Boston Scientific Scimed Inc. TAVI anchoring assist device
WO2016145250A1 (en) 2015-03-12 2016-09-15 Cedars-Sinai Medical Center Devices, systems, and methods to optimize annular orientation of transcatheter valves
US10080652B2 (en) 2015-03-13 2018-09-25 Boston Scientific Scimed, Inc. Prosthetic heart valve having an improved tubular seal
US10231827B2 (en) 2015-03-18 2019-03-19 Medtronic Vascular, Inc. Valve prostheses having an integral centering mechanism and methods of use thereof
CA2980163A1 (en) 2015-03-19 2016-09-22 Caisson Interventional, LLC Systems and methods for heart valve therapy
EP4353203A3 (en) 2015-03-20 2024-07-03 JenaValve Technology, Inc. Heart valve prosthesis delivery system
US10070954B2 (en) 2015-03-24 2018-09-11 St. Jude Medical, Cardiology Division, Inc. Mitral heart valve replacement
CN204581598U (zh) 2015-03-26 2015-08-26 杭州启明医疗器械有限公司 减小压缩长度的瓣膜支架及具有该支架的瓣膜置换装置
CN104720936B (zh) 2015-03-26 2017-07-07 杭州启明医疗器械有限公司 使用安全的瓣膜支架以及具有该瓣膜支架的瓣膜置换装置
CN204581599U (zh) 2015-03-26 2015-08-26 杭州启明医疗器械有限公司 使用安全的瓣膜支架以及具有该瓣膜支架的瓣膜置换装置
EP3280359A1 (en) 2015-04-07 2018-02-14 St. Jude Medical, Cardiology Division, Inc. System and method for intraprocedural assessment of geometry and compliance of valve annulus for trans-catheter valve implantation
DE102015004246A1 (de) 2015-04-07 2016-10-13 Coramaze Technologies Gmbh System zur Applikation eines Implantates, Implantat und Applikationsvorrichtung
US10314696B2 (en) 2015-04-09 2019-06-11 Boston Scientific Scimed, Inc. Prosthetic heart valves having fiber reinforced leaflets
US10368986B2 (en) 2015-04-15 2019-08-06 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method
US10010417B2 (en) 2015-04-16 2018-07-03 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
JP6694948B2 (ja) 2015-04-16 2020-05-20 テンダイン ホールディングス，インコーポレイテッド 経カテーテル人工弁の送達、再配置及び回収のための装置及び方法
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
DE102015005933A1 (de) 2015-05-12 2016-11-17 Coramaze Technologies Gmbh Implantierbare Vorrichtung zur Verbesserung oder Behebung einer Herzklappeninsuffizienz
DE102015005934A1 (de) 2015-05-12 2016-11-17 Coramaze Technologies Gmbh Implantierbare Vorrichtung zur Verbesserung oder Behebung einer Herzklappeninsuffizienz
EP3294219B1 (en) 2015-05-14 2020-05-13 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US10052202B2 (en) 2015-05-25 2018-08-21 Venus Medtech (Hangzhou) Inc Transcatheter pulmonary ball valve assembly
US20160346081A1 (en) 2015-05-25 2016-12-01 Horizon Scientific Corp. Transcatheter Pulmonary Ball Valve Assembly
EP3307207A1 (en) 2015-06-12 2018-04-18 St. Jude Medical, Cardiology Division, Inc. Heart valve repair and replacement
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
US9713520B2 (en) 2015-06-29 2017-07-25 Ethicon, Inc. Skirted tissue repair implant having position indication feature
US10639149B2 (en) 2015-07-16 2020-05-05 St. Jude Medical, Cardiology Division, Inc. Sutureless prosthetic heart valve
US10327892B2 (en) 2015-08-11 2019-06-25 Boston Scientific Scimed Inc. Integrated adaptive seal for prosthetic heart valves
US11026788B2 (en) 2015-08-20 2021-06-08 Edwards Lifesciences Corporation Loader and retriever for transcatheter heart valve, and methods of crimping transcatheter heart valve
US10238490B2 (en) 2015-08-21 2019-03-26 Twelve, Inc. Implant heart valve devices, mitral valve repair devices and associated systems and methods
US10195023B2 (en) 2015-09-15 2019-02-05 Boston Scientific Scimed, Inc. Prosthetic heart valves including pre-stressed fibers
US10327894B2 (en) 2015-09-18 2019-06-25 Tendyne Holdings, Inc. Methods for delivery of prosthetic mitral valves
WO2017061956A1 (en) 2015-10-08 2017-04-13 National University Of Singapore A naturally designed mitral prosthesis
US9872765B2 (en) 2015-10-12 2018-01-23 Venus Medtech (Hangzhou) Inc Mitral valve assembly
CA3001338A1 (en) 2015-10-14 2017-04-20 Heart Repair Technologies, Inc. Transvalvular intraannular band for mitral valve repair
US11154239B2 (en) 2015-10-21 2021-10-26 Autonomix Medical, Inc. Controlled and precise treatment of cardiac tissues
FR3043907A1 (fr) 2015-11-23 2017-05-26 Alain Dibie Assemblage pour le remplacement de la valve atrio-ventriculaire tricuspide
EP3383258B1 (en) 2015-12-01 2019-06-05 Koninklijke Philips N.V. Device, system and method for determining vital sign information of a subject
EP3389566B1 (en) 2015-12-14 2024-05-08 Medtronic Vascular, Inc. Devices for transcatheter valve loading and implantation
ITUB20159133A1 (it) 2015-12-15 2017-06-15 Innovheart S R L Protesi per valvola cardiaca
PL3184081T3 (pl) * 2015-12-22 2021-10-04 Medira Ag Urządzenie protetyczne do wspomagania koaptacji zastawki mitralnej
CN106913408B (zh) 2015-12-28 2018-10-26 先健科技(深圳)有限公司 输送系统及管腔支架系统
CN205286438U (zh) 2015-12-30 2016-06-08 郭利斌 左心耳封堵器
WO2017147140A1 (en) 2016-02-22 2017-08-31 Conventus Orthopaedics, Inc. Apparatus and methods for spine and sacroiliac joint repair
EP3423005A4 (en) 2016-03-01 2019-11-13 Paul A. Spence SYSTEM, DEVICES AND METHODS FOR ANCHORING AND / OR SEALING A CARDIAC VALVES PROSTHESIS
US10405974B2 (en) 2016-04-26 2019-09-10 Boston Scientific Scimed, Inc. Replacement heart valve with improved stitching
WO2017194504A1 (en) 2016-05-09 2017-11-16 Qvanteq Ag Arrangement for storing and loading a self-expanding stent-like device
EP4183371A1 (en) 2016-05-13 2023-05-24 JenaValve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
JP6916814B2 (ja) 2016-05-16 2021-08-11 バルブ メディカル リミテッド 反転臨時弁シース
EP3457989B1 (en) 2016-05-19 2021-09-29 Boston Scientific Scimed, Inc. Prosthetic valves, valve leaflets and related methods
EP3484411A1 (en) 2016-07-12 2019-05-22 Tendyne Holdings, Inc. Apparatus and methods for trans-septal retrieval of prosthetic heart valves
US11096781B2 (en) 2016-08-01 2021-08-24 Edwards Lifesciences Corporation Prosthetic heart valve
US10828152B2 (en) 2016-08-11 2020-11-10 4C Medical Technologies, Inc. Heart chamber prosthetic valve implant with base, spring and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function
WO2018039543A1 (en) 2016-08-26 2018-03-01 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
CA3034006A1 (en) 2016-08-26 2018-03-01 Edwards Lifesciences Corporation Multi-portion replacement heart valve prosthesis
US10874512B2 (en) 2016-10-05 2020-12-29 Cephea Valve Technologies, Inc. System and methods for delivering and deploying an artificial heart valve within the mitral annulus
US10702408B2 (en) 2016-10-31 2020-07-07 Cook Medical Technologies Llc Suture esophageal stent introducer
US10492907B2 (en) 2016-11-07 2019-12-03 Medtronic Vascular, Inc. Valve delivery system
US10835401B2 (en) 2016-12-29 2020-11-17 Boston Scientific Scimed, Inc. Hydration delivery system for stents
CN108261255B (zh) 2016-12-30 2020-12-25 先健科技(深圳)有限公司 人工心脏瓣膜装置及其瓣叶和支架主体
WO2018132503A1 (en) 2017-01-10 2018-07-19 Conventus Orthopaedics, Inc. Articular surface repair
US10653523B2 (en) 2017-01-19 2020-05-19 4C Medical Technologies, Inc. Systems, methods and devices for delivery systems, methods and devices for implanting prosthetic heart valves
EP4209196A1 (en) 2017-01-23 2023-07-12 Cephea Valve Technologies, Inc. Replacement mitral valves
US10561495B2 (en) 2017-01-24 2020-02-18 4C Medical Technologies, Inc. Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve
EP3573579B1 (en) 2017-01-27 2023-12-20 JenaValve Technology, Inc. Heart valve mimicry
US10932909B2 (en) 2017-02-07 2021-03-02 Shanghai Joy Medical Devices Co., Ltd Device for treating regurgitation of tricuspid and implantation method therefor
CN107007887B (zh) 2017-02-27 2020-10-02 杭州启明医疗器械股份有限公司 一种交联人工生物瓣膜及其制备方法
CN106913909B (zh) 2017-02-27 2020-09-01 杭州启明医疗器械股份有限公司 一种干燥人工生物瓣膜及其制备方法
CN109561961B (zh) 2017-04-07 2021-02-23 上海甲悦医疗器械有限公司 一种人工瓣膜及人工瓣膜植入方法
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US10973634B2 (en) 2017-04-26 2021-04-13 Edwards Lifesciences Corporation Delivery apparatus for a prosthetic heart valve
CA3063604A1 (en) 2017-05-15 2018-11-22 Hlt, Inc. Valve sealing tissue and mesh structure
US20180360602A1 (en) 2017-06-14 2018-12-20 4C Medical Technologies, Inc. Delivery of heart chamber prosthetic valve implant
SG11201913126YA (en) 2017-06-30 2020-01-30 Edwards Lifesciences Corp Lock and release mechanisms for trans-catheter implantable devices
CA3068313A1 (en) 2017-06-30 2019-01-03 Edwards Lifesciences Corporation Docking stations for transcatheter valves
WO2019010252A2 (en) 2017-07-04 2019-01-10 Conventus Orthopaedics, Inc. APPARATUS AND METHODS FOR TREATING BONES
WO2019028264A1 (en) 2017-08-03 2019-02-07 The Regents Of The University Of California AURICULAR CAGE FOR THE PLACEMENT, FASTENING AND ANCHORING OF ATRIOVENTRICULAR VALVES
US10856971B2 (en) 2017-08-18 2020-12-08 Edwards Lifesciences Corporation Sealing members for prosthetic heart valve
US20190201192A1 (en) 2018-01-02 2019-07-04 4C Medical Technologies, Inc. Stent features and methods to aid with apposition and alignment to native anatomy, mitigation of paravalvular leak and functional efficiency of prosthetic heart valve
US10874513B2 (en) 2018-02-12 2020-12-29 4C Medical Technologies, Inc. Expandable frames and paravalvular leak mitigation systems for implantable prosthetic heart valve devices
WO2019170698A1 (en) 2018-03-08 2019-09-12 Symetis Sa Implantable valve with attached polymeric components
US20190365538A1 (en) 2018-06-04 2019-12-05 4C Medical Technologies, Inc. Devices, systems and methods for preventing prolapse of native cardiac valve leaflets
US11351028B2 (en) 2018-09-04 2022-06-07 4C Medical Technologies, Inc. Stent loading device with fluid reservoir
US11857441B2 (en) 2018-09-04 2024-01-02 4C Medical Technologies, Inc. Stent loading device
US11000000B2 (en) 2018-09-14 2021-05-11 4C Medical Technologies, Inc. Repositioning wires and methods for repositioning prosthetic heart valve devices within a heart chamber and related systems, devices and methods
WO2020146684A2 (en) 2019-01-09 2020-07-16 Conventus Orthopaedics, Inc. Apparatus and methods for bone treatment
US20200261219A1 (en) 2019-02-14 2020-08-20 4C Medical Technologies, Inc. Hydrophilic skirt for paravalvular leak mitigation and fit and apposition optimization for prosthetic heart valve implants
US11452628B2 (en) 2019-04-15 2022-09-27 4C Medical Technologies, Inc. Loading systems for collapsible prosthetic heart valve devices and methods thereof
US20200375733A1 (en) 2019-05-30 2020-12-03 4C Medical Technologies, Inc. Devices, systems and methods for collapsible and expandable implant loading, transseptal delivery, positioning deployment and repositioning deployment
CN114502105A (zh) 2019-10-03 2022-05-13 楚利福医疗有限公司 对接元件
US20210236274A1 (en) 2020-01-31 2021-08-05 4C Medical Technologies, Inc. Prosthetic heart valve delivery system: paddle attachment feature
US11931253B2 (en) 2020-01-31 2024-03-19 4C Medical Technologies, Inc. Prosthetic heart valve delivery system: ball-slide attachment
US20210275301A1 (en) 2020-03-05 2021-09-09 4C Medical Technologies, Inc. Prosthetic mitral valve with improved atrial and/or annular apposition and paravalvular leakage mitigation
US11992403B2 (en) 2020-03-06 2024-05-28 4C Medical Technologies, Inc. Devices, systems and methods for improving recapture of prosthetic heart valve device with stent frame having valve support with inwardly stent cells

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020072710A1 (en) * 2000-12-08 2002-06-13 Medtronic, Inc. Medical device delivery catheter with distal locator
US20080234814A1 (en) * 2003-12-23 2008-09-25 Sadra Medical, Inc. Low Profile Heart Valve and Delivery System
US20130238089A1 (en) * 2006-06-28 2013-09-12 Kardium Inc. Method for anchoring a mitral valve
US20140276395A1 (en) * 2008-06-13 2014-09-18 Cardiosolutions Inc. Steerable Catheter and Dilator and System and Method for Implanting a Heart Implant
CN102985033A (zh) * 2010-02-25 2013-03-20 耶拿阀门科技公司 用于瓣膜假体在病人心脏中的植入部位的定位和锚定的支架
CN104302247A (zh) * 2011-11-23 2015-01-21 内奥瓦斯克迪亚拉公司 依次展开的经导管二尖瓣假体
CN105101911A (zh) * 2013-03-15 2015-11-25 托尔福公司 人造心瓣装置、人造二尖瓣以及相关系统和方法
US20160242905A1 (en) * 2015-02-20 2016-08-25 4C Medical Technologies, Inc. Devices, systems and methods for cardiac treatment
CN104720937A (zh) * 2015-03-26 2015-06-24 杭州启明医疗器械有限公司 减小压缩长度的瓣膜支架及具有该瓣膜支架的瓣膜置换装置
WO2016186909A1 (en) * 2015-05-18 2016-11-24 Mayo Foundation For Medical Education And Research Percutaneously-deployable prosthetic tricuspid valve

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113855334A (zh) * 2021-10-26 2021-12-31 金仕生物科技（常熟）有限公司 预压弯远端外管及输送系统

Also Published As

Publication number Publication date
JP2020505117A (ja) 2020-02-20
US20200276013A1 (en) 2020-09-03
EP3570783A1 (en) 2019-11-27
AU2018210336B2 (en) 2019-09-12
US20200222179A1 (en) 2020-07-16
CA3050113A1 (en) 2018-07-26
AU2019280018B2 (en) 2021-10-28
CN115068170A (zh) 2022-09-20
EP3570783A4 (en) 2020-07-15
US20180200049A1 (en) 2018-07-19
CN110198683B (zh) 2022-04-01
AU2019280018A1 (en) 2020-01-16
WO2018136726A1 (en) 2018-07-26
CA3050113C (en) 2021-03-30
US10653523B2 (en) 2020-05-19
US11957577B2 (en) 2024-04-16

Similar Documents

Publication Publication Date Title
CN110198683A (zh) 用于植入假体心脏瓣膜的输送系统、方法和装置的系统、方法和装置
CN111200995B (zh) 用于心脏瓣膜的假体间隔件装置
US11116636B2 (en) Device for the deployment of a system of guide wires within a cardiac chamber for implanting a prosthetic heart valve
AU2018200730B2 (en) A prosthetic system for heart valve replacement
KR102213051B1 (ko) 인공 보철 심장 판막을 이식하기 위해 심방실 내에 가이드 와이어들의 시스템을 전개하는 전개 장치
CN109152641A (zh) 具有隔膜孔闭合末端组件的经导管瓣膜递送系统
CN106714734A (zh) 双凸缘人工瓣膜框架
CN110225728A (zh) 用于假体心脏瓣膜的两步式输送和植入的系统、方法和装置
US11000000B2 (en) Repositioning wires and methods for repositioning prosthetic heart valve devices within a heart chamber and related systems, devices and methods
WO2014080339A1 (en) Prosthetic system for heart valve replacement
TW202017538A (zh) 具有流體儲槽之支架裝載裝置
WO2023216812A1 (zh) 人工瓣膜及经导管人工瓣膜置换系统

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant